Inicio
Resultado de la búsqueda
24 búsqueda de la palabra clave 'sepsis'
Clasificado(s) por (Año de edición descendente) Refinar búsqueda Genera el flujo rss de la búsqueda
Enlace permanente de la investigaciónGut microbiota alterations in critically ill older patients: a multicenter study / Adriana Giraldo Villa
Título : Gut microbiota alterations in critically ill older patients: a multicenter study Tipo de documento : documento electrónico Autores : Adriana Giraldo Villa, Fecha de publicación : 2022 Títulos uniformes : BMC Geriatrics Idioma : Inglés (eng) Palabras clave : Older adults Critically ill Gut microbiota ICU Sepsis Dysbiosis Resumen : Background: Aging generates changes in the gut microbiota, affecting its functionality. Little is known about gut microbiota in critically ill older adults. The objective of this study was to describe the profile of gut microbiota in a cohort of critically ill older adults. Methods: This observational study was conducted in five health institutions. Over a 6-month study period, critically ill patients over 18 years old who were admitted to the intensive care unit were enrolled. Fecal microbiota profiles were determined from 155 individuals, over 60 years old (n = 72) and under 60 years old (n = 83). Gut microbiota was analyzed by sequencing the V3-V4 region of the 16S rRNA gene. Alpha and beta diversity, operational taxonomic units and the interaction of gut microbiota with variables under study were analyzed. Amplicon sequence variants (ASVs) specifically associated with age were recovered by including gender, discharge condition, BMI, ICU stay and antibiotics as covariates in a linear mixed model. Results: In older adults, sepsis, malnutrition, antibiotic prescription and severity (APACHE and SOFA scores) were higher than in the group under 60 years of age. Alpha diversity showed lower gut microbiota diversity in those over 60 years of age (p Mención de responsabilidad : Mesa Victoria, Valdés-Duque Beatriz Elena, Giraldo-Giraldo Nubia Amparo, Jailler-R Ana María, Giraldo-Villa Adriana, Acevedo-Castaño Irene, Yepes-M Mónica Alejandra, Barbosa-Barbosa Janeth & Agudelo-Ochoa Gloria María Referencia : BMC Geriatr. 2022 Apr 28;22(1):373. DOI (Digital Object Identifier) : 10.1186/s12877-022-02981-0 PMID : 35484500 Derechos de uso : CC BY En línea : https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-022-02981-0 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6025 Gut microbiota alterations in critically ill older patients: a multicenter study [documento electrónico] / Adriana Giraldo Villa, . - 2022.
Obra : BMC Geriatrics
Idioma : Inglés (eng)
Palabras clave : Older adults Critically ill Gut microbiota ICU Sepsis Dysbiosis Resumen : Background: Aging generates changes in the gut microbiota, affecting its functionality. Little is known about gut microbiota in critically ill older adults. The objective of this study was to describe the profile of gut microbiota in a cohort of critically ill older adults. Methods: This observational study was conducted in five health institutions. Over a 6-month study period, critically ill patients over 18 years old who were admitted to the intensive care unit were enrolled. Fecal microbiota profiles were determined from 155 individuals, over 60 years old (n = 72) and under 60 years old (n = 83). Gut microbiota was analyzed by sequencing the V3-V4 region of the 16S rRNA gene. Alpha and beta diversity, operational taxonomic units and the interaction of gut microbiota with variables under study were analyzed. Amplicon sequence variants (ASVs) specifically associated with age were recovered by including gender, discharge condition, BMI, ICU stay and antibiotics as covariates in a linear mixed model. Results: In older adults, sepsis, malnutrition, antibiotic prescription and severity (APACHE and SOFA scores) were higher than in the group under 60 years of age. Alpha diversity showed lower gut microbiota diversity in those over 60 years of age (p Mención de responsabilidad : Mesa Victoria, Valdés-Duque Beatriz Elena, Giraldo-Giraldo Nubia Amparo, Jailler-R Ana María, Giraldo-Villa Adriana, Acevedo-Castaño Irene, Yepes-M Mónica Alejandra, Barbosa-Barbosa Janeth & Agudelo-Ochoa Gloria María Referencia : BMC Geriatr. 2022 Apr 28;22(1):373. DOI (Digital Object Identifier) : 10.1186/s12877-022-02981-0 PMID : 35484500 Derechos de uso : CC BY En línea : https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-022-02981-0 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6025 Reserva
