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Enlace permanente de la investigaciónDifferential characteristics in drug-induced autoimmune hepatitis / Juan Ignacio Marín Zuluaga ; Octavio Germán Muñoz Maya ; Óscar Mauricio Santos Sánchez ; Jorge Hernando Donado Gómez ; Juan Carlos Restrepo Gutiérrez
Título : Differential characteristics in drug-induced autoimmune hepatitis Tipo de documento : documento electrónico Autores : Juan Ignacio Marín Zuluaga, ; Octavio Germán Muñoz Maya, ; Óscar Mauricio Santos Sánchez, ; Jorge Hernando Donado Gómez, ; Juan Carlos Restrepo Gutiérrez, Fecha de publicación : 2018 Títulos uniformes : JGH Open Idioma : Inglés (eng) Palabras clave : Autoimmune hepatitis autoimmunity drug‐induced liver injury immunosuppression prognosis Resumen : Background and Aim: Drug‐induced autoimmune hepatitis (DIAIH) is an adverse effect associated with several drugs that usually occurs acutely, with variable latency, and it may potentially be mortal. There are a few reports and studies about DIAIH. Methods: This was an analytical study of a retrospective cohort of patients, discriminated according to idiopathic or drug‐induced etiology, followed up for a 7‐year period until 31 December 2016. Results: A total of 190 patients were selected for the analysis, 12 (6.3%) with DIAIH. The two main drugs related to DIAIH were nitrofurantoin, n = 8 (67%), and NSAID, n = 2 (17%), constituting 84% of the cases. There were no significant differences in seropositivity between AIH with DIAIH in antinuclear antibodies (ANA) and anti‐smooth muscle antibodies (ASMA) antibodies, with 82.6% versus 82.6% and 34% versus 16%, respectively. The fibrosis stages were similar, except for the F4 stage, in a greater proportion in AIH. None of the patients with DIAIH had cirrhosis or developed it during follow‐up, but it was present in 42.1% of the AIH cases at diagnosis (P = 0.003). Biochemical remission with management was higher in DIAIH but not significant (91.7% vs 80.9%, P = 0.35). The definitive interruption of immunosuppression was successfully performed in 25% of those with DIAIH without relapses but was only possible in 2.8% in AIH (P Mención de responsabilidad : Omar Yesid Martínez-Casas, Gabriel Sebastián Díaz-Ramírez, Juan Ignacio Marín-Zuluaga, Octavio Muñoz-Maya, Oscar Santos, Jorge Hernando Donado-Gómez, Juan Carlos Restrepo-Gutiérrez Referencia : JGH Open. 2018 May 24;2(3):97-104. DOI (Digital Object Identifier) : 10.1002/jgh3.12054 PMID : 30483571 Derechos de uso : CC BY-NC En línea : https://onlinelibrary.wiley.com/doi/full/10.1002/jgh3.12054 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Differential characteristics in drug-induced autoimmune hepatitis [documento electrónico] / Juan Ignacio Marín Zuluaga, ; Octavio Germán Muñoz Maya, ; Óscar Mauricio Santos Sánchez, ; Jorge Hernando Donado Gómez, ; Juan Carlos Restrepo Gutiérrez, . - 2018.
