[Publicación periódica]  Ver los números disponibles 

Título :	Hepatología : Revista de la Asociación Colombiana de Hepatología
Tipo de documento :	texto impreso
Autores :	Asociación Colombiana de Hepatología
ISBN/ISSN/DL :	2711-2330
Idioma :	Español (spa)
Materias :	HEPATOLOGÍA
Clasificación:	WI Sistema digestivo
En línea :	https://revistahepatologia.com/
Enlace permanente :	./index.php?lvl=notice_display&id=5198

[Publicación periódica]  Ver los números disponibles Hepatología : Revista de la Asociación Colombiana de Hepatología [texto impreso] / Asociación Colombiana de Hepatología.
ISSN : 2711-2330
Idioma : Español (spa)

Materias :	HEPATOLOGÍA
Clasificación:	WI Sistema digestivo
En línea :	https://revistahepatologia.com/
Enlace permanente :	./index.php?lvl=notice_display&id=5198

Título :	Falla hepática subaguda secundaria a hepatotoxicidad severa por medicamentos: reporte de caso
Otros títulos :	Subacute liver failure secondary to severe drug-related hepatotoxicity: case report
Tipo de documento :	documento electrónico
Autores :	Juan Camilo Pérez Cadavid, Autor asociado al HPTU ; Juan Carlos Restrepo Gutiérrez, Autor asociado al HPTU ; Octavio Germán Muñoz Maya, Autor asociado al HPTU
Fecha de publicación :	2020
Títulos uniformes :	Hepatología
Idioma :	Español (spa)
Palabras clave :	falla hepática  enfermedad hepática inducida por medicamentos  toxicidad  hepatitis  trasplante hepático  amiodarona
Resumen :	La falla hepática aguda es una patología rara con una mortalidad alta y causas variadas, entre ellas, la hepatotoxicidad secundaria al uso de medicamentos, con un diagnóstico diferencial difícil, en particular en presencia de polifarmacia. Esta patología se asocia con falla orgánica multisistémica que puede hacer necesario el trasplante hepático si no se logra la estabilización del paciente. Se presenta el caso de una mujer de 50 años con un cuadro de 6 semanas de evolución, consistente en dolor en hipocondrio derecho, náuseas e ictericia generalizada, quien presentó falla hepática aguda de tipo subagudo que finalmente requirió trasplante hepático. Se describe el abordaje diagnóstico hacia la identificación de una etiología medicamentosa probable por el uso de amiodarona, con la evolución positiva de la paciente después de 3 años de seguimiento postrasplante.
Mención de responsabilidad :	Juan Felipe Morantes-Rubiano, Juan Camilo Pérez-Cadavid, Juan Carlos Restrepo-Gutiérrez, Octavio Muñoz-Maya
Derechos de uso :	CC BY-NC-ND
En línea :	https://revistahepatologia.com/wp-content/uploads/2020/12/165-175-Hepatotoxicida [...]
Enlace permanente :	./index.php?lvl=notice_display&id=5197

Falla hepática subaguda secundaria a hepatotoxicidad severa por medicamentos: reporte de caso = Subacute liver failure secondary to severe drug-related hepatotoxicity: case report [documento electrónico] / Juan Camilo Pérez Cadavid, Autor asociado al HPTU ; Juan Carlos Restrepo Gutiérrez, Autor asociado al HPTU ; Octavio Germán Muñoz Maya, Autor asociado al HPTU . - 2020.
Obra : Hepatología

Idioma : Español (spa)

Palabras clave :	falla hepática  enfermedad hepática inducida por medicamentos  toxicidad  hepatitis  trasplante hepático  amiodarona
Resumen :	La falla hepática aguda es una patología rara con una mortalidad alta y causas variadas, entre ellas, la hepatotoxicidad secundaria al uso de medicamentos, con un diagnóstico diferencial difícil, en particular en presencia de polifarmacia. Esta patología se asocia con falla orgánica multisistémica que puede hacer necesario el trasplante hepático si no se logra la estabilización del paciente. Se presenta el caso de una mujer de 50 años con un cuadro de 6 semanas de evolución, consistente en dolor en hipocondrio derecho, náuseas e ictericia generalizada, quien presentó falla hepática aguda de tipo subagudo que finalmente requirió trasplante hepático. Se describe el abordaje diagnóstico hacia la identificación de una etiología medicamentosa probable por el uso de amiodarona, con la evolución positiva de la paciente después de 3 años de seguimiento postrasplante.
Mención de responsabilidad :	Juan Felipe Morantes-Rubiano, Juan Camilo Pérez-Cadavid, Juan Carlos Restrepo-Gutiérrez, Octavio Muñoz-Maya
Derechos de uso :	CC BY-NC-ND
En línea :	https://revistahepatologia.com/wp-content/uploads/2020/12/165-175-Hepatotoxicida [...]
Enlace permanente :	./index.php?lvl=notice_display&id=5197

