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Enlace permanente de la investigaciónA global point prevalence survey of antimicrobial use in neonatal intensive care units: The no-more-antibiotics and resistance (NO-MAS-R) study
Título : A global point prevalence survey of antimicrobial use in neonatal intensive care units: The no-more-antibiotics and resistance (NO-MAS-R) study Tipo de documento : documento electrónico Fecha de publicación : 2021 Títulos uniformes : eClinicalMedicine Idioma : Inglés (eng) Palabras clave : Global point prevalence study Neonatal infection Neonatal antimicrobial stewardship Antibiotics Antifungal Resumen : Background: Global assessment of antimicrobial agents prescribed to infants in the neonatal intensive care unit (NICU) may inform antimicrobial stewardship efforts. Methods: We conducted a one-day global point prevalence study of all antimicrobials provided to NICU infants. Demographic, clinical, and microbiologic data were obtained including NICU level, census, birth weight, gestational/chronologic age, diagnoses, antimicrobial therapy (reason for use; length of therapy), antimicrobial stewardship program (ASP), and 30-day in-hospital mortality. Findings: On July 1, 2019, 26% of infants (580/2,265; range, 0–100%; median gestational age, 33 weeks; median birth weight, 1800 g) in 84 NICUs (51, high-income; 33, low-to-middle income) from 29 countries (14, high-income; 15, low-to-middle income) in five continents received ≥1 antimicrobial agent (92%, antibacterial; 19%, antifungal; 4%, antiviral). The most common reasons for antibiotic therapy were “rule-out” sepsis (32%) and “culture-negative” sepsis (16%) with ampicillin (40%), gentamicin (35%), amikacin (19%), vancomycin (15%), and meropenem (9%) used most frequently. For definitive treatment of presumed/confirmed infection, vancomycin (26%), amikacin (20%), and meropenem (16%) were the most prescribed agents. Length of therapy for culture-positive and “culture-negative” infections was 12 days (median; IQR, 8–14) and 7 days (median; IQR, 5–10), respectively. Mortality was 6% (42%, infection-related). An NICU ASP was associated with lower rate of antibiotic utilization (p = 0·02). Interpretation: Global NICU antibiotic use was frequent and prolonged regardless of culture results. NICU-specific ASPs were associated with lower antibiotic utilization rates, suggesting the need for their implementation worldwide. Mención de responsabilidad : Pavel Prusakov, PharmD, Debra A. Goff, PharmD, Phillip S. Wozniak, BA, Azraa Cassim, BPharm, Catherine E.A. Scipion, MD, Soledad Urzua, MD, Andrea Ronchi, MD, Lingkong Zeng, MD, Oluwaseun Ladipo-Ajayi, MBChB, Noelia Aviles-Otero, MD, Chisom R. Udeigwe-Okeke, MBBS, Rimma Melamed, MD, Rita C. Silveira, MD,Cinzia Auriti, MD, Claudia Beltran-Arroyave, MD, Elena Zamora-Flores, MD, Maria Sanchez-Codez, MD, Eric S. Donkor, PhD, Satu Kekomaki, MD, Nicoletta Mainini, MD, Rosalba Vivas Trochez, MD, Jamalyn Casey, PharmD, Juan M. Graus, MD, Mallory Muller, PharmD, Sara Singh, MBBS, Yvette Loeffen, MD, María Eulalia Tamayo Perez, MD, Gloria Isabel Ferreyra, MD, Victoria Lima-Rogel, MD, Barbara Perrone, MD, Giannina Izquierdo, MD, María Cernada, MD, Sylvia Stoffella, PharmD, Sebastian Okwuchukwu Ekenze, MD, Concepcion de Alba-Romero, MD, Chryssoula Tzialla, MD, Jennifer T. Pham, PharmD, Kenichiro Hosoi, MD, Magdalena Cecilia Calero Consuegra, MD, Pasqua Betta, MD, O. Alvaro Hoyos, MD, Emmanuel Roi Referencia : EClinicalMedicine. 2021 Jan 29;32:100727. DOI (Digital Object Identifier) : 10.1016/j.eclinm.2021.100727 PMID : 33554094 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S2589537021000079 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5860 A global point prevalence survey of antimicrobial use in neonatal intensive care units: The no-more-antibiotics and resistance (NO-MAS-R) study [documento electrónico] . - 2021.
