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Enlace permanente de la investigaciónClinical differentiation of inflammatory bowel disease (IBD) in Latin America and the Caribbean / Fabián Juliao Baños
Título : Clinical differentiation of inflammatory bowel disease (IBD) in Latin America and the Caribbean Tipo de documento : documento electrónico Autores : Fabián Juliao Baños, Fecha de publicación : 2022 Títulos uniformes : Medicine (Baltimore) Idioma : Inglés (eng) Palabras clave : Crohn disease epidemiology inflammatory bowel disease Latin America ulcerative colitis Resumen : The aim of the present study was to describe the epidemiological and clinical characteristics of inflammatory bowel disease (IBD), including medical and surgical treatments, in several countries in Latin America and the Caribbean. IBD is recognized as a global health problem because its incidence and prevalence have increased significantly over the last few years. This multicenter retrospective cohort study included 4714 patients with IBD diagnosed from 9 countries in Latin America and the Caribbean: Colombia, Cuba, Dominican Republic, Ecuador, Mexico, Peru, Puerto Rico, Uruguay, and Venezuela. Crohn disease (CD) was more frequent in Puerto Rico (71.9%), the Dominican Republic (61.0%), and Peru (53.1%). Ulcerative colitis was more frequent in Colombia (78.6%), Venezuela (78.2%), Mexico (75.5%), Cuba (69.9%), Ecuador (64.1%), and Uruguay (60.9%). The following clinical characteristics were more frequent in the Caribbean: penetrating behavior in CD, steroid dependence, steroid resistance, intolerance to thiopurines, extraintestinal manifestations, surgeries, hospitalizations due to IBD, and family history of IBD. The factors associated with the use of biological therapy were pancolitis in ulcerative colitis, penetrating behavior in CD, steroid resistance and dependence, presence of extraintestinal manifestations, and the need for surgery. This study from Latin America and the Caribbean demonstrated the different epidemiological and clinical characteristics of IBD. Mención de responsabilidad : Yamamoto-Furusho, Jesús K. MD, PhD, MSc; Parra-Holguín, Norma N. MD; Juliao-Baños, Fabián MD; Puentes, Fabián MD; López, Rocio MD; Bosques-Padilla, Francisco MD; Torres, Esther A. MD; Nieves-Jimenéz, Humberto MD; Veitia-Velásquez, Guillermo R. MD; Jara-Alba, Maria L. MD; Bautista, Sócrates MD; Piñol-Jimenez, Felipe N. MD; Salgado-Rosado, Pablo MD; Villa-Ovalle, Keyla C. MD; Abreu-Martinez, Yudelka A. MD; Borges, Zunilda MD; Davila-Bedoya, Santiago MD; Otoya-Moreno, Guillermo MD; Iadé-Vergara, Beatriz MD Referencia : Medicine (Baltimore). 2022 Jan 21;101(3):e28624. DOI (Digital Object Identifier) : 10.1097/MD.0000000000028624 PMID : 35060539 Derechos de uso : CC BY En línea : https://journals.lww.com/md-journal/Fulltext/2022/01210/Clinical_differentiation [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6097 Clinical differentiation of inflammatory bowel disease (IBD) in Latin America and the Caribbean [documento electrónico] / Fabián Juliao Baños, . - 2022.