Título :	Caracterización clínica y microbiológica de pacientes con pie diabético que requieren hospitalización en alta complejidad. Serie de casos
Otros títulos :	Clinical and microbiological profile of patients with diabetic foot requiring admissionto a high complexity hospital. Case Series
Tipo de documento :	documento electrónico
Autores :	Carlos Oliver Valderrama Molina, Autor asociado al HPTU ; Jaime Andrés Puerta Gómez, Autor asociado al HPTU ; Carlos Ignacio Gómez Roldán, Autor asociado al HPTU
Fecha de publicación :	2020
Títulos uniformes :	Revista Colombiana de Ortopedia y Traumatología
Idioma :	Español (spa)
Palabras clave :	Pie diabético  Infección  Diabetes Mellitus  Hospitalización
Resumen :	Introducción: El pie diabético infectado es una complicación frecuente de la diabetes y un marcador de deterioro del paciente. Existe escasa información en Colombia sobre características de los pacientes que ingresan a los servicios de urgencias de alta complejidad con esta patología y desenlaces como amputación y perfil microbiológico. Materiales y Métodos: Serie de casos de pacientes que ingresaron al servicio de urgencias del Hospital Pablo Tobón Uribe con motivo de consulta principal pie diabético infectado. Se analizaron las historias clínicas de manera retrospectiva y se utilizaron herramientas de estadística descriptiva para la caracterización de la población y de variables relacionadas con diagnóstico, tratamiento y resultados tempranos intrahospitalarios. Resultados: Entre enero de 2009 y diciembre de 2013 ingresaron 118 pacientes con 145 úlceras infectadas por pie diabético, el 90% con HbAc >6.5, el 52% con disfunción renal, el 51% con enfermedad arterial periférica. El 57% tenía úlceras grado 3 o mayor en la clasificación de Wagner, la infección fue polimicrobiana en el 63%. El 58% requirió amputación, el 62% de las amputaciones fueron amputaciones menores. La mortalidad fue del 10%, la mortalidad atribuible a infección del pie diabético o complicaciones derivadas de la amputación fue del 1,7%. Discusión: Los pacientes con pie diabético que ingresaron a urgencias de un hospital de alta complejidad en Colombia tienen una enfermedad sistémica avanzada, relacionada con disfunción renal y vascular periférica, lesiones locales graves con compromiso óseo y articular avanzado; dada la gravedad de estas condiciones, la prevalencia de amputaciones mayores puede ser superior a la reportada en la literatura. Nivel de Evidencia: IV
Mención de responsabilidad :	Carlos Oliver Valderrama-Molina, Andrés Puerta Gómez, Ana María Arango Rivas, Daniel Mejía Arrieta, Juan Camilo Lopera Restrepo y Carlos Ignacio Gómez Roldán
DOI (Digital Object Identifier) :	10.1016/j.rccot.2020.06.009
En línea :	https://linkinghub.elsevier.com/retrieve/pii/S0120884520300675
Enlace permanente :	./index.php?lvl=notice_display&id=5196

Caracterización clínica y microbiológica de pacientes con pie diabético que requieren hospitalización en alta complejidad. Serie de casos = Clinical and microbiological profile of patients with diabetic foot requiring admissionto a high complexity hospital. Case Series [documento electrónico] / Carlos Oliver Valderrama Molina, Autor asociado al HPTU ; Jaime Andrés Puerta Gómez, Autor asociado al HPTU ; Carlos Ignacio Gómez Roldán, Autor asociado al HPTU . - 2020.
Obra : Revista Colombiana de Ortopedia y Traumatología

Idioma : Español (spa)

Palabras clave :	Pie diabético  Infección  Diabetes Mellitus  Hospitalización
Resumen :	Introducción: El pie diabético infectado es una complicación frecuente de la diabetes y un marcador de deterioro del paciente. Existe escasa información en Colombia sobre características de los pacientes que ingresan a los servicios de urgencias de alta complejidad con esta patología y desenlaces como amputación y perfil microbiológico. Materiales y Métodos: Serie de casos de pacientes que ingresaron al servicio de urgencias del Hospital Pablo Tobón Uribe con motivo de consulta principal pie diabético infectado. Se analizaron las historias clínicas de manera retrospectiva y se utilizaron herramientas de estadística descriptiva para la caracterización de la población y de variables relacionadas con diagnóstico, tratamiento y resultados tempranos intrahospitalarios. Resultados: Entre enero de 2009 y diciembre de 2013 ingresaron 118 pacientes con 145 úlceras infectadas por pie diabético, el 90% con HbAc >6.5, el 52% con disfunción renal, el 51% con enfermedad arterial periférica. El 57% tenía úlceras grado 3 o mayor en la clasificación de Wagner, la infección fue polimicrobiana en el 63%. El 58% requirió amputación, el 62% de las amputaciones fueron amputaciones menores. La mortalidad fue del 10%, la mortalidad atribuible a infección del pie diabético o complicaciones derivadas de la amputación fue del 1,7%. Discusión: Los pacientes con pie diabético que ingresaron a urgencias de un hospital de alta complejidad en Colombia tienen una enfermedad sistémica avanzada, relacionada con disfunción renal y vascular periférica, lesiones locales graves con compromiso óseo y articular avanzado; dada la gravedad de estas condiciones, la prevalencia de amputaciones mayores puede ser superior a la reportada en la literatura. Nivel de Evidencia: IV
Mención de responsabilidad :	Carlos Oliver Valderrama-Molina, Andrés Puerta Gómez, Ana María Arango Rivas, Daniel Mejía Arrieta, Juan Camilo Lopera Restrepo y Carlos Ignacio Gómez Roldán
DOI (Digital Object Identifier) :	10.1016/j.rccot.2020.06.009
En línea :	https://linkinghub.elsevier.com/retrieve/pii/S0120884520300675
Enlace permanente :	./index.php?lvl=notice_display&id=5196

