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Nephrotic syndrome associated with primary atypical hemolytic uremic syndrome / John Fredy Nieto Ríos
Título : Nephrotic syndrome associated with primary atypical hemolytic uremic syndrome Tipo de documento : documento electrónico Autores : John Fredy Nieto Ríos, Fecha de publicación : 2020 Títulos uniformes : Brazilian Journal of Nephrology Idioma : Inglés (eng) Palabras clave : Atypical Hemolytic Uremic Syndrome Nephrotic Syndrome Acute Renal Injury Hypertension Complement System Proteins Resumen : Primary atypical hemolytic-uremic syndrome is a rare disease characterized by non-immune microangiopathic hemolytic anemia, thrombocytopenia, and renal dysfunction; it is related to alterations in the regulation of the alternative pathway of complement due to genetic mutations. The association with nephrotic syndrome is unusual. We present here a pediatric patient diagnosed with primary atypical hemolytic-uremic syndrome associated with nephrotic syndrome who responded to eculizumab treatment. Mención de responsabilidad : Diana Carolina Bello-Marquez, John Fredy Nieto-Rios, Lina Maria Serna-Higuita, Alfonso Jose Gonzalez-Vergara Referencia : J Bras Nefrol. Jul-Sep 2021;43(3):440-444. DOI (Digital Object Identifier) : 10.1590/2175-8239-jbn-2020-0050 PMID : 32779691 Derechos de uso : CC BY En línea : https://bjnephrology.org/en/article/nephrotic-syndrome-associated-with-primary-a [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5738 Nephrotic syndrome associated with primary atypical hemolytic uremic syndrome [documento electrónico] / John Fredy Nieto Ríos, . - 2020.
Obra : Brazilian Journal of Nephrology
Idioma : Inglés (eng)
Palabras clave : Atypical Hemolytic Uremic Syndrome Nephrotic Syndrome Acute Renal Injury Hypertension Complement System Proteins Resumen : Primary atypical hemolytic-uremic syndrome is a rare disease characterized by non-immune microangiopathic hemolytic anemia, thrombocytopenia, and renal dysfunction; it is related to alterations in the regulation of the alternative pathway of complement due to genetic mutations. The association with nephrotic syndrome is unusual. We present here a pediatric patient diagnosed with primary atypical hemolytic-uremic syndrome associated with nephrotic syndrome who responded to eculizumab treatment. Mención de responsabilidad : Diana Carolina Bello-Marquez, John Fredy Nieto-Rios, Lina Maria Serna-Higuita, Alfonso Jose Gonzalez-Vergara Referencia : J Bras Nefrol. Jul-Sep 2021;43(3):440-444. DOI (Digital Object Identifier) : 10.1590/2175-8239-jbn-2020-0050 PMID : 32779691 Derechos de uso : CC BY En línea : https://bjnephrology.org/en/article/nephrotic-syndrome-associated-with-primary-a [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5738 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001677 AC-2020-148 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2020-148Adobe Acrobat PDF Clinical and immunological factors associated with lupus nephritis in patients from northwestern Colombia / Luis Fernando Pinto Peñaranda
Título : Clinical and immunological factors associated with lupus nephritis in patients from northwestern Colombia Otros títulos : Factores clínicos y epidemiológicos asociados con nefritis lúpica en pacientes del noroccidente colombiano Tipo de documento : documento electrónico Autores : Luis Fernando Pinto Peñaranda, Fecha de publicación : 2003 Títulos uniformes : Biomédica Idioma : Inglés (eng) Palabras clave : systemic lupus erythematosus lupus nephritis risk factors autoantibodies hypertension hyperlipidemia Colombia Resumen : A cross-sectional and multicenter study was undertaken to analyze the clinical and immunological characteristics at diagnosis associated with nephritis in northwestern Colombian patients with systemic lupus erythematosus (SLE). Thirty-nine patients with lupus nephritis were included and were compared to 100 SLE patients without nephritis. A multivariate analysis was performed. The patients who developed nephritis had a higher frequency of oral ulcers (41% vs. 21%, OR = 3.1, 95% CI: 1.3-7.5 p = 0.01) and malar erythema (77% vs. 45%, OR = 4.4, 95% CI: 1.8-10.8 p = 0.001). Lupus nephritis was observed in 77% of cases during the first year of the disease. The frequency of anti-DNA antibodies was higher in patients with nephritis, however, differences were not statistically significant (83% vs 64%, OR = 2.6, 95% CI: 1.03-6.41, p = 0.06). The presence of other autoantibodies (anti-Ro, anti-La, anti-RNP, anti-Sm and anticardiolipin) at diagnosis was similar in both groups. This autoantibody profile remained unchanged throughout the evolution of the disease. Patients with lupus nephritis had a higher prevalence of arterial hypertension (60% vs 10%, OR = 13.7, 95% IC: 5-37, p = 0.00001) and hyperlipidemia (30% vs 7%, OR = 8.1, 95% IC: 2.5-27, p = 0.0006) at onset. Finally, patients with lupus nephritis required more hospitalizations (> 1) over the course of disease (89% vs 60%, OR = 7.8, 95% CI: 2.1-29, p = 0.002). In conclusion, lupus nephritis appears early during the course of SLE. Malar erythema, oral ulcers, hypertension and hyperlipidemia at onset of disease are associated factors. Lupus nephritis is a major risk factor leading to repeated hospitalizations. This study may help to assist in public health policies in our population in order to improve patient outcomes while simultaneously reducing disease costs. Mención de responsabilidad : Juan Manuel Anaya, Mauricio Uribe, Adriana Pérez, Juan F. Sánchez, Luis F. Pinto, José F. Molina, María C. Londoño, Martha E. Cadavid, Gustavo Matute Referencia : Biomedica. 2003 Sep;23(3):293-300. DOI (Digital Object Identifier) : 10.7705/biomedica.v23i3.1223 PMID : 14582332 En línea : https://revistabiomedica.org/index.php/biomedica/article/view/1223 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5056 Clinical and immunological factors associated with lupus nephritis in patients from northwestern Colombia = Factores clínicos y epidemiológicos asociados con nefritis lúpica en pacientes del noroccidente colombiano [documento electrónico] / Luis Fernando Pinto Peñaranda, . - 2003.
Obra : Biomédica
Idioma : Inglés (eng)
Palabras clave : systemic lupus erythematosus lupus nephritis risk factors autoantibodies hypertension hyperlipidemia Colombia Resumen : A cross-sectional and multicenter study was undertaken to analyze the clinical and immunological characteristics at diagnosis associated with nephritis in northwestern Colombian patients with systemic lupus erythematosus (SLE). Thirty-nine patients with lupus nephritis were included and were compared to 100 SLE patients without nephritis. A multivariate analysis was performed. The patients who developed nephritis had a higher frequency of oral ulcers (41% vs. 21%, OR = 3.1, 95% CI: 1.3-7.5 p = 0.01) and malar erythema (77% vs. 45%, OR = 4.4, 95% CI: 1.8-10.8 p = 0.001). Lupus nephritis was observed in 77% of cases during the first year of the disease. The frequency of anti-DNA antibodies was higher in patients with nephritis, however, differences were not statistically significant (83% vs 64%, OR = 2.6, 95% CI: 1.03-6.41, p = 0.06). The presence of other autoantibodies (anti-Ro, anti-La, anti-RNP, anti-Sm and anticardiolipin) at diagnosis was similar in both groups. This autoantibody profile remained unchanged throughout the evolution of the disease. Patients with lupus nephritis had a higher prevalence of arterial hypertension (60% vs 10%, OR = 13.7, 95% IC: 5-37, p = 0.00001) and hyperlipidemia (30% vs 7%, OR = 8.1, 95% IC: 2.5-27, p = 0.0006) at onset. Finally, patients with lupus nephritis required more hospitalizations (> 1) over the course of disease (89% vs 60%, OR = 7.8, 95% CI: 2.1-29, p = 0.002). In conclusion, lupus nephritis appears early during the course of SLE. Malar erythema, oral ulcers, hypertension and hyperlipidemia at onset of disease are associated factors. Lupus nephritis is a major risk factor leading to repeated hospitalizations. This study may help to assist in public health policies in our population in order to improve patient outcomes while simultaneously reducing disease costs. Mención de responsabilidad : Juan Manuel Anaya, Mauricio Uribe, Adriana Pérez, Juan F. Sánchez, Luis F. Pinto, José F. Molina, María C. Londoño, Martha E. Cadavid, Gustavo Matute Referencia : Biomedica. 2003 Sep;23(3):293-300. DOI (Digital Object Identifier) : 10.7705/biomedica.v23i3.1223 PMID : 14582332 En línea : https://revistabiomedica.org/index.php/biomedica/article/view/1223 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5056 Reserva
Reservar este documentoEjemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001618 AC-2003-006 Archivo digital Producción Científica Artículos científicos Disponible