Obra : Medicine (Baltimore)
Idioma : Inglés (eng)
Palabras clave : Crohn disease epidemiology inflammatory bowel disease Latin America ulcerative colitis Resumen : The aim of the present study was to describe the epidemiological and clinical characteristics of inflammatory bowel disease (IBD), including medical and surgical treatments, in several countries in Latin America and the Caribbean. IBD is recognized as a global health problem because its incidence and prevalence have increased significantly over the last few years. This multicenter retrospective cohort study included 4714 patients with IBD diagnosed from 9 countries in Latin America and the Caribbean: Colombia, Cuba, Dominican Republic, Ecuador, Mexico, Peru, Puerto Rico, Uruguay, and Venezuela. Crohn disease (CD) was more frequent in Puerto Rico (71.9%), the Dominican Republic (61.0%), and Peru (53.1%). Ulcerative colitis was more frequent in Colombia (78.6%), Venezuela (78.2%), Mexico (75.5%), Cuba (69.9%), Ecuador (64.1%), and Uruguay (60.9%). The following clinical characteristics were more frequent in the Caribbean: penetrating behavior in CD, steroid dependence, steroid resistance, intolerance to thiopurines, extraintestinal manifestations, surgeries, hospitalizations due to IBD, and family history of IBD. The factors associated with the use of biological therapy were pancolitis in ulcerative colitis, penetrating behavior in CD, steroid resistance and dependence, presence of extraintestinal manifestations, and the need for surgery. This study from Latin America and the Caribbean demonstrated the different epidemiological and clinical characteristics of IBD. Mención de responsabilidad : Yamamoto-Furusho, Jesús K. MD, PhD, MSc; Parra-Holguín, Norma N. MD; Juliao-Baños, Fabián MD; Puentes, Fabián MD; López, Rocio MD; Bosques-Padilla, Francisco MD; Torres, Esther A. MD; Nieves-Jimenéz, Humberto MD; Veitia-Velásquez, Guillermo R. MD; Jara-Alba, Maria L. MD; Bautista, Sócrates MD; Piñol-Jimenez, Felipe N. MD; Salgado-Rosado, Pablo MD; Villa-Ovalle, Keyla C. MD; Abreu-Martinez, Yudelka A. MD; Borges, Zunilda MD; Davila-Bedoya, Santiago MD; Otoya-Moreno, Guillermo MD; Iadé-Vergara, Beatriz MD Referencia : Medicine (Baltimore). 2022 Jan 21;101(3):e28624. DOI (Digital Object Identifier) : 10.1097/MD.0000000000028624 PMID : 35060539 Derechos de uso : CC BY En línea : https://journals.lww.com/md-journal/Fulltext/2022/01210/Clinical_differentiation [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6097 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001945 AC-2022-106 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
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Título : Genetic diversity of hepatitis C virus and resistance associated substitutions to direct-acting antiviral treatment in Colombia Tipo de documento : documento electrónico Autores : Sergio Iván Hoyos Duque, ; Juan Carlos Restrepo Gutiérrez, Fecha de publicación : 2022 Títulos uniformes : Virus Research Idioma : Inglés (eng) Palabras clave : Hepatitis C virus Infection Epidemiology Genetic diversity Evolution Resumen : Hepatitis C virus (HCV) infection is one of the leading risk factors for end-stage liver disease development worldwide. This RNA virus displays high genetic diversity with 8 genotypes and 96 subgenotypes with heterogeneous geographical distribution around the world. In this study, we carried out an active case finding of individuals with a history of transfusion events before 1996 in three cities in Colombia. Then, the characterization of the HCV genotypes, subgenotypes, and resistance associate substitutions (RAS) was performed in samples positives for antibodies anti-HCV + from this study population. In addition, samples from PWID and patients with end-stage liver disease submitted to liver transplantation were included in the phylogenetic and RAS analysis. The 5′UTR, NS5A, and NS5B regions of the HCV genome were amplified in serum or liver explants samples. After the edition, assembly, and alignment of the sequences, genotyping through phylogenetic analysis was performed using IQTREE V2.0.5 based on the maximum likelihood approach. The identification of RAS was carried out by alignments based on the reference sequence (GenBank NC_004102). Two hundred sixty individuals with blood transfusion events before 1996 were recruited. The seroprevalence of antibodies anti-HCV was 2.69% in this population. The HCV genotypes 1, 2, and 4 and subgenotypes 1a, 1b, 2a, 4a and 4d were characterized in samples of the study populations. Three RAS (Q30R, C316N, and Y93H) were identified in samples obtained from 2 individuals who received blood transfusion before 1996 and without previous antiviral treatment and 6 samples obtained from patients with end-stage liver disease. Among the 20 samples analyzed, the HCV genotype 1, subgenotype 1b, was the most frequent (60%). We report the first characterization of HCV subgenotypes 4a and 4d and the first RAS identification in patients in Colombia. Mención de responsabilidad : Maria C Lopez-Osorio, José Aldemar Usme-Ciro, José William Martínez, Dioselina Peláez-Carvajal, Javier Hernández, Sergio Hoyos, Juan Carlos Restrepo, Maria-Cristina Navas Referencia : Virus Res. 2022 Sep;318:198847. DOI (Digital Object Identifier) : 10.1016/j.virusres.2022.198847 PMID : 35697300 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0168170222001757 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6090 Genetic diversity of hepatitis C virus and resistance associated substitutions to direct-acting antiviral treatment in Colombia [documento electrónico] / Sergio Iván Hoyos Duque, ; Juan Carlos Restrepo Gutiérrez, . - 2022.
