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Autor Parra Izquierdo, Viviana
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Documentos disponibles escritos por este autor (3)
Clasificado(s) por (Año de edición descendente) Refinar búsquedaDysplasia and Colorectal Cancer Surveillance in Ulcerative Colitis Patients in Latin America: Real-World Data / Parra Izquierdo, Viviana ; Otero Regino, William ; Fabián Juliao Baños ; Frías Ordoñez, Juan Sebastián ; Ibañez Pinilla, Edgar ; Gil Parada, Fabio Leonel ; Marulanda Fernández, Hernando ; Otero Parra, Lina ; Otero Ramos, Elder ; Puentes Manosalva, Fabian Eduardo ; Guzmán Rojas, Gerardo Andrés ; Ernest Suarez, Kenneth ; Villa Ovalles, Keyla ; Paredes Mendez, Juan Eloy ; Jara Alba, María Luisa ; Andrade Zamora, David ; Ardila Báez, Manuel Alonso ; Floréz Sarmiento, Cristian ; Veitia, Guillermo ; Sánchez, Abel ; Arango Molano, Lazaro Antonio ; Fluxa, Fernando ; Freitas Queiroz, Natália Sousa ; Serrano, Mariastella
Título : Dysplasia and Colorectal Cancer Surveillance in Ulcerative Colitis Patients in Latin America: Real-World Data Tipo de documento : documento electrónico Autores : Parra Izquierdo, Viviana, Autor ; Otero Regino, William, Autor ; Fabián Juliao Baños, Autor ; Frías Ordoñez, Juan Sebastián, Autor ; Ibañez Pinilla, Edgar, Autor ; Gil Parada, Fabio Leonel, Autor ; Marulanda Fernández, Hernando, Autor ; Otero Parra, Lina, Autor ; Otero Ramos, Elder, Autor ; Puentes Manosalva, Fabian Eduardo, Autor ; Guzmán Rojas, Gerardo Andrés, Autor ; Ernest Suarez, Kenneth, Autor ; Villa Ovalles, Keyla, Autor ; Paredes Mendez, Juan Eloy, Autor ; Jara Alba, María Luisa, Autor ; Andrade Zamora, David, Autor ; Ardila Báez, Manuel Alonso, Autor ; Floréz Sarmiento, Cristian, Autor ; Veitia, Guillermo, Autor ; Sánchez, Abel, Autor ; Arango Molano, Lazaro Antonio, Autor ; Fluxa, Fernando, Autor ; Freitas Queiroz, Natália Sousa, Autor ; Serrano, Mariastella, Autor Fecha de publicación : 2025 Títulos uniformes : Crohn's and Colitis 360 Idioma : Inglés (eng) Palabras clave : (MeSH): inflammatory bowel diseases; colitis; colonic neoplasms; colonoscopy; prognosis; ulcerative Resumen : Background: The prevalence of colorectal cancer (CRC) in patients with ulcerative colitis (UC) is higher than in the general population, in Latin America there is a progressive increase of UC, and information about CRC screening in inflammatory bowel disease (IBD) is scarce. The aim of this study was to analyze the findings of endoscopic surveillance of CRC in patients with IBD according to available technology. Methods: Multicenter, cross-sectional, analytical study conducted in Latin American countries, in patients with UC, predominantly with more than 8 years of diagnosis and different degrees of disease activity. Surveillance colonoscopies were performed according to available technology. Risk factors for dysplasia detection were analyzed. Results: One hundred and forty-four patients, 55.5% women, mean age 47.3 (range 17.1 to 90; SD 15.64) years and mean duration of disease 12.71 (range 0.64 to 57.13; SD 8.08) years. Forty-nine lesions were identified, 18 corresponded to dysplasia. The detection rate of dysplasia per lesion and per procedure was 36.7% and 12.5%, respectively. By logistic regression analysis, the duration of disease (OR 1.12;95%CI:1.047 to 1.215, P = .002) and the presence of post-inflammatory polyps (OR 3.4;95%CI:1.11 to 10.36, P = .031) were risk factors for higher detection of dysplasia. Digital chromoendoscopy was associated with greater detection of dysplasia (OR 4.99, 95%CI: 1.092 to 22.864, P = .038). Conclusions: In our region, the duration of disease and the presence of post-inflammatory polyps were the factors with the highest association for dysplasia detection, and digital chromoendoscopy with directed biopsies was the technique of choice. The implementation of a specific surveillance program in colonoscopy in IBD is an effective strategy to achieve high detection rates. © 2025 The Author(s). Mención de responsabilidad : Parra-Izquierdo, Viviana, Otero-Regino, William, Juliao-Baños, Fabian, Frías-Ordoñez, Juan Sebastián, Ibañez-Pinilla, Edgar, Gil-Parada, Fabio Leonel, Marulanda-Fernández, Hernando, Otero-Parra, Lina, Otero-Ramos, Elder, Puentes-Manosalva, Fabian Eduardo, Guzmán Rojas, Gerardo Andres, Ernest-Suárez, Kenneth, Villa-Ovalles, Keyla, Paredes-Mendez, Juan Eloy, Jara-Alba, María Luisa, Andrade-Zamora, David, Ardila-Báez, Manuel Alonso, Flórez-Sarmiento, Cristian, Veitia, Guillermo, Sánchez, Abel, Arango-Molano, Lazaro Antonio, Fluxa, Fernando, Freitas Queiroz, Natália Sousa, Serrano, Mariastella Referencia : Crohns Colitis 360 . 