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Changes in the incidence of acute bacterial meningitis caused by Streptococcus pneumoniae and the implications of serotype replacement in children in Colombia after mass vaccination with PCV10 / Mónica Rosa Trujillo Honeysberg  

Público ISBD Título : Changes in the incidence of acute bacterial meningitis caused by Streptococcus pneumoniae and the implications of serotype replacement in children in Colombia after mass vaccination with PCV10 Tipo de documento : documento electrónico Autores : Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2022 Títulos uniformes : Frontiers in Pediatrics Idioma : Inglés (eng) Palabras clave : pneumococcal meningitis  pediatrics  infections  vaccines  microbiology  serotype Resumen : Introduction: Acute bacterial meningitis (ABM) is a public health problem. The disease has reemerged after the introduction of pneumococcal conjugate vaccines (PCVs) due to an increase in serotypes that are not covered. The objective was to determine the changes in the disease incidence before and after the introduction of the 10-valent vaccine (PCV10) in Colombia. Methods: This multicenter study was conducted in 17 hospitals in Colombia. Data were collected from January 2008 to December 2019 in 10 hospitals in Bogotá and from January 2017 to December 2019 in seven hospitals in Cali, Medellín and Cartagena. The data were grouped into three periods: 2008–2011, 2012–2015, and 2016-2019. Results: Of the 706 cases of invasive pneumococcal disease, 81 (11.4%) corresponded to meningitis. The relative incidence in Bogotá in the first period was 0.6 per 100,000 patients ≤ 5 years, decreased to 0.4 per 100,000 patients ≤ 5 years in the second period and increased in the third period to 0.7 per 100,000 patients ≤ 5 years. Serotypes covered by PCV10 decreased from 75 to 9.1%, with Spn19A (31.8%) and Spn34 (13.6%) emerging in the third period. Increased resistance to penicillin (13 to 37%) and to ceftriaxone (5.9 to 16%) was due to the emergence of multidrug-resistant Spn19A. The total mortality rate was 23.5% and increased from 12 to 33%. Conclusions: ABM due to pneumococcus has high morbidity and mortality rates. Reemergence of the disease has been observed due to the inclusion of polymerase chain reaction (PCR) for diagnosis and replacement of circulating serotypes after the introduction of PCV10, with an increase in Spn19A, which causes death and exhibits antimicrobial resistance. Continued surveillance is needed. Mención de responsabilidad : Juan David Farfán-Albarracín, Germán Camacho-Moreno, Aura Lucia Leal, Jaime Patiño, Wilfrido Coronell, Iván Felipe Gutiérrez, Sandra Beltrán, Martha I Álvarez-Olmos, Cristina Mariño, Rocio Barrero, Juan Pablo Rojas, Fabio Espinosa, Catalina Arango-Ferreira, Maria Alejandra Suarez, Monica Trujillo, Eduardo López-Medina, Pio López, Hernando Pinzón, Nicolás Ramos, Vivian Marcela Moreno, Anita Montañez Referencia : Front Pediatr. 2022 Sep 23;10:1006887. DOI (Digital Object Identifier) : 10.3389/fped.2022.1006887 PMID : 36210950 En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.1006887/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6088 Changes in the incidence of acute bacterial meningitis caused by Streptococcus pneumoniae and the implications of serotype replacement in children in Colombia after mass vaccination with PCV10 [documento electrónico] / Mónica Rosa Trujillo Honeysberg,  . - 2022. Obra : Frontiers in Pediatrics Idioma : Inglés (eng) Palabras clave : pneumococcal meningitis  pediatrics  infections  vaccines  microbiology  serotype Resumen : Introduction: Acute bacterial meningitis (ABM) is a public health problem. The disease has reemerged after the introduction of pneumococcal conjugate vaccines (PCVs) due to an increase in serotypes that are not covered. The objective was to determine the changes in the disease incidence before and after the introduction of the 10-valent vaccine (PCV10) in Colombia. Methods: This multicenter study was conducted in 17 hospitals in Colombia. Data were collected from January 2008 to December 2019 in 10 hospitals in Bogotá and from January 2017 to December 2019 in seven hospitals in Cali, Medellín and Cartagena. The data were grouped into three periods: 2008–2011, 2012–2015, and 2016-2019. Results: Of the 706 cases of invasive pneumococcal disease, 81 (11.4%) corresponded to meningitis. The relative incidence in Bogotá in the