Cardio-oncology clinical assessment and screening in patients undergoing high toxicity chemotherapy: a retrospective cohort study / Andrés Felipe Miranda Arboleda ; Juan Guillermo Gamboa Arroyave    

Público ISBD Título : Cardio-oncology clinical assessment and screening in patients undergoing high toxicity chemotherapy: a retrospective cohort study Tipo de documento : documento electrónico Autores : Andrés Felipe Miranda Arboleda, ; Juan Guillermo Gamboa Arroyave, Fecha de publicación : 2022 Títulos uniformes : Cureus Idioma : Inglés (eng) Palabras clave : cardio-oncology  solid tumors  hematological malignancies  chemotherapy  cardiotoxicity Resumen : Objective: To describe the clinical characteristics and cardio-oncological assessment in patients undertaking highly toxic chemotherapy and/or chest radiotherapy in a high-complexity hospital. Methods: A single-center retrospective cohort study was carried out between January 1st, 2017 and December 31st, 2019. The medical records of patients with solid or hematological neoplasms were reviewed. Descriptive information was obtained on demographic characteristics, chemotherapeutic agents, pre-chemotherapy cardiovascular (CV) evaluation, and CV outcomes. The risk of complications was assessed using the Mayo Clinic risk score. Results: A total of 499 patients were included, the most common neoplasm was non-Hodgkin's lymphoma (21.6%), followed by breast cancer (19.4%). A very high risk of cardiotoxicity was present in 44.1% and 90% were not evaluated by cardiology. Pre-chemotherapy echocardiography was obtained in 65%, but only 19.4% underwent echocardiographic control after finishing chemotherapy. The most frequent CV outcomes were chemotherapy-related systolic dysfunction (4.4%) and rhythm disturbances (2.8%), with atrial fibrillation and atrial flutter being the most frequent arrhythmias. Conclusion: Despite the recognized CV toxicity of chemotherapeutic drugs, the majority of patients receiving highly toxic regimens at high risk of CV complications are not previously evaluated by a cardiologist and the CV workup was not routinely used in our study. The implementation of cardio-oncology programs will facilitate the identification of high-risk patients, aiming to detect and treat complications early. Mención de responsabilidad : Carlos A. Regino, Jonathan Cardona-Vélez, Jesus D. Bello Simanca, Andres F. Miranda Arboleda, Juan G. Gamboa Arroyave, Fabian Jaimes DOI (Digital Object Identifier) : 10.7759/cureus.32513 Derechos de uso : CC BY En línea : https://www.cureus.com/articles/127878-cardio-oncology-clinical-assessment-and-s [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6076 Cardio-oncology clinical assessment and screening in patients undergoing high toxicity chemotherapy: a retrospective cohort study [documento electrónico] / Andrés Felipe Miranda Arboleda, ; Juan Guillermo Gamboa Arroyave,  . - 2022. Obra : Cureus Idioma : Inglés (eng) Palabras clave : cardio-oncology  solid tumors  hematological malignancies  chemotherapy  cardiotoxicity Resumen : Objective: To describe the clinical characteristics and cardio-oncological assessment in patients undertaking highly toxic chemotherapy and/or chest radiotherapy in a high-complexity hospital. Methods: A single-center retrospective cohort study was carried out between January 1st, 2017 and December 31st, 2019. The medical records of patients with solid or hematological neoplasms were reviewed. Descriptive information was obtained on demographic characteristics, chemotherapeutic agents, pre-chemotherapy cardiovascular (CV) evaluation, and CV outcomes. The risk of complications was assessed using the Mayo Clinic risk score. Results: A total of 499 patients were included, the most common neoplasm was non-Hodgkin's lymphoma (21.6%), followed by breast cancer (19.4%). A very high risk of cardiotoxicity was present in 44.1% and 90% were not evaluated by cardiology. Pre-chemotherapy echocardiography was obtained in 65%, but only 19.4% underwent echocardiographic control after finishing chemotherapy. The most frequent CV outcomes were chemotherapy-related systolic dysfunction (4.4%) and rhythm disturbances (2.8%), with atrial fibrillation and atrial flutter being the most frequent arrhythmias. Conclusion: Despite the recognized CV toxicity of chemotherapeutic drugs, the majority of patients receiving highly toxic regimens at high risk of CV complications are not previously evaluated by a cardiologist and the CV workup was not routinely used in our study. The implementation of cardio-oncology programs will facilitate the identification of high-risk patients, aiming to detect and treat complications early. Mención de responsabilidad : Carlos A. Regino, Jonathan Cardona-Vélez, Jesus D. Bello Simanca, Andres F. Miranda Arboleda, Juan G. Gamboa Arroyave, Fabian Jaimes DOI (Digital Object Identifier) : 10.7759/cureus.32513 Derechos de uso : CC BY En línea : https://www.cureus.com/articles/127878-cardio-oncology-clinical-assessment-and-s [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6076