2025 Jan 14;7(1):otae081 DOI (Digital Object Identifier) : 10.1093/crocol/otae081 PMID : 39834355 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/39834355/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Dysplasia and Colorectal Cancer Surveillance in Ulcerative Colitis Patients in Latin America: Real-World Data [documento electrónico] / Parra Izquierdo, Viviana, Autor ; Otero Regino, William, Autor ; Fabián Juliao Baños, Autor ; Frías Ordoñez, Juan Sebastián, Autor ; Ibañez Pinilla, Edgar, Autor ; Gil Parada, Fabio Leonel, Autor ; Marulanda Fernández, Hernando, Autor ; Otero Parra, Lina, Autor ; Otero Ramos, Elder, Autor ; Puentes Manosalva, Fabian Eduardo, Autor ; Guzmán Rojas, Gerardo Andrés, Autor ; Ernest Suarez, Kenneth, Autor ; Villa Ovalles, Keyla, Autor ; Paredes Mendez, Juan Eloy, Autor ; Jara Alba, María Luisa, Autor ; Andrade Zamora, David, Autor ; Ardila Báez, Manuel Alonso, Autor ; Floréz Sarmiento, Cristian, Autor ; Veitia, Guillermo, Autor ; Sánchez, Abel, Autor ; Arango Molano, Lazaro Antonio, Autor ; Fluxa, Fernando, Autor ; Freitas Queiroz, Natália Sousa, Autor ; Serrano, Mariastella, Autor . - 2025.
Obra : Crohn's and Colitis 360
Idioma : Inglés (eng)
Palabras clave : (MeSH): inflammatory bowel diseases; colitis; colonic neoplasms; colonoscopy; prognosis; ulcerative Resumen : Background: The prevalence of colorectal cancer (CRC) in patients with ulcerative colitis (UC) is higher than in the general population, in Latin America there is a progressive increase of UC, and information about CRC screening in inflammatory bowel disease (IBD) is scarce. The aim of this study was to analyze the findings of endoscopic surveillance of CRC in patients with IBD according to available technology. Methods: Multicenter, cross-sectional, analytical study conducted in Latin American countries, in patients with UC, predominantly with more than 8 years of diagnosis and different degrees of disease activity. Surveillance colonoscopies were performed according to available technology. Risk factors for dysplasia detection were analyzed. Results: One hundred and forty-four patients, 55.5% women, mean age 47.3 (range 17.1 to 90; SD 15.64) years and mean duration of disease 12.71 (range 0.64 to 57.13; SD 8.08) years. Forty-nine lesions were identified, 18 corresponded to dysplasia. The detection rate of dysplasia per lesion and per procedure was 36.7% and 12.5%, respectively. By logistic regression analysis, the duration of disease (OR 1.12;95%CI:1.047 to 1.215, P = .002) and the presence of post-inflammatory polyps (OR 3.4;95%CI:1.11 to 10.36, P = .031) were risk factors for higher detection of dysplasia. Digital chromoendoscopy was associated with greater detection of dysplasia (OR 4.99, 95%CI: 1.092 to 22.864, P = .038). Conclusions: In our region, the duration of disease and the presence of post-inflammatory polyps were the factors with the highest association for dysplasia detection, and digital chromoendoscopy with directed biopsies was the technique of choice. The implementation of a specific surveillance program in colonoscopy in IBD is an effective strategy to achieve high detection rates. © 2025 The Author(s). Mención de responsabilidad : Parra-Izquierdo, Viviana, Otero-Regino, William, Juliao-Baños, Fabian, Frías-Ordoñez, Juan Sebastián, Ibañez-Pinilla, Edgar, Gil-Parada, Fabio Leonel, Marulanda-Fernández, Hernando, Otero-Parra, Lina, Otero-Ramos, Elder, Puentes-Manosalva, Fabian Eduardo, Guzmán Rojas, Gerardo Andres, Ernest-Suárez, Kenneth, Villa-Ovalles, Keyla, Paredes-Mendez, Juan Eloy, Jara-Alba, María Luisa, Andrade-Zamora, David, Ardila-Báez, Manuel Alonso, Flórez-Sarmiento, Cristian, Veitia, Guillermo, Sánchez, Abel, Arango-Molano, Lazaro Antonio, Fluxa, Fernando, Freitas Queiroz, Natália Sousa, Serrano, Mariastella Referencia : Crohns Colitis 360 . 