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Enlace permanente de la investigaciónMolecular profiling of papillary thyroid carcinomas in healthcare workers exposed to low dose radiation at the workplace / Carlos Simón Duque Fisher ; Alejandro Vélez Hoyos ; Juan Pablo Dueñas Muñoz
Título : Molecular profiling of papillary thyroid carcinomas in healthcare workers exposed to low dose radiation at the workplace Tipo de documento : documento electrónico Autores : Carlos Simón Duque Fisher, ; Alejandro Vélez Hoyos, ; Juan Pablo Dueñas Muñoz, Fecha de publicación : 2022 Títulos uniformes : Endocrine Idioma : Inglés (eng) Palabras clave : Healthcare specialists Papillary thyroid carcinoma (PTC) Radiation ThyroSeq Thyroid cancer Resumen : Purpose: Exposure to ionizing radiation, especially during childhood, is a well-established risk factor for thyroid cancer. The vast majority of radiation-induced cancers are papillary carcinomas (PTCs). These tumors typically have gene fusions in contrast to point mutations prevalent in sporadic PTCs. The aim of this study was to investigate the molecular profiles of PTC patients with workplace exposure to ionizing radiation. Methods: A retrospective review of 543 patients who underwent surgery with diagnosis of PTC was performed. A cohort of nine healthcare specialists previously exposed to radiation sources during their professional practice was selected and analyzed using the ThyroSeq mutation panel for point mutations and gene fusions associated with thyroid cancer. Results: The molecular analysis of surgical samples of PTCs was informative and revealed genetic alterations in five patients. BRAF V600E was found in four (67%) cases whereas RET/PTC1 fusion in one (17%) and one sample (17%) was wild type for point mutations and fusions. One sample completely failed molecular analysis while two others were negative for genes fusions but failed DNA analysis; these three samples were excluded. Conclusions: In this limited cohort of healthcare workers exposed to low dose of ionizing radiation at the workplace and developed PTC, the molecular profiling determined BRAF V600E point mutation as the most common event, arguing against the role of workplace radiation exposure in the etiology of these tumors. Mención de responsabilidad : Carlos S. Duque, Alejandro Vélez, Jorge Cuartas, Fabian Jaimes, Juan Pablo Dueñas, Miguel Agudelo, Marina N. Nikiforova, Yuri E. Nikiforov & Vincenzo Condello Referencia : Endocrine. 2022 Apr;76(1):95-100. DOI (Digital Object Identifier) : 10.1007/s12020-021-02972-y PMID : 35094311 En línea : https://link.springer.com/article/10.1007/s12020-021-02972-y Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6009 Molecular profiling of papillary thyroid carcinomas in healthcare workers exposed to low dose radiation at the workplace [documento electrónico] / Carlos Simón Duque Fisher, ; Alejandro Vélez Hoyos, ; Juan Pablo Dueñas Muñoz, . - 2022.
Obra : Endocrine
Idioma : Inglés (eng)
Palabras clave : Healthcare specialists Papillary thyroid carcinoma (PTC) Radiation ThyroSeq Thyroid cancer Resumen : Purpose: Exposure to ionizing radiation, especially during childhood, is a well-established risk factor for thyroid cancer. The vast majority of radiation-induced cancers are papillary carcinomas (PTCs). These tumors typically have gene fusions in contrast to point mutations prevalent in sporadic PTCs. The aim of this study was to investigate the molecular profiles of PTC patients with workplace exposure to ionizing radiation. Methods: A retrospective review of 543 patients who underwent surgery with diagnosis of PTC was performed. A cohort of nine healthcare specialists previously exposed to radiation sources during their professional practice was selected and analyzed using the ThyroSeq mutation panel for point mutations and gene fusions associated with thyroid cancer. Results: The molecular analysis of surgical samples of PTCs was informative and revealed genetic alterations in five patients. BRAF V600E was found in four (67%) cases whereas RET/PTC1 fusion in one (17%) and one sample (17%) was wild type for point mutations and fusions. One sample completely failed molecular analysis while two others were negative for genes fusions but failed DNA analysis; these three samples were excluded. Conclusions: In this limited cohort of healthcare workers exposed to low dose of ionizing radiation at the workplace and developed PTC, the molecular profiling determined BRAF V600E point mutation as the most common event, arguing against the role of workplace radiation exposure in the etiology of these tumors. Mención de responsabilidad : Carlos S. Duque, Alejandro Vélez, Jorge Cuartas, Fabian Jaimes, Juan Pablo Dueñas, Miguel Agudelo, Marina N. Nikiforova, Yuri E. Nikiforov & Vincenzo Condello Referencia : Endocrine. 