first period was 0.6 per 100,000 patients ≤ 5 years, decreased to 0.4 per 100,000 patients ≤ 5 years in the second period and increased in the third period to 0.7 per 100,000 patients ≤ 5 years. Serotypes covered by PCV10 decreased from 75 to 9.1%, with Spn19A (31.8%) and Spn34 (13.6%) emerging in the third period. Increased resistance to penicillin (13 to 37%) and to ceftriaxone (5.9 to 16%) was due to the emergence of multidrug-resistant Spn19A. The total mortality rate was 23.5% and increased from 12 to 33%. Conclusions: ABM due to pneumococcus has high morbidity and mortality rates. Reemergence of the disease has been observed due to the inclusion of polymerase chain reaction (PCR) for diagnosis and replacement of circulating serotypes after the introduction of PCV10, with an increase in Spn19A, which causes death and exhibits antimicrobial resistance. Continued surveillance is needed. Mención de responsabilidad : Juan David Farfán-Albarracín, Germán Camacho-Moreno, Aura Lucia Leal, Jaime Patiño, Wilfrido Coronell, Iván Felipe Gutiérrez, Sandra Beltrán, Martha I Álvarez-Olmos, Cristina Mariño, Rocio Barrero, Juan Pablo Rojas, Fabio Espinosa, Catalina Arango-Ferreira, Maria Alejandra Suarez, Monica Trujillo, Eduardo López-Medina, Pio López, Hernando Pinzón, Nicolás Ramos, Vivian Marcela Moreno, Anita Montañez Referencia : Front Pediatr. 2022 Sep 23;10:1006887. DOI (Digital Object Identifier) : 10.3389/fped.2022.1006887 PMID : 36210950 En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.1006887/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6088

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Clinical characteristics of children with SARS-CoV-2 infection in a hospital in Latin America / Laura Fernanda Niño Serna ; Eliana López Barón ; Isabel Cristina Maya Ángel ; Carolina Tamayo Múnera    

Público ISBD Título : Clinical characteristics of children with SARS-CoV-2 infection in a hospital in Latin America Tipo de documento : documento electrónico Autores : Laura Fernanda Niño Serna, ; Eliana López Barón, ; Isabel Cristina Maya Ángel, ; Carolina Tamayo Múnera, Fecha de publicación : 2022 Títulos uniformes : Frontiers in Pediatrics Idioma : Inglés (eng) Palabras clave : pediatrics  comorbidity  inpatients  pediatric intensive care unit  Latin America  COVID-19 Resumen : Objective: COVID-19 infections have shown a different behavior in children than in adults. The objective of this study was to describe the clinical characteristics and severity of SARS-CoV-2 infection in pediatric patients seen at a reference hospital in Colombia. Method: A descriptive, observational study in patients under the age of 18 years with a positive test for SARS-CoV-2 infection (RT-PCR or antigen) between April 2020 and March 2021. Multiple variables were studied, including demographic data, clinical characteristics, lab measurements, treatments administered, intensive care unit admission, and mortality. Results: A total of 361 patients were included of whom 196 (54%) were males. The median age was 3 years. Of all the patients, 65 (18%) were asymptomatic. The majority of patients had no comorbidities (n = 225, 76%). In those who were symptomatic (n = 296, 82%), the most frequent complaints were fever (n = 178, 60%), nasal congestion (n = 164, 55%) and cough (n = 149, 50%). Chest x-rays were normal in 73 patients (50%). When abnormalities were found, interstitial (29%) and alveolar (12%) patterns were the most prevalent. One hundred and fifty-seven children (53%) required general ward hospitalization, and 24 patients (8%) required pediatric intensive care admission. The global mortality was 0.8% (3 patients). Conclusions: The majority of cases were asymptomatic or mild. However, a significant percentage of patients required general ward admission, and some even required intensive care. The main symptom of COVID-19 infections in newborns was apnea. A second COVID-19 RT-PCR may be necessary to detect infections in critically ill patients with a high clinical suspicion of the disease if an initial test was negative. Mención de responsabilidad : Laura F. Niño-Serna, Eliana López-Barón, Isabel Cristina Maya Ángel and Carolina Tamayo-Múnera Referencia : Front Pediatr. 