Título :	Harvesting the anterolateral thigh flap with non-sizable perforators
Tipo de documento :	documento electrónico
Autores :	Alejandro Zapata Ospina, Autor asociado al HPTU
Fecha de publicación :	2020
Títulos uniformes :	Journal of Plastic, Reconstructive & Aesthetic Surgery
Idioma :	Inglés (eng)
Palabras clave :	anterolateral thigh flap  non-sizable perforator  myocutaneous flap  capillary perforator
Resumen :	Background: The anterolateral thigh flap (ALT) has proven over time to be one of the best reconstructive workhorse thanks to its versatility and reliability. Without preoperative imaging, vascular anomalies such as having no sizable perforator are sometimes encountered during dissection. We propose a technique, based on a modified version of the traditional myocutaneous ALT to allow harvest of the flap based on non-sizable perforators. This technique can also enable splitting of a flap when only one sizable perforator is present. Methods: A retrospective review was done of patients who received reconstruction with free ALT flap from 2013 to 2019 by the senior author HSS and included all flaps in which non-sizable perforators were harvested. Data collected for analysis included patient demographics, flap size, defect location, inset type and flap survival. Surgical Technique: Despite detachment of the majority of skin paddle from the muscle, the flap is harvested with a sleeve of areolar tissue containing preferably more than one non-sizable perforators attached to a small muscular segment of the vastus lateralis containing the pedicle. Results: A total of 349 ALT flaps were performed during the review period by senior author HSS, and 25 flaps were harvested with non-sizable perforator, 10 of which were to enable a split. There were no total losses and 6 partial losses; 2 were amenable to direct closure after debridement, 1 required skin graft, and 3 required a new flap for wound coverage. Incorporating more than one non-sizable perforator increases the reliability of the flap. This technique should be used with caution in patients with multiple underlying comorbidities and when a flow-through flap is required. We were able to achieve primary closure of all donor sites. Conclusions: It is possible to harvest the anterolateral thigh flap without sizable perforators by conversion to a modified version of myocutaneous flap. In well selected patients, using our technique, several non-sizable perforators can reliably perfuse an ALT without the need to use an alternative donor site. This maximizes the number of harvestable ALTs and also increases the reconstructive potential by splitting previously “un-splitable” flaps.
Mención de responsabilidad :	Alejandro Zapata-Ospina, Jill Chen, Richard Tee, Seng-Feng Jeng, Bishal Karki y Hsiang-Shun Shih
DOI (Digital Object Identifier) :	10.1016/j.bjps.2020.10.063
En línea :	https://linkinghub.elsevier.com/retrieve/pii/S1748681520305611
Enlace permanente :	./index.php?lvl=notice_display&id=5195

Harvesting the anterolateral thigh flap with non-sizable perforators [documento electrónico] / Alejandro Zapata Ospina, Autor asociado al HPTU . - 2020.
Obra : Journal of Plastic, Reconstructive & Aesthetic Surgery

Idioma : Inglés (eng)

Palabras clave :	anterolateral thigh flap  non-sizable perforator  myocutaneous flap  capillary perforator
Resumen :	Background: The anterolateral thigh flap (ALT) has proven over time to be one of the best reconstructive workhorse thanks to its versatility and reliability. Without preoperative imaging, vascular anomalies such as having no sizable perforator are sometimes encountered during dissection. We propose a technique, based on a modified version of the traditional myocutaneous ALT to allow harvest of the flap based on non-sizable perforators. This technique can also enable splitting of a flap when only one sizable perforator is present. Methods: A retrospective review was done of patients who received reconstruction with free ALT flap from 2013 to 2019 by the senior author HSS and included all flaps in which non-sizable perforators were harvested. Data collected for analysis included patient demographics, flap size, defect location, inset type and flap survival. Surgical Technique: Despite detachment of the majority of skin paddle from the muscle, the flap is harvested with a sleeve of areolar tissue containing preferably more than one non-sizable perforators attached to a small muscular segment of the vastus lateralis containing the pedicle. Results: A total of 349 ALT flaps were performed during the review period by senior author HSS, and 25 flaps were harvested with non-sizable perforator, 10 of which were to enable a split. There were no total losses and 6 partial losses; 2 were amenable to direct closure after debridement, 1 required skin graft, and 3 required a new flap for wound coverage. Incorporating more than one non-sizable perforator increases the reliability of the flap. This technique should be used with caution in patients with multiple underlying comorbidities and when a flow-through flap is required. We were able to achieve primary closure of all donor sites. Conclusions: It is possible to harvest the anterolateral thigh flap without sizable perforators by conversion to a modified version of myocutaneous flap. In well selected patients, using our technique, several non-sizable perforators can reliably perfuse an ALT without the need to use an alternative donor site. This maximizes the number of harvestable ALTs and also increases the reconstructive potential by splitting previously “un-splitable” flaps.
Mención de responsabilidad :	Alejandro Zapata-Ospina, Jill Chen, Richard Tee, Seng-Feng Jeng, Bishal Karki y Hsiang-Shun Shih
DOI (Digital Object Identifier) :	10.1016/j.bjps.2020.10.063
En línea :	https://linkinghub.elsevier.com/retrieve/pii/S1748681520305611
Enlace permanente :	./index.php?lvl=notice_display&id=5195

