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Enlace permanente de la investigaciónResting-state EEG alpha/theta ratio related to neuropsychological test performance in Parkinson's Disease / Leonardo Fabio Moreno Gómez
Título : Resting-state EEG alpha/theta ratio related to neuropsychological test performance in Parkinson's Disease Tipo de documento : documento electrónico Autores : Leonardo Fabio Moreno Gómez, Fecha de publicación : 2021 Títulos uniformes : Clinical Neurophysiology Idioma : Inglés (eng) Palabras clave : Alpha rhythm Electroencephalography Neuropsychological tests Parkinson’s Disease Theta rhythm Resumen : Objective: To determine possible associations of hemispheric-regional alpha/theta ratio (α/θ) with neuropsychological test performance in Parkinson's Disease (PD) non-demented patients. Methods: 36 PD were matched to 36 Healthy Controls (HC). The α/θ in eight hemispheric regions was computed from the relative power spectral density of the resting-state quantitative electroencephalogram (qEEG). Correlations between α/θ and performance in several neuropsychological tests were conducted, significant findings were included in a moderation analysis. Results: The α/θ in all regions was lower in PD than in HC, with larger effect sizes in the posterior regions. Right parietal, and right and left occipital α/θ had significant positive correlations with performance in Judgement of Line Orientation Test (JLOT) in PD. Adjusted moderation analysis indicated that right, but not left, occipital α/θ influenced the JLOT performance related to PD. Conclusions: Reduction of the occipital α/θ, in particular on the right side, was associated with visuospatial performance impairment in PD. Significance: Visuospatial impairment in PD, which is highly correlated with the subsequent development of dementia, is reflected in α/θ in the right posterior regions. The right occipital α/θ may represent a useful qEEG marker for evaluating the presence of early signs of cognitive decline in PD and the subsequent risk of dementia. Mención de responsabilidad : Alberto Jaramillo-Jimenez, Jazmin Ximena Suarez-Revelo, John Fredy Ochoa-Gomez, Jairo Alexander Carmona Arroyave, Yamile Bocanegra, Francisco Lopera, Omar Buriticá, David Antonio Pineda-Salazar, Leonardo Moreno Gómez, Carlos Andrés Tobón Quintero, Miguel Germán Borda, Laura Bonanni, Dominic H Ffytche, Kolbjørn Brønnick, Dag Aarsland Referencia : Clin Neurophysiol. 2021 Jan 13;132(3):756-764. DOI (Digital Object Identifier) : 10.1016/j.clinph.2021.01.001 PMID : 33571883 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(21)00003-1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5758 Resting-state EEG alpha/theta ratio related to neuropsychological test performance in Parkinson's Disease [documento electrónico] / Leonardo Fabio Moreno Gómez, . - 2021.
Obra : Clinical Neurophysiology
Idioma : Inglés (eng)
Palabras clave : Alpha rhythm Electroencephalography Neuropsychological tests Parkinson’s Disease Theta rhythm Resumen : Objective: To determine possible associations of hemispheric-regional alpha/theta ratio (α/θ) with neuropsychological test performance in Parkinson's Disease (PD) non-demented patients. Methods: 36 PD were matched to 36 Healthy Controls (HC). The α/θ in eight hemispheric regions was computed from the relative power spectral density of the resting-state quantitative electroencephalogram (qEEG). Correlations between α/θ and performance in several neuropsychological tests were conducted, significant findings were included in a moderation analysis. Results: The α/θ in all regions was lower in PD than in HC, with larger effect sizes in the posterior regions. Right parietal, and right and left occipital α/θ had significant positive correlations with performance in Judgement of Line Orientation Test (JLOT) in PD. Adjusted moderation analysis indicated that right, but not left, occipital α/θ influenced the JLOT performance related to PD. Conclusions: Reduction of the occipital α/θ, in particular on the right side, was associated with visuospatial performance impairment in PD. Significance: Visuospatial impairment in PD, which is highly correlated with the subsequent development of dementia, is reflected in α/θ in the right posterior regions. The right occipital α/θ may represent a useful qEEG marker for evaluating the presence of early signs of cognitive decline in PD and the subsequent risk of dementia. Mención de responsabilidad : Alberto Jaramillo-Jimenez, Jazmin Ximena Suarez-Revelo, John Fredy Ochoa-Gomez, Jairo Alexander Carmona Arroyave, Yamile Bocanegra, Francisco Lopera, Omar Buriticá, David Antonio Pineda-Salazar, Leonardo Moreno Gómez, Carlos Andrés Tobón Quintero, Miguel Germán Borda, Laura Bonanni, Dominic H Ffytche, Kolbjørn Brønnick, Dag Aarsland Referencia : Clin Neurophysiol. 