2022 Apr;76(1):95-100. DOI (Digital Object Identifier) : 10.1007/s12020-021-02972-y PMID : 35094311 En línea : https://link.springer.com/article/10.1007/s12020-021-02972-y Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6009 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001844 AC-2022-015 Archivo digital Producción Científica Artículos científicos Disponible 
Título : Clinical behavior and outcome of papillary T1 thyroid cancers: South Korea vs. Turkey vs. Colombia. A cohort study analyzing oncological outcomes Tipo de documento : documento electrónico Autores : Juan Pablo Dueñas Muñoz, Fecha de publicación : 2020 Títulos uniformes : Asian Journal of Surgery Idioma : Inglés (eng) Palabras clave : Colombia Geographical difference South Korea Thyroid cancer Turkey Resumen : Background/purpose: There has not been an international multicentric study to examine the relationship between thyroid cancer clinical outcomes and geographic location for South Korea, Colombia, and Turkey, whereas thyroid cancer is amongst the highest three cancer types seen in South Korea and Turkey. The aim of the study was to assess regional differences of T1 papillary thyroid cancer outcomes in Korea, Turkey and Colombia. Methods: This is an observational non-randomized study. A total of 2720 patients who have been operated for T1 papillary thyroid cancer between 2011 and 2014 and are on routine follow-up have been recruited. The mean follow-up was 46.4 ± 10.7 months. Data were collected in a commonly used database and analyses were conducted. Results: Patients participated in South Korea (88.2%), Turkey (9.1%) and Colombia (2.6%). Eighty percent were female. Female dominance tended to be higher in Colombia (p = 0.01). Mean age at diagnosis was 45.2 years. There was no mortality. Recurrence tended to be higher in Colombia (p Mención de responsabilidad : Murat Ozdemir, Yong-Sang Lee, Ozer Makay, Juan Pablo Dueñas, Bulent Yazici, Aysegul Akgun, Gokhan Icoz, Mahir Akyildiz, Soo Young Kim, Seok-Mo Kim, Hojin Chang, Hang-Seok Chang, Cheong Soo Park Referencia : Asian J Surg. 2020 Aug;43(8):795-798. DOI (Digital Object Identifier) : 10.1016/j.asjsur.2019.10.005 PMID : 31791715 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S1015-9584(19)30823-1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5079 Clinical behavior and outcome of papillary T1 thyroid cancers: South Korea vs. Turkey vs. Colombia. A cohort study analyzing oncological outcomes [documento electrónico] / Juan Pablo Dueñas Muñoz, . - 2020.
Obra : Asian Journal of Surgery
Idioma : Inglés (eng)
Palabras clave : Colombia Geographical difference South Korea Thyroid cancer Turkey Resumen : Background/purpose: There has not been an international multicentric study to examine the relationship between thyroid cancer clinical outcomes and geographic location for South Korea, Colombia, and Turkey, whereas thyroid cancer is amongst the highest three cancer types seen in South Korea and Turkey. The aim of the study was to assess regional differences of T1 papillary thyroid cancer outcomes in Korea, Turkey and Colombia. Methods: This is an observational non-randomized study. A total of 2720 patients who have been operated for T1 papillary thyroid cancer between 2011 and 2014 and are on routine follow-up have been recruited. The mean follow-up was 46.4 ± 10.7 months. Data were collected in a commonly used database and analyses were conducted. Results: Patients participated in South Korea (88.2%), Turkey (9.1%) and Colombia (2.6%). Eighty percent were female. Female dominance tended to be higher in Colombia (p = 0.01). Mean age at diagnosis was 45.2 years. There was no mortality. Recurrence tended to be higher in Colombia (p Mención de responsabilidad : Murat Ozdemir, Yong-Sang Lee, Ozer Makay, Juan Pablo Dueñas, Bulent Yazici, Aysegul Akgun, Gokhan Icoz, Mahir Akyildiz, Soo Young Kim, Seok-Mo Kim, Hojin Chang, Hang-Seok Chang, Cheong Soo Park Referencia : Asian J Surg. 2020 Aug;43(8):795-798. DOI (Digital Object Identifier) : 10.1016/j.asjsur.2019.10.005 PMID : 31791715 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S1015-9584(19)30823-1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5079 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001309 AC-2020-013 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2020-013.pdfAdobe Acrobat PDF