Obra : Virus Research
Idioma : Inglés (eng)
Palabras clave : Hepatitis C virus Infection Epidemiology Genetic diversity Evolution Resumen : Hepatitis C virus (HCV) infection is one of the leading risk factors for end-stage liver disease development worldwide. This RNA virus displays high genetic diversity with 8 genotypes and 96 subgenotypes with heterogeneous geographical distribution around the world. In this study, we carried out an active case finding of individuals with a history of transfusion events before 1996 in three cities in Colombia. Then, the characterization of the HCV genotypes, subgenotypes, and resistance associate substitutions (RAS) was performed in samples positives for antibodies anti-HCV + from this study population. In addition, samples from PWID and patients with end-stage liver disease submitted to liver transplantation were included in the phylogenetic and RAS analysis. The 5′UTR, NS5A, and NS5B regions of the HCV genome were amplified in serum or liver explants samples. After the edition, assembly, and alignment of the sequences, genotyping through phylogenetic analysis was performed using IQTREE V2.0.5 based on the maximum likelihood approach. The identification of RAS was carried out by alignments based on the reference sequence (GenBank NC_004102). Two hundred sixty individuals with blood transfusion events before 1996 were recruited. The seroprevalence of antibodies anti-HCV was 2.69% in this population. The HCV genotypes 1, 2, and 4 and subgenotypes 1a, 1b, 2a, 4a and 4d were characterized in samples of the study populations. Three RAS (Q30R, C316N, and Y93H) were identified in samples obtained from 2 individuals who received blood transfusion before 1996 and without previous antiviral treatment and 6 samples obtained from patients with end-stage liver disease. Among the 20 samples analyzed, the HCV genotype 1, subgenotype 1b, was the most frequent (60%). We report the first characterization of HCV subgenotypes 4a and 4d and the first RAS identification in patients in Colombia. Mención de responsabilidad : Maria C Lopez-Osorio, José Aldemar Usme-Ciro, José William Martínez, Dioselina Peláez-Carvajal, Javier Hernández, Sergio Hoyos, Juan Carlos Restrepo, Maria-Cristina Navas Referencia : Virus Res. 2022 Sep;318:198847. DOI (Digital Object Identifier) : 10.1016/j.virusres.2022.198847 PMID : 35697300 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0168170222001757 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6090 Reserva
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Título : Global hospitalization trends for Crohn's disease and ulcerative colitis in the 21st century: a systematic review with temporal analyses Tipo de documento : documento electrónico Autores : Fabián Juliao Baños, Fecha de publicación : 2022 Títulos uniformes : Clinical Gastroenterology and Hepatology Idioma : Inglés (eng) Palabras clave : Inflammatory Bowel Disease Crohn’s Disease Ulcerative Colitis Hospitalization Rates Epidemiology Resumen : Background & Aims: The evolving