2021 Jan 13;132(3):756-764. DOI (Digital Object Identifier) : 10.1016/j.clinph.2021.01.001 PMID : 33571883 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(21)00003-1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5758 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001678 AC-2021-009 Archivo digital Producción Científica Artículos científicos Disponible
Título : Subjective cognitive and communicative complaints and health-related quality of life in Parkinson's disease with and without mild cognitive impairment Otros títulos : Quejas subjetivas cognitivas y comunicativas y calidad de vida relacionada con la salud en la enfermedad de Parkinson con y sin deterioro cognitivo leve Tipo de documento : documento electrónico Autores : Leonardo Fabio Moreno Gómez, Fecha de publicación : 2021 Títulos uniformes : Revista Colombiana de Psiquiatría Idioma : Inglés (eng) Palabras clave : Parkinson’s disease Health-related quality of life Quality of life Cognitive decline Mild cognitive impairment Resumen : Introduction: Mild Cognitive Impairment (MCI) is common in Parkinson's Disease (PD). Few studies have compared the Health-Related Quality of Life (HRQoL) in patients with and without MCI due to PD (PD-MCI), and its correlation to patients’ subjective cognitive and communicative difficulties has not been explored. Objective: We aimed to compare HRQoL in PD-MCI and PD without MCI (PD-nMCI), and explore its possible relationship to subjective cognitive and communicative complaints. Methods: We included 29 PD-nMCI and 11 PD-MCI patients. The HRQoL was assessed with the Parkinson's Disease Questionnaire-39 (PDQ-39): its Cognition dimension was used as a measure of subjective cognitive complaints, its Communication dimension for subjective communicative complaints, and the summary index (PDQ-39 SI) as an indicator of HRQoL. Non-parametric partial correlations between the Cognition and Communication dimensions, and the adjusted PDQ-39 SI were conducted. Results: PD-MCI patients had greater subjective cognitive and communicative complaints and worse HRQoL than PD-nMCI patients. In the PD-MCI group, both subjective cognitive and communicative complaints exhibited significant direct correlations with the adjusted HRQoL scores. Conclusions: HRQoL seems to be affected in PD-MCI, and it might be influenced by greater subjective cognitive and communicative complaints. Including patient-reported outcome measures of HRQoL, and providing cognitive and speech rehabilitation, as well as psychotherapeutic strategies to face these deficits can enhance the patient-centred approach in PD. Mención de responsabilidad : Alberto Jaramillo-Jimenez, Yamile Bocanegra, Omar Buriticá, David Antonio Pineda Salazar, Leonardo Moreno Gómez, Carlos Andrés Tobón Quintero, Daniel Camilo Aguirre-Acevedo, Melissa Sierra Castrillon, Daniel Vasquez, Juan Esteban Velez-Hernandez, Miguel Germán Borda, Elkin García-Cifuentes, David Fernando Aguillón, Lucía Madrigal-Zapata, Dag Aarsland y Francisco Lopera Referencia : Rev Colomb Psiquiatr (Engl Ed). 2021 Sep 3;S0034-7450(21)00134-7. DOI (Digital Object Identifier) : 10.1016/j.rcp.2021.07.005 PMID : 34489098 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0034745021001347 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5869 Subjective cognitive and communicative complaints and health-related quality of life in Parkinson's disease with and without mild cognitive impairment = Quejas subjetivas cognitivas y comunicativas y calidad de vida relacionada con la salud en la enfermedad de Parkinson con y sin deterioro cognitivo leve [documento electrónico] / Leonardo Fabio Moreno Gómez, . - 2021.