Título :	Haplotype analysis of the internationally distributed BRCA1 c.3331_3334delCAAG founder mutation reveals a common ancestral origin in Iberia
Tipo de documento :	documento electrónico
Autores :	Alejandro Vélez Hoyos, Autor asociado al HPTU
Fecha de publicación :	2020
Títulos uniformes :	Breast Cancer Research
Idioma :	Inglés (eng)
Palabras clave :	BRCA1 c.3331_3334delCAAG  Breast cancer  Founder mutation  Haplotype
Resumen :	Background: The BRCA1 c.3331_3334delCAAG founder mutation has been reported in hereditary breast and ovarian cancer families from multiple Hispanic groups. We aimed to evaluate BRCA1 c.3331_3334delCAAG haplotype diversity in cases of European, African, and Latin American ancestry. Methods: BC mutation carrier cases from Colombia (n = 32), Spain (n = 13), Portugal (n = 2), Chile (n = 10), Africa (n = 1), and Brazil (n = 2) were genotyped with the genome-wide single nucleotide polymorphism (SNP) arrays to evaluate haplotype diversity around BRCA1 c.3331_3334delCAAG. Additional Portuguese (n = 13) and Brazilian (n = 18) BC mutation carriers were genotyped for 15 informative SNPs surrounding BRCA1. Data were phased using SHAPEIT2, and identical by descent regions were determined using BEAGLE and GERMLINE. DMLE+ was used to date the mutation in Colombia and Iberia. Results: The haplotype reconstruction revealed a shared 264.4-kb region among carriers from all six countries. The estimated mutation age was ~ 100 generations in Iberia and that it was introduced to South America early during the European colonization period. Conclusions: Our results suggest that this mutation originated in Iberia and later introduced to Colombia and South America at the time of Spanish colonization during the early 1500s. We also found that the Colombian mutation carriers had higher European ancestry, at the BRCA1 gene harboring chromosome 17, than controls, which further supported the European origin of the mutation. Understanding founder mutations in diverse populations has implications in implementing cost-effective, ancestry-informed screening.
Mención de responsabilidad :	Anna Marie De Asis Tuazon, Paul Lott, Mabel Bohórquez, Jennyfer Benavides, Carolina Ramirez, Angel Criollo, Ana Estrada-Florez, Gilbert Mateus, Alejandro Velez, Jenny Carmona, Justo Olaya, Elisha Garcia, Guadalupe Polanco-Echeverry, Jacob Stultz, Carolina Alvarez, Teresa Tapia, Patricia Ashton-Prolla, Brazilian Familial Cancer Network, Ana Vega, Conxi Lazaro, Eva Tornero, Cristina Martinez-Bouzas, Mar Infante, Miguel De La Hoya, Orland Diez, Brian L. Browning, COLUMBUS Consortium, Bruce Rannala, Manuel R. Teixeira, Pilar Carvallo, Magdalena Echeverry & Luis G. Carvajal-Carmona
Referencia :	Breast Cancer Res. 2020 Oct 21;22(1):108.
DOI (Digital Object Identifier) :	10.1186/s13058-020-01341-3
PMID :	33087180
Derechos de uso :	CC BY
En línea :	https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-020-013 [...]
Enlace permanente :	./index.php?lvl=notice_display&id=5194

Haplotype analysis of the internationally distributed BRCA1 c.3331_3334delCAAG founder mutation reveals a common ancestral origin in Iberia [documento electrónico] / Alejandro Vélez Hoyos, Autor asociado al HPTU . - 2020.
Obra : Breast Cancer Research

Idioma : Inglés (eng)

Palabras clave :	BRCA1 c.3331_3334delCAAG  Breast cancer  Founder mutation  Haplotype
Resumen :	Background: The BRCA1 c.3331_3334delCAAG founder mutation has been reported in hereditary breast and ovarian cancer families from multiple Hispanic groups. We aimed to evaluate BRCA1 c.3331_3334delCAAG haplotype diversity in cases of European, African, and Latin American ancestry. Methods: BC mutation carrier cases from Colombia (n = 32), Spain (n = 13), Portugal (n = 2), Chile (n = 10), Africa (n = 1), and Brazil (n = 2) were genotyped with the genome-wide single nucleotide polymorphism (SNP) arrays to evaluate haplotype diversity around BRCA1 c.3331_3334delCAAG. Additional Portuguese (n = 13) and Brazilian (n = 18) BC mutation carriers were genotyped for 15 informative SNPs surrounding BRCA1. Data were phased using SHAPEIT2, and identical by descent regions were determined using BEAGLE and GERMLINE. DMLE+ was used to date the mutation in Colombia and Iberia. Results: The haplotype reconstruction revealed a shared 264.4-kb region among carriers from all six countries. The estimated mutation age was ~ 100 generations in Iberia and that it was introduced to South America early during the European colonization period. Conclusions: Our results suggest that this mutation originated in Iberia and later introduced to Colombia and South America at the time of Spanish colonization during the early 1500s. We also found that the Colombian mutation carriers had higher European ancestry, at the BRCA1 gene harboring chromosome 17, than controls, which further supported the European origin of the mutation. Understanding founder mutations in diverse populations has implications in implementing cost-effective, ancestry-informed screening.
Mención de responsabilidad :	Anna Marie De Asis Tuazon, Paul Lott, Mabel Bohórquez, Jennyfer Benavides, Carolina Ramirez, Angel Criollo, Ana Estrada-Florez, Gilbert Mateus, Alejandro Velez, Jenny Carmona, Justo Olaya, Elisha Garcia, Guadalupe Polanco-Echeverry, Jacob Stultz, Carolina Alvarez, Teresa Tapia, Patricia Ashton-Prolla, Brazilian Familial Cancer Network, Ana Vega, Conxi Lazaro, Eva Tornero, Cristina Martinez-Bouzas, Mar Infante, Miguel De La Hoya, Orland Diez, Brian L. Browning, COLUMBUS Consortium, Bruce Rannala, Manuel R. Teixeira, Pilar Carvallo, Magdalena Echeverry & Luis G. Carvajal-Carmona
Referencia :	Breast Cancer Res. 2020 Oct 21;22(1):108.
DOI (Digital Object Identifier) :	10.1186/s13058-020-01341-3
PMID :	33087180
Derechos de uso :	CC BY
En línea :	https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-020-013 [...]
Enlace permanente :	./index.php?lvl=notice_display&id=5194

