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Prevalence of celiac autoimmunity in children and adolescents with type 1 diabetes mellitus in a high complexity hospital in Colombia / Carolina Jaramillo Arango ; Carlos Enrique Yepes Delgado ; Verónica Abad Londoño    

Público ISBD Título : Prevalence of celiac autoimmunity in children and adolescents with type 1 diabetes mellitus in a high complexity hospital in Colombia Tipo de documento : documento electrónico Autores : Carolina Jaramillo Arango, ; Carlos Enrique Yepes Delgado, ; Verónica Abad Londoño, Fecha de publicación : 2018 Títulos uniformes : Endocrinology and Metabolism International Journal Idioma : Inglés (eng) Palabras clave : celiac disease  type 1 diabetes  tissue transglutaminase autoantibody  autoimmunity  and prevalence Resumen : Background: The prevalence of celiac disease in patients with type 1 diabetes mellitus is 5 to 10 times higher than in the general population. However, diagnosis is difficult given that patients are asymptomatic or with nonspecific symptoms and are confused with poor glycemic control or thyroid comorbidity. Objective: To assess the prevalence of celiac autoimmunity in children and adolescents diagnosed with type 1 diabetes mellitus and to identify the clinical profile of patients with celiac autoimmunity. Methods: One hundred patients with type 1 diabetes mellitus under 18 years, who consulted the department of pediatric endocrinology at Hospital Pablo Tobón Uribe – Medellin, between May and December 2015, were included. The concentration of antibodies, anti-tissue transglutaminase IgA, and total immunoglobulin A were measured in all patients; also a survey of signs and symptoms of celiac disease was applied. Results: Patients were aged between 3 and 17 years. Four had celiac autoimmunity evidenced by positive anti-tissue transglutaminase IgA. The clinical profile of patients with celiac autoimmunity was patient Mención de responsabilidad : Carolina Jaramillo Arango, Yúrika López-Alarcón, Alejandro Marín-Agudelo, Carlos Yepes Delgado, Verónica Abad-Londoño DOI (Digital Object Identifier) : 10.15406/emij.2018.06.00172 Derechos de uso : CC BY-NC En línea : https://medcraveonline.com/EMIJ/prevalence-of-celiac-autoimmunity-in-children-an [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4734 Prevalence of celiac autoimmunity in children and adolescents with type 1 diabetes mellitus in a high complexity hospital in Colombia [documento electrónico] / Carolina Jaramillo Arango, ; Carlos Enrique Yepes Delgado, ; Verónica Abad Londoño,  . - 2018. Obra : Endocrinology and Metabolism International Journal Idioma : Inglés (eng) Palabras clave : celiac disease  type 1 diabetes  tissue transglutaminase autoantibody  autoimmunity  and prevalence Resumen : Background: The prevalence of celiac disease in patients with type 1 diabetes mellitus is 5 to 10 times higher than in the general population. However, diagnosis is difficult given that patients are asymptomatic or with nonspecific symptoms and are confused with poor glycemic control or thyroid comorbidity. Objective: To assess the prevalence of celiac autoimmunity in children and adolescents diagnosed with type 1 diabetes mellitus and to identify the clinical profile of patients with celiac autoimmunity. Methods: One hundred patients with type 1 diabetes mellitus under 18 years, who consulted the department of pediatric endocrinology at Hospital Pablo Tobón Uribe – Medellin, between May and December 2015, were included. The concentration of antibodies, anti-tissue transglutaminase IgA, and total immunoglobulin A were measured in all patients; also a survey of signs and symptoms of celiac disease was applied. Results: Patients were aged between 3 and 17 years. Four had celiac autoimmunity evidenced by positive anti-tissue transglutaminase IgA. The clinical profile of patients with celiac autoimmunity was patient Mención de responsabilidad : Carolina Jaramillo Arango, Yúrika López-Alarcón, Alejandro Marín-Agudelo, Carlos Yepes Delgado, Verónica Abad-Londoño DOI (Digital Object Identifier) : 10.15406/emij.2018.06.00172 Derechos de uso : CC BY-NC En línea : https://medcraveonline.com/EMIJ/prevalence-of-celiac-autoimmunity-in-children-an [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4734