Obra : eClinicalMedicine
Idioma : Inglés (eng)
Palabras clave : Global point prevalence study Neonatal infection Neonatal antimicrobial stewardship Antibiotics Antifungal Resumen : Background: Global assessment of antimicrobial agents prescribed to infants in the neonatal intensive care unit (NICU) may inform antimicrobial stewardship efforts. Methods: We conducted a one-day global point prevalence study of all antimicrobials provided to NICU infants. Demographic, clinical, and microbiologic data were obtained including NICU level, census, birth weight, gestational/chronologic age, diagnoses, antimicrobial therapy (reason for use; length of therapy), antimicrobial stewardship program (ASP), and 30-day in-hospital mortality. Findings: On July 1, 2019, 26% of infants (580/2,265; range, 0–100%; median gestational age, 33 weeks; median birth weight, 1800 g) in 84 NICUs (51, high-income; 33, low-to-middle income) from 29 countries (14, high-income; 15, low-to-middle income) in five continents received ≥1 antimicrobial agent (92%, antibacterial; 19%, antifungal; 4%, antiviral). The most common reasons for antibiotic therapy were “rule-out” sepsis (32%) and “culture-negative” sepsis (16%) with ampicillin (40%), gentamicin (35%), amikacin (19%), vancomycin (15%), and meropenem (9%) used most frequently. For definitive treatment of presumed/confirmed infection, vancomycin (26%), amikacin (20%), and meropenem (16%) were the most prescribed agents. Length of therapy for culture-positive and “culture-negative” infections was 12 days (median; IQR, 8–14) and 7 days (median; IQR, 5–10), respectively. Mortality was 6% (42%, infection-related). An NICU ASP was associated with lower rate of antibiotic utilization (p = 0·02). Interpretation: Global NICU antibiotic use was frequent and prolonged regardless of culture results. NICU-specific ASPs were associated with lower antibiotic utilization rates, suggesting the need for their implementation worldwide. Mención de responsabilidad : Pavel Prusakov, PharmD, Debra A. Goff, PharmD, Phillip S. Wozniak, BA, Azraa Cassim, BPharm, Catherine E.A. Scipion, MD, Soledad Urzua, MD, Andrea Ronchi, MD, Lingkong Zeng, MD, Oluwaseun Ladipo-Ajayi, MBChB, Noelia Aviles-Otero, MD, Chisom R. Udeigwe-Okeke, MBBS, Rimma Melamed, MD, Rita C. Silveira, MD,Cinzia Auriti, MD, Claudia Beltran-Arroyave, MD, Elena Zamora-Flores, MD, Maria Sanchez-Codez, MD, Eric S. Donkor, PhD, Satu Kekomaki, MD, Nicoletta Mainini, MD, Rosalba Vivas Trochez, MD, Jamalyn Casey, PharmD, Juan M. Graus, MD, Mallory Muller, PharmD, Sara Singh, MBBS, Yvette Loeffen, MD, María Eulalia Tamayo Perez, MD, Gloria Isabel Ferreyra, MD, Victoria Lima-Rogel, MD, Barbara Perrone, MD, Giannina Izquierdo, MD, María Cernada, MD, Sylvia Stoffella, PharmD, Sebastian Okwuchukwu Ekenze, MD, Concepcion de Alba-Romero, MD, Chryssoula Tzialla, MD, Jennifer T. Pham, PharmD, Kenichiro Hosoi, MD, Magdalena Cecilia Calero Consuegra, MD, Pasqua Betta, MD, O. Alvaro Hoyos, MD, Emmanuel Roi Referencia : EClinicalMedicine. 2021 Jan 29;32:100727. DOI (Digital Object Identifier) : 10.1016/j.eclinm.2021.100727 PMID : 33554094 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S2589537021000079 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5860 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001798 AC-2021-110 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
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Título : High rates of antibiotic prescriptions in children with COVID-19 or multisystem inflammatory syndrome: A multinational experience in 990 cases from Latin America Tipo de documento : documento electrónico Autores : Andrea Parra Buitrago, ; Lina María Betancur Londoño, Fecha de publicación : 2021 Títulos uniformes : Acta Paediatrica Idioma : Inglés (eng) Palabras clave : COVID-19 SARS-COV-2 antibiotics stewardship Resumen : Aim: This study aims to assess rates of antibiotic prescriptions and its determinants in in children with COVID-19 or Multisystem Inflammatory Syndrome (MIS-C). Methods: Children Mención de responsabilidad : Acta Paediatr. 2021 Jun;110(6):1902-1910. Referencia : 10.1111/apa.15847 DOI (Digital Object Identifier) : 33742466 En línea : https://onlinelibrary.wiley.com/doi/10.1111/apa.15847 Formato del recurso electrónico : Adriana Yock-Corrales, Jacopo Lenzi, Rolando Ulloa-Gutiérrez, Jessica Gómez-Vargas, Omar Yassef Antúnez-Montes, Jorge Alberto Rios Aida, Olguita del Aguila, Erick Arteaga-Menchaca, Francisco Campos, Fadia Uribe, Andrea Parra Buitrago, Lina Maria Betancur Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5857 High rates of antibiotic prescriptions in children with COVID-19 or multisystem inflammatory syndrome: A multinational experience in 990 cases from Latin America [documento electrónico] / Andrea Parra Buitrago, ; Lina María Betancur Londoño, . - 2021.