Título : Metastatic papillary carcinoma to the neck, thinking beyond the thyroid gland Otros títulos : Carcinoma papilar metastásico a cuello, pensar más allá de la glándula tiroides Tipo de documento : documento electrónico Autores : Carlos Simón Duque Fisher, Fecha de publicación : 2020 Títulos uniformes : Revista Mexicana de Patología Clínica Idioma : Inglés (eng) Palabras clave : Lung cancer thyroid cancer neck dissection immunohistochemistry Resumen : Introduction: A description of a male patient with prior treatment for a right lung adenocarcinoma and a close follow-up for a right thyroid lobe 7 mm papillary cancer, who developed massive right neck metastasis. Objective: To describe the diagnostic dilemma to confirm or rule out the origin of the multiple neck metastasis to avoid unnecessary treatments. Methods: The biopsies from the lung, thyroid and neck tissues were reviewed and examined with immunohistochemistry. Results: The neck metastasis originated from an adenocarcinoma of the lung with papillary features. Conclusions: Unnecessary radioactive iodine treatments were avoided, thanks to the tumor markers. Mención de responsabilidad : Duque CS, Moreno A, Serna OC, Agudelo M DOI (Digital Object Identifier) : 10.35366/96680 En línea : https://www.medigraphic.com/cgi-bin/new/resumenI.cgi?IDARTICULO=96680 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5747 Metastatic papillary carcinoma to the neck, thinking beyond the thyroid gland = Carcinoma papilar metastásico a cuello, pensar más allá de la glándula tiroides [documento electrónico] / Carlos Simón Duque Fisher, . - 2020.
Obra : Revista Mexicana de Patología Clínica
Idioma : Inglés (eng)
Palabras clave : Lung cancer thyroid cancer neck dissection immunohistochemistry Resumen : Introduction: A description of a male patient with prior treatment for a right lung adenocarcinoma and a close follow-up for a right thyroid lobe 7 mm papillary cancer, who developed massive right neck metastasis. Objective: To describe the diagnostic dilemma to confirm or rule out the origin of the multiple neck metastasis to avoid unnecessary treatments. Methods: The biopsies from the lung, thyroid and neck tissues were reviewed and examined with immunohistochemistry. Results: The neck metastasis originated from an adenocarcinoma of the lung with papillary features. Conclusions: Unnecessary radioactive iodine treatments were avoided, thanks to the tumor markers. Mención de responsabilidad : Duque CS, Moreno A, Serna OC, Agudelo M DOI (Digital Object Identifier) : 10.35366/96680 En línea : https://www.medigraphic.com/cgi-bin/new/resumenI.cgi?IDARTICULO=96680 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5747 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001740 AC-2020-157 Archivo digital Producción Científica Artículos científicos Disponible
Título : Clinical features of Hispanic thyroid cancer cases and the role of known genetic variants on disease risk Tipo de documento : documento electrónico Autores : Carlos Simón Duque Fisher, ; Alejandro Vélez Hoyos, ; Jorge Hernando Donado Gómez, Fecha de publicación : 2016 Títulos uniformes : Medicine (Baltimore) Idioma : Inglés (eng) Palabras clave : Association Hispanics risk variants thyroid cancer Resumen : Thyroid cancer (TC) is the second most common cancer among Hispanic women. Recent genome-wide association (GWA) and candidate studies identified 6 single nucleotide polymorphisms (SNPs; rs966423, rs2439302, rs965513, rs6983267, rs944289, and rs116909374), associated with increased TC risk in Europeans but their effects on disease risk have not been comprehensively tested in Hispanics. In this study, we aimed to describe the main clinicopathological manifestations and to evaluate the effects of known SNPs on TC risk and on clinicopathological manifestations in a Hispanic population. We analyzed 281 nonmedullary TC cases and 1146 cancer-free controls recruited in a multicenter population-based study in Colombia. SNPs were genotyped by Kompetitive allele specific polymerase chain reaction (KASP) technique. Association between genetic variants and TC risk was assessed by computing odds ratios (OR) and confidence intervals (CIs). Consistent with published data in U.S. Hispanics, our cases had a high prevalence of large tumors (>2 cm, 43%) and a high female/male