Título : |
Silent somatotroph adenoma: a morphologic, immunohistochemical and electron microscopic study: a case report |
Tipo de documento : |
documento electrónico |
Autores : |
Carlos Esteban Builes Montaño, ; Luis Vicente Syro Moreno, |
Fecha de publicación : |
2012 |
Títulos uniformes : |
Journal of Medical Cases
|
Idioma : |
Inglés (eng) |
Palabras clave : |
Electron microscopy histology immunohistochemistry pituitary adenoma endocrine silence |
Resumen : |
Pituitary adenoma, removed surgically from a 22 old young man with normal serum growth hormone level, and no evidence of acromegaly by histology, immunohistochemistry and electron microscopy was studied. Ultrastructurally the tumor cells were shown to correspond to sparsely granulated somatotrophs and immunohisto chemistry showed no, moderate, or little growth hormone. Clinically silent somatotroph adenomas so far are unresolved entities; although electron microscopy shows that they are consisted of sparsely granulated somatotrophs they do not secrete substantial amounts to raise growth hormone and IGF-1 blood levels. Further work is required to clarify the mechanisms accounting for the clinical and biochemical silence of these tumors. |
Mención de responsabilidad : |
Aydin Sav, Luis V Syro, Bernd W Scheithauer, Fabio Rotondo, Carlos A Builes, Eva Horvath, Kalman Kovacs |
Referencia : |
J Med Cases. 2012;3(1):43-8. |
DOI (Digital Object Identifier) : |
10.4021/jmc416w |
Derechos de uso : |
CC BY-NC |
En línea : |
https://www.journalmc.org/index.php/JMC/article/view/416 |
Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3612 |
Silent somatotroph adenoma: a morphologic, immunohistochemical and electron microscopic study: a case report [documento electrónico] / Carlos Esteban Builes Montaño, ; Luis Vicente Syro Moreno, . - 2012. Obra : Journal of Medical CasesIdioma : Inglés ( eng) Palabras clave : |
Electron microscopy histology immunohistochemistry pituitary adenoma endocrine silence |
Resumen : |
Pituitary adenoma, removed surgically from a 22 old young man with normal serum growth hormone level, and no evidence of acromegaly by histology, immunohistochemistry and electron microscopy was studied. Ultrastructurally the tumor cells were shown to correspond to sparsely granulated somatotrophs and immunohisto chemistry showed no, moderate, or little growth hormone. Clinically silent somatotroph adenomas so far are unresolved entities; although electron microscopy shows that they are consisted of sparsely granulated somatotrophs they do not secrete substantial amounts to raise growth hormone and IGF-1 blood levels. Further work is required to clarify the mechanisms accounting for the clinical and biochemical silence of these tumors. |
Mención de responsabilidad : |
Aydin Sav, Luis V Syro, Bernd W Scheithauer, Fabio Rotondo, Carlos A Builes, Eva Horvath, Kalman Kovacs |
Referencia : |
J Med Cases. 2012;3(1):43-8. |
DOI (Digital Object Identifier) : |
10.4021/jmc416w |
Derechos de uso : |
CC BY-NC |
En línea : |
https://www.journalmc.org/index.php/JMC/article/view/416 |
Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3612 |
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