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First report of survival in two patients with hematologic malignancy and Stenotrophomonas maltophilia hemorrhagic pneumonia treated with trimethoprim-sulfamethoxazole-based combination antibiotic therapy / Nelson Darío Giraldo Ramírez ; Óscar Iván McEwen Tamayo ; Alicia Inés Hidrón Botero  

Público ISBD Título : First report of survival in two patients with hematologic malignancy and Stenotrophomonas maltophilia hemorrhagic pneumonia treated with trimethoprim-sulfamethoxazole-based combination antibiotic therapy Tipo de documento : documento electrónico Autores : Nelson Darío Giraldo Ramírez, ; Óscar Iván McEwen Tamayo, ; Alicia Inés Hidrón Botero, Fecha de publicación : 2020 Títulos uniformes : Journal of Infection and Chemotherapy Idioma : Inglés (eng) Palabras clave : Combination therapy  Hemorrhagic pneumonia  Stenotrophomonas maltophilia  Trimethoprim-sulfamethoxazole Resumen : Stenotrophomonas maltophilia has become a common cause of opportunistic infections in immunocompromised hosts and critical care patients. The most common disease manifestations are pneumonia and bacteremia, with a mortality ranging from 9% to 60.5% depending of the type of infection and host related underlying risk factors. Patients with hematological malignancies may develop a hemorrhagic pneumonia with a rapidly progressive and universally fatal disease course, despite appropriate treatment with trimethoprim/sulfamethoxazole or combination therapy. We report the first two patients with hematologic malignancies and hemorrhagic pneumonia due to S. maltophilia with successful treatment outcomes after early institution of combination therapy with TMP/SMX, polymyxin, and/or moxifloxacin. Mención de responsabilidad : Sara Catalina Penagos, Nelson Giraldo, Camilo Vallejo, Oscar McEwen, Alicia Hidron Referencia : J Infect Chemother. 2020 Apr;26(4):397-399. DOI (Digital Object Identifier) : 10.1016/j.jiac.2019.12.003 PMID : 31882384 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1341-321X(19)30371-X Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5076 First report of survival in two patients with hematologic malignancy and Stenotrophomonas maltophilia hemorrhagic pneumonia treated with trimethoprim-sulfamethoxazole-based combination antibiotic therapy [documento electrónico] / Nelson Darío Giraldo Ramírez, ; Óscar Iván McEwen Tamayo, ; Alicia Inés Hidrón Botero,  . - 2020. Obra : Journal of Infection and Chemotherapy Idioma : Inglés (eng) Palabras clave : Combination therapy  Hemorrhagic pneumonia  Stenotrophomonas maltophilia  Trimethoprim-sulfamethoxazole Resumen : Stenotrophomonas maltophilia has become a common cause of opportunistic infections in immunocompromised hosts and critical care patients. The most common disease manifestations are pneumonia and bacteremia, with a mortality ranging from 9% to 60.5% depending of the type of infection and host related underlying risk factors. Patients with hematological malignancies may develop a hemorrhagic pneumonia with a rapidly progressive and universally fatal disease course, despite appropriate treatment with trimethoprim/sulfamethoxazole or combination therapy. We report the first two patients with hematologic malignancies and hemorrhagic pneumonia due to S. maltophilia with successful treatment outcomes after early institution of combination therapy with TMP/SMX, polymyxin, and/or moxifloxacin. Mención de responsabilidad : Sara Catalina Penagos, Nelson Giraldo, Camilo Vallejo, Oscar McEwen, Alicia Hidron Referencia : J Infect Chemother. 2020 Apr;26(4):397-399. DOI (Digital Object Identifier) : 10.1016/j.jiac.2019.12.003 PMID : 31882384 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1341-321X(19)30371-X Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5076

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Urinary tract infection leading to hospital admission during the first year after kidney transplantation: A retrospective cohort study / Fabián Alberto Jaimes Barragán    

