2 búsqueda de la palabra clave 'Glucose metabolism'

Main glucose hepatic fluxes in healthy subjects predicted from a phenomenological-based model / Carlos Esteban Builes Montaño    

Público ISBD Título : Main glucose hepatic fluxes in healthy subjects predicted from a phenomenological-based model Tipo de documento : documento electrónico Autores : Carlos Esteban Builes Montaño, Fecha de publicación : 2022 Títulos uniformes : Computers in Biology and Medicine Idioma : Inglés (eng) Palabras clave : Mathematical model  Diabetes mellitus  Glucose metabolism  Liver Resumen : Background: The liver has a unique role in blood glucose regulation in postprandial, postabsorptive, and fasting states. In the context of diabetes technology, current maximal models of glucose homeostasis lack a proper dynamical description of main glucose-related fluxes acting over and from the liver, providing a rather simplistic estimation of key quantities as endogenous glucose production and insulin and glucagon clearance. Methods: Using a three-phase well-established phenomenological-based semi-physical modeling (PBSM) methodology, we built a detailed physiological model of hepatic glucose metabolism, including glucose utilization, endogenous glucose production through gluconeogenesis and glycogenolysis, and insulin and glucagon clearance. Mean absolute errors (MAE) were used to assess the goodness of fit of the proposed model against the data from three different in-vivo experiments -two oral glucose tolerance tests (OGTT) and a mixed meal challenge following overnight fasting-in healthy subjects. Results: Needing little parameter calibration, the proposed model predicts experimental systemic glucose mean ± std 5.4 ± 5.2, 7.5 ± 6.8, and 7.5 ± 7.5 mg/dL, in all three experiments. Low MAEs were also obtained for insulin and glucagon at the hepatic vein. Conclusions: The quantitative concordance of our model to the experimental data exhibits a potential for its use in the physiological study of glucose liver metabolism. The model structure and parameter interpretability allow the union with other semi-physical models for a better understanding of whole-body glucose homeostasis and its use in developing diabetes technology tools. Mención de responsabilidad : Carlos E. Builes-Montaño, Laura Lema-Perez, Jose Garcia-Tirado y Hernan Alvarez Referencia : Comput Biol Med. 2022 Mar;142:105232. DOI (Digital Object Identifier) : 10.1016/j.compbiomed.2022.105232 PMID : 35077932 Derechos de uso : CC BY En línea : https://linkinghub.elsevier.com/retrieve/pii/S0010482522000245 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6012 Main glucose hepatic fluxes in healthy subjects predicted from a phenomenological-based model [documento electrónico] / Carlos Esteban Builes Montaño,  . - 2022. Obra : Computers in Biology and Medicine Idioma : Inglés (eng) Palabras clave : Mathematical model  Diabetes mellitus  Glucose metabolism  Liver Resumen : Background: The liver has a unique role in blood glucose regulation in postprandial, postabsorptive, and fasting states. In the context of diabetes technology, current maximal models of glucose homeostasis lack a proper dynamical description of main glucose-related fluxes acting over and from the liver, providing a rather simplistic estimation of key quantities as endogenous glucose production and insulin and glucagon clearance. Methods: Using a three-phase well-established phenomenological-based semi-physical modeling (PBSM) methodology, we built a detailed physiological model of hepatic glucose metabolism, including glucose utilization, endogenous glucose production through gluconeogenesis and glycogenolysis, and insulin and glucagon clearance. Mean absolute errors (MAE) were used to assess the goodness of fit of the proposed model against the data from three different in-vivo experiments -two oral glucose tolerance tests (OGTT) and a mixed meal challenge following overnight fasting-in healthy subjects. Results: Needing little parameter calibration, the proposed model predicts experimental systemic glucose mean ± std 5.4 ± 5.2, 7.5 ± 6.8, and 7.5 ± 7.5 mg/dL, in all three experiments. Low MAEs were also obtained for insulin and glucagon at the hepatic vein. Conclusions: The quantitative concordance of our model to the experimental data exhibits a potential for its use in the physiological study of glucose liver metabolism. The model structure and parameter interpretability allow the union with other semi-physical models for a better understanding of whole-body glucose homeostasis and its use in developing diabetes technology tools. Mención de responsabilidad : Carlos E. Builes-Montaño, Laura Lema-Perez, Jose Garcia-Tirado y Hernan Alvarez Referencia : Comput Biol Med. 2022 Mar;142:105232. DOI (Digital Object Identifier) : 10.1016/j.compbiomed.2022.105232 PMID : 35077932 Derechos de uso : CC BY En línea : https://linkinghub.elsevier.com/retrieve/pii/S0010482522000245 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6012

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DD001848	AC-2022-018	Archivo digital	Producción Científica	Artículos científicos	Disponible