Reservar este documentoEjemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001865 AC-2022-031 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-031Adobe Acrobat PDF
Título : Mortality and clinical characteristics of multisystem inflammatory syndrome in children (MIS-C) associated with covid-19 in critically ill patients: an observational multicenter study (MISCO study) Tipo de documento : documento electrónico Autores : Laura Fernanda Niño Serna, ; Carolina Giraldo Alzate, Fecha de publicación : 2021 Títulos uniformes : BMC Pediatrics Idioma : Inglés (eng) Palabras clave : Sepsis SARS-CoV2 PIMS-TS infammatory mortality Resumen : Background: The clinical presentation and severity of Multisystem Inflammatory Syndrome in Children associated with COVID-19 (MIS-C) is widespread and presents a very low mortality rate in high-income countries. This research describes the clinical characteristics of MIS-C in critically ill children in middle-income countries and the factors associated with the rate of mortality and patients with critical outcomes. Methods: An observational cohort study was conducted in 14 pediatric intensive care units (PICUs) in Colombia between April 01, 2020, and January 31, 2021. Patient age ranged between one month and 18 years, and each patient met the requirements set forth by the World Health Organization (WHO) for MIS-C. Results: There were seventy-eight children in this study. The median age was seven years (IQR 1-11), 18 % (14/78) were under one year old, and 56 % were male. 35 % of patients (29/78) were obese or overweight. The PICU stay per individual was six days (IQR 4-7), and 100 % had a fever upon arrival to the clinic lasting at least five days (IQR 3.7-6). 70 % (55/78) of patients had diarrhea, and 87 % (68/78) had shock or systolic myocardial dysfunction (78 %). Coronary aneurysms were found in 35 % (27/78) of cases, and pericardial effusion was found in 36 %. When compared to existing data in high-income countries, there was a higher mortality rate observed (9 % vs. 1.8 %; p=0.001). When assessing the group of patients that did not survive, a higher frequency of ferritin levels was found, above 500 ngr/mL (100 % vs. 45 %; p=0.012), as well as more cardiovascular complications (100 % vs. 54 %; p = 0.019) when compared to the group that survived. The main treatments received were immunoglobulin (91 %), vasoactive support (76 %), steroids (70.5 %) and antiplatelets (44 %). Conclusions: Multisystem Inflammatory Syndrome in Children due to SARS-CoV-2 in critically ill children living in a middle-income country has some clinical, laboratory, and echocardiographic characteristics similar to those described in high-income countries. The observed inflammatory response and cardiovascular involvement were conditions that, added to the later presentation, may explain the higher mortality seen in these children. Mención de responsabilidad : Lorena Acevedo, Byron Enrique Piñeres-Olave, Laura Fernanda Niño-Serna, Liliana Mazzillo Vega, Ivan Jose Ardila Gomez, Shayl Chacón, Juan Camilo Jaramillo-Bustamante, Hernando Mulett-Hoyos, Otto González-Pardo, Eliana Zemanate, Ledys Izquierdo, Jaime Piracoca Mejìa, Jose Luis Junco González, Beatriz Giraldo Duran, Carolina Bonilla Gonzalez, Helen Preciado, Rafael Orozco Marun, Martha I Alvarez-Olmos, Carolina Giraldo Alzate, Jorge Rojas, Juan Carlos Salazar-Uribe, Juan-Manuel Anaya & Jaime Fernández-Sarmiento Referencia : BMC Pediatr. 2021 Nov 18;21(1):516. DOI (Digital Object Identifier) : 10.1186/s12887-021-02974-9 PMID : 34794410 Derechos de uso : CC BY En línea : https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-021-02974-9 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5839 Mortality and clinical characteristics of multisystem inflammatory syndrome in children (MIS-C) associated with covid-19 in critically ill patients: an observational multicenter study (MISCO study) [documento electrónico] / Laura Fernanda Niño Serna, ; Carolina Giraldo Alzate, . - 2021.
