2 búsqueda de la palabra clave 'Autosomal dominant Alzheimer’s disease'

Global cardiovascular risk profile and cerebrovascular abnormalities in presymptomatic individuals with CADASIL or autosomal dominant Alzheimer's disease / Sergio Álvarez Vallejo ; Martín Ochoa Escudero  

Público ISBD Título : Global cardiovascular risk profile and cerebrovascular abnormalities in presymptomatic individuals with CADASIL or autosomal dominant Alzheimer's disease Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, Fecha de publicación : 2021 Títulos uniformes : Journal of Alzheimer's Disease Idioma : Inglés (eng) Palabras clave : Autosomal dominant Alzheimer’s disease  CADASIL  cardiovascular risk factors  cerebral small vessel disease  cognition  magnetic resonance imaging Resumen : Background:Cardiovascular risk factors increase the risk of developing dementia, including Alzheimer’s disease and vascular dementia. Objective:Studying individuals with autosomal dominant mutations leading to the early onset of dementia, this study examines the effect of the global cardiovascular risk profile on early cognitive and neuroimaging features of Alzheimer’s disease and vascular dementia. Methods:We studied 85 non-demented and stroke-free individuals, including 20 subjects with Presenilin1 (PSEN1) E280A mutation leading to the early onset of autosomal dominant Alzheimer’s disease (ADAD), 20 subjects with NOTCH3 mutations leading to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and to the early onset of vascular dementia, and 45 non-affected family members (non-carriers). All subjects underwent clinical and neuropsychological evaluations and an MRI. The global cardiovascular risk profile was estimated using the office-based Framingham Cardiovascular Risk Profile (FCRP) score. Results:In individuals with CADASIL, a higher FCRP score was associated with a reduced hippocampal volume (B = –0.06, p  Mención de responsabilidad : Schoemaker, Dorothee, Velilla-Jimenez, Lina, Zuluaga, Yesica, Baena, Ana, Ospina, Carolina, Bocanegra, Yamile, Alvarez, Sergio, Ochoa-Escudero, Martin, Guzmán-Vélez, Edmarie, Martinez, Jairo, Lopera, Francisco, Arboleda-Velasquez, Joseph F., Quiroz, Yakeel T. Referencia : J Alzheimers Dis. 2021;82(2):841-853. DOI (Digital Object Identifier) : 10.3233/JAD-210313 PMID : 34092645 En línea : https://content.iospress.com/articles/journal-of-alzheimers-disease/jad210313 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5872 Global cardiovascular risk profile and cerebrovascular abnormalities in presymptomatic individuals with CADASIL or autosomal dominant Alzheimer's disease [documento electrónico] / Sergio Álvarez Vallejo, ; Martín Ochoa Escudero,  . - 2021. Obra : Journal of Alzheimer's Disease Idioma : Inglés (eng) Palabras clave : Autosomal dominant Alzheimer’s disease  CADASIL  cardiovascular risk factors  cerebral small vessel disease  cognition  magnetic resonance imaging Resumen : Background:Cardiovascular risk factors increase the risk of developing dementia, including Alzheimer’s disease and vascular dementia. Objective:Studying individuals with autosomal dominant mutations leading to the early onset of dementia, this study examines the effect of the global cardiovascular risk profile on early cognitive and neuroimaging features of Alzheimer’s disease and vascular dementia. Methods:We studied 85 non-demented and stroke-free individuals, including 20 subjects with Presenilin1 (PSEN1) E280A mutation leading to the early onset of autosomal dominant Alzheimer’s disease (ADAD), 20 subjects with NOTCH3 mutations leading to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and to the early onset of vascular dementia, and 45 non-affected family members (non-carriers). All subjects underwent clinical and neuropsychological evaluations and an MRI. The global cardiovascular risk profile was estimated using the office-based Framingham Cardiovascular Risk Profile (FCRP) score. Results:In individuals with CADASIL, a higher FCRP score was associated with a reduced hippocampal volume (B = –0.06, p  Mención de responsabilidad : Schoemaker, Dorothee, Velilla-Jimenez, Lina, Zuluaga, Yesica, Baena, Ana, Ospina, Carolina, Bocanegra, Yamile, Alvarez, Sergio, Ochoa-Escudero, Martin, Guzmán-Vélez, Edmarie, Martinez, Jairo, Lopera, Francisco, Arboleda-Velasquez, Joseph F., Quiroz, Yakeel T. Referencia : J Alzheimers Dis. 2021;82(2):841-853. DOI (Digital Object Identifier) : 10.3233/JAD-210313 PMID : 34092645 En línea : https://content.iospress.com/articles/journal-of-alzheimers-disease/jad210313 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5872

Reserva

Reservar este documento

Ejemplares(1)

Código de barras	Número de Ubicación	Tipo de medio	Ubicación	Sección	Estado
DD001810	AC-2021-122	Archivo digital	Producción Científica	Artículos científicos	Disponible

PET evidence of preclinical cerebellar amyloid plaque deposition in autosomal dominant Alzheimer's disease-causing Presenilin-1 E280A mutation carriers / Sergio Álvarez Vallejo    