Documentos electrónicos

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A phenomenological-based semi-physical model of the kidneys and its role in glucose metabolism / Carlos Esteban Builes Montaño  

Público ISBD Título : A phenomenological-based semi-physical model of the kidneys and its role in glucose metabolism Tipo de documento : documento electrónico Autores : Carlos Esteban Builes Montaño, Fecha de publicación : 2021 Títulos uniformes : Journal of Theoretical Biology Idioma : Inglés (eng) Palabras clave : Physiological systems  Kidneys  Glucose metabolism  Parameter interpretability  Phenomenological-based semi-physical model (PBSM) Resumen : The kidneys play an important role in glucose homeostasis in three ways: Via endogenous glucose production from non-carbohydrate precursors (e.g. glutamine, lactate, alanine, glycerol) during both postprandial and post-absorptive states; via glucose filtration and reabsorption by the glomerulus and proximal tubule, respectively; and via glucod the elimination of its excess in the urine when glucose levels exceed 180 mg/dl. The renal release of glucose into the circulation occurs mainly in the renal cortex and results from the glucose phosphorylating capacity of those renal cells, meaning that, cells in the renal cortex can form glucose-6-phosphate. Considering glucose filtration and reabsorption, the kidneys filtrate and reabsorb all circulating glucose, rendering the urine virtually glucose-free in a healthy person. Finally, the kidneys take up glucose from the circulation for energetic self-supply. Besides their role in glucose metabolism, the kidneys are the major site of insulin clearance from the systemic circulation, removing approximately 50% of peripheral insulin. In this regard, insulin clearance by kidneys occurs by degradation in the proximal tubule after being filtered in the glomerulus. All the aforementioned mechanisms affect the glucose concentration levels in the blood, preventing the parametrization of a mathematical model for patients with diabetes mellitus, in the implementation of an artificial pancreas. Aiming for a complete physiological model of the glucose homeostasis, a physiological submodel of the kidneys is presented in a way not described in the literature so far. This submodel is a phenomenological-based semi-physical model with a basic structure rooted in the conservation law and for which the parameters are interpretable. The model’s results coincide well with the available clinical data reported for kidney functions associated with glucose and insulin. Mención de responsabilidad : Laura Lema-Perez, Carlos E. Builes-Montaño, Hernan Alvarez Referencia : J Theor Biol. 2020 Sep 18;110489. DOI (Digital Object Identifier) : 10.1016/j.jtbi.2020.110489 PMID : 32956669 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0022519320303441 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5728 A phenomenological-based semi-physical model of the kidneys and its role in glucose metabolism [documento electrónico] / Carlos Esteban Builes Montaño,  . - 2021. Obra : Journal of Theoretical Biology Idioma : Inglés (eng) Palabras clave : Physiological systems  Kidneys  Glucose metabolism  Parameter interpretability  Phenomenological-based semi-physical model (PBSM) Resumen : The kidneys play an important role in glucose homeostasis in three ways: Via endogenous glucose production from non-carbohydrate precursors (e.g. glutamine, lactate, alanine, glycerol) during both postprandial and post-absorptive states; via glucose filtration and reabsorption by the glomerulus and proximal tubule, respectively; and via glucod the elimination of its excess in the urine when glucose levels exceed 180 mg/dl. The renal release of glucose into the circulation occurs mainly in the renal cortex and results from the glucose phosphorylating capacity of those renal cells, meaning that, cells in the renal cortex can form glucose-6-phosphate. Considering glucose filtration and reabsorption, the kidneys filtrate and reabsorb all circulating glucose, rendering the urine virtually glucose-free in a healthy person. Finally, the kidneys take up glucose from the circulation for energetic self-supply. Besides their role in glucose metabolism, the kidneys are the major site of insulin clearance from the systemic circulation, removing approximately 50% of peripheral insulin. In this regard, insulin clearance by kidneys occurs by degradation in the proximal tubule after being filtered in the glomerulus. All the aforementioned mechanisms affect the glucose concentration levels in the blood, preventing the parametrization of a mathematical model for patients with diabetes mellitus, in the implementation of an artificial pancreas. Aiming for a complete physiological model of the glucose homeostasis, a physiological submodel of the kidneys is presented in a way not described in the literature so far. This submodel is a phenomenological-based semi-physical model with a basic structure rooted in the conservation law and for which the parameters are interpretable. The model’s results coincide well with the available clinical data reported for kidney functions associated with glucose and insulin. Mención de responsabilidad : Laura Lema-Perez, Carlos E. Builes-Montaño, Hernan Alvarez Referencia : J Theor Biol. 2020 Sep 18;110489. DOI (Digital Object Identifier) : 10.1016/j.jtbi.2020.110489 PMID : 32956669 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0022519320303441 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5728

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