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Documentos electrónicos

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Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type I diabetes mellitus and their close family members / Verónica Abad Londoño  

Público ISBD Título : Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type I diabetes mellitus and their close family members Tipo de documento : documento electrónico Autores : Verónica Abad Londoño, Fecha de publicación : 2009 Títulos uniformes : Annals of the New York Academy of Sciences Idioma : Inglés (eng) Palabras clave : Autoimmunity  infection  epstein barr virus  cytomegalovirus  helicobacter pylori  toxoplasma  celiac disease Resumen : Type 1 diabetes mellitus (T1DM) is an autoimmune disease with complex interactions between genetic and environmental factors. We compared antibody levels to various infectious agents and of autoimmune‐associated autoantibodies between Colombian T1DM patients, their close family members and healthy controls. Significantly lower levels of antibodies against several infectious agents were detected in the T1DM patients. These included Helicobacter pylori (P= 0.01), cytomegalovirus (P= 0.001), Epstein‐Barr virus (P= 0.02) and Toxoplasma (P= 0.001). T1DM patients had significantly higher levels of IgG‐anti‐gliadin antibodies (P= 0.001) and IgG‐antitissue transglutaminase antibodies (P= 0.03), and a borderline association with anticentromere antibodies (P= 0.06). The lower level of antibodies against infectious agents in T1DM patients may be related to their younger ages, but may also point to a protective role of those infections in T1DM development in susceptible individuals. Our results confirm the association between T1DM and celiac disease. A possible association with anticentromere antibody needs further studies. Mención de responsabilidad : Ilan Krause, Juan Manuel Anaya, Abigail Fraser, Ori Barzilai, Maya Ram Verónica Abad, Alvaro Arango, Jorge García, Yehuda Shoenfeld Referencia : Ann N Y Acad Sci. 2009 Sep;1173:633-9. DOI (Digital Object Identifier) : 10.1111/j.1749-6632.2009.04619.x PMID : 19758209 En línea : https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.04619.x Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3471 Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type I diabetes mellitus and their close family members [documento electrónico] / Verónica Abad Londoño,  . - 2009. Obra : Annals of the New York Academy of Sciences Idioma : Inglés (eng) Palabras clave : Autoimmunity  infection  epstein barr virus  cytomegalovirus  helicobacter pylori  toxoplasma  celiac disease Resumen : Type 1 diabetes mellitus (T1DM) is an autoimmune disease with complex interactions between genetic and environmental factors. We compared antibody levels to various infectious agents and of autoimmune‐associated autoantibodies between Colombian T1DM patients, their close family members and healthy controls. Significantly lower levels of antibodies against several infectious agents were detected in the T1DM patients. These included Helicobacter pylori (P= 0.01), cytomegalovirus (P= 0.001), Epstein‐Barr virus (P= 0.02) and Toxoplasma (P= 0.001). T1DM patients had significantly higher levels of IgG‐anti‐gliadin antibodies (P= 0.001) and IgG‐antitissue transglutaminase antibodies (P= 0.03), and a borderline association with anticentromere antibodies (P= 0.06). The lower level of antibodies against infectious agents in T1DM patients may be related to their younger ages, but may also point to a protective role of those infections in T1DM development in susceptible individuals. Our results confirm the association between T1DM and celiac disease. A possible association with anticentromere antibody needs further studies. Mención de responsabilidad : Ilan Krause, Juan Manuel Anaya, Abigail Fraser, Ori Barzilai, Maya Ram Verónica Abad, Alvaro Arango, Jorge García, Yehuda Shoenfeld Referencia : Ann N Y Acad Sci. 2009 Sep;1173:633-9. DOI (Digital Object Identifier) : 10.1111/j.1749-6632.2009.04619.x PMID : 19758209 En línea : https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.04619.x Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3471

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DD000039	AC-2009-001	Archivo digital	Producción Científica	Artículos científicos	Disponible