Obra : BMC Pediatrics
Idioma : Inglés (eng)
Palabras clave : Sepsis SARS-CoV2 PIMS-TS infammatory mortality Resumen : Background: The clinical presentation and severity of Multisystem Inflammatory Syndrome in Children associated with COVID-19 (MIS-C) is widespread and presents a very low mortality rate in high-income countries. This research describes the clinical characteristics of MIS-C in critically ill children in middle-income countries and the factors associated with the rate of mortality and patients with critical outcomes. Methods: An observational cohort study was conducted in 14 pediatric intensive care units (PICUs) in Colombia between April 01, 2020, and January 31, 2021. Patient age ranged between one month and 18 years, and each patient met the requirements set forth by the World Health Organization (WHO) for MIS-C. Results: There were seventy-eight children in this study. The median age was seven years (IQR 1-11), 18 % (14/78) were under one year old, and 56 % were male. 35 % of patients (29/78) were obese or overweight. The PICU stay per individual was six days (IQR 4-7), and 100 % had a fever upon arrival to the clinic lasting at least five days (IQR 3.7-6). 70 % (55/78) of patients had diarrhea, and 87 % (68/78) had shock or systolic myocardial dysfunction (78 %). Coronary aneurysms were found in 35 % (27/78) of cases, and pericardial effusion was found in 36 %. When compared to existing data in high-income countries, there was a higher mortality rate observed (9 % vs. 1.8 %; p=0.001). When assessing the group of patients that did not survive, a higher frequency of ferritin levels was found, above 500 ngr/mL (100 % vs. 45 %; p=0.012), as well as more cardiovascular complications (100 % vs. 54 %; p = 0.019) when compared to the group that survived. The main treatments received were immunoglobulin (91 %), vasoactive support (76 %), steroids (70.5 %) and antiplatelets (44 %). Conclusions: Multisystem Inflammatory Syndrome in Children due to SARS-CoV-2 in critically ill children living in a middle-income country has some clinical, laboratory, and echocardiographic characteristics similar to those described in high-income countries. The observed inflammatory response and cardiovascular involvement were conditions that, added to the later presentation, may explain the higher mortality seen in these children. Mención de responsabilidad : Lorena Acevedo, Byron Enrique Piñeres-Olave, Laura Fernanda Niño-Serna, Liliana Mazzillo Vega, Ivan Jose Ardila Gomez, Shayl Chacón, Juan Camilo Jaramillo-Bustamante, Hernando Mulett-Hoyos, Otto González-Pardo, Eliana Zemanate, Ledys Izquierdo, Jaime Piracoca Mejìa, Jose Luis Junco González, Beatriz Giraldo Duran, Carolina Bonilla Gonzalez, Helen Preciado, Rafael Orozco Marun, Martha I Alvarez-Olmos, Carolina Giraldo Alzate, Jorge Rojas, Juan Carlos Salazar-Uribe, Juan-Manuel Anaya & Jaime Fernández-Sarmiento Referencia : BMC Pediatr. 2021 Nov 18;21(1):516. DOI (Digital Object Identifier) : 10.1186/s12887-021-02974-9 PMID : 34794410 Derechos de uso : CC BY En línea : https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-021-02974-9 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5839 Reserva
Reservar este documentoEjemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001773 AC-2021-089 Archivo digital Producción Científica Artículos científicos Disponible
Título : Declaración consenso de la Asociación Colombiana de Medicina Crítica y Cuidados Intensivos (AMCI) para atención y manejo del paciente pediátrico con sospecha o confirmación de infección severa por SARS-CoV-2 Otros títulos : Consensus statement of the Colombian Association of Critical Medicine and Intensive Care (AMCI) for the care and management of the paediatric patient with suspicion or confirmation of severe infection by SARS-CoV-2 Tipo de documento : documento electrónico Autores : Mauricio Fernández Laverde, ; Byron Enrique Piñeres Olave, Fecha de publicación : 2020 Títulos uniformes : Acta