Título :	Recurrence of hepatocellular carcinoma after liver transplantation: Prognostic and predictive factors of survival in a Latin American cohort
Tipo de documento :	documento electrónico
Autores :	Sergio Iván Hoyos Duque, Autor asociado al HPTU
Fecha de publicación :	2020
Títulos uniformes :	Liver International
Idioma :	Inglés (eng)
Palabras clave :	hepatocellular carcinoma  liver transplantation  prognosis  recurrence  treatment
Resumen :	Background & aim: Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) has a poor prognosis, and the adjusted effect of different treatments on post-recurrence survival (PRS) has not been well defined. This study aims to evaluate prognostic and predictive variables associated with PRS. Methods: This Latin American multicenter retrospective cohort study included HCC patients who underwent LT between the years 2005-2018. We evaluated the effect of baseline characteristics at time of HCC recurrence diagnosis and PRS (Cox regression analysis). Early recurrences were those occurring within 12 months of LT. To evaluate the adjusted treatment effect for HCC recurrence, a propensity score matching analysis was performed to assess the probability of having received any specific treatment for recurrence. Results: From a total of 1085 transplanted HCC patients, the cumulative incidence of recurrence was 16.6% (CI 13.5-20.3), with median time to recurrence of 13.0 months (IQR 6.0-26.0). Factors independently associated with PRS were early recurrence (47.6%), treatment with sorafenib and surgery/trans-arterial chemoembolization (TACE). Patients who underwent any treatment presented "early recurrences" less frequently, and more extrahepatic metastasis. This unbalanced distribution was included in the propensity score matching, with correct calibration and discrimination (receiving operator curve of 0.81 [CI 0.72;0.88]). After matching, the adjusted effect on PRS for any treatment was HR of 0.2 (0.10;0.33); P < .0001, for sorafenib therapy HR of 0.4 (0.27;0.77); P = .003, and for surgery/TACE HR of 0.4 (0.18;0.78); P = .009. Conclusion: Although early recurrence was associated with worse outcome, even in this population, systemic or locoregional treatments were associated with better PRS.
Mención de responsabilidad :	Claudia Maccali, Aline L Chagas, Ilka Boin, Emilio Quiñonez, Sebastián Marciano, Mario Vilatobá, Adriana Varón, Margarita Anders, Sergio Hoyos Duque, Agnaldo S Lima, Josemaría Menendez, Martín Padilla-Machaca, Jaime Poniachik, Rodrigo Zapata, Martín Maraschio, Ricardo Chong Menéndez, Linda Muñoz, Diego Arufe, Rodrigo Figueroa, Alejandro Soza, Martín Fauda, Simone R Perales, Rodrigo Vergara Sandoval, Carla Bermudez, Oscar Beltran, Isabel Arenas Hoyos, Lucas McCormack, Francisco Juan Mattera, Adrián Gadano, Jose H Parente García , Claudia Megumi Tani, Luiz Augusto Carneiro D'Albuquerque, Flair J Carrilho, Marcelo Silva, Federico Piñero
Referencia :	Liver Int. 2020 Nov 20.
DOI (Digital Object Identifier) :	10.1111/liv.14736
PMID :	33217193
En línea :	https://onlinelibrary.wiley.com/doi/10.1111/liv.14736
Enlace permanente :	./index.php?lvl=notice_display&id=5193

Recurrence of hepatocellular carcinoma after liver transplantation: Prognostic and predictive factors of survival in a Latin American cohort [documento electrónico] / Sergio Iván Hoyos Duque, Autor asociado al HPTU . - 2020.
Obra : Liver International

Idioma : Inglés (eng)

