Título : |
Microvessel density and VEGF expression in pituitaries of pregnant women |
Tipo de documento : |
documento electrónico |
Autores : |
Jorge Hernando Donado Gómez, ; Luis Vicente Syro Moreno, |
Fecha de publicación : |
2013 |
Títulos uniformes : |
Hormones
|
Idioma : |
Inglés (eng) |
Palabras clave : |
Angiogenesis Immunohistochemistry Pituitary Pregnancy Vascular endothelial growth factor |
Resumen : |
Objective: In pregnant women, the pituitary is enlarged and the prolactin (PRL) secreting cells increase in size and number. This PRL cell hyperplasia is associated with hyperprol-actinemia. The aim of the present work was to investigate adenohypophysial vascularization and immunoexpression of vascular endothelial growth factor (VEGF) in pituitaries of pregnant and post-partum women and compare the results with age-matched adenohypophyses of non pregnant women who had no endocrine diseases. Design: Pituitaries (n=18) obtained by autopsy from female patients of reproductive age who had died during pregnancy, after abor- tion or during post-partum were immunostained for CD-34 and VEGF using the streptavidin-biotin-peroxidase complex method. Results: The results showed that microvessel densities and VEGF immunoexpression in the adenohypophyses of pregnant and post-partum women were similar to those found in the control pituitaries. Conclusion: It can be concluded that pituitary enlargement and PRL cell hyperplasia in pregnant women may occur without neovascularization and increased VEGF immunoexpression. |
Mención de responsabilidad : |
Fabio Rotondo, Angelo Rotondo, Mark Jentoft, Bernd W Scheithauer, Luis V Syro, Jorge H Donado, James E Tarara, Kalman Kovacs |
Referencia : |
Hormones. 2013;12(2):292-7. |
DOI (Digital Object Identifier) : |
10.14310/horm.2002.1413 |
PMID : |
23933698 |
En línea : |
https://link.springer.com/article/10.14310/horm.2002.1413 |
Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
Microvessel density and VEGF expression in pituitaries of pregnant women [documento electrónico] / Jorge Hernando Donado Gómez, ; Luis Vicente Syro Moreno, . - 2013. Obra : HormonesIdioma : Inglés ( eng) Palabras clave : |
Angiogenesis Immunohistochemistry Pituitary Pregnancy Vascular endothelial growth factor |
Resumen : |
Objective: In pregnant women, the pituitary is enlarged and the prolactin (PRL) secreting cells increase in size and number. This PRL cell hyperplasia is associated with hyperprol-actinemia. The aim of the present work was to investigate adenohypophysial vascularization and immunoexpression of vascular endothelial growth factor (VEGF) in pituitaries of pregnant and post-partum women and compare the results with age-matched adenohypophyses of non pregnant women who had no endocrine diseases. Design: Pituitaries (n=18) obtained by autopsy from female patients of reproductive age who had died during pregnancy, after abor- tion or during post-partum were immunostained for CD-34 and VEGF using the streptavidin-biotin-peroxidase complex method. Results: The results showed that microvessel densities and VEGF immunoexpression in the adenohypophyses of pregnant and post-partum women were similar to those found in the control pituitaries. Conclusion: It can be concluded that pituitary enlargement and PRL cell hyperplasia in pregnant women may occur without neovascularization and increased VEGF immunoexpression. |
Mención de responsabilidad : |
Fabio Rotondo, Angelo Rotondo, Mark Jentoft, Bernd W Scheithauer, Luis V Syro, Jorge H Donado, James E Tarara, Kalman Kovacs |
Referencia : |
Hormones. 2013;12(2):292-7. |
DOI (Digital Object Identifier) : |
10.14310/horm.2002.1413 |
PMID : |
23933698 |
En línea : |
https://link.springer.com/article/10.14310/horm.2002.1413 |
Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
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