Colombiana de Cuidado Intensivo Idioma : Español (spa) Palabras clave : Sepsis COVID-19 Virus Choque Síndrome inflamatorio multisistémico Resumen : Una nueva pandemia fue declarada por la Organización Mundial de la Salud por el virus SARS-CoV-2 recientemente. Este virus se caracteriza por ser altamente transmisible, letal y afectar a todos los grupos etarios. Esta declaración permitió la activación en todos los países de mecanismos de urgencia para atender esta crisis de salud pública que ha expuesto las debilidades de los sistemas de salud y el déficit de camas de cuidado intensivo adulto (UCIA) y pediátrico (UCIP). Colombia tiene un número reducido de camas de UCIP con respecto a otros países de medianos y bajos ingresos. Por esta razón, debemos optimizar los recursos, anticiparse a los casos graves y conocer el comportamiento de la enfermedad por el virus del SARS-CoV-2 (llamada COVID-19) en pediatría, especialmente en las formas severas de presentación en niños. La severidad y grado de afectación por el virus en todos los países ha sido muy similar con una mayor gravedad y frecuencia de infección en la población adulta, particularmente en personas mayores de 60 años y con comorbilidades (obesidad, hipertensión, diabetes, entre otros). No obstante, también se ha registrado en la población pediátrica casos graves que requieren intervenciones avanzadas en terapia intensiva, incluyendo una forma de presentación con gran respuesta inflamatoria en niños denominada síndrome inflamatorio multisistémico (MIS-C por sus siglas en inglés). La Asociación Colombiana de Medicina crítica y Cuidados Intensivos (AMCI) convocó un equipo multidisciplinario de expertos en medicina crítica pediátrica para establecer una declaratoria de consenso de buena práctica clínica para la atención de niños con COVID-19 grave que requieran atención en cuidado intermedio o cuidado intensivo pediátrico. El objetivo de esta declaración de consenso es facilitar y estandarizar la toma de decisiones en los aspectos más relevantes en la atención y realizar un abordaje integral del paciente pediátrico basado en la mejor evidencia disponible y opinión de expertos en cuidado intensivo pediátrico de al menos 10 años de experiencia de trabajo en el área. Adicionalmente, se buscó involucrar a aquellos intensivistas pediatras que deben hacer atención directa de los niños con COVID-19, pertenecen a hospitales de referencia o universitarios y tienen demostrada trayectoria en investigación y docencia en cuidado crítico pediátrico. Esta declaración de consenso se buscará actualizar con la frecuencia que sea necesaria de acuerdo con el cambio de la mejor evidencia disponible, que les permita a los médicos que atienden niños críticos con COVID-19 realizar una atención integral y adecuada acorde con la mejor literatura disponible. Mención de responsabilidad : Vanessa Rina Torres Viñas, Jaime Fernández Sarmiento, Hernando Mulett Hoyos, Lorena Acevedo Sedano, Pablo Vásquez Hoyos, María Piedad Sarmiento, Rosalba Pardo, Mauricio Fernández Laverde, Byron Piñeres Olave, Yurika López Alarcón, Carolina Tamayo, Juan Camilo Jaramillo Bustamante, Rubén Lasso, María Teresa Agudelo, Rafael Orozco Marún, Liliana Mazzilli Vega, Eliana Zemanate Zúñiga y Víctor Hugo Nieto Estrada DOI (Digital Object Identifier) : 10.1016/j.acci.2020.09.005 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0122726220300860 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5162 Declaración consenso de la Asociación Colombiana de Medicina Crítica y Cuidados Intensivos (AMCI) para atención y manejo del paciente pediátrico con sospecha o confirmación de infección severa por SARS-CoV-2 = Consensus statement of the Colombian Association of Critical Medicine and Intensive Care (AMCI) for the care and management of the paediatric patient with suspicion or confirmation of severe infection by SARS-CoV-2 [documento electrónico] / Mauricio Fernández Laverde, ; Byron Enrique Piñeres Olave, . - 2020.