2022 Jun 9;10:921880. DOI (Digital Object Identifier) : 10.3389/fped.2022.921880 PMID : 35757135 Derechos de uso : CC BY En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.921880/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6032 Clinical characteristics of children with SARS-CoV-2 infection in a hospital in Latin America [documento electrónico] / Laura Fernanda Niño Serna, ; Eliana López Barón, ; Isabel Cristina Maya Ángel, ; Carolina Tamayo Múnera,  . - 2022. Obra : Frontiers in Pediatrics Idioma : Inglés (eng) Palabras clave : pediatrics  comorbidity  inpatients  pediatric intensive care unit  Latin America  COVID-19 Resumen : Objective: COVID-19 infections have shown a different behavior in children than in adults. The objective of this study was to describe the clinical characteristics and severity of SARS-CoV-2 infection in pediatric patients seen at a reference hospital in Colombia. Method: A descriptive, observational study in patients under the age of 18 years with a positive test for SARS-CoV-2 infection (RT-PCR or antigen) between April 2020 and March 2021. Multiple variables were studied, including demographic data, clinical characteristics, lab measurements, treatments administered, intensive care unit admission, and mortality. Results: A total of 361 patients were included of whom 196 (54%) were males. The median age was 3 years. Of all the patients, 65 (18%) were asymptomatic. The majority of patients had no comorbidities (n = 225, 76%). In those who were symptomatic (n = 296, 82%), the most frequent complaints were fever (n = 178, 60%), nasal congestion (n = 164, 55%) and cough (n = 149, 50%). Chest x-rays were normal in 73 patients (50%). When abnormalities were found, interstitial (29%) and alveolar (12%) patterns were the most prevalent. One hundred and fifty-seven children (53%) required general ward hospitalization, and 24 patients (8%) required pediatric intensive care admission. The global mortality was 0.8% (3 patients). Conclusions: The majority of cases were asymptomatic or mild. However, a significant percentage of patients required general ward admission, and some even required intensive care. The main symptom of COVID-19 infections in newborns was apnea. A second COVID-19 RT-PCR may be necessary to detect infections in critically ill patients with a high clinical suspicion of the disease if an initial test was negative. Mención de responsabilidad : Laura F. Niño-Serna, Eliana López-Barón, Isabel Cristina Maya Ángel and Carolina Tamayo-Múnera Referencia : Front Pediatr. 2022 Jun 9;10:921880. DOI (Digital Object Identifier) : 10.3389/fped.2022.921880 PMID : 35757135 Derechos de uso : CC BY En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.921880/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6032

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Acute infectious diarrhea and gastroenteritis in children / Laura Fernanda Niño Serna  

Público ISBD Título : Acute infectious diarrhea and gastroenteritis in children Tipo de documento : documento electrónico Autores : Laura Fernanda Niño Serna, Fecha de publicación : 2020 Títulos uniformes : Current Infectious Disease Reports Idioma : Inglés (eng) Palabras clave : Antidiarrheals  Antiemetics  Dehydration  Diarrhea  Gastroenteritis  Pediatrics  Rotavirus Resumen : Purpose of review: We aimed to summarize the most current evidence on the main aspects of the diarrheal diseases in children. The following key elements were addressed: definitions, etiology, pathogenesis, diagnosis, dietary management, pharmacological treatments, and prevention. We covered the following questions: What are the most important clinical and laboratory features of the disease? What are the best approaches for the dietary management? What is the best way to classify the hydration status, and to prevent and treat the dehydration? What are the most effective and safe interventions for reducing the diarrhea and vomiting? Recent findings: Diarrheal diseases are one of the most common diseases in childhood. The most common cause is rotavirus. A key element in the approach of a child with diarrhea is determining their hydration status, which determines the fluid management. Laboratory tests are nor routinely required, as most of the cases, they do not affect the management and it should be indicated only in selected cases. Several treatments have been studied to reduce the duration of the diarrhea. Only symbiotics and zinc have shown to be effective and safe with high certainty on the evidence. Rest of the interventions although seem to be effective have low to very low quality of the evidence. The only effective and safe antiemetic