Obra : JGH Open
Idioma : Inglés (eng)
Palabras clave : Autoimmune hepatitis autoimmunity drug‐induced liver injury immunosuppression prognosis Resumen : Background and Aim: Drug‐induced autoimmune hepatitis (DIAIH) is an adverse effect associated with several drugs that usually occurs acutely, with variable latency, and it may potentially be mortal. There are a few reports and studies about DIAIH. Methods: This was an analytical study of a retrospective cohort of patients, discriminated according to idiopathic or drug‐induced etiology, followed up for a 7‐year period until 31 December 2016. Results: A total of 190 patients were selected for the analysis, 12 (6.3%) with DIAIH. The two main drugs related to DIAIH were nitrofurantoin, n = 8 (67%), and NSAID, n = 2 (17%), constituting 84% of the cases. There were no significant differences in seropositivity between AIH with DIAIH in antinuclear antibodies (ANA) and anti‐smooth muscle antibodies (ASMA) antibodies, with 82.6% versus 82.6% and 34% versus 16%, respectively. The fibrosis stages were similar, except for the F4 stage, in a greater proportion in AIH. None of the patients with DIAIH had cirrhosis or developed it during follow‐up, but it was present in 42.1% of the AIH cases at diagnosis (P = 0.003). Biochemical remission with management was higher in DIAIH but not significant (91.7% vs 80.9%, P = 0.35). The definitive interruption of immunosuppression was successfully performed in 25% of those with DIAIH without relapses but was only possible in 2.8% in AIH (P Mención de responsabilidad : Omar Yesid Martínez-Casas, Gabriel Sebastián Díaz-Ramírez, Juan Ignacio Marín-Zuluaga, Octavio Muñoz-Maya, Oscar Santos, Jorge Hernando Donado-Gómez, Juan Carlos Restrepo-Gutiérrez Referencia : JGH Open. 2018 May 24;2(3):97-104. DOI (Digital Object Identifier) : 10.1002/jgh3.12054 PMID : 30483571 Derechos de uso : CC BY-NC En línea : https://onlinelibrary.wiley.com/doi/full/10.1002/jgh3.12054 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000756 AC-2018-043 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2018-043.pdfAdobe Acrobat PDF
Título : Prevalence of celiac autoimmunity in children and adolescents with type 1 diabetes mellitus in a high complexity hospital in Colombia Tipo de documento : documento electrónico Autores : Carolina Jaramillo Arango, ; Carlos Enrique Yepes Delgado, ; Verónica Abad Londoño, Fecha de publicación : 2018 Títulos uniformes : Endocrinology and Metabolism International Journal Idioma : Inglés (eng) Palabras clave : celiac disease type 1 diabetes tissue transglutaminase autoantibody autoimmunity and prevalence Resumen : Background: The prevalence of celiac disease in patients with type 1 diabetes mellitus is 5 to 10 times higher than in the general population. However, diagnosis is difficult given that patients are asymptomatic or with nonspecific symptoms and are confused with poor glycemic control or thyroid comorbidity. Objective: To assess the prevalence of celiac autoimmunity in children and adolescents diagnosed with type 1 diabetes mellitus and to identify the clinical profile of patients with celiac autoimmunity. Methods: One hundred patients with type 1 diabetes mellitus under 18 years, who consulted the department of pediatric endocrinology at Hospital Pablo Tobón Uribe – Medellin, between May and December 2015, were included. The concentration of antibodies, anti-tissue transglutaminase IgA, and total immunoglobulin A were measured in all patients; also a survey of signs and symptoms of celiac disease was applied. Results: Patients were aged between 3 and 17 years. Four had celiac autoimmunity evidenced by positive anti-tissue transglutaminase IgA. The clinical profile of patients with celiac autoimmunity was patient Mención de responsabilidad : Carolina Jaramillo Arango, Yúrika López-Alarcón, Alejandro Marín-Agudelo, Carlos Yepes Delgado, Verónica Abad-Londoño DOI (Digital Object Identifier) : 10.15406/emij.2018.06.00172 Derechos de uso : CC BY-NC En línea : https://medcraveonline.com/EMIJ/prevalence-of-celiac-autoimmunity-in-children-an [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Prevalence of celiac autoimmunity in children and adolescents with type 1 diabetes mellitus in a high complexity hospital in Colombia [documento electrónico] / Carolina Jaramillo Arango, ; Carlos Enrique Yepes Delgado, ; Verónica Abad Londoño, . - 2018.