Obra : Acta Colombiana de Cuidado Intensivo
Idioma : Español (spa)
Palabras clave : Sepsis COVID-19 Virus Choque Síndrome inflamatorio multisistémico Resumen : Una nueva pandemia fue declarada por la Organización Mundial de la Salud por el virus SARS-CoV-2 recientemente. Este virus se caracteriza por ser altamente transmisible, letal y afectar a todos los grupos etarios. Esta declaración permitió la activación en todos los países de mecanismos de urgencia para atender esta crisis de salud pública que ha expuesto las debilidades de los sistemas de salud y el déficit de camas de cuidado intensivo adulto (UCIA) y pediátrico (UCIP). Colombia tiene un número reducido de camas de UCIP con respecto a otros países de medianos y bajos ingresos. Por esta razón, debemos optimizar los recursos, anticiparse a los casos graves y conocer el comportamiento de la enfermedad por el virus del SARS-CoV-2 (llamada COVID-19) en pediatría, especialmente en las formas severas de presentación en niños. La severidad y grado de afectación por el virus en todos los países ha sido muy similar con una mayor gravedad y frecuencia de infección en la población adulta, particularmente en personas mayores de 60 años y con comorbilidades (obesidad, hipertensión, diabetes, entre otros). No obstante, también se ha registrado en la población pediátrica casos graves que requieren intervenciones avanzadas en terapia intensiva, incluyendo una forma de presentación con gran respuesta inflamatoria en niños denominada síndrome inflamatorio multisistémico (MIS-C por sus siglas en inglés). La Asociación Colombiana de Medicina crítica y Cuidados Intensivos (AMCI) convocó un equipo multidisciplinario de expertos en medicina crítica pediátrica para establecer una declaratoria de consenso de buena práctica clínica para la atención de niños con COVID-19 grave que requieran atención en cuidado intermedio o cuidado intensivo pediátrico. El objetivo de esta declaración de consenso es facilitar y estandarizar la toma de decisiones en los aspectos más relevantes en la atención y realizar un abordaje integral del paciente pediátrico basado en la mejor evidencia disponible y opinión de expertos en cuidado intensivo pediátrico de al menos 10 años de experiencia de trabajo en el área. Adicionalmente, se buscó involucrar a aquellos intensivistas pediatras que deben hacer atención directa de los niños con COVID-19, pertenecen a hospitales de referencia o universitarios y tienen demostrada trayectoria en investigación y docencia en cuidado crítico pediátrico. Esta declaración de consenso se buscará actualizar con la frecuencia que sea necesaria de acuerdo con el cambio de la mejor evidencia disponible, que les permita a los médicos que atienden niños críticos con COVID-19 realizar una atención integral y adecuada acorde con la mejor literatura disponible. Mención de responsabilidad : Vanessa Rina Torres Viñas, Jaime Fernández Sarmiento, Hernando Mulett Hoyos, Lorena Acevedo Sedano, Pablo Vásquez Hoyos, María Piedad Sarmiento, Rosalba Pardo, Mauricio Fernández Laverde, Byron Piñeres Olave, Yurika López Alarcón, Carolina Tamayo, Juan Camilo Jaramillo Bustamante, Rubén Lasso, María Teresa Agudelo, Rafael Orozco Marún, Liliana Mazzilli Vega, Eliana Zemanate Zúñiga y Víctor Hugo Nieto Estrada DOI (Digital Object Identifier) : 10.1016/j.acci.2020.09.005 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0122726220300860 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5162 Reserva
Reservar este documentoEjemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001595 AC-2020-101 Archivo digital Producción Científica Artículos científicos Disponible
Título : Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis Tipo de documento : documento electrónico Autores : Adriana Giraldo Villa, Fecha de publicación : 2020 Títulos uniformes : Gut Microbes Idioma : Inglés (eng) Palabras clave : Intestinal microbiota antibiotics critically ill patient intensive care unit sepsis Resumen : Critically ill patients are physiologically unstable and recent studies indicate that the intestinal microbiota could be involved in the health decline of such patients during ICU stays. This study aims to assess the intestinal microbiota in critically ill patients with and without sepsis and to determine its impact on outcome variables, such as medical complications, ICU stay time, and mortality. A multi-center study was conducted with a total of 