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Late systemic lupus erythematosus-associated insulin resistance syndrome: a rare cause of de novo diabetes mellitus / Carlos Esteban Builes Montaño ; Carolina Prieto Saldarriaga ; Clara María Arango Toro ; Juan Guillermo Gamboa Arroyave    

Público ISBD Título : Late systemic lupus erythematosus-associated insulin resistance syndrome: a rare cause of de novo diabetes mellitus Tipo de documento : documento electrónico Autores : Carlos Esteban Builes Montaño, ; Carolina Prieto Saldarriaga, ; Clara María Arango Toro, ; Juan Guillermo Gamboa Arroyave, Fecha de publicación : 2022 Títulos uniformes : Case Reports in Medicine Idioma : Inglés (eng) Resumen : The association of type B insulin resistance syndrome (TBIRS) due to autoimmune diseases such as systemic lupus erythematosus (SLE) is uncommon. This is partly due to the lack of established criteria for the diagnosis of this resistance. However, some clinical aspects may suggest that the diagnosis does not necessarily have to be positive insulin receptor antibodies as such patients could respond to immunosuppressive treatment. Methods. We describe a case and have performed a literature review on PubMed/MEDLINE, EMBASE, and Google Scholar bibliographic databases to identify all case reports. All available studies from January 1975 through December 2020 were included. Data collected were tabulated, and outcomes were analyzed cumulatively. Results. Thirty-one cases of TBIRS associated with SLE have been described. These patients presented with catabolic symptoms and hyperglycemia in most cases, with an average time from the onset of symptoms of four months. In addition to that clinical characteristics related to SLE were variable, along with certain common characteristics such as acanthosis in 60% of patients. Almost all the patients had antibodies against insulin receptors. The insulin doses required by the patients ranged from 450 to 25,000 U daily. Remission was achieved in 80% of the patients with a two-year follow-up. Most patients associated with late-onset SLE, like our patient, achieved metabolic control after immunosuppressive treatment. Conclusion. High insulin resistance in patients with de novo diabetes mellitus (DM) without obesity should be considered as a possible clinical manifestation of an autoimmune disease such as SLE, with a good metabolic response to the immunosuppressive management established. Mención de responsabilidad : José C Alvarez-Payares, Daniel Ribero, Luis Rodríguez, Carlos E Builes, Carolina Prieto, Clara Arango, Juan G Gamboa, Cristian Alvarez-Payares Referencia : Case Rep Med. 2022 Oct 14;2022:4655804. DOI (Digital Object Identifier) : 10.1155/2022/4655804 PMID : 36275943 Derechos de uso : CC BY En línea : https://www.hindawi.com/journals/crim/2022/4655804/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6075 Late systemic lupus erythematosus-associated insulin resistance syndrome: a rare cause of de novo diabetes mellitus [documento electrónico] / Carlos Esteban Builes Montaño, ; Carolina Prieto Saldarriaga, ; Clara María Arango Toro, ; Juan Guillermo Gamboa Arroyave,  . - 2022. Obra : Case Reports in Medicine Idioma : Inglés (eng) Resumen : The association of type B insulin resistance syndrome (TBIRS) due to autoimmune diseases such as systemic lupus erythematosus (SLE) is uncommon. This is partly due to the lack of established criteria for the diagnosis of this resistance. However, some clinical aspects may suggest that the diagnosis does not necessarily have to be positive insulin receptor antibodies as such patients could respond to immunosuppressive treatment. Methods. We describe a case and have performed a literature review on PubMed/MEDLINE, EMBASE, and Google Scholar bibliographic databases to identify all case reports. All available studies from January 1975 through December 2020 were included. Data collected were tabulated, and outcomes were analyzed cumulatively. Results. Thirty-one cases of TBIRS associated with SLE have been described. These patients presented with catabolic symptoms and hyperglycemia in most cases, with an average time from the onset of symptoms of four months. In addition to that clinical characteristics related to SLE were variable, along with certain common characteristics such as acanthosis in 60% of patients. Almost all the patients had antibodies against insulin receptors. The insulin doses required by the patients ranged from 450 to 25,000 U daily. Remission was achieved in 80% of the patients with a two-year follow-up. Most patients associated with late-onset SLE, like our patient, achieved metabolic control after immunosuppressive treatment. Conclusion. High insulin resistance in patients with de novo diabetes mellitus (DM) without obesity should be considered as a possible clinical manifestation of an autoimmune disease such as SLE, with a good metabolic response to the immunosuppressive management established. Mención de responsabilidad : José C Alvarez-Payares, Daniel Ribero, Luis Rodríguez, Carlos E Builes, Carolina Prieto, Clara Arango, Juan G Gamboa, Cristian Alvarez-Payares Referencia : Case Rep Med. 2022 Oct 14;2022:4655804. DOI (Digital Object Identifier) : 10.1155/2022/4655804 PMID : 36275943 Derechos de uso : CC BY En línea : https://www.hindawi.com/journals/crim/2022/4655804/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6075