Obra : Revista Colombiana de Psiquiatría
Idioma : Inglés (eng)
Palabras clave : Parkinson’s disease Health-related quality of life Quality of life Cognitive decline Mild cognitive impairment Resumen : Introduction: Mild Cognitive Impairment (MCI) is common in Parkinson's Disease (PD). Few studies have compared the Health-Related Quality of Life (HRQoL) in patients with and without MCI due to PD (PD-MCI), and its correlation to patients’ subjective cognitive and communicative difficulties has not been explored. Objective: We aimed to compare HRQoL in PD-MCI and PD without MCI (PD-nMCI), and explore its possible relationship to subjective cognitive and communicative complaints. Methods: We included 29 PD-nMCI and 11 PD-MCI patients. The HRQoL was assessed with the Parkinson's Disease Questionnaire-39 (PDQ-39): its Cognition dimension was used as a measure of subjective cognitive complaints, its Communication dimension for subjective communicative complaints, and the summary index (PDQ-39 SI) as an indicator of HRQoL. Non-parametric partial correlations between the Cognition and Communication dimensions, and the adjusted PDQ-39 SI were conducted. Results: PD-MCI patients had greater subjective cognitive and communicative complaints and worse HRQoL than PD-nMCI patients. In the PD-MCI group, both subjective cognitive and communicative complaints exhibited significant direct correlations with the adjusted HRQoL scores. Conclusions: HRQoL seems to be affected in PD-MCI, and it might be influenced by greater subjective cognitive and communicative complaints. Including patient-reported outcome measures of HRQoL, and providing cognitive and speech rehabilitation, as well as psychotherapeutic strategies to face these deficits can enhance the patient-centred approach in PD. Mención de responsabilidad : Alberto Jaramillo-Jimenez, Yamile Bocanegra, Omar Buriticá, David Antonio Pineda Salazar, Leonardo Moreno Gómez, Carlos Andrés Tobón Quintero, Daniel Camilo Aguirre-Acevedo, Melissa Sierra Castrillon, Daniel Vasquez, Juan Esteban Velez-Hernandez, Miguel Germán Borda, Elkin García-Cifuentes, David Fernando Aguillón, Lucía Madrigal-Zapata, Dag Aarsland y Francisco Lopera Referencia : Rev Colomb Psiquiatr (Engl Ed). 2021 Sep 3;S0034-7450(21)00134-7. DOI (Digital Object Identifier) : 10.1016/j.rcp.2021.07.005 PMID : 34489098 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0034745021001347 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5869 Reserva
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Título : Resting functional connectivity and mild cognitive impairment in Parkinson's disease. An electroencephalogram study Tipo de documento : documento electrónico Autores : Leonardo Fabio Moreno Gómez, Fecha de publicación : 2019 Títulos uniformes : Future Neurology Idioma : Inglés (eng) Palabras clave : cognitive impairment electroencephalography executive functions functional connectivity Parkinson’s disease resting state Resumen : Objective: Parkinson’s disease (PD) is characterized by cognitive deficits. There is not clarity about electroencephalogram (EEG) connectivity related to the cognitive profile of patients. Our objective was to evaluate connectivity over resting EEG in nondemented PD. Methods: PD subjects with and without mild cognitive impairment (MCI) were assessed using coherence from resting EEG for local, intra and interhemispheric connectivity. Results: PD subjects without MCI (PD-nMCI) had lower intra and interhemispheric coherence in alpha2 compared with controls. PD with MCI (PD-MCI) showed higher intra and posterior interhemispheric coherence in alpha2 and beta1, respectively, in comparison to PD-nMCI. PD-MCI presented lower frontal coherence in beta frequencies compared with PD-nMCI. Conclusion: EEG coherence measures indicate distinct cortical activity in PD with and without MCI. Mención de responsabilidad : Jairo Alexander Carmona Arroyave, Carlos Andrés Tobón Quintero, Jasmín Jimena Suárez Revelo, John Fredy Ochoa Gómez, Yamile Bocanegra García, Leonardo Moreno Gómez & David Antonio Pineda Salazar DOI (Digital Object Identifier) : 10.2217/fnl-2018-0048 Derechos de uso : CC BY-NC-ND En línea : https://www.futuremedicine.com/doi/10.2217/fnl-2018-0048 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4293 Resting functional connectivity and mild cognitive impairment in Parkinson's disease. An electroencephalogram study [documento electrónico] / Leonardo Fabio Moreno Gómez, . - 2019.
