Inicio
Resultado de la búsqueda
1 búsqueda de la palabra clave 'tumor necrosis factor α- Anti-tumor necrosis factor α'
Clasificado(s) por (Año de edición descendente) Refinar búsqueda Genera el flujo rss de la búsqueda
Enlace permanente de la investigación
Clinical efficacy of infliximab in moderate to severe ulcerative colitis in a latin american referral population / Fabián Juliao Baños ; Natalia Aristizábal Henao ; Carlos Enrique Yepes Delgado ; Julio Eduardo Zuleta Muñoz
Título : Clinical efficacy of infliximab in moderate to severe ulcerative colitis in a latin american referral population Tipo de documento : documento electrónico Autores : Fabián Juliao Baños, ; Natalia Aristizábal Henao, ; Carlos Enrique Yepes Delgado, ; Julio Eduardo Zuleta Muñoz, Fecha de publicación : 2013 Títulos uniformes : Digestion Idioma : Inglés (eng) Palabras clave : Ulcerative colitis infliximab tumor necrosis factor α- Anti-tumor necrosis factor α Resumen : Background: Previous research has shown that infliximab (IFX) is effective in the management of moderate to severe active ulcerative colitis (UC). Latin American studies are lacking. Aim: To evaluate the efficacy of IFX treatment (including corticosteroid withdrawal, complete mucosal healing, colectomy and hospitalization rates) in patients with moderate to severe UC. Methods: A retrospective and descriptive study was conducted on patients with UC in Medellín (Colombia). We included patients steroid dependent or refractory to conventional treatment. Results: Between October 2005 and July 2011, 28 patients with moderate to severe UC received IFX infusions; the median of the follow-up was 27.4 months (range: 1-69 months). Twenty-four patients (86%) had a short-term primary response, whilst 19 (68%) achieved initial clinical remission. After 1 year, 17 (71%) out of the 24 patients who had an initial response were also showing a sustained response, and 10 (42%) remained in clinical remission. At 6 months, complete mucosal healing was observed in 29% of patients and endoscopic improvement in 57%. Conclusions: This is the first study to evaluate the IFX use in patients with moderate to severe active UC in a Latin American population. We found that IFX therapy is effective for inducing clinical remission, and that most patients who had an initial response showed a long-term sustained response. Mención de responsabilidad : Fabian Juliao, Juan Marquez, Natalia Aristizabal, Carlos Yepes, Julio Zuleta, Javier P Gisbert Referencia : Digestion. 2013;88(4):222-8. DOI (Digital Object Identifier) : 10.1159/000355529 PMID : 24281150 En línea : https://www.karger.com/Article/Abstract/355529 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3750 Clinical efficacy of infliximab in moderate to severe ulcerative colitis in a latin american referral population [documento electrónico] / Fabián Juliao Baños, ; Natalia Aristizábal Henao, ; Carlos Enrique Yepes Delgado, ; Julio Eduardo Zuleta Muñoz, . - 2013.
Obra : Digestion
Idioma : Inglés (eng)
Palabras clave : Ulcerative colitis infliximab tumor necrosis factor α- Anti-tumor necrosis factor α Resumen : Background: Previous research has shown that infliximab (IFX) is effective in the management of moderate to severe active ulcerative colitis (UC). Latin American studies are lacking. Aim: To evaluate the efficacy of IFX treatment (including corticosteroid withdrawal, complete mucosal healing, colectomy and hospitalization rates) in patients with moderate to severe UC. Methods: A retrospective and descriptive study was conducted on patients with UC in Medellín (Colombia). We included patients steroid dependent or refractory to conventional treatment. Results: Between October 2005 and July 2011, 28 patients with moderate to severe UC received IFX infusions; the median of the follow-up was 27.4 months (range: 1-69 months). Twenty-four patients (86%) had a short-term primary response, whilst 19 (68%) achieved initial clinical remission. After 1 year, 17 (71%) out of the 24 patients who had an initial response were also showing a sustained response, and 10 (42%) remained in clinical remission. At 6 months, complete mucosal healing was observed in 29% of patients and endoscopic improvement in 57%. Conclusions: This is the first study to evaluate the IFX use in patients with moderate to severe active UC in a Latin American population. We found that IFX therapy is effective for inducing clinical remission, and that most patients who had an initial response showed a long-term sustained response. Mención de responsabilidad : Fabian Juliao, Juan Marquez, Natalia Aristizabal, Carlos Yepes, Julio Zuleta, Javier P Gisbert Referencia : Digestion. 2013;88(4):222-8. DOI (Digital Object Identifier) : 10.1159/000355529 PMID : 24281150 En línea : https://www.karger.com/Article/Abstract/355529 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3750 Reserva
Reservar este documentoEjemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000325 AC-2013-093 Archivo digital Producción Científica Artículos científicos Disponible