Palabras clave :	hepatocellular carcinoma  liver transplantation  prognosis  recurrence  treatment
Resumen :	Background & aim: Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) has a poor prognosis, and the adjusted effect of different treatments on post-recurrence survival (PRS) has not been well defined. This study aims to evaluate prognostic and predictive variables associated with PRS. Methods: This Latin American multicenter retrospective cohort study included HCC patients who underwent LT between the years 2005-2018. We evaluated the effect of baseline characteristics at time of HCC recurrence diagnosis and PRS (Cox regression analysis). Early recurrences were those occurring within 12 months of LT. To evaluate the adjusted treatment effect for HCC recurrence, a propensity score matching analysis was performed to assess the probability of having received any specific treatment for recurrence. Results: From a total of 1085 transplanted HCC patients, the cumulative incidence of recurrence was 16.6% (CI 13.5-20.3), with median time to recurrence of 13.0 months (IQR 6.0-26.0). Factors independently associated with PRS were early recurrence (47.6%), treatment with sorafenib and surgery/trans-arterial chemoembolization (TACE). Patients who underwent any treatment presented "early recurrences" less frequently, and more extrahepatic metastasis. This unbalanced distribution was included in the propensity score matching, with correct calibration and discrimination (receiving operator curve of 0.81 [CI 0.72;0.88]). After matching, the adjusted effect on PRS for any treatment was HR of 0.2 (0.10;0.33); P < .0001, for sorafenib therapy HR of 0.4 (0.27;0.77); P = .003, and for surgery/TACE HR of 0.4 (0.18;0.78); P = .009. Conclusion: Although early recurrence was associated with worse outcome, even in this population, systemic or locoregional treatments were associated with better PRS.
Mención de responsabilidad :	Claudia Maccali, Aline L Chagas, Ilka Boin, Emilio Quiñonez, Sebastián Marciano, Mario Vilatobá, Adriana Varón, Margarita Anders, Sergio Hoyos Duque, Agnaldo S Lima, Josemaría Menendez, Martín Padilla-Machaca, Jaime Poniachik, Rodrigo Zapata, Martín Maraschio, Ricardo Chong Menéndez, Linda Muñoz, Diego Arufe, Rodrigo Figueroa, Alejandro Soza, Martín Fauda, Simone R Perales, Rodrigo Vergara Sandoval, Carla Bermudez, Oscar Beltran, Isabel Arenas Hoyos, Lucas McCormack, Francisco Juan Mattera, Adrián Gadano, Jose H Parente García , Claudia Megumi Tani, Luiz Augusto Carneiro D'Albuquerque, Flair J Carrilho, Marcelo Silva, Federico Piñero
Referencia :	Liver Int. 2020 Nov 20.
DOI (Digital Object Identifier) :	10.1111/liv.14736
PMID :	33217193
En línea :	https://onlinelibrary.wiley.com/doi/10.1111/liv.14736
Enlace permanente :	./index.php?lvl=notice_display&id=5193

Título :	Breast Implant-associated Anaplastic Large Cell Lymphoma in Colombia: Report of a Multidisciplinary National Registry
Tipo de documento :	documento electrónico
Autores :	Carolina Echeverri Jaramillo, Autor asociado al HPTU
Fecha de publicación :	2020
Títulos uniformes :	Plastic and Reconstructive Surgery. Global Open
Idioma :	Inglés (eng)
Resumen :	An estimated 43,390 breast augmentation surgeries (86,780 implants) and 1486 breast implant reconstructions are performed annually in Colombia, representing the second-most breast surgery destination in South America, the fourth in the western hemisphere, and the fifth country worldwide. No previous reports have evaluated the incidence of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) epidemiology or outcomes in a Hispanic population. Published data on the incidence of this disease in Colombia are unknown; therefore, a National Joint Multidisciplinary Committee was developed between the Colombian scientific societies of Mastology, Plastic Surgery, Hemato-Oncology, and the Invima (The National Food and Drug Surveillance Institute) to track national cases of BIA-ALCL. Materials and methods: We performed a retrospective review (survey-based study) of historical cases since 2011-2019, and a prospective collection of all patients with a confirmed World Health Organization diagnosis of BIA-ALCL identified in a newly established National Registry of BIA-ALCL. The trial was approved by Institutional Review Board (IRB). Results: Eighteen cases of BIA-ALCL were identified in Colombia between 2011 and 2019. Hundred percent developed as sequelae of textured implants. Six patients (33.3%) presented either a peri-implant capsule mass or axillary lymph node involvement. Seven (38.9%) required adjuvant chemotherapy most commonly with CHOP regimen. Different brands of implants were associated with our cases. One death (5.6%) was attributed to BIA-ALCL, and one (5.6%) case displayed with relapsed with bone marrow involvement requiring a bone marrow transplantation. Six cases (33.3%) were identified with advanced stage (IIB-IV). Disease-free survival of 92.3% was achieved at 30.8-month follow-up. Conclusions: Colombia has one of the highest volumes of breast surgery and use of textured surface breast implants in the world. This study is the initial report of an implant registry in South America. A high proportion of advanced disease may be a consequence of delayed presentation, lack of disease awareness, and timely access to tertiary cancer centers for diagnosis and treatment. Brands other than Allergan and Mentor were found to be associated with BIA-ALCL in our study.
Mención de responsabilidad :	Carlos Andres Ossa Gomez, Jose Fernando Robledo Abad, Alejandro Duque, Ramiro Huertas, Ana Maria Fidalgo, Giovanna Rivas Taffur, Jose Joaquin Caicedo Mallarino, Fabio Torres, William Armando Mantilla Duran, Virginia Abello, Roberto N Miranda, Carolina Echeverri, Mark Warren Clemens
Referencia :	Plast Reconstr Surg Glob Open. 2020 Aug 18;8(8):e3013.
DOI (Digital Object Identifier) :	10.1097/GOX.0000000000003013
PMID :	32983773
En línea :	https://journals.lww.com/prsgo/Fulltext/2020/08000/Breast_Implant_associated_Ana [...]
Enlace permanente :	./index.php?lvl=notice_display&id=5192