Obra : Future Neurology
Idioma : Inglés (eng)
Palabras clave : cognitive impairment electroencephalography executive functions functional connectivity Parkinson’s disease resting state Resumen : Objective: Parkinson’s disease (PD) is characterized by cognitive deficits. There is not clarity about electroencephalogram (EEG) connectivity related to the cognitive profile of patients. Our objective was to evaluate connectivity over resting EEG in nondemented PD. Methods: PD subjects with and without mild cognitive impairment (MCI) were assessed using coherence from resting EEG for local, intra and interhemispheric connectivity. Results: PD subjects without MCI (PD-nMCI) had lower intra and interhemispheric coherence in alpha2 compared with controls. PD with MCI (PD-MCI) showed higher intra and posterior interhemispheric coherence in alpha2 and beta1, respectively, in comparison to PD-nMCI. PD-MCI presented lower frontal coherence in beta frequencies compared with PD-nMCI. Conclusion: EEG coherence measures indicate distinct cortical activity in PD with and without MCI. Mención de responsabilidad : Jairo Alexander Carmona Arroyave, Carlos Andrés Tobón Quintero, Jasmín Jimena Suárez Revelo, John Fredy Ochoa Gómez, Yamile Bocanegra García, Leonardo Moreno Gómez & David Antonio Pineda Salazar DOI (Digital Object Identifier) : 10.2217/fnl-2018-0048 Derechos de uso : CC BY-NC-ND En línea : https://www.futuremedicine.com/doi/10.2217/fnl-2018-0048 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4293 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001273 AC-2019-063 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
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Título : The Road Less Traveled: Alternative Pathways for Action-Verb Processing in Parkinson’s Disease Tipo de documento : documento electrónico Autores : Omar Fredy Buriticá Henao, Fecha de publicación : 2017 Títulos uniformes : Journal of Alzheimer's Disease Idioma : Inglés (eng) Palabras clave : Functional magnetic resonance imaging language motor cortex Parkinson’s disease semantics Resumen : Action verbs are critically embodied in motor brain networks. In Parkinson’s disease (PD), damage to the latter compromises access to such words. However, patients are not fully incapable of processing them, as their performance is far from floor level. Here we tested the hypothesis that action-verb processing in PD may rely on alternative disembodied semantic circuits. Seventeen PD patients and 15 healthy controls listened to action verbs and nouns during functional MRI scanning. Using cluster-mass analysis with a permutation test, we assessed task-related functional connectivity considering seeds differentially engaged by action and non-action words (namely, putamen and M1 versus posterior superior temporal lobe, respectively). The putamen seed showed reduced connectivity within the basal ganglia in patients for both lexical categories. However, only action verbs recruited different cortical networks in each group. Specifically, the M1 seed exhibited more anterior connectivity for controls and more posterior connectivity for patients, with no differences in the temporal seed. Moreover, the patients’ level of basal ganglia atrophy positively correlated with their reliance on M1-posterior connectivity during action-verb processing. PD patients seem to have processed action verbs via non-motor cortical networks subserving amodal semantics. Such circuits may afford alternative pathways to process words when default embodied mechanisms are disturbed. Moreover, the greater the level of basal ganglia atrophy, the greater the patients’ reliance on this alternative route. Our findings offer new insights into differential neurofunctional mechanisms recruited to process action semantics in PD. Mención de responsabilidad : Sofía Abrevaya, Lucas Sedeño, Sol Fitipaldi, David Pineda, Francisco Lopera, Omar Buritica, Andrés Villegas, Catalina Bustamante, Diana Gomez, Natalia Trujillo, Ricardo Pautassi, Agustín Ibáñez, Adolfo M García Referencia : J Alzheimers Dis. 2017;55(4):1429-1435. DOI (Digital Object Identifier) : 10.3233/JAD-160737 PMID : 27834777 En línea : https://content.iospress.com/articles/journal-of-alzheimers-disease/jad160737 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4017 The Road Less Traveled: Alternative Pathways for Action-Verb Processing in Parkinson’s Disease [documento electrónico] / Omar Fredy Buriticá Henao, . - 2017.
Obra : Journal of Alzheimer's Disease
Idioma : Inglés (eng)
Palabras clave : Functional magnetic resonance imaging language motor cortex Parkinson’s disease semantics Resumen : Action verbs are critically embodied in motor brain networks. In Parkinson’s disease (PD), damage to the latter compromises access to such words. However, patients are not fully incapable of processing them, as their performance is far from floor level. Here we tested the hypothesis that action-verb processing in PD may rely on alternative disembodied semantic circuits. Seventeen PD patients and 15 healthy controls listened to action verbs and nouns during functional MRI scanning. Using cluster-mass analysis with a permutation test, we assessed task-related functional connectivity considering seeds differentially engaged by action and non-action words (namely, putamen and M1 versus posterior superior temporal lobe, respectively). The putamen seed showed reduced connectivity within the basal ganglia in patients for both lexical categories. However, only action verbs recruited different cortical networks in each group. Specifically, the M1 seed exhibited more anterior connectivity for controls and more posterior connectivity for