Obra : Acta Paediatrica
Idioma : Inglés (eng)
Palabras clave : COVID-19 SARS-COV-2 antibiotics stewardship Resumen : Aim: This study aims to assess rates of antibiotic prescriptions and its determinants in in children with COVID-19 or Multisystem Inflammatory Syndrome (MIS-C). Methods: Children Mención de responsabilidad : Acta Paediatr. 2021 Jun;110(6):1902-1910. Referencia : 10.1111/apa.15847 DOI (Digital Object Identifier) : 33742466 En línea : https://onlinelibrary.wiley.com/doi/10.1111/apa.15847 Formato del recurso electrónico : Adriana Yock-Corrales, Jacopo Lenzi, Rolando Ulloa-Gutiérrez, Jessica Gómez-Vargas, Omar Yassef Antúnez-Montes, Jorge Alberto Rios Aida, Olguita del Aguila, Erick Arteaga-Menchaca, Francisco Campos, Fadia Uribe, Andrea Parra Buitrago, Lina Maria Betancur Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5857 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001795 AC-2021-107 Archivo digital Producción Científica Artículos científicos Disponible
Título : Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis Tipo de documento : documento electrónico Autores : Adriana Giraldo Villa, Fecha de publicación : 2020 Títulos uniformes : Gut Microbes Idioma : Inglés (eng) Palabras clave : Intestinal microbiota antibiotics critically ill patient intensive care unit sepsis Resumen : Critically ill patients are physiologically unstable and recent studies indicate that the intestinal microbiota could be involved in the health decline of such patients during ICU stays. This study aims to assess the intestinal microbiota in critically ill patients with and without sepsis and to determine its impact on outcome variables, such as medical complications, ICU stay time, and mortality. A multi-center study was conducted with a total of 250 peri-rectal swabs obtained from 155 patients upon admission and during ICU stays. Intestinal microbiota was assessed by sequencing the V3-V4 hypervariable regions of the 16S rRNA gene. Linear mixed models were used to integrate microbiota data with more than 40 clinical and demographic variables to detect covariates and minimize the effect of confounding factors. We found that the microbiota of ICU patients with sepsis has an increased abundance of microbes tightly associated with inflammation, such as Parabacteroides, Fusobacterium and Bilophila species. Female sex and aging would represent an increased risk for sepsis possibly because of some of their microbiota features. We also evidenced a remarkable loss of microbial diversity, during the ICU stay. Concomitantly, we detected that the abundance of pathogenic species, such as Enterococcus spp., was differentially increased in sepsis patients who died, indicating these species as potential biomarkers for monitoring during ICU stay. We concluded that particular intestinal microbiota signatures could predict sepsis development in ICU patients. We propose potential biomarkers for evaluation in the clinical management of ICU patients. Mención de responsabilidad : Gloria M Agudelo-Ochoa, Beatriz E Valdés-Duque, Nubia A Giraldo-Giraldo, Ana M Jaillier-Ramírez, Adriana Giraldo-Villa, Irene Acevedo-Castaño, Mónica A Yepes-Molina, Janeth Barbosa-Barbosa, Alfonso Benítez-Paéz Referencia : Gut Microbes. 2020 Nov 9;12(1):1707610. DOI (Digital Object Identifier) : 10.1080/19490976.2019.1707610 PMID : 31924126 Derechos de uso : CC BY-NC-ND En línea : https://www.tandfonline.com/doi/full/10.1080/19490976.2019.1707610 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5072 Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis [documento electrónico] / Adriana Giraldo Villa, . - 2020.