ratio (5:1). We detected significant associations between TC risk and rs965513A (OR = 1.41), rs944289T (OR = 1.26), rs116909374A (OR = 1.96), rs2439302G (OR = 1.19), and rs6983267G (OR = 1.18). Cases carried more risk alleles than controls (5.16 vs. 4.78, P = 4.8 × 10−6). Individuals with ≥6 risk alleles had >6-fold increased TC risk (OR = 6.33, P = 4.0 × 10−6) compared to individuals with ≤2 risk alleles. rs944289T and rs116909374A were strongly associated with follicular histology (ORs = 1.61 and 3.33, respectively); rs2439302G with large tumors (OR = 1.50); and rs965513A with regional disease (OR = 1.92). To our knowledge, this is the first study of known TC risk variants in South American Hispanics and suggests that they increase TC susceptibility in this population and can identify patients at higher risk of severe disease. Back to Top | Article Outline Mención de responsabilidad : Ana P Estrada-Florez, Mabel E Bohórquez, Ruta Sahasrabudhe, Rodrigo Prieto, Paul Lott, Carlos S Duque, Jorge Donado, Gilbert Mateus, Fernando Bolaños, Alejandro Vélez, Magdalena Echeverry, Luis G Carvajal-Carmona Referencia : Medicine (Baltimore). 2016 Aug;95(32):e4148. DOI (Digital Object Identifier) : 10.1097/MD.0000000000004148. PMID : 27512836 En línea : https://journals.lww.com/md-journal/fulltext/2016/08090/Clinical_features_of_His [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3954 Clinical features of Hispanic thyroid cancer cases and the role of known genetic variants on disease risk [documento electrónico] / Carlos Simón Duque Fisher, ; Alejandro Vélez Hoyos, ; Jorge Hernando Donado Gómez, . - 2016.
Obra : Medicine (Baltimore)
Idioma : Inglés (eng)
Palabras clave : Association Hispanics risk variants thyroid cancer Resumen : Thyroid cancer (TC) is the second most common cancer among Hispanic women. Recent genome-wide association (GWA) and candidate studies identified 6 single nucleotide polymorphisms (SNPs; rs966423, rs2439302, rs965513, rs6983267, rs944289, and rs116909374), associated with increased TC risk in Europeans but their effects on disease risk have not been comprehensively tested in Hispanics. In this study, we aimed to describe the main clinicopathological manifestations and to evaluate the effects of known SNPs on TC risk and on clinicopathological manifestations in a Hispanic population. We analyzed 281 nonmedullary TC cases and 1146 cancer-free controls recruited in a multicenter population-based study in Colombia. SNPs were genotyped by Kompetitive allele specific polymerase chain reaction (KASP) technique. Association between genetic variants and TC risk was assessed by computing odds ratios (OR) and confidence intervals (CIs). Consistent with published data in U.S. Hispanics, our cases had a high prevalence of large tumors (>2 cm, 43%) and a high female/male ratio (5:1). We detected significant associations between TC risk and rs965513A (OR = 1.41), rs944289T (OR = 1.26), rs116909374A (OR = 1.96), rs2439302G (OR = 1.19), and rs6983267G (OR = 1.18). Cases carried more risk alleles than controls (5.16 vs. 4.78, P = 4.8 × 10−6). Individuals with ≥6 risk alleles had >6-fold increased TC risk (OR = 6.33, P = 4.0 × 10−6) compared to individuals with ≤2 risk alleles. rs944289T and rs116909374A were strongly associated with follicular histology (ORs = 1.61 and 3.33, respectively); rs2439302G with large tumors (OR = 1.50); and rs965513A with regional disease (OR = 1.92). To our knowledge, this is the first study of known TC risk variants in South American Hispanics and suggests that they increase TC susceptibility in this population and can identify patients at higher risk of severe disease. Back to Top | Article Outline Mención de responsabilidad : Ana P Estrada-Florez, Mabel E Bohórquez, Ruta Sahasrabudhe, Rodrigo Prieto, Paul Lott, Carlos S Duque, Jorge Donado, Gilbert Mateus, Fernando Bolaños, Alejandro Vélez, Magdalena Echeverry, Luis G Carvajal-Carmona Referencia : Medicine (Baltimore). 2016 Aug;95(32):e4148. DOI (Digital Object Identifier) : 10.1097/MD.0000000000004148. PMID : 27512836 En línea : https://journals.lww.com/md-journal/fulltext/2016/08090/Clinical_features_of_His [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3954 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000540 AC-2016-015 Archivo digital Producción Científica Artículos científicos Disponible