for controlling vomiting is ondansetron. A list of antimicrobials indications according to the identified microorganisms is provided. We summarized the most current evidence on diagnosis, management, and prevention of diarrhea in children. More research is needed in some areas such as dehydration scales, rehydration management, antidiarrheals, and antibiotic treatments. Mención de responsabilidad : Ivan D Florez, Laura F Niño-Serna, Claudia P Beltrán-Arroyave Referencia : Curr Infect Dis Rep. 2020 Jan 28;22(2):4. DOI (Digital Object Identifier) : 10.1007/s11908-020-0713-6 PMID : 31993758 En línea : https://link.springer.com/article/10.1007%2Fs11908-020-0713-6 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5068 Acute infectious diarrhea and gastroenteritis in children [documento electrónico] / Laura Fernanda Niño Serna,  . - 2020. Obra : Current Infectious Disease Reports Idioma : Inglés (eng) Palabras clave : Antidiarrheals  Antiemetics  Dehydration  Diarrhea  Gastroenteritis  Pediatrics  Rotavirus Resumen : Purpose of review: We aimed to summarize the most current evidence on the main aspects of the diarrheal diseases in children. The following key elements were addressed: definitions, etiology, pathogenesis, diagnosis, dietary management, pharmacological treatments, and prevention. We covered the following questions: What are the most important clinical and laboratory features of the disease? What are the best approaches for the dietary management? What is the best way to classify the hydration status, and to prevent and treat the dehydration? What are the most effective and safe interventions for reducing the diarrhea and vomiting? Recent findings: Diarrheal diseases are one of the most common diseases in childhood. The most common cause is rotavirus. A key element in the approach of a child with diarrhea is determining their hydration status, which determines the fluid management. Laboratory tests are nor routinely required, as most of the cases, they do not affect the management and it should be indicated only in selected cases. Several treatments have been studied to reduce the duration of the diarrhea. Only symbiotics and zinc have shown to be effective and safe with high certainty on the evidence. Rest of the interventions although seem to be effective have low to very low quality of the evidence. The only effective and safe antiemetic for controlling vomiting is ondansetron. A list of antimicrobials indications according to the identified microorganisms is provided. We summarized the most current evidence on diagnosis, management, and prevention of diarrhea in children. More research is needed in some areas such as dehydration scales, rehydration management, antidiarrheals, and antibiotic treatments. Mención de responsabilidad : Ivan D Florez, Laura F Niño-Serna, Claudia P Beltrán-Arroyave Referencia : Curr Infect Dis Rep. 2020 Jan 28;22(2):4. DOI (Digital Object Identifier) : 10.1007/s11908-020-0713-6 PMID : 31993758 En línea : https://link.springer.com/article/10.1007%2Fs11908-020-0713-6 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5068

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Hematopoietic stem cell transplantation in children with inborn errors of immunity: a multi-center experience in Colombia / Luz Natalia Builes Restrepo  

Público ISBD Título : Hematopoietic stem cell transplantation in children with inborn errors of immunity: a multi-center experience in Colombia Tipo de documento : documento electrónico Autores : Luz Natalia Builes Restrepo, Fecha de publicación : 2020 Títulos uniformes : Journal of Clinical Immunology Idioma : Inglés (eng) Palabras clave : Hematopoietic stem cell transplantation  child  haploidentical transplantations  pediatrics  primary immunodeficiency diseases  transplant recipients Resumen : Purpose: To characterize the pediatric population with inborn errors of immunity (IEI) that was treated with hematopoietic stem cell transplantation (HSCT) in three reference centers in Colombia. What have been the characteristics and outcomes of hematopoietic stem cell transplantation in pediatric patients with inborn errors of immunity in three reference care centers in Colombia between 2007 and 2018. Methods: We conducted an observational, retrospective cohort study in children with a diagnosis of IEI who underwent HSCT between 2007 and 2018. Results: Forty-seven patients were identified, and 5 were