Obra : Gut Microbes
Idioma : Inglés (eng)
Palabras clave : Intestinal microbiota antibiotics critically ill patient intensive care unit sepsis Resumen : Critically ill patients are physiologically unstable and recent studies indicate that the intestinal microbiota could be involved in the health decline of such patients during ICU stays. This study aims to assess the intestinal microbiota in critically ill patients with and without sepsis and to determine its impact on outcome variables, such as medical complications, ICU stay time, and mortality. A multi-center study was conducted with a total of 250 peri-rectal swabs obtained from 155 patients upon admission and during ICU stays. Intestinal microbiota was assessed by sequencing the V3-V4 hypervariable regions of the 16S rRNA gene. Linear mixed models were used to integrate microbiota data with more than 40 clinical and demographic variables to detect covariates and minimize the effect of confounding factors. We found that the microbiota of ICU patients with sepsis has an increased abundance of microbes tightly associated with inflammation, such as Parabacteroides, Fusobacterium and Bilophila species. Female sex and aging would represent an increased risk for sepsis possibly because of some of their microbiota features. We also evidenced a remarkable loss of microbial diversity, during the ICU stay. Concomitantly, we detected that the abundance of pathogenic species, such as Enterococcus spp., was differentially increased in sepsis patients who died, indicating these species as potential biomarkers for monitoring during ICU stay. We concluded that particular intestinal microbiota signatures could predict sepsis development in ICU patients. We propose potential biomarkers for evaluation in the clinical management of ICU patients. Mención de responsabilidad : Gloria M Agudelo-Ochoa, Beatriz E Valdés-Duque, Nubia A Giraldo-Giraldo, Ana M Jaillier-Ramírez, Adriana Giraldo-Villa, Irene Acevedo-Castaño, Mónica A Yepes-Molina, Janeth Barbosa-Barbosa, Alfonso Benítez-Paéz Referencia : Gut Microbes. 2020 Nov 9;12(1):1707610. DOI (Digital Object Identifier) : 10.1080/19490976.2019.1707610 PMID : 31924126 Derechos de uso : CC BY-NC-ND En línea : https://www.tandfonline.com/doi/full/10.1080/19490976.2019.1707610 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5072 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001302 AC-2020-006 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
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Título : Antibiotics has more impact on mortality than other early goal-directed therapy components in patients with sepsis: An instrumental variable analysis Tipo de documento : documento electrónico Autores : Jessica María Londoño Agudelo, ; Andrea Yiseth Archila León, ; Diana Patricia Cárdenas Cuervo, ; Mayla Andrea Perdomo Amar, ; Jairo Giovanni Moncayo Viveros, Fecha de publicación : 2018 Títulos uniformes : Journal of Critical Care Idioma : Inglés (eng) Palabras clave : Sepsis resuscitation lactic acid antibiotics shock hyperlactatemia Resumen : Purpose: To estimate the effect of each of the EGDT components, as well as of the antibiotics, on length-of-stay and mortality. Methods: Prospective cohort in three hospitals. Adult patients admitted by the Emergency Rooms (ER) with infection and any of systolic blood pressure b 90 mmHg or lactate N4 mmol/L. An instrumental analysis with hospital of admission as the instrumental variable was performed to estimate the effect of each intervention on hospital mortality and secondary outcomes. Results: Among 2587 patients evaluated 884 met inclusion criteria, with a hospital mortality rate of 17% (n =150). In the instrumental analysis, the only intervention associated with an absolute reduction in mortality (21%) was the use of antibiotics in the first 3 h. In patients with lactate values ≥4 mmol/L in the ER, a nondecrease of at least 10% at six hours was independently associated with mortality (OR = 3.1; 95%CI = 1.5–6.2). Conclusions: Among patients entering ER with infection and shock or hypoperfusion criteria, the use of appropriate antibiotics in the first 3 h is the measure that has the greatest impact on survival. In addition, among patients with hyperlactatemia N4 mmol/L, the clearance of N10% of lactate during resuscitation is associated with better outcomes. Mención de responsabilidad : Jessica Londoño, César Niño, Andrea Archila, Marta Valencia, Diana Cárdenas, Mayla Perdomo, Giovanny Moncayo, César Vargas, Carlos E Vallejo, Carolina Hincapié, Johana Ascuntar, Alba León, Fabián Jaimes Referencia : J Crit Care. 2018 Dec;48:191-197. DOI (Digital Object Identifier) : 10.1016/j.jcrc.2018.08.035 PMID : 30218959 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0883-9441(18)30531-8 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4175 Antibiotics has more impact on mortality than other early goal-directed therapy components in patients with sepsis: An instrumental variable analysis [documento electrónico] / Jessica María Londoño Agudelo, ; Andrea Yiseth Archila León, ; Diana Patricia Cárdenas Cuervo, ; Mayla Andrea Perdomo Amar, ; Jairo Giovanni Moncayo Viveros, . - 2018.