Título : The HABP2 G534E polymorphism does not increase nonmedullary thyroid cancer risk in Hispanics Tipo de documento : documento electrónico Autores : Carlos Simón Duque Fisher, ; Jorge Hernando Donado Gómez, ; Alejandro Vélez Hoyos, Fecha de publicación : 2016 Títulos uniformes : Endocrine Connections Idioma : Inglés (eng) Palabras clave : HABP2 G534E thyroid cancer hispanics Resumen : Familial nonmedullary thyroid cancer (NMTC) has not been clearly linked to causal germline variants, despite the large role that genetic factors play in risk. Recently, HABP2 G534E (rs7080536A) has been implicated as a causal variant in NMTC. We have previously shown that the HABP2 G534E variant is not associated with TC risk in patients from the British Isles. Hispanics are the largest and the youngest minority in the United States and NMTC is now the second most common malignancy in women from this population. In order to determine if the HABP2 G534E variant played a role in NMTC risk among Hispanic populations, we analyzed 281 cases and 1105 population-matched controls from a multicenter study in Colombia, evaluating the association through logistic regression. We found that the HABP2 G534E variant was not significantly associated with NMTC risk (P=0.843) in this Hispanic group. We also stratified available clinical data by multiple available clinicopathological variables and further analyzed the effect of HABP2 on NMTC presentation. However, we failed to detect associations between HABP2 G534E and NMTC risk, regardless of disease presentation (P≥0.273 for all cases). Therefore, without any significant associations between the HABP2 G534E variant and NMTC risk, we conclude that the variant is not causal of NMTC in this Hispanic population. Mención de responsabilidad : Mabel E Bohórquez, Ana P Estrada, Jacob Stultz, Ruta Sahasrabudhe, John Williamson, Paul Lott, Carlos S Duque, Jorge Donado, Gilbert Mateus, Fernando Bolaños, Alejandro Vélez, Magdalena Echeverry, Luis G Carvajal-Carmona Referencia : Endocr Connect. 2016 May;5(3):123-7. DOI (Digital Object Identifier) : 10.1530/EC-16-0017 PMID : 27097599 Derechos de uso : CC BY-NC En línea : https://ec.bioscientifica.com/view/journals/ec/5/3/123.xml Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3953 The HABP2 G534E polymorphism does not increase nonmedullary thyroid cancer risk in Hispanics [documento electrónico] / Carlos Simón Duque Fisher, ; Jorge Hernando Donado Gómez, ; Alejandro Vélez Hoyos, . - 2016.
Obra : Endocrine Connections
Idioma : Inglés (eng)
Palabras clave : HABP2 G534E thyroid cancer hispanics Resumen : Familial nonmedullary thyroid cancer (NMTC) has not been clearly linked to causal germline variants, despite the large role that genetic factors play in risk. Recently, HABP2 G534E (rs7080536A) has been implicated as a causal variant in NMTC. We have previously shown that the HABP2 G534E variant is not associated with TC risk in patients from the British Isles. Hispanics are the largest and the youngest minority in the United States and NMTC is now the second most common malignancy in women from this population. In order to determine if the HABP2 G534E variant played a role in NMTC risk among Hispanic populations, we analyzed 281 cases and 1105 population-matched controls from a multicenter study in Colombia, evaluating the association through logistic regression. We found that the HABP2 G534E variant was not significantly associated with NMTC risk (P=0.843) in this Hispanic group. We also stratified available clinical data by multiple available clinicopathological variables and further analyzed the effect of HABP2 on NMTC presentation. However, we failed to detect associations between HABP2 G534E and NMTC risk, regardless of disease presentation (P≥0.273 for all cases). Therefore, without any significant associations between the HABP2 G534E variant and NMTC risk, we conclude that the variant is not causal of NMTC in this Hispanic population. Mención de responsabilidad : Mabel E Bohórquez, Ana P Estrada, Jacob Stultz, Ruta Sahasrabudhe, John Williamson, Paul Lott, Carlos S Duque, Jorge Donado, Gilbert Mateus, Fernando Bolaños, Alejandro Vélez, Magdalena Echeverry, Luis G Carvajal-Carmona Referencia : Endocr Connect. 2016 May;5(3):123-7. DOI (Digital Object Identifier) : 10.1530/EC-16-0017 PMID : 27097599 Derechos de uso : CC BY-NC En línea : https://ec.bioscientifica.com/view/journals/ec/5/3/123.xml Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3953 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000538 AC-2016-013 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2016-013.pdfAdobe Acrobat PDF