Público ISBD Título : PET evidence of preclinical cerebellar amyloid plaque deposition in autosomal dominant Alzheimer's disease-causing Presenilin-1 E280A mutation carriers Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, Fecha de publicación : 2021 Títulos uniformes : NeuroImage. Clinical Idioma : Inglés (eng) Palabras clave : Brain imaging  PET  Amyloid  Cerebellum  Pons  Autosomal dominant Alzheimer’s disease Resumen : Background: In contrast to sporadic Alzheimer’s disease, autosomal dominant Alzheimer’s disease (ADAD) is associated with greater neuropathological evidence of cerebellar amyloid plaque (Aβ) deposition. In this study, we used positron emission tomography (PET) measurements of fibrillar Aβ burden to characterize the presence and age at onset of cerebellar Aβ deposition in cognitively unimpaired (CU) Presenilin-1 (PSEN1) E280A mutation carriers from the world’s largest extended family with ADAD. Methods: 18F florbetapir and 11C Pittsburgh compound B (PiB) PET data from two independent studies – API ADAD Colombia Trial (NCT01998841) and Colombia-Boston (COLBOS) longitudinal biomarker study were included. The tracers were selected independently by the respective sponsors prior to the start of each study and used exclusively throughout. Template-based cerebellar Aβ-SUVR (standard-uptake value ratios) using a known-to-be-spared pons reference region (cerebellar SUVR_pons), to a) compare 28–56-year-old CU carriers and non-carriers; b) estimate the age at which cerebellar SUVR_pons began to differ significantly in carrier and non-carrier groups; and c) characterize in carriers associations with age, cortical SUVR_pons, delayed recall memory, and API ADAD composite score. Results: Florbetapir and PiB cerebellar SUVR_pons were significantly higher in carriers than non-carriers (p Mención de responsabilidad : Valentina Ghisays, Francisco Lopera, Dhruman D. Goradia, Hillary D. Protas, Michael H. Malek-Ahmadi, Yinghua Chen, Vivek Devadas, Ji Luo, Wendy Lee, Ana Baena, Yamile Bocanegra, Edmarie Guzman-Vélez, Enmanuelle Pardilla-Delgado, Clara Vila-Castelar, Joshua T. Fox-Fuller, Nan Hu, David Clayton, Ronald G. Thomas, Sergio Alvarez, Alejandro Espinosa, Natalia Acosta-Baena, Margarita M. Giraldo, Silvia Rios-Romenets, Jessica B. Langbaum, Kewei Chen, Yi Su, Pierre N. Tariot, Yakeel T. Quiroz, Eric M. Reiman, API ADAD Colombia Trial Group Referencia : Neuroimage Clin. 2021;31:102749. DOI (Digital Object Identifier) : 10.1016/j.nicl.2021.102749 PMID : 34252876 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S2213158221001935 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5875 PET evidence of preclinical cerebellar amyloid plaque deposition in autosomal dominant Alzheimer's disease-causing Presenilin-1 E280A mutation carriers [documento electrónico] / Sergio Álvarez Vallejo,  . - 2021. Obra : NeuroImage. Clinical Idioma : Inglés (eng) Palabras clave : Brain imaging  PET  Amyloid  Cerebellum  Pons  Autosomal dominant Alzheimer’s disease Resumen : Background: In contrast to sporadic Alzheimer’s disease, autosomal dominant Alzheimer’s disease (ADAD) is associated with greater neuropathological evidence of cerebellar amyloid plaque (Aβ) deposition. In this study, we used positron emission tomography (PET) measurements of fibrillar Aβ burden to characterize the presence and age at onset of cerebellar Aβ deposition in cognitively unimpaired (CU) Presenilin-1 (PSEN1) E280A mutation carriers from the world’s largest extended family with ADAD. Methods: 18F florbetapir and 11C Pittsburgh compound B (PiB) PET data from two independent studies – API ADAD Colombia Trial (NCT01998841) and Colombia-Boston (COLBOS) longitudinal biomarker study were included. The tracers were selected independently by the respective sponsors prior to the start of each study and used exclusively throughout. Template-based cerebellar Aβ-SUVR (standard-uptake value ratios) using a known-to-be-spared pons reference region (cerebellar SUVR_pons), to a) compare 28–56-year-old CU carriers and non-carriers; b) estimate the age at which cerebellar SUVR_pons began to differ significantly in carrier and non-carrier groups; and c) characterize in carriers associations with age, cortical SUVR_pons, delayed recall memory, and API ADAD composite score. Results: Florbetapir and PiB cerebellar SUVR_pons were significantly higher in carriers than non-carriers (p Mención de responsabilidad : Valentina Ghisays, Francisco Lopera, Dhruman D. Goradia, Hillary D. Protas, Michael H. Malek-Ahmadi, Yinghua Chen, Vivek Devadas, Ji Luo, Wendy Lee, Ana Baena, Yamile Bocanegra, Edmarie Guzman-Vélez, Enmanuelle Pardilla-Delgado, Clara Vila-Castelar, Joshua T. Fox-Fuller, Nan Hu, David Clayton, Ronald G. Thomas, Sergio Alvarez, Alejandro Espinosa, Natalia Acosta-Baena, Margarita M. Giraldo, Silvia Rios-Romenets, Jessica B. Langbaum, Kewei Chen, Yi Su, Pierre N. Tariot, Yakeel T. Quiroz, Eric M. Reiman, API ADAD Colombia Trial Group Referencia : Neuroimage Clin. 2021;31:102749. DOI (Digital Object Identifier) : 10.1016/j.nicl.2021.102749 PMID : 34252876 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S2213158221001935 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5875

Reserva

Reservar este documento

Ejemplares(1)

Código de barras	Número de Ubicación	Tipo de medio	Ubicación	Sección	Estado
DD001813	AC-2021-125	Archivo digital	Producción Científica	Artículos científicos	Disponible

Documentos electrónicos

2021-125 Adobe Acrobat PDF