Título : |
Therapeutic plasmapheresis for the treatment of thyrotoxicosis: A retrospective multi-center study |
Tipo de documento : |
documento electrónico |
Autores : |
Carlos Esteban Builes Montaño, Autor asociado al HPTU ; Carolina Prieto Saldarriaga, Autor asociado al HPTU ; Clara María Arango Toro, Autor asociado al HPTU |
Fecha de publicación : |
2021 |
Títulos uniformes : |
Journal of Clinical Apheresis
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Idioma : |
Inglés (eng) |
Palabras clave : |
anti-thyroid agents hyperthyroidism Latin America plasmapheresis thyrotoxicosis |
Resumen : |
Background and aims: Thyroid storm and severe thyrotoxicosis remain among the most frequent endocrine emergencies, and first-line hyperthyroidism treatment is not always an option. Since the first report in 1970, plasmapheresis is a second-line treatment for severe or otherwise untreatable thyrotoxicosis when rapid euthyroidism is desired. Methods: We present a retrospective study of the experience in treating thyrotoxicosis with plasmapheresis between 2012 and 2020 in two specialized centers in Colombia. We register the demographic and clinical characteristic and compare the thyroid hormones and other biochemical measurements before and after treatment. Results: Data from 19 patients was obtained, 58% female with a median age of 35 years (IQR 23.5), and most of them with Graves' disease. The most frequent indication for plasmapheresis was thyroid storm. A median of 4 (IQR 2) sessions lead to a significant reduction in FT4 (P .0001) and TT3 (P < .0003) with a nonsignificant decrease in beta-blocker (P .7353) dose, no change in hepatic enzymes, and no adverse events. After plasmapheresis, thyroidectomy was performed in 10 patients. Conclusions: Plasmapheresis is an effective and safe treatment option for reducing circulating thyroid hormones in severe thyrotoxicosis when other forms of treatment are contraindicated or in case of urgent thyroid and non-thyroid surgery. It is limited by its cost and the need for highly specialized resources. |
Mención de responsabilidad : |
Carlos E. Builes-Montaño,Luis A. Rodriguez-Arrieta,Alejandro Román-González,Carolina Prieto-Saldarriaga,Jose C. Alvarez-Payares,Carlos A. Builes-Barrera,Clara M. Arango-Toro |
Referencia : |
J Clin Apher. 2021 Oct;36(5):759-765. |
DOI (Digital Object Identifier) : |
10.1002/jca.21927 |
PMID : |
34273178 |
En línea : |
https://onlinelibrary.wiley.com/doi/10.1002/jca.21927 |
Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
Therapeutic plasmapheresis for the treatment of thyrotoxicosis: A retrospective multi-center study [documento electrónico] / Carlos Esteban Builes Montaño, Autor asociado al HPTU ; Carolina Prieto Saldarriaga, Autor asociado al HPTU ; Clara María Arango Toro, Autor asociado al HPTU . - 2021. Obra : Journal of Clinical ApheresisIdioma : Inglés ( eng)
Palabras clave : |
anti-thyroid agents hyperthyroidism Latin America plasmapheresis thyrotoxicosis |
Resumen : |
Background and aims: Thyroid storm and severe thyrotoxicosis remain among the most frequent endocrine emergencies, and first-line hyperthyroidism treatment is not always an option. Since the first report in 1970, plasmapheresis is a second-line treatment for severe or otherwise untreatable thyrotoxicosis when rapid euthyroidism is desired. Methods: We present a retrospective study of the experience in treating thyrotoxicosis with plasmapheresis between 2012 and 2020 in two specialized centers in Colombia. We register the demographic and clinical characteristic and compare the thyroid hormones and other biochemical measurements before and after treatment. Results: Data from 19 patients was obtained, 58% female with a median age of 35 years (IQR 23.5), and most of them with Graves' disease. The most frequent indication for plasmapheresis was thyroid storm. A median of 4 (IQR 2) sessions lead to a significant reduction in FT4 (P .0001) and TT3 (P < .0003) with a nonsignificant decrease in beta-blocker (P .7353) dose, no change in hepatic enzymes, and no adverse events. After plasmapheresis, thyroidectomy was performed in 10 patients. Conclusions: Plasmapheresis is an effective and safe treatment option for reducing circulating thyroid hormones in severe thyrotoxicosis when other forms of treatment are contraindicated or in case of urgent thyroid and non-thyroid surgery. It is limited by its cost and the need for highly specialized resources. |
Mención de responsabilidad : |
Carlos E. Builes-Montaño,Luis A. Rodriguez-Arrieta,Alejandro Román-González,Carolina Prieto-Saldarriaga,Jose C. Alvarez-Payares,Carlos A. Builes-Barrera,Clara M. Arango-Toro |
Referencia : |
J Clin Apher. 2021 Oct;36(5):759-765. |
DOI (Digital Object Identifier) : |
10.1002/jca.21927 |
PMID : |
34273178 |
En línea : |
https://onlinelibrary.wiley.com/doi/10.1002/jca.21927 |
Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
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