Obra : Journal of Critical Care
Idioma : Inglés (eng)
Palabras clave : Sepsis resuscitation lactic acid antibiotics shock hyperlactatemia Resumen : Purpose: To estimate the effect of each of the EGDT components, as well as of the antibiotics, on length-of-stay and mortality. Methods: Prospective cohort in three hospitals. Adult patients admitted by the Emergency Rooms (ER) with infection and any of systolic blood pressure b 90 mmHg or lactate N4 mmol/L. An instrumental analysis with hospital of admission as the instrumental variable was performed to estimate the effect of each intervention on hospital mortality and secondary outcomes. Results: Among 2587 patients evaluated 884 met inclusion criteria, with a hospital mortality rate of 17% (n =150). In the instrumental analysis, the only intervention associated with an absolute reduction in mortality (21%) was the use of antibiotics in the first 3 h. In patients with lactate values ≥4 mmol/L in the ER, a nondecrease of at least 10% at six hours was independently associated with mortality (OR = 3.1; 95%CI = 1.5–6.2). Conclusions: Among patients entering ER with infection and shock or hypoperfusion criteria, the use of appropriate antibiotics in the first 3 h is the measure that has the greatest impact on survival. In addition, among patients with hyperlactatemia N4 mmol/L, the clearance of N10% of lactate during resuscitation is associated with better outcomes. Mención de responsabilidad : Jessica Londoño, César Niño, Andrea Archila, Marta Valencia, Diana Cárdenas, Mayla Perdomo, Giovanny Moncayo, César Vargas, Carlos E Vallejo, Carolina Hincapié, Johana Ascuntar, Alba León, Fabián Jaimes Referencia : J Crit Care. 2018 Dec;48:191-197. DOI (Digital Object Identifier) : 10.1016/j.jcrc.2018.08.035 PMID : 30218959 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0883-9441(18)30531-8 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4175 Reserva
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Título : Prescription of antibiotics in intensive care units in Latin America: An observational study Tipo de documento : documento electrónico Autores : Franco Eduardo Montúfar Andrade, Fecha de publicación : 2009 Títulos uniformes : Journal of Chemotherapy Idioma : Inglés (eng) Palabras clave : intensive care unit antibiotics carbapenems resistance Resumen : A one-day point prevalence study to investigate the patterns of antibiotic use was undertaken in 43 Latin American (LA) intensive care units. Of 510 patients admitted, 231 received antibiotic treatment on the day of the study (45%); in 125 cases (54%) due to nosocomial-acquired infections. The most frequent infection reported was nosocomial pneumonia (43%). Only in 122 patients (53%) were cultures performed before starting antibiotic treatment. 33% of the isolated microorganisms were Enterobacteriaceae (40% extended-spectrum β-lactamase-producing), 23% methicillin-resistant Staphylococcus aureus and 17% carbapenems-resistant non-fermentative Gram-negatives. The antibiotics most frequently prescribed were carbapenems (99/231, 43%);alone (60/99, 60%) or in combination with vancomycin (39/99, 40%). “Restricted” antibiotics (carbapenems, vancomycin, piperacillin-tazobactam, broad-spectrum cephalosporins, tigecycline, polymixins and linezolid) were most frequently indicated inseverely ill patients (APACHE II score at admission ≥15, p=0.0007 and, SOFA scoreat the beginning of the antibiotic treatment ≥3, p=0.0000). Only 36% of antibiotictreatments were cultured-directed. Our findings