250 peri-rectal swabs obtained from 155 patients upon admission and during ICU stays. Intestinal microbiota was assessed by sequencing the V3-V4 hypervariable regions of the 16S rRNA gene. Linear mixed models were used to integrate microbiota data with more than 40 clinical and demographic variables to detect covariates and minimize the effect of confounding factors. We found that the microbiota of ICU patients with sepsis has an increased abundance of microbes tightly associated with inflammation, such as Parabacteroides, Fusobacterium and Bilophila species. Female sex and aging would represent an increased risk for sepsis possibly because of some of their microbiota features. We also evidenced a remarkable loss of microbial diversity, during the ICU stay. Concomitantly, we detected that the abundance of pathogenic species, such as Enterococcus spp., was differentially increased in sepsis patients who died, indicating these species as potential biomarkers for monitoring during ICU stay. We concluded that particular intestinal microbiota signatures could predict sepsis development in ICU patients. We propose potential biomarkers for evaluation in the clinical management of ICU patients. Mención de responsabilidad : Gloria M Agudelo-Ochoa, Beatriz E Valdés-Duque, Nubia A Giraldo-Giraldo, Ana M Jaillier-Ramírez, Adriana Giraldo-Villa, Irene Acevedo-Castaño, Mónica A Yepes-Molina, Janeth Barbosa-Barbosa, Alfonso Benítez-Paéz Referencia : Gut Microbes. 2020 Nov 9;12(1):1707610. DOI (Digital Object Identifier) : 10.1080/19490976.2019.1707610 PMID : 31924126 Derechos de uso : CC BY-NC-ND En línea : https://www.tandfonline.com/doi/full/10.1080/19490976.2019.1707610 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5072 Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis [documento electrónico] / Adriana Giraldo Villa, . - 2020.
Obra : Gut Microbes
Idioma : Inglés (eng)
Palabras clave : Intestinal microbiota antibiotics critically ill patient intensive care unit sepsis Resumen : Critically ill patients are physiologically unstable and recent studies indicate that the intestinal microbiota could be involved in the health decline of such patients during ICU stays. This study aims to assess the intestinal microbiota in critically ill patients with and without sepsis and to determine its impact on outcome variables, such as medical complications, ICU stay time, and mortality. A multi-center study was conducted with a total of 250 peri-rectal swabs obtained from 155 patients upon admission and during ICU stays. Intestinal microbiota was assessed by sequencing the V3-V4 hypervariable regions of the 16S rRNA gene. Linear mixed models were used to integrate microbiota data with more than 40 clinical and demographic variables to detect covariates and minimize the effect of confounding factors. We found that the microbiota of ICU patients with sepsis has an increased abundance of microbes tightly associated with inflammation, such as Parabacteroides, Fusobacterium and Bilophila species. Female sex and aging would represent an increased risk for sepsis possibly because of some of their microbiota features. We also evidenced a remarkable loss of microbial diversity, during the ICU stay. Concomitantly, we detected that the abundance of pathogenic species, such as Enterococcus spp., was differentially increased in sepsis patients who died, indicating these species as potential biomarkers for monitoring during ICU stay. We concluded that particular intestinal microbiota signatures could predict sepsis development in ICU patients. We propose potential biomarkers for evaluation in the clinical management of ICU patients. Mención de responsabilidad : Gloria M Agudelo-Ochoa, Beatriz E Valdés-Duque, Nubia A Giraldo-Giraldo, Ana M Jaillier-Ramírez, Adriana Giraldo-Villa, Irene Acevedo-Castaño, Mónica A Yepes-Molina, Janeth Barbosa-Barbosa, Alfonso Benítez-Paéz Referencia : Gut Microbes. 2020 Nov 9;12(1):1707610. DOI (Digital Object Identifier) : 10.1080/19490976.2019.1707610 PMID : 31924126 Derechos de uso : CC BY-NC-ND En línea : https://www.tandfonline.com/doi/full/10.1080/19490976.2019.1707610 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5072 Reserva
Reservar este documentoEjemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001302 AC-2020-006 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2020-006.pdfAdobe Acrobat PDF