epidemiologic patterns of inflammatory bowel disease (IBD) throughout the world, in conjunction with advances in therapeutic treatments, may influence hospitalization rates of IBD. We performed a systematic review with temporal analysis of hospitalization rates for IBD across the world in the 21st century. Methods: We systematically reviewed Medline and Embase for population-based studies reporting hospitalization rates for IBD, Crohn’s disease (CD), or ulcerative colitis (UC) in the 21st century. Log-linear models were used to calculate the average annual percentage change (AAPC) with associated 95% confidence intervals (95% CIs). Random-effects meta-analysis pooled country-level AAPCs. Data were stratified by the epidemiologic stage of a region: compounding prevalence (stage 3) in North America, Western Europe, and Oceania vs acceleration of incidence (stage 2) in Asia, Eastern Europe, and Latin America vs emergence (stage 1) in developing countries. Results: Hospitalization rates for a primary diagnosis of IBD were stable in countries in stage 3 (AAPC, −0.13%; 95% CI, −0.72 to 0.97), CD (AAPC, 0.20%; 95% CI, −1.78 to 2.17), and UC (AAPC, 0.02%; 95% CI, −0.91 to 0.94). In contrast, hospitalization rates for a primary diagnosis were increasing in countries in stage 2 for IBD (AAPC, 4.44%; 95% CI, 2.75 to 6.14), CD (AAPC, 8.34%; 95% CI, 4.38 to 12.29), and UC (AAPC, 3.90; 95% CI, 1.29 to 6.52). No population-based studies were available for developing regions in stage 1 (emergence). Conclusions: Hospitalization rates for IBD are stabilizing in countries in stage 3, whereas newly industrialized countries in stage 2 have rapidly increasing hospitalization rates, contributing to an increasing burden on global health care systems. Mención de responsabilidad : Michael J. Buie, Joshua Quan, Joseph W. Windsor, Stephanie Coward, Tawnya M. Hansen, James A. King, Paulo G. Kotze, Richard B. Gearry, Siew C. Ng, Joyce W.Y. Mak, Maria T. Abreu, David T. Rubin, Charles N. Bernstein, Rupa Banerjee, Jesus K. Yamamoto-Furusho, Remo Panaccione, Cynthia H. Seow, Christopher Ma, Fox E. Underwood, Vineet Ahuja, Nicola Panaccione, Abdel-Aziz Shaheen, Jayna Holroyd-Leduc, Gilaad G. Kaplan, Domingo Balderramo, Vui Heng Chong, Fabián Juliao-Baños, Usha Dutta, Marcellus Simadibrata, Jamilya Kaibullayeva, Yang Sun, Ida Hilmi, Raja Affendi Raja Ali, Mukesh Sharma Paudel, Mansour Altuwaijri, Juanda Leo Hartono, Shu Chen Wei, Julajak Limsrivilai, Sara El Ouali, Beatriz Iade Vergara, Viet Hang Dao, Paul Kelly, Phoebe Hodges, Yinglei Miao y Maojuan Li Referencia : Clin Gastroenterol Hepatol. 2022 Jul 19;S1542-3565(22)00670-X. DOI (Digital Object Identifier) : 10.1016/j.cgh.2022.06.030 PMID : 35863682 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S154235652200670X Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6106 Global hospitalization trends for Crohn's disease and ulcerative colitis in the 21st century: a systematic review with temporal analyses [documento electrónico] / Fabián Juliao Baños, . - 2022.