Público ISBD Título : Urinary tract infection leading to hospital admission during the first year after kidney transplantation: A retrospective cohort study Tipo de documento : documento electrónico Autores : Fabián Alberto Jaimes Barragán, Fecha de publicación : 2016 Títulos uniformes : Transplantation Reports Idioma : Inglés (eng) Palabras clave : CKD  Chronic kidney disease  CKF  Chronic kidney failure  ESRD  end stage renal disease  HD  hemodialysis  KTR  kidney transplant recipients  MDR  Multidrug resistant  MMF  mycophenolate mofetil  mTOR  mammalian target of rapamycin  PD  peritoneal dialysis  RRT  renal replacement therapy  UTI  Urinary tract infection  TMP/SMX  Trimethoprim-sulfamethoxazole  XDR  Extensively drug-resistant Resumen : Introduction: Urinary tract infection (UTI) is the most common infectious problem in kidney transplant recipients (KTR). It has been associated with risk factors inherent to the transplant and it could negatively affect clinical outcomes. The aim of this study was to describe demographic, clinical and microbiological characteristics of patients with UTI. Methods: We underwent a retrospective study reviewing the database of kidney transplants patients in a national reference center in Colombia. We included patients admitted for inpatient treatment related to urinary tract infection in the first year after transplantation. Results: We describe clinical information from 65 patients, the mean age was 46 years, the most common comorbidity was hypertension (n=48/62, 77.4%) followed by diabetes mellitus (n=11/62, 17.7%); 77% (n=50/65) of the infections were diagnosed in the first 6 months after transplant and 70% (n=45/65) had pyelonephritis. Acute dysfunction of the graft was the most common complication in 59% (n=33/56) of cases. The most common etiological agent described was E. coli in 67% (n=37/55) of patients followed by Klebsiella pneumoniae (n=13/55). Bacteremia was present in 25% of cases. Infection with extended-spectrum betalactamases producing bacteria was present in 42% (n=18/42) of our isolations and multidrug resistance was documented in 39% (n=21/54) of isolates. Conclusion: Most UTI leading to hospitalization in KTR occur in the first six months. Pyelonephritis explains the majority of clinical diagnosis. The rate of blood stream infections and multidrug resistance bacteria is high, justifying an empiric broad-spectrum antibiotic treatment. Mención de responsabilidad : Santiago Giraldo-Ramírez, Oscar Emilio Díaz-Portilla, Andrés Felipe Miranda-Arboleda, Jorge Henao-Sierra, Lina María Echeverri-Toro, Fabian Jaimes DOI (Digital Object Identifier) : 10.1016/j.tpr.2016.09.001 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S2451959616300154 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4616 Urinary tract infection leading to hospital admission during the first year after kidney transplantation: A retrospective cohort study [documento electrónico] / Fabián Alberto Jaimes Barragán,  . - 2016. Obra : Transplantation Reports Idioma : Inglés (eng) Palabras clave : CKD  Chronic kidney disease  CKF  Chronic kidney failure  ESRD  end stage renal disease  HD  hemodialysis  KTR  kidney transplant recipients  MDR  Multidrug resistant  MMF  mycophenolate mofetil  mTOR  mammalian target of rapamycin  PD  peritoneal dialysis  RRT  renal replacement therapy  UTI  Urinary tract infection  TMP/SMX  Trimethoprim-sulfamethoxazole  XDR  Extensively drug-resistant Resumen : Introduction: Urinary tract infection (UTI) is the most common infectious problem in kidney transplant recipients (KTR). It has been associated with risk factors inherent to the transplant and it could negatively affect clinical outcomes. The aim of this study was to describe demographic, clinical and microbiological characteristics of patients with UTI. Methods: We underwent a retrospective study reviewing the database of kidney transplants patients in a national reference center in Colombia. We included patients admitted for inpatient treatment related to urinary tract infection in the first year after transplantation. Results: We describe clinical information from 65 patients, the mean age was 46 years, the most common comorbidity was hypertension (n=48/62, 77.4%) followed by diabetes mellitus (n=11/62, 17.7%); 77% (n=50/65) of the infections were diagnosed in the first 6 months after transplant and 70% (n=45/65) had pyelonephritis. Acute dysfunction of the graft was the most common complication in 59% (n=33/56) of cases. The most common etiological agent described was E. coli in 67% (n=37/55) of patients followed by Klebsiella pneumoniae (n=13/55). Bacteremia was present in 25% of cases. Infection with extended-spectrum betalactamases producing bacteria was present in 42% (n=18/42) of our isolations and multidrug resistance was documented in 39% (n=21/54) of isolates. Conclusion: Most UTI leading to hospitalization in KTR occur in the first six months. Pyelonephritis explains the majority of clinical diagnosis. The rate of blood stream infections and multidrug resistance bacteria is high, justifying an empiric broad-spectrum antibiotic treatment. Mención de responsabilidad : Santiago Giraldo-Ramírez, Oscar Emilio Díaz-Portilla, Andrés Felipe Miranda-Arboleda, Jorge Henao-Sierra, Lina María Echeverri-Toro, Fabian Jaimes DOI (Digital Object Identifier) : 10.1016/j.tpr.2016.09.001 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S2451959616300154 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4616

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