re-transplanted. Sixty-eight percent were male. The median age at diagnosis was 0.6 years, and for HSCT was 1.4 years. The most common diseases were chronic granulomatous disease (38%) followed by severe combined immune deficiencies (19%) and hemophagocytic lymphohistiocytosis (15%). Cord blood donors were the most used source of HSCT (44%). T cell-replete grafts from haploidentical donors using post-transplantation cyclophosphamide represent 37% of the cohort. All patients received conditioning, 62% with a non-myeloablative regimen. Calcineurin inhibitors were the main graft-versus-host disease prophylaxis (63.8%). Acute graft-versus-host disease developed in 35% of the total patients. The most frequent post-transplant infections were viral and fungal infections. The 1-year overall survival rates for the patients who received HSCT from identical, haploidentical, and cord sources were 80%, 72%, and 63%, respectively. The 5-year overall survival was 63%. Conclusions: HSCT is a curative treatment option for some IEI and can be performed with any donor type. Early and timely treatment in referral centers can improve survival. Mención de responsabilidad : Manuela Olaya, Alexis Franco, Mauricio Chaparro, Marcela Estupiñan, David Aristizabal, Natalia Builes-Restrepo, José L Franco, Andrés F Zea-Vera, Mayra Estacio, Eliana Manzi, Estefania Beltran, Paola Perez, Jaime Patiño, Harry Pachajoa & Diego Medina-Valencia Referencia : J Clin Immunol. 2020 Nov;40(8):1116-1123. DOI (Digital Object Identifier) : 10.1007/s10875-020-00856-w PMID : 32880086 En línea : https://link.springer.com/article/10.1007/s10875-020-00856-w Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5135 Hematopoietic stem cell transplantation in children with inborn errors of immunity: a multi-center experience in Colombia [documento electrónico] / Luz Natalia Builes Restrepo,  . - 2020. Obra : Journal of Clinical Immunology Idioma : Inglés (eng) Palabras clave : Hematopoietic stem cell transplantation  child  haploidentical transplantations  pediatrics  primary immunodeficiency diseases  transplant recipients Resumen : Purpose: To characterize the pediatric population with inborn errors of immunity (IEI) that was treated with hematopoietic stem cell transplantation (HSCT) in three reference centers in Colombia. What have been the characteristics and outcomes of hematopoietic stem cell transplantation in pediatric patients with inborn errors of immunity in three reference care centers in Colombia between 2007 and 2018. Methods: We conducted an observational, retrospective cohort study in children with a diagnosis of IEI who underwent HSCT between 2007 and 2018. Results: Forty-seven patients were identified, and 5 were re-transplanted. Sixty-eight percent were male. The median age at diagnosis was 0.6 years, and for HSCT was 1.4 years. The most common diseases were chronic granulomatous disease (38%) followed by severe combined immune deficiencies (19%) and hemophagocytic lymphohistiocytosis (15%). Cord blood donors were the most used source of HSCT (44%). T cell-replete grafts from haploidentical donors using post-transplantation cyclophosphamide represent 37% of the cohort. All patients received conditioning, 62% with a non-myeloablative regimen. Calcineurin inhibitors were the main graft-versus-host disease prophylaxis (63.8%). Acute graft-versus-host disease developed in 35% of the total patients. The most frequent post-transplant infections were viral and fungal infections. The 1-year overall survival rates for the patients who received HSCT from identical, haploidentical, and cord sources were 80%, 72%, and 63%, respectively. The 5-year overall survival was 63%. Conclusions: HSCT is a curative treatment option for some IEI and can be performed with any donor type. Early and timely treatment in referral centers can improve survival. Mención de responsabilidad : Manuela Olaya, Alexis Franco, Mauricio Chaparro, Marcela Estupiñan, David Aristizabal, Natalia Builes-Restrepo, José L Franco, Andrés F Zea-Vera, Mayra Estacio, Eliana Manzi, Estefania Beltran, Paola Perez, Jaime Patiño, Harry Pachajoa & Diego Medina-Valencia Referencia : J Clin Immunol. 2020 Nov;40(8):1116-1123. DOI (Digital Object Identifier) : 10.1007/s10875-020-00856-w PMID : 32880086 En línea : https://link.springer.com/article/10.1007/s10875-020-00856-w Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5135

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