2025 Jan 14;7(1):otae081 DOI (Digital Object Identifier) : 10.1093/crocol/otae081 PMID : 39834355 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/39834355/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : P1261 Reproductive Health Outcomes in Colombian Women with Inflammatory Bowel Disease: A Multicenter Cohort Study on Pregnancy, Fertility, and Disease Impact (REINFORCE Study) Tipo de documento : documento electrónico Autores : Osorio Castrillón, Laura Marcela, Autor ; Fabián Juliao Baños, Autor ; Parra Izquierdo, Viviana, Autor ; Frías Ordoñez, Juan Sebastián, Autor Fecha de publicación : 2025 Títulos uniformes : Journal of Crohn's and Colitis Idioma : Inglés (eng) Resumen : Background: The impact of Inflammatory Bowel Disease (IBD) on women's health, particularly in relation to reproductive health, remains an underexplored area in Latin American populations. This study aims to assess the effects of IBD on women's reproductive health, including pregnancy outcomes, fertility, and related complications, within a cohort of Colombian women. Methods: Observational, multicenter and descriptive study involving adult and pediatric patients from two IBD Centers in different cities in Colombia. The study focused on evaluating aspects of sexual and reproductive health in women with IBD, with detailed data collection on pregnancy, fertility, childbirth, and cancer screening Results: Out of a total of 121 women with IBD, 63.6% (77/121 patients) were in reproductive age (15–44 years according to World Health Organization) (Table 1), the mean age was 33.2 years (range: 17.2–44.8 years, SD: 8), with a mean age at diagnosis of 28 years (range: 9.3–45.1 years, SD: 8.8) and a disease duration of 5.2 years (range: 0.3–21.9 years, SD: 4.7). UC was more prevalent in this group (71.4%). Most women had low rates of smoking, hospitalization, and surgical interventions for IBD, and pregnancy-related complications were generally rare. The majority of births were vaginal deliveries, and breastfeeding beyond 6 months was common, suggesting protective effects against IBD risk in offspring. Notably, while HPV vaccination rates were low, the prevalence of cervical cancer was also low. Family planning was reported by 48% of participants, and 1% required assisted reproductive technologies. Statistical analysis showed no significant association between age and pregnancy complications across age groups. However, UC was significantly associated with a higher risk of pregnancy complications (OR 5.5; 95% CI: 1.9–14.9; p=0.0001), and Crohn's disease (CD) also showed a trend toward increased risk (OR 4.6; 95% CI : 0.2–20.4; p=0.00002). Previous history of hospitalization due to disease activity, surgery, and the use of biological therapy was associated with an increased risk of pregnancy complications when it occurred (OR 1.97; 95% CI: 1.6–2.5; p= 0.07 for hospitalization, OR 12.12; 95% CI: 4.2–27.8; p=0.03 for surgery, OR 5.2; 95% CI: 1.64-13.1 ;p=0.00001). Conclusion: This study underscores the significant impact of IBD on reproductive health in Colombian women, similar to trends in other populations. It emphasizes the importance of effective disease management before conception, given that the use of biological therapies that usually are associated with more severe disease, ongoing disease activity, and prior surgical interventions are risk factors for increased pregnancy complications. Mención de responsabilidad : V Parra Izquierdo , L Osorio-Castrillon , F Juliao-Baños , J Frías-Ordoñez Referencia : Journal of Crohn's and Colitis, Volume 19, Issue Supplement_1, January 2025, Pages i2282–i2283, DOI (Digital Object Identifier) : 10.1093/ecco-jcc/jjae190.1435 Derechos de uso : CC BY-NC-ND En línea : https://academic.oup.com/ecco-jcc/article/19/Supplement_1/i2282/7972126 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis P1261 Reproductive Health Outcomes in Colombian Women with Inflammatory Bowel Disease: A Multicenter Cohort Study on Pregnancy, Fertility, and Disease Impact (REINFORCE Study) [documento electrónico] / Osorio Castrillón, Laura Marcela, Autor ; Fabián Juliao Baños, Autor ; Parra Izquierdo, Viviana, Autor ; Frías Ordoñez, Juan Sebastián, Autor . - 2025.