Título : Positive culture and prognosis in patients with sepsis: a prospective cohort study Tipo de documento : documento electrónico Autores : Fabián Alberto Jaimes Barragán, Fecha de publicación : 2020 Títulos uniformes : Journal of Intensive Care Medicine Idioma : Inglés (eng) Palabras clave : Blood culture epidemiology microbiological culture mortality sepsis Resumen : Purpose: To analyze the prognostic role of positive cultures in patients with sepsis. Methods: A prospective cohort study in a tertiary referral hospital in Medellín, Colombia. Adults older than 18 years of age with a bacterial infection diagnosis according to Centers for Disease Control criteria and sepsis (evidence of organ dysfunction) were included. A logistic regression model was used to determine the association between positive cultures and hospital mortality, and a Cox regression with a competing risk modeling approach was used to determine the association between positive cultures and hospital stay as well as secondary infections. Results: Overall, 408 patients had positive cultures, of which 257 were blood culture, and 153 had negative cultures. Patients with positive cultures had a lower risk of mortality (odds ratio [OR], 0.43; 95% confidence interval [CI], 0.27-0.68), but this association was not maintained after adjusting for confounding factors (OR, 0.56; 95% CI, 0.31-1.01). No association was found with the hospital stay (adjusted subhazard ratio [SHR], 1.06; 95% CI, 0.83-1.35). There was no association between positive cultures and the presence of secondary infections (adjusted SHR, 0.99; 95% CI, 0.58-1.71). Conclusion: Positive cultures are not associated with prognosis in patients with sepsis. Mención de responsabilidad : Fernando Molina, Pablo Castaño, Maribel Plaza, Carolina Hincapié, Wilmar Maya, Juan Carlos Cataño, Javier González, Alba León, Fabián Jaimes Referencia : J Intensive Care Med. 2020 Aug;35(8):755-762. DOI (Digital Object Identifier) : 10.1177/0885066618783656 PMID : 29925284 En línea : https://journals.sagepub.com/doi/abs/10.1177/0885066618783656?journalCode=jica Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4696 Positive culture and prognosis in patients with sepsis: a prospective cohort study [documento electrónico] / Fabián Alberto Jaimes Barragán, . - 2020.
Obra : Journal of Intensive Care Medicine
Idioma : Inglés (eng)
Palabras clave : Blood culture epidemiology microbiological culture mortality sepsis Resumen : Purpose: To analyze the prognostic role of positive cultures in patients with sepsis. Methods: A prospective cohort study in a tertiary referral hospital in Medellín, Colombia. Adults older than 18 years of age with a bacterial infection diagnosis according to Centers for Disease Control criteria and sepsis (evidence of organ dysfunction) were included. A logistic regression model was used to determine the association between positive cultures and hospital mortality, and a Cox regression with a competing risk modeling approach was used to determine the association between positive cultures and hospital stay as well as secondary infections. Results: Overall, 408 patients had positive cultures, of which 257 were blood culture, and 153 had negative cultures. Patients with positive cultures had a lower risk of mortality (odds ratio [OR], 0.43; 95% confidence interval [CI], 0.27-0.68), but this association was not maintained after adjusting for confounding factors (OR, 0.56; 95% CI, 0.31-1.01). No association was found with the hospital stay (adjusted subhazard ratio [SHR], 1.06; 95% CI, 0.83-1.35). There was no association between positive cultures and the presence of secondary infections (adjusted SHR, 0.99; 95% CI, 0.58-1.71). Conclusion: Positive cultures are not associated with prognosis in patients with sepsis. Mención de responsabilidad : Fernando Molina, Pablo Castaño, Maribel Plaza, Carolina Hincapié, Wilmar Maya, Juan Carlos Cataño, Javier González, Alba León, Fabián Jaimes Referencia : J Intensive Care Med. 2020 Aug;35(8):755-762. DOI (Digital Object Identifier) : 10.1177/0885066618783656 PMID : 29925284 En línea : https://journals.sagepub.com/doi/abs/10.1177/0885066618783656?journalCode=jica Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4696 Reserva
Reservar este documentoEjemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001170 AC-2018-109 Archivo digital Producción Científica Artículos científicos Disponible PermalinkPermalinkPermalinkPermalinkPermalink