Obra : Endocrinology and Metabolism International Journal
Idioma : Inglés (eng)
Palabras clave : celiac disease type 1 diabetes tissue transglutaminase autoantibody autoimmunity and prevalence Resumen : Background: The prevalence of celiac disease in patients with type 1 diabetes mellitus is 5 to 10 times higher than in the general population. However, diagnosis is difficult given that patients are asymptomatic or with nonspecific symptoms and are confused with poor glycemic control or thyroid comorbidity. Objective: To assess the prevalence of celiac autoimmunity in children and adolescents diagnosed with type 1 diabetes mellitus and to identify the clinical profile of patients with celiac autoimmunity. Methods: One hundred patients with type 1 diabetes mellitus under 18 years, who consulted the department of pediatric endocrinology at Hospital Pablo Tobón Uribe – Medellin, between May and December 2015, were included. The concentration of antibodies, anti-tissue transglutaminase IgA, and total immunoglobulin A were measured in all patients; also a survey of signs and symptoms of celiac disease was applied. Results: Patients were aged between 3 and 17 years. Four had celiac autoimmunity evidenced by positive anti-tissue transglutaminase IgA. The clinical profile of patients with celiac autoimmunity was patient Mención de responsabilidad : Carolina Jaramillo Arango, Yúrika López-Alarcón, Alejandro Marín-Agudelo, Carlos Yepes Delgado, Verónica Abad-Londoño DOI (Digital Object Identifier) : 10.15406/emij.2018.06.00172 Derechos de uso : CC BY-NC En línea : https://medcraveonline.com/EMIJ/prevalence-of-celiac-autoimmunity-in-children-an [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001208 AC-2018-152 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2018-152.pdfAdobe Acrobat PDF
Título : Dynamic cross-regulation of antigen-specific effector and regulatory T cell subpopulations and microglia in brain autoimmunity Tipo de documento : documento electrónico Autores : Iván Martínez Forero, Fecha de publicación : 2013 Títulos uniformes : BMC Systems Biology Idioma : Inglés (eng) Palabras clave : T cells effector regulatory B cells dynamics autoimmunity multiple sclerosis systems biology immunotherapy anti-CD20 Resumen : Background: Multiple Sclerosis (MS) is considered a T-cell-mediated autoimmune disease with a prototypical oscillatory behavior, as evidenced by the presence of clinical relapses. Understanding the dynamics of immune cells governing the course of MS, therefore, has many implications for immunotherapy. Here, we used flow cytometry to analyze the time-dependent behavior of antigen-specific effector (Teff) and regulatory (Treg) T cells and microglia in mice model of MS, Experimental Autoimmune Encephalomyelitis (EAE), and compared the observations with a mathematical cross-regulation model of T-cell dynamics in autoimmune disease. Results: We found that Teff and Treg cells specific to myelin olygodendrocyte glycoprotein (MOG) developed coupled oscillatory dynamics with a 4- to 5-day period and decreasing amplitude that was always higher for the Teff populations, in agreement with the mathematical model. Microglia activation followed the oscillations of MOG specific Teff cells in the secondary lymphoid organs, but they were activated before MOG-specific T-cell peaks in the CNS. Finally, we assessed the role of B-cell depletion induced by anti-CD20 therapy in the dynamics of T cells in anEAE model with more severe disease after therapy. We observed that B-cell depletion decreases Teff expansion, although its oscillatory behavior persists. However, the effect of B cell depletion was more significant in the Treg opulation within the CNS, which matched with activation of microglia and worsening of the disease. Mathematical modeling of T-cell cross-regulation after anti-CD20 therapy suggests that B-cell depletion maY influence the dynamics of T cells by fine-tuning their activation. Conclusions: The oscillatory dynamics of T-cells have an intrinsic origin in the physiological regulation of the adaptive immune response, which influences both disease phenotype and response to immunotherapy. Mención de responsabilidad : Sara Martinez-Pasamar, Elena Abad, Beatriz Moreno, Nieves Velez de Mendizabal, Ivan Martinez-Forero, Jordi Garcia-Ojalvo, Pablo Villoslada Referencia : BMC Syst Biol. 2013 Apr 26;7:34. DOI (Digital Object Identifier) : 10.1186/1752-0509-7-34|| PMID : 23618467 Derechos de uso : CC BY En línea : https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-7-34 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Dynamic cross-regulation of antigen-specific effector and regulatory T cell subpopulations and microglia in brain autoimmunity [documento electrónico] / Iván Martínez Forero, . - 2013.