Obra : Journal of Crohn's and Colitis
Idioma : Inglés (eng)
Resumen : Background: The impact of Inflammatory Bowel Disease (IBD) on women's health, particularly in relation to reproductive health, remains an underexplored area in Latin American populations. This study aims to assess the effects of IBD on women's reproductive health, including pregnancy outcomes, fertility, and related complications, within a cohort of Colombian women. Methods: Observational, multicenter and descriptive study involving adult and pediatric patients from two IBD Centers in different cities in Colombia. The study focused on evaluating aspects of sexual and reproductive health in women with IBD, with detailed data collection on pregnancy, fertility, childbirth, and cancer screening Results: Out of a total of 121 women with IBD, 63.6% (77/121 patients) were in reproductive age (15–44 years according to World Health Organization) (Table 1), the mean age was 33.2 years (range: 17.2–44.8 years, SD: 8), with a mean age at diagnosis of 28 years (range: 9.3–45.1 years, SD: 8.8) and a disease duration of 5.2 years (range: 0.3–21.9 years, SD: 4.7). UC was more prevalent in this group (71.4%). Most women had low rates of smoking, hospitalization, and surgical interventions for IBD, and pregnancy-related complications were generally rare. The majority of births were vaginal deliveries, and breastfeeding beyond 6 months was common, suggesting protective effects against IBD risk in offspring. Notably, while HPV vaccination rates were low, the prevalence of cervical cancer was also low. Family planning was reported by 48% of participants, and 1% required assisted reproductive technologies. Statistical analysis showed no significant association between age and pregnancy complications across age groups. However, UC was significantly associated with a higher risk of pregnancy complications (OR 5.5; 95% CI: 1.9–14.9; p=0.0001), and Crohn's disease (CD) also showed a trend toward increased risk (OR 4.6; 95% CI : 0.2–20.4; p=0.00002). Previous history of hospitalization due to disease activity, surgery, and the use of biological therapy was associated with an increased risk of pregnancy complications when it occurred (OR 1.97; 95% CI: 1.6–2.5; p= 0.07 for hospitalization, OR 12.12; 95% CI: 4.2–27.8; p=0.03 for surgery, OR 5.2; 95% CI: 1.64-13.1 ;p=0.00001). Conclusion: This study underscores the significant impact of IBD on reproductive health in Colombian women, similar to trends in other populations. It emphasizes the importance of effective disease management before conception, given that the use of biological therapies that usually are associated with more severe disease, ongoing disease activity, and prior surgical interventions are risk factors for increased pregnancy complications. Mención de responsabilidad : V Parra Izquierdo , L Osorio-Castrillon , F Juliao-Baños , J Frías-Ordoñez Referencia : Journal of Crohn's and Colitis, Volume 19, Issue Supplement_1, January 2025, Pages i2282–i2283, DOI (Digital Object Identifier) : 10.1093/ecco-jcc/jjae190.1435 Derechos de uso : CC BY-NC-ND En línea : https://academic.oup.com/ecco-jcc/article/19/Supplement_1/i2282/7972126 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Colombian experience with the use of tofacitinib in severe acute ulcerative colitis: A case series study Tipo de documento : documento electrónico Autores : Fabián Juliao Baños, Autor ; Parra Izquierdo, Viviana, Autor ; Frías Ordoñez, Juan Sebastián, Autor ; Floréz Sarmiento, Cristian, Autor Fecha de publicación : 2024 Títulos uniformes : Gastroenterología y Hepatología Idioma : Español (spa) Palabras clave : Colitis ulcerosa; Disease management; Enfermedades inflamatorias del intestino; Inflammatory bowel diseases; Inhibidores de las quinasas janus; Janus kinase inhibitors; Manejo de la enfermedad; Terapéutica; Therapeutics; Tofacitinib; Ulcerative colitis. Resumen : Introduction: Tofacitinib is indicated in patients with moderate to severe ulcerative colitis (UC); however, given its rapid onset of action, it may constitute an alternative in patients with hospitalized severe acute UC. There are few data on this indication in the literature. The aim of this study was to describe the efficacy and safety of tofacitinib in the management of patients with hospitalized UC, as well as its