help explain the high rates of multidrug-resistant pathogens in LA settings (i.e. ESBL-producing Gram-negatives) and the severity of the registered patients' illnesses. Mención de responsabilidad : D Curcio, A Alí, A Duarte, A Defilippi Pauta, C Ibáñez-Guzmán, M Chung Sang, E Valencia, F Plano, F Paredes Oña, F Arancibia, F Montufar Andrade, F Morales Alava, G Cañarte Bermudez, G La Fuente Zerain, V Alanis Mirones, J Rojas Suarez, J Guzmán Torrico, J Silva, J Vergara Centeno, J C Medina, K Marín, L A Caero, L Durán Crespo, M Gómez Duque, M Játiva, R Belloni, R Romero, R Aguilera Perrogón, R Camacho Alarcón, R Camargo, S Cevallos, V Intriago Cedeño, Z Urbina Contreras, Latin American Antibiotic Use in Intensive Care Unit Group Referencia : J Chemother. 2009 Nov;21(5):527-34. DOI (Digital Object Identifier) : 10.1179/joc.2009.21.5.527 PMID : 19933044 En línea : https://www.tandfonline.com/doi/abs/10.1179/joc.2009.21.5.527 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4457 Prescription of antibiotics in intensive care units in Latin America: An observational study [documento electrónico] / Franco Eduardo Montúfar Andrade, . - 2009.
Obra : Journal of Chemotherapy
Idioma : Inglés (eng)
Palabras clave : intensive care unit antibiotics carbapenems resistance Resumen : A one-day point prevalence study to investigate the patterns of antibiotic use was undertaken in 43 Latin American (LA) intensive care units. Of 510 patients admitted, 231 received antibiotic treatment on the day of the study (45%); in 125 cases (54%) due to nosocomial-acquired infections. The most frequent infection reported was nosocomial pneumonia (43%). Only in 122 patients (53%) were cultures performed before starting antibiotic treatment. 33% of the isolated microorganisms were Enterobacteriaceae (40% extended-spectrum β-lactamase-producing), 23% methicillin-resistant Staphylococcus aureus and 17% carbapenems-resistant non-fermentative Gram-negatives. The antibiotics most frequently prescribed were carbapenems (99/231, 43%);alone (60/99, 60%) or in combination with vancomycin (39/99, 40%). “Restricted” antibiotics (carbapenems, vancomycin, piperacillin-tazobactam, broad-spectrum cephalosporins, tigecycline, polymixins and linezolid) were most frequently indicated inseverely ill patients (APACHE II score at admission ≥15, p=0.0007 and, SOFA scoreat the beginning of the antibiotic treatment ≥3, p=0.0000). Only 36% of antibiotictreatments were cultured-directed. Our findings help explain the high rates of multidrug-resistant pathogens in LA settings (i.e. ESBL-producing Gram-negatives) and the severity of the registered patients' illnesses. Mención de responsabilidad : D Curcio, A Alí, A Duarte, A Defilippi Pauta, C Ibáñez-Guzmán, M Chung Sang, E Valencia, F Plano, F Paredes Oña, F Arancibia, F Montufar Andrade, F Morales Alava, G Cañarte Bermudez, G La Fuente Zerain, V Alanis Mirones, J Rojas Suarez, J Guzmán Torrico, J Silva, J Vergara Centeno, J C Medina, K Marín, L A Caero, L Durán Crespo, M Gómez Duque, M Játiva, R Belloni, R Romero, R Aguilera Perrogón, R Camacho Alarcón, R Camargo, S Cevallos, V Intriago Cedeño, Z Urbina Contreras, Latin American Antibiotic Use in Intensive Care Unit Group Referencia : J Chemother. 2009 Nov;21(5):527-34. DOI (Digital Object Identifier) : 10.1179/joc.2009.21.5.527 PMID : 19933044 En línea : https://www.tandfonline.com/doi/abs/10.1179/joc.2009.21.5.527 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4457 Reserva
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