Breast Implant-associated Anaplastic Large Cell Lymphoma in Colombia: Report of a Multidisciplinary National Registry [documento electrónico] / Carolina Echeverri Jaramillo, Autor asociado al HPTU . - 2020.
Obra : Plastic and Reconstructive Surgery. Global Open

Idioma : Inglés (eng)

Resumen :	An estimated 43,390 breast augmentation surgeries (86,780 implants) and 1486 breast implant reconstructions are performed annually in Colombia, representing the second-most breast surgery destination in South America, the fourth in the western hemisphere, and the fifth country worldwide. No previous reports have evaluated the incidence of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) epidemiology or outcomes in a Hispanic population. Published data on the incidence of this disease in Colombia are unknown; therefore, a National Joint Multidisciplinary Committee was developed between the Colombian scientific societies of Mastology, Plastic Surgery, Hemato-Oncology, and the Invima (The National Food and Drug Surveillance Institute) to track national cases of BIA-ALCL. Materials and methods: We performed a retrospective review (survey-based study) of historical cases since 2011-2019, and a prospective collection of all patients with a confirmed World Health Organization diagnosis of BIA-ALCL identified in a newly established National Registry of BIA-ALCL. The trial was approved by Institutional Review Board (IRB). Results: Eighteen cases of BIA-ALCL were identified in Colombia between 2011 and 2019. Hundred percent developed as sequelae of textured implants. Six patients (33.3%) presented either a peri-implant capsule mass or axillary lymph node involvement. Seven (38.9%) required adjuvant chemotherapy most commonly with CHOP regimen. Different brands of implants were associated with our cases. One death (5.6%) was attributed to BIA-ALCL, and one (5.6%) case displayed with relapsed with bone marrow involvement requiring a bone marrow transplantation. Six cases (33.3%) were identified with advanced stage (IIB-IV). Disease-free survival of 92.3% was achieved at 30.8-month follow-up. Conclusions: Colombia has one of the highest volumes of breast surgery and use of textured surface breast implants in the world. This study is the initial report of an implant registry in South America. A high proportion of advanced disease may be a consequence of delayed presentation, lack of disease awareness, and timely access to tertiary cancer centers for diagnosis and treatment. Brands other than Allergan and Mentor were found to be associated with BIA-ALCL in our study.
Mención de responsabilidad :	Carlos Andres Ossa Gomez, Jose Fernando Robledo Abad, Alejandro Duque, Ramiro Huertas, Ana Maria Fidalgo, Giovanna Rivas Taffur, Jose Joaquin Caicedo Mallarino, Fabio Torres, William Armando Mantilla Duran, Virginia Abello, Roberto N Miranda, Carolina Echeverri, Mark Warren Clemens
Referencia :	Plast Reconstr Surg Glob Open. 2020 Aug 18;8(8):e3013.
DOI (Digital Object Identifier) :	10.1097/GOX.0000000000003013
PMID :	32983773
En línea :	https://journals.lww.com/prsgo/Fulltext/2020/08000/Breast_Implant_associated_Ana [...]
Enlace permanente :	./index.php?lvl=notice_display&id=5192

Título :	Institutional arthroplasty registry: what is the minimum acceptable dataset to be included in your hospital? Recommendations from a single-country national consensus using the Delphi method
Tipo de documento :	documento electrónico
Autores :	José Luis Moore Velásquez, Autor asociado al HPTU
Fecha de publicación :	2020
Títulos uniformes :	International Orthopaedics
Idioma :	Inglés (eng)
Palabras clave :	Arthroplasty  Database  Dataset  Hip arthroplasty  Institutional Arthroplasty Registry  Knee arthroplasty  Quality improvement  Register
Resumen :	Purpose: Institutional arthroplasty registries are very popular nowadays; however, very few efforts have been made in order to standardize the information to be collected, thus limiting the possibility of inter-institutional data interpretation. This manuscript reports the results of a single-country consensus designed to define the minimum standardized dataset to be recorded within an institutional arthroplasty registry. Methods: A national consensus was carried out among all members of the Colombian Society of Hip and Knee Surgeons using the Delphi method. Eleven questions and answers comprising every potential domain of an institutional registry of hip and knee arthroplasty were defined. According to the methodology, anonymous voting and multiple discussion rounds were performed. Three levels of agreement were defined: Strong consensus: equal to or greater than 80%, weak consensus between 70 and 79.9%, and no consensus below 70%. Results: All of the questions reached consensus level. The minimum dataset was defined to include demographic and clinical information, intraoperative and implant details, follow-up and early complications, implant survival, and functional outcome scores, as well as the validation model to assess information quality within the database. Currently, this dataset is being implemented voluntarily by the members of our national society. Discussion: A national consensus is a feasible method to build homogeneous arthroplasty registries. We recommend such an exercise since it establishes the basis to compare and add data between institutions and the joint analysis of said information in a national registry.
Mención de responsabilidad :	Guillermo A. Bonilla, Beatriz E. Montoya, Victoria E. Restrepo, Miguel M. Gomez, Alfredo A. Sánchez, Jose I. Sánchez, Hugo A. Rodríguez, Jairo A. Rincón, Antonio L. Solano, Diego Cardona, Saúl L. Martínez, Alejandro López, Jose L. Moore & on behalf of the members of the Colombian Society of Hip and Knee Surgeons (SOCCAR)
Referencia :	Int Orthop. 2020 Nov 15.
DOI (Digital Object Identifier) :	10.1007/s00264-020-04866-6
PMID :	33191451
En línea :	https://link.springer.com/article/10.1007%2Fs00264-020-04866-6
Enlace permanente :	./index.php?lvl=notice_display&id=5191