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Síndrome pulmón-riñón secundario a vasculitis por cocaína/levamisol: reporte de caso / Mauricio Restrepo Escobar ; Juan Guillermo Gamboa Arroyave ; Carolina Echeverri Jaramillo ; Javier Darío Márquez Hernández  

Público ISBD Título : Síndrome pulmón-riñón secundario a vasculitis por cocaína/levamisol: reporte de caso Otros títulos : Pulmonary-renal syndrome secondary to cocaine-levamisole-induced vasculitis: A case report Tipo de documento : documento electrónico Autores : Mauricio Restrepo Escobar, ; Juan Guillermo Gamboa Arroyave, ; Carolina Echeverri Jaramillo, ; Javier Darío Márquez Hernández, Fecha de publicación : 2020 Títulos uniformes : Reumatología Clínica Idioma : Español (spa) Palabras clave : Vasculitis  cocaína levamisol  hemorragia alveolar  síndrome pulmón-rinón Resumen : El síndrome pulmón-riñón rara vez ha sido reportado como cuadro clínico de presentación de vasculitis causada por el consumo de cocaína contaminada con levamisol. Se reporta el caso de un paciente con este cuadro clínico y se senalan ̃ las dificultades que se presentaron durante el abordaje diagnóstico y terapéutico. Mención de responsabilidad : Mauricio Restrepo-Escobar, Dayana Sylva, Juan Guillermo Gamboa, Andrés Echeverri, Javier Márquez, Luis Fernando Pinto Referencia : Reumatol Clin. May-Jun 2020;16(3):239-241. DOI (Digital Object Identifier) : 10.1016/j.reuma.2018.02.014 PMID : 29784435 En línea : https://www.reumatologiaclinica.org/es-linkresolver-sindrome-pulmon-rinon-secund [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4124 Síndrome pulmón-riñón secundario a vasculitis por cocaína/levamisol: reporte de caso = Pulmonary-renal syndrome secondary to cocaine-levamisole-induced vasculitis: A case report [documento electrónico] / Mauricio Restrepo Escobar, ; Juan Guillermo Gamboa Arroyave, ; Carolina Echeverri Jaramillo, ; Javier Darío Márquez Hernández,  . - 2020. Obra : Reumatología Clínica Idioma : Español (spa) Palabras clave : Vasculitis  cocaína levamisol  hemorragia alveolar  síndrome pulmón-rinón Resumen : El síndrome pulmón-riñón rara vez ha sido reportado como cuadro clínico de presentación de vasculitis causada por el consumo de cocaína contaminada con levamisol. Se reporta el caso de un paciente con este cuadro clínico y se senalan ̃ las dificultades que se presentaron durante el abordaje diagnóstico y terapéutico. Mención de responsabilidad : Mauricio Restrepo-Escobar, Dayana Sylva, Juan Guillermo Gamboa, Andrés Echeverri, Javier Márquez, Luis Fernando Pinto Referencia : Reumatol Clin. May-Jun 2020;16(3):239-241. DOI (Digital Object Identifier) : 10.1016/j.reuma.2018.02.014 PMID : 29784435 En línea : https://www.reumatologiaclinica.org/es-linkresolver-sindrome-pulmon-rinon-secund [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4124

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