Obra : BMC Systems Biology
Idioma : Inglés (eng)
Palabras clave : T cells effector regulatory B cells dynamics autoimmunity multiple sclerosis systems biology immunotherapy anti-CD20 Resumen : Background: Multiple Sclerosis (MS) is considered a T-cell-mediated autoimmune disease with a prototypical oscillatory behavior, as evidenced by the presence of clinical relapses. Understanding the dynamics of immune cells governing the course of MS, therefore, has many implications for immunotherapy. Here, we used flow cytometry to analyze the time-dependent behavior of antigen-specific effector (Teff) and regulatory (Treg) T cells and microglia in mice model of MS, Experimental Autoimmune Encephalomyelitis (EAE), and compared the observations with a mathematical cross-regulation model of T-cell dynamics in autoimmune disease. Results: We found that Teff and Treg cells specific to myelin olygodendrocyte glycoprotein (MOG) developed coupled oscillatory dynamics with a 4- to 5-day period and decreasing amplitude that was always higher for the Teff populations, in agreement with the mathematical model. Microglia activation followed the oscillations of MOG specific Teff cells in the secondary lymphoid organs, but they were activated before MOG-specific T-cell peaks in the CNS. Finally, we assessed the role of B-cell depletion induced by anti-CD20 therapy in the dynamics of T cells in anEAE model with more severe disease after therapy. We observed that B-cell depletion decreases Teff expansion, although its oscillatory behavior persists. However, the effect of B cell depletion was more significant in the Treg opulation within the CNS, which matched with activation of microglia and worsening of the disease. Mathematical modeling of T-cell cross-regulation after anti-CD20 therapy suggests that B-cell depletion maY influence the dynamics of T cells by fine-tuning their activation. Conclusions: The oscillatory dynamics of T-cells have an intrinsic origin in the physiological regulation of the adaptive immune response, which influences both disease phenotype and response to immunotherapy. Mención de responsabilidad : Sara Martinez-Pasamar, Elena Abad, Beatriz Moreno, Nieves Velez de Mendizabal, Ivan Martinez-Forero, Jordi Garcia-Ojalvo, Pablo Villoslada Referencia : BMC Syst Biol. 2013 Apr 26;7:34. DOI (Digital Object Identifier) : 10.1186/1752-0509-7-34|| PMID : 23618467 Derechos de uso : CC BY En línea : https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-7-34 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000244 AC-2013-012 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2013-012.pdfAdobe Acrobat PDF
Título : Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type I diabetes mellitus and their close family members Tipo de documento : documento electrónico Autores : Verónica Abad Londoño, Fecha de publicación : 2009 Títulos uniformes : Annals of the New York Academy of Sciences Idioma : Inglés (eng) Palabras clave : Autoimmunity infection epstein barr virus cytomegalovirus helicobacter pylori toxoplasma celiac disease Resumen : Type 1 diabetes mellitus (T1DM) is an autoimmune disease with complex interactions between genetic and environmental factors. We compared antibody levels to various infectious agents and of autoimmune‐associated autoantibodies between Colombian T1DM patients, their close family members and healthy controls. Significantly lower levels of antibodies against several infectious agents were detected in the T1DM patients. These included Helicobacter pylori (P= 0.01), cytomegalovirus (P= 0.001), Epstein‐Barr virus (P= 0.02) and Toxoplasma (P= 0.001). T1DM patients had significantly higher levels of IgG‐anti‐gliadin antibodies (P= 0.001) and IgG‐antitissue transglutaminase antibodies (P= 0.03), and a borderline association with anticentromere antibodies (P= 0.06). The lower level of antibodies against infectious agents in T1DM patients may be related to their younger ages, but may also point to a protective role of those infections in T1DM development in susceptible individuals. Our results confirm the association between T1DM and celiac disease. A possible association with anticentromere antibody needs further studies. Mención de responsabilidad : Ilan Krause, Juan Manuel Anaya, Abigail Fraser, Ori Barzilai, Maya Ram Verónica Abad, Alvaro Arango, Jorge García, Yehuda Shoenfeld Referencia : Ann N Y Acad Sci. 2009 Sep;1173:633-9. DOI (Digital Object Identifier) : 10.1111/j.1749-6632.2009.04619.x PMID : 19758209 En línea : https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.04619.x Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type I diabetes mellitus and their close family members [documento electrónico] / Verónica Abad Londoño, . - 2009.
Obra : Annals of the New York Academy of Sciences
Idioma : Inglés (eng)