Obra : Clinical Gastroenterology and Hepatology
Idioma : Inglés (eng)
Palabras clave : Inflammatory Bowel Disease Crohn’s Disease Ulcerative Colitis Hospitalization Rates Epidemiology Resumen : Background & Aims: The evolving epidemiologic patterns of inflammatory bowel disease (IBD) throughout the world, in conjunction with advances in therapeutic treatments, may influence hospitalization rates of IBD. We performed a systematic review with temporal analysis of hospitalization rates for IBD across the world in the 21st century. Methods: We systematically reviewed Medline and Embase for population-based studies reporting hospitalization rates for IBD, Crohn’s disease (CD), or ulcerative colitis (UC) in the 21st century. Log-linear models were used to calculate the average annual percentage change (AAPC) with associated 95% confidence intervals (95% CIs). Random-effects meta-analysis pooled country-level AAPCs. Data were stratified by the epidemiologic stage of a region: compounding prevalence (stage 3) in North America, Western Europe, and Oceania vs acceleration of incidence (stage 2) in Asia, Eastern Europe, and Latin America vs emergence (stage 1) in developing countries. Results: Hospitalization rates for a primary diagnosis of IBD were stable in countries in stage 3 (AAPC, −0.13%; 95% CI, −0.72 to 0.97), CD (AAPC, 0.20%; 95% CI, −1.78 to 2.17), and UC (AAPC, 0.02%; 95% CI, −0.91 to 0.94). In contrast, hospitalization rates for a primary diagnosis were increasing in countries in stage 2 for IBD (AAPC, 4.44%; 95% CI, 2.75 to 6.14), CD (AAPC, 8.34%; 95% CI, 4.38 to 12.29), and UC (AAPC, 3.90; 95% CI, 1.29 to 6.52). No population-based studies were available for developing regions in stage 1 (emergence). Conclusions: Hospitalization rates for IBD are stabilizing in countries in stage 3, whereas newly industrialized countries in stage 2 have rapidly increasing hospitalization rates, contributing to an increasing burden on global health care systems. Mención de responsabilidad : Michael J. Buie, Joshua Quan, Joseph W. Windsor, Stephanie Coward, Tawnya M. Hansen, James A. King, Paulo G. Kotze, Richard B. Gearry, Siew C. Ng, Joyce W.Y. Mak, Maria T. Abreu, David T. Rubin, Charles N. Bernstein, Rupa Banerjee, Jesus K. Yamamoto-Furusho, Remo Panaccione, Cynthia H. Seow, Christopher Ma, Fox E. Underwood, Vineet Ahuja, Nicola Panaccione, Abdel-Aziz Shaheen, Jayna Holroyd-Leduc, Gilaad G. Kaplan, Domingo Balderramo, Vui Heng Chong, Fabián Juliao-Baños, Usha Dutta, Marcellus Simadibrata, Jamilya Kaibullayeva, Yang Sun, Ida Hilmi, Raja Affendi Raja Ali, Mukesh Sharma Paudel, Mansour Altuwaijri, Juanda Leo Hartono, Shu Chen Wei, Julajak Limsrivilai, Sara El Ouali, Beatriz Iade Vergara, Viet Hang Dao, Paul Kelly, Phoebe Hodges, Yinglei Miao y Maojuan Li Referencia : Clin Gastroenterol Hepatol. 2022 Jul 19;S1542-3565(22)00670-X. DOI (Digital Object Identifier) : 10.1016/j.cgh.2022.06.030 PMID : 35863682 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S154235652200670X Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6106 Reserva
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Título : Trends in the epidemiology of inflammatory bowel disease in Colombia by demographics and region using a nationally representative claims database and characterization of inflammatory bowel disease phenotype in a case series of Colombian patients Tipo de documento : documento electrónico Autores : Fabián Juliao Baños, ; Jorge Hernando Donado Gómez, Fecha de publicación : 2021 Títulos uniformes : Medicine (Baltimore) Idioma : Inglés (eng) Palabras clave : Colombians Crohn’s disease Epidemiology Hispanics Latinos Ulcerative colitis Resumen : The incidence of inflammatory bowel disease (IBD) is on the rise in Latin America. The aims of this study were to examine epidemiologic trends of IBD in Colombia by demographics, region, urbanicity, and to describe the IBD phenotype in a large well-characterized Colombian