patients, with no differences in the temporal seed. Moreover, the patients’ level of basal ganglia atrophy positively correlated with their reliance on M1-posterior connectivity during action-verb processing. PD patients seem to have processed action verbs via non-motor cortical networks subserving amodal semantics. Such circuits may afford alternative pathways to process words when default embodied mechanisms are disturbed. Moreover, the greater the level of basal ganglia atrophy, the greater the patients’ reliance on this alternative route. Our findings offer new insights into differential neurofunctional mechanisms recruited to process action semantics in PD. Mención de responsabilidad : Sofía Abrevaya, Lucas Sedeño, Sol Fitipaldi, David Pineda, Francisco Lopera, Omar Buritica, Andrés Villegas, Catalina Bustamante, Diana Gomez, Natalia Trujillo, Ricardo Pautassi, Agustín Ibáñez, Adolfo M García Referencia : J Alzheimers Dis. 2017;55(4):1429-1435. DOI (Digital Object Identifier) : 10.3233/JAD-160737 PMID : 27834777 En línea : https://content.iospress.com/articles/journal-of-alzheimers-disease/jad160737 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4017 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000613 AC-2017-002 Archivo digital Producción Científica Artículos científicos Disponible
Título : Unspeakable motion: Selective action-verb impairments in Parkinson’s disease patients without mild cognitive impairment Tipo de documento : documento electrónico Autores : Omar Fredy Buriticá Henao, ; Leonardo Fabio Moreno Gómez, Fecha de publicación : 2017 Títulos uniformes : Brain & Language Idioma : Inglés (eng) Palabras clave : Parkinson’s disease Mild cognitive impairment Picture naming Action verbs Manipulable nouns Motor semantics Resumen : Parkinson's disease (PD) patients show marked impairments in processing action verbs, and to a lesser extent, concrete (specially, manipulable) nouns. However, it is still unclear to what extent deficits in each of these categories are influenced by more general cognitive dysfunctions, and whether they are modulated by the words' implied motility. To examine these issues, we evaluated 49 non-demented PD patients and 49 healthy volunteers in an oral production task. The patients were divided into two groups depending on the presence or absence of mild cognitive impairment (PD-MCI and PD-nMCI, respectively). Participants named pictures of actions varying in motion content (low and high) and of objects varying in manipulability (low and high). The PD-MCI group showed deficits across all four categories. However, PD-nMCI patients exhibited a selective difficulty for high-motion action verbs. This finding corroborates and refines previous results suggesting that disturbances of action-related lexico-semantic information in PD constitute a sui generis alteration manifested early in the course of the disease's physiopathology. Moreover, it suggests that the grounding of action verbs on motor circuits could depend on fine-grained intracategorical semantic distinctions. Mención de responsabilidad : Yamile Bocanegra, Adolfo M García, Francisco Lopera, David Pineda, Ana Baena, Paula Ospina, Diana Alzate, Omar Buriticá, Leonardo Moreno, Agustín Ibáñez, Fernando Cuetos Referencia : Brain Lang. 2017 May;168:37-46. DOI (Digital Object Identifier) : 10.1016/j.bandl.2017.01.005 PMID : 28131052 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0093934X16301262 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4038 Unspeakable motion: Selective action-verb impairments in Parkinson’s disease patients without mild cognitive impairment [documento electrónico] / Omar Fredy Buriticá Henao, ; Leonardo Fabio Moreno Gómez, . - 2017.
Obra : Brain & Language
Idioma : Inglés (eng)
Palabras clave : Parkinson’s disease Mild cognitive impairment Picture naming Action verbs Manipulable nouns Motor semantics Resumen : Parkinson's disease (PD) patients show marked impairments in processing action verbs, and to a lesser extent, concrete (specially, manipulable) nouns. However, it is still unclear to what extent deficits in each of these categories are influenced by more general cognitive dysfunctions, and whether they are modulated by the words' implied motility. To examine these issues, we evaluated 49 non-demented PD patients and 49 healthy volunteers in an oral production task. The patients were divided into two groups depending on the presence or absence of mild cognitive impairment (PD-MCI and PD-nMCI, respectively). Participants named pictures of actions varying in motion content (low and high) and of objects varying in manipulability (low and high). The PD-MCI group showed deficits across all four categories. However, PD-nMCI patients exhibited a selective difficulty for high-motion action verbs. This finding corroborates and refines previous results suggesting that disturbances of action-related lexico-semantic information in PD constitute a sui generis alteration manifested early in the course of the disease's physiopathology. Moreover, it suggests that the grounding of action verbs on motor circuits could depend on fine-grained intracategorical semantic distinctions. Mención de responsabilidad : Yamile Bocanegra, Adolfo M García, Francisco Lopera, David Pineda, Ana Baena, Paula Ospina, Diana Alzate, Omar Buriticá, Leonardo Moreno, Agustín Ibáñez, Fernando Cuetos Referencia : Brain Lang. 2017 May;168:37-46. DOI (Digital Object Identifier) : 10.1016/j.bandl.2017.01.005 PMID : 28131052 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0093934X16301262 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4038 Reserva
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