clinical characteristics and other treatment patterns. Materials and methods: Descriptive observational study of adults and children with CUAG treated with tofacitinib between June 2019 and December 2022 in Colombia. Sociodemographic and clinical variables were collected, therapeutic response was evaluated in different periods of time and descriptive analysis of quantitative and qualitative variables was performed. Results: Six patients (five adults and one pediatric), mean age 33.2 (SD: 8.5) years, with CUAG. Symptom remission was obtained in 100% of patients at day 7 after tofacitinib initiation. In three patients information was obtained beyond 6 months, with 100% clinical, biochemical, and endoscopic remission and without requiring colectomy. In the case of the pediatric patient, symptom remission was achieved one week after starting tofacitinib, remaining in clinical, biochemical and endoscopic remission beyond 6 months. No serious adverse events were reported in any of the cases. Conclusions: Tofacitinib represents a rescue therapeutic alternative in CUAG, with rapid clinical response, adequate tolerance and less need for colectomy, being sustained for periods beyond 6 months. Mención de responsabilidad : Parra-Izquierdo, Viviana; Frías-Ordoñez, Juan Sebastián; Juliao-Baños, Fabián; Cuadros, Carlos; Romero Sanchez, Consuelo; Flórez-Sarmiento, Cristian Referencia : Gastroenterol Hepatol . 2024 Jun-Jul;47(6):582-590. DOI (Digital Object Identifier) : 10.1016/j.gastrohep.2023.10.003 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/37806342/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Colombian experience with the use of tofacitinib in severe acute ulcerative colitis: A case series study [documento electrónico] / Fabián Juliao Baños, Autor ; Parra Izquierdo, Viviana, Autor ; Frías Ordoñez, Juan Sebastián, Autor ; Floréz Sarmiento, Cristian, Autor . - 2024.
Obra : Gastroenterología y Hepatología
Idioma : Español (spa)
Palabras clave : Colitis ulcerosa; Disease management; Enfermedades inflamatorias del intestino; Inflammatory bowel diseases; Inhibidores de las quinasas janus; Janus kinase inhibitors; Manejo de la enfermedad; Terapéutica; Therapeutics; Tofacitinib; Ulcerative colitis. Resumen : Introduction: Tofacitinib is indicated in patients with moderate to severe ulcerative colitis (UC); however, given its rapid onset of action, it may constitute an alternative in patients with hospitalized severe acute UC. There are few data on this indication in the literature. The aim of this study was to describe the efficacy and safety of tofacitinib in the management of patients with hospitalized UC, as well as its clinical characteristics and other treatment patterns. Materials and methods: Descriptive observational study of adults and children with CUAG treated with tofacitinib between June 2019 and December 2022 in Colombia. Sociodemographic and clinical variables were collected, therapeutic response was evaluated in different periods of time and descriptive analysis of quantitative and qualitative variables was performed. Results: Six patients (five adults and one pediatric), mean age 33.2 (SD: 8.5) years, with CUAG. Symptom remission was obtained in 100% of patients at day 7 after tofacitinib initiation. In three patients information was obtained beyond 6 months, with 100% clinical, biochemical, and endoscopic remission and without requiring colectomy. In the case of the pediatric patient, symptom remission was achieved one week after starting tofacitinib, remaining in clinical, biochemical and endoscopic remission beyond 6 months. No serious adverse events were reported in any of the cases. Conclusions: Tofacitinib represents a rescue therapeutic alternative in CUAG, with rapid clinical response, adequate tolerance and less need for colectomy, being sustained for periods beyond 6 months. Mención de responsabilidad : Parra-Izquierdo, Viviana; Frías-Ordoñez, Juan Sebastián; Juliao-Baños, Fabián; Cuadros, Carlos; Romero Sanchez, Consuelo; Flórez-Sarmiento, Cristian Referencia : Gastroenterol Hepatol . 2024 Jun-Jul;47(6):582-590. DOI (Digital Object Identifier) : 10.1016/j.gastrohep.2023.10.003 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/37806342/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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