cohort. We used a national database of 33 million adults encompassing 97.6% of the Colombian population in order to obtain epidemiologic trends of IBD using International Classification of Diseases 10codes for adults with ulcerative colitis (UC) and Crohn disease (CD). We calculated the incidence and prevalence of UC and CD from 2010–2017 and examined epidemiologic trends by urbanicity, demographics, and region. We then examined the IBD phenotype (using Montreal Classification), prevalence of IBD-related surgeries, and types of IBD-medications prescribed to adult patients attending a regional IBD clinic in Medellin, Colombia between 2001 and 2017. The incidence of UC increased from 5.59/100,000 in 2010 to 6.3/100,000 in 2017 (relative risk [RR] 1.12, confidence interval (CI) (1.09–1.18), P Mención de responsabilidad : Juliao-Baños, Fabian MD; Kock, Joshua MD, MSc; Arrubla, Mateo MD; Calixto, Omar MD; Camargo, Joselyn MD; Cruz, Lina MD; Hurtado, Juan MD; Clavijo, Absalon MD; Donado, Jorge MD, MSc; Schwartz, Seth PhD; Abreu, Maria T. MD; Damas, Oriana M. MD Referencia : Medicine (Baltimore). 2021 Feb 19;100(7):e24729. DOI (Digital Object Identifier) : 10.1097/MD.0000000000024729 PMID : 33607817 Derechos de uso : CC BY-NC En línea : https://journals.lww.com/md-journal/Fulltext/2021/02190/Trends_in_the_epidemiolo [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5760 Trends in the epidemiology of inflammatory bowel disease in Colombia by demographics and region using a nationally representative claims database and characterization of inflammatory bowel disease phenotype in a case series of Colombian patients [documento electrónico] / Fabián Juliao Baños, ; Jorge Hernando Donado Gómez, . - 2021.
Obra : Medicine (Baltimore)
Idioma : Inglés (eng)
Palabras clave : Colombians Crohn’s disease Epidemiology Hispanics Latinos Ulcerative colitis Resumen : The incidence of inflammatory bowel disease (IBD) is on the rise in Latin America. The aims of this study were to examine epidemiologic trends of IBD in Colombia by demographics, region, urbanicity, and to describe the IBD phenotype in a large well-characterized Colombian cohort. We used a national database of 33 million adults encompassing 97.6% of the Colombian population in order to obtain epidemiologic trends of IBD using International Classification of Diseases 10codes for adults with ulcerative colitis (UC) and Crohn disease (CD). We calculated the incidence and prevalence of UC and CD from 2010–2017 and examined epidemiologic trends by urbanicity, demographics, and region. We then examined the IBD phenotype (using Montreal Classification), prevalence of IBD-related surgeries, and types of IBD-medications prescribed to adult patients attending a regional IBD clinic in Medellin, Colombia between 2001 and 2017. The incidence of UC increased from 5.59/100,000 in 2010 to 6.3/100,000 in 2017 (relative risk [RR] 1.12, confidence interval (CI) (1.09–1.18), P Mención de responsabilidad : Juliao-Baños, Fabian MD; Kock, Joshua MD, MSc; Arrubla, Mateo MD; Calixto, Omar MD; Camargo, Joselyn MD; Cruz, Lina MD; Hurtado, Juan MD; Clavijo, Absalon MD; Donado, Jorge MD, MSc; Schwartz, Seth PhD; Abreu, Maria T. MD; Damas, Oriana M. MD Referencia : Medicine (Baltimore). 2021 Feb 19;100(7):e24729. DOI (Digital Object Identifier) : 10.1097/MD.0000000000024729 PMID : 33607817 Derechos de uso : CC BY-NC En línea : https://journals.lww.com/md-journal/Fulltext/2021/02190/Trends_in_the_epidemiolo [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5760 Reserva