Palabras clave : Autoimmunity infection epstein barr virus cytomegalovirus helicobacter pylori toxoplasma celiac disease Resumen : Type 1 diabetes mellitus (T1DM) is an autoimmune disease with complex interactions between genetic and environmental factors. We compared antibody levels to various infectious agents and of autoimmune‐associated autoantibodies between Colombian T1DM patients, their close family members and healthy controls. Significantly lower levels of antibodies against several infectious agents were detected in the T1DM patients. These included Helicobacter pylori (P= 0.01), cytomegalovirus (P= 0.001), Epstein‐Barr virus (P= 0.02) and Toxoplasma (P= 0.001). T1DM patients had significantly higher levels of IgG‐anti‐gliadin antibodies (P= 0.001) and IgG‐antitissue transglutaminase antibodies (P= 0.03), and a borderline association with anticentromere antibodies (P= 0.06). The lower level of antibodies against infectious agents in T1DM patients may be related to their younger ages, but may also point to a protective role of those infections in T1DM development in susceptible individuals. Our results confirm the association between T1DM and celiac disease. A possible association with anticentromere antibody needs further studies. Mención de responsabilidad : Ilan Krause, Juan Manuel Anaya, Abigail Fraser, Ori Barzilai, Maya Ram Verónica Abad, Alvaro Arango, Jorge García, Yehuda Shoenfeld Referencia : Ann N Y Acad Sci. 2009 Sep;1173:633-9. DOI (Digital Object Identifier) : 10.1111/j.1749-6632.2009.04619.x PMID : 19758209 En línea : https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.04619.x Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000039 AC-2009-001 Archivo digital Producción Científica Artículos científicos Disponible
Título : Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus Tipo de documento : documento electrónico Autores : Alejandro Daniel Velásquez Urzola, Fecha de publicación : 2006 Títulos uniformes : Journal of Autoimmunity Idioma : Inglés (eng) Palabras clave : Aggregation autoimmunity type 1 diabetes mellitus hypothyroidism genetics Resumen : We investigated the familial aggregation of autoimmune diseases (AIDs) among first-degree relatives (FDR) of patients with type 1 diabetes mellitus (T1D). Relatives of 98 T1D patients defined according to the guidelines diagnosis of the American Diabetes Association and 113 matched controls without any AID, were interviewed using a questionnaire that sought information about demographic and medical characteristics including a list of 18 AIDs. Genetic analysis was performed using the program ASSOC and by calculating recurrent risk ratios. In cases, 25.5% of the families had at least one member having an AID, while in controls there were 9% (odds ratio [OR]: 3.96, 95% confidence interval [CI] 1⁄4 1.74e9.0, p 1⁄4 0.0006). An AID was registered in 8.3% of 312 FDR of patients as compared with 2.4% of 362 FDR in controls (OR: 3.56, 95% CI 1⁄4 1.64e7.73, p 1⁄4 0.0008). The most frequent AIDs registered in FDR of cases were autoimmune thyroid disease (AITD) and T1D, which disclosed coefficients of aggregation. These results indicate that AIDs cluster within families of T1D patients adding further evidence to consider that clinically different autoimmune phenotypes may share common susceptibility gene variants, which may act pleiotropically as risk factors for autoimmunity. Mención de responsabilidad : Juan-Manuel Anaya, John Castiblanco, Gabriel J Tobón, Jorge García, Verónica Abad, Héctor Cuervo, Alejandro Velásquez, Ivan D Angel, Patricia Vega, Alvaro Arango Referencia : J Autoimmun. 2006 May;26(3):208-14. DOI (Digital Object Identifier) : 10.1016/j.jaut.2006.01.001 PMID : 16503115 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0896841106000096 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus [documento electrónico] / Alejandro Daniel Velásquez Urzola, . - 2006.
Obra : Journal of Autoimmunity
Idioma : Inglés (eng)
Palabras clave : Aggregation autoimmunity type 1 diabetes mellitus hypothyroidism genetics Resumen : We investigated the familial aggregation of autoimmune diseases (AIDs) among first-degree relatives (FDR) of patients with type 1 diabetes mellitus (T1D). Relatives of 98 T1D patients defined according to the guidelines diagnosis of the American Diabetes Association and 113 matched controls without any AID, were interviewed using a questionnaire that sought information about demographic and medical characteristics including a list of 18 AIDs. Genetic analysis was performed using the program ASSOC and by calculating recurrent risk ratios. In cases, 25.5% of the families had at least one member having an AID, while in controls there were 9% (odds ratio [OR]: 3.96, 95% confidence interval [CI] 1⁄4 1.74e9.0, p 1⁄4 0.0006). An AID was registered in 8.3% of 312 FDR of patients as compared with 2.4% of 362 FDR in controls (OR: 3.56, 95% CI 1⁄4 1.64e7.73, p 1⁄4 0.0008). The most frequent AIDs registered in FDR of cases were autoimmune thyroid disease (AITD) and T1D, which disclosed coefficients of aggregation. These results indicate that AIDs cluster within families of T1D patients adding further evidence to consider that clinically different autoimmune phenotypes may share common susceptibility gene variants, which may act pleiotropically as risk factors for autoimmunity. Mención de responsabilidad : Juan-Manuel Anaya, John Castiblanco, Gabriel J Tobón, Jorge García, Verónica Abad, Héctor Cuervo, Alejandro Velásquez, Ivan D Angel, Patricia Vega, Alvaro Arango Referencia : J Autoimmun. 2006 May;26(3):208-14. DOI (Digital Object Identifier) : 10.1016/j.jaut.2006.01.001 PMID : 16503115 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0896841106000096 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000006 AC-2006-001 Archivo digital Producción Científica Artículos científicos Disponible