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Título : Positive culture and prognosis in patients with sepsis: a prospective cohort study Tipo de documento : documento electrónico Autores : Fabián Alberto Jaimes Barragán, Fecha de publicación : 2020 Títulos uniformes : Journal of Intensive Care Medicine Idioma : Inglés (eng) Palabras clave : Blood culture epidemiology microbiological culture mortality sepsis Resumen : Purpose: To analyze the prognostic role of positive cultures in patients with sepsis. Methods: A prospective cohort study in a tertiary referral hospital in Medellín, Colombia. Adults older than 18 years of age with a bacterial infection diagnosis according to Centers for Disease Control criteria and sepsis (evidence of organ dysfunction) were included. A logistic regression model was used to determine the association between positive cultures and hospital mortality, and a Cox regression with a competing risk modeling approach was used to determine the association between positive cultures and hospital stay as well as secondary infections. Results: Overall, 408 patients had positive cultures, of which 257 were blood culture, and 153 had negative cultures. Patients with positive cultures had a lower risk of mortality (odds ratio [OR], 0.43; 95% confidence interval [CI], 0.27-0.68), but this association was not maintained after adjusting for confounding factors (OR, 0.56; 95% CI, 0.31-1.01). No association was found with the hospital stay (adjusted subhazard ratio [SHR], 1.06; 95% CI, 0.83-1.35). There was no association between positive cultures and the presence of secondary infections (adjusted SHR, 0.99; 95% CI, 0.58-1.71). Conclusion: Positive cultures are not associated with prognosis in patients with sepsis. Mención de responsabilidad : Fernando Molina, Pablo Castaño, Maribel Plaza, Carolina Hincapié, Wilmar Maya, Juan Carlos Cataño, Javier González, Alba León, Fabián Jaimes Referencia : J Intensive Care Med. 2020 Aug;35(8):755-762. DOI (Digital Object Identifier) : 10.1177/0885066618783656 PMID : 29925284 En línea : https://journals.sagepub.com/doi/abs/10.1177/0885066618783656?journalCode=jica Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4696 Positive culture and prognosis in patients with sepsis: a prospective cohort study [documento electrónico] / Fabián Alberto Jaimes Barragán, . - 2020.
Obra : Journal of Intensive Care Medicine
Idioma : Inglés (eng)
Palabras clave : Blood culture epidemiology microbiological culture mortality sepsis Resumen : Purpose: To analyze the prognostic role of positive cultures in patients with sepsis. Methods: A prospective cohort study in a tertiary referral hospital in Medellín, Colombia. Adults older than 18 years of age with a bacterial infection diagnosis according to Centers for Disease Control criteria and sepsis (evidence of organ dysfunction) were included. A logistic regression model was used to determine the association between positive cultures and hospital mortality, and a Cox regression with a competing risk modeling approach was used to determine the association between positive cultures and hospital stay as well as secondary infections. Results: Overall, 408 patients had positive cultures, of which 257 were blood culture, and 153 had negative cultures. Patients with positive cultures had a lower risk of mortality (odds ratio [OR], 0.43; 95% confidence interval [CI], 0.27-0.68), but this association was not maintained after adjusting for confounding factors (OR, 0.56; 95% CI, 0.31-1.01). No association was found with the hospital stay (adjusted subhazard ratio [SHR], 1.06; 95% CI, 0.83-1.35). There was no association between positive cultures and the presence of secondary infections (adjusted SHR, 0.99; 95% CI, 0.58-1.71). Conclusion: Positive cultures are not associated with prognosis in patients with sepsis. Mención de responsabilidad : Fernando Molina, Pablo Castaño, Maribel Plaza, Carolina Hincapié, Wilmar Maya, Juan Carlos Cataño, Javier González, Alba León, Fabián Jaimes Referencia : J Intensive Care Med. 2020 Aug;35(8):755-762. DOI (Digital Object Identifier) : 10.1177/0885066618783656 PMID : 29925284 En línea : https://journals.sagepub.com/doi/abs/10.1177/0885066618783656?journalCode=jica Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4696 Reserva
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