Institutional arthroplasty registry: what is the minimum acceptable dataset to be included in your hospital? Recommendations from a single-country national consensus using the Delphi method [documento electrónico] / José Luis Moore Velásquez, Autor asociado al HPTU . - 2020.
Obra : International Orthopaedics

Idioma : Inglés (eng)

Palabras clave :	Arthroplasty  Database  Dataset  Hip arthroplasty  Institutional Arthroplasty Registry  Knee arthroplasty  Quality improvement  Register
Resumen :	Purpose: Institutional arthroplasty registries are very popular nowadays; however, very few efforts have been made in order to standardize the information to be collected, thus limiting the possibility of inter-institutional data interpretation. This manuscript reports the results of a single-country consensus designed to define the minimum standardized dataset to be recorded within an institutional arthroplasty registry. Methods: A national consensus was carried out among all members of the Colombian Society of Hip and Knee Surgeons using the Delphi method. Eleven questions and answers comprising every potential domain of an institutional registry of hip and knee arthroplasty were defined. According to the methodology, anonymous voting and multiple discussion rounds were performed. Three levels of agreement were defined: Strong consensus: equal to or greater than 80%, weak consensus between 70 and 79.9%, and no consensus below 70%. Results: All of the questions reached consensus level. The minimum dataset was defined to include demographic and clinical information, intraoperative and implant details, follow-up and early complications, implant survival, and functional outcome scores, as well as the validation model to assess information quality within the database. Currently, this dataset is being implemented voluntarily by the members of our national society. Discussion: A national consensus is a feasible method to build homogeneous arthroplasty registries. We recommend such an exercise since it establishes the basis to compare and add data between institutions and the joint analysis of said information in a national registry.
Mención de responsabilidad :	Guillermo A. Bonilla, Beatriz E. Montoya, Victoria E. Restrepo, Miguel M. Gomez, Alfredo A. Sánchez, Jose I. Sánchez, Hugo A. Rodríguez, Jairo A. Rincón, Antonio L. Solano, Diego Cardona, Saúl L. Martínez, Alejandro López, Jose L. Moore & on behalf of the members of the Colombian Society of Hip and Knee Surgeons (SOCCAR)
Referencia :	Int Orthop. 2020 Nov 15.
DOI (Digital Object Identifier) :	10.1007/s00264-020-04866-6
PMID :	33191451
En línea :	https://link.springer.com/article/10.1007%2Fs00264-020-04866-6
Enlace permanente :	./index.php?lvl=notice_display&id=5191

Título :	Subacute Acromioclavicular Dislocation After Basal Coracoid Process Fracture: Indirect Reduction without Open Reduction and Internal Fixation: A Case Report
Tipo de documento :	documento electrónico
Autores :	Hernán Darío Gallego Eusse, Autor asociado al HPTU
Fecha de publicación :	2020
Títulos uniformes :	JBJS Case Connector
Idioma :	Inglés (eng)
Resumen :	Case: A 55-year-old man presented with an isolated undisplaced basal coracoid process (CP) fracture after direct trauma over his right shoulder. One week later, he presented with pain and anatomical deformity over the acromioclavicular joint (ACJ). Shoulder x-rays and computerized tomography revealed a complete acromioclavicular (AC) dislocation and displaced CP fracture. Anatomical AC reduction and ipsilateral coracoid fracture reduction were obtained using fixation with a hook plate. At 12-month follow-up, the patient regained functionality and showed complete CP consolidation and anatomic alignment of the ACJ. Conclusion: Our alternative treatment of coracoid fracture associated with secondary subacute AC dislocation showed satisfactory functional results.
Mención de responsabilidad :	Andres Arismendi, Hernan Gallego, Daniela Galeano, Catalina Hurtado, Ana Milena Herrera
Referencia :	JBJS Case Connect. Jul-Sep 2020;10(3):e1900637.
DOI (Digital Object Identifier) :	10.2106/JBJS.CC.19.00637
PMID :	32910608
En línea :	https://journals.lww.com/jbjscc/Abstract/2020/09000/Subacute_Acromioclavicular_D [...]
Enlace permanente :	./index.php?lvl=notice_display&id=5190

Subacute Acromioclavicular Dislocation After Basal Coracoid Process Fracture: Indirect Reduction without Open Reduction and Internal Fixation: A Case Report [documento electrónico] / Hernán Darío Gallego Eusse, Autor asociado al HPTU . - 2020.
Obra : JBJS Case Connector

Idioma : Inglés (eng)

Resumen :	Case: A 55-year-old man presented with an isolated undisplaced basal coracoid process (CP) fracture after direct trauma over his right shoulder. One week later, he presented with pain and anatomical deformity over the acromioclavicular joint (ACJ). Shoulder x-rays and computerized tomography revealed a complete acromioclavicular (AC) dislocation and displaced CP fracture. Anatomical AC reduction and ipsilateral coracoid fracture reduction were obtained using fixation with a hook plate. At 12-month follow-up, the patient regained functionality and showed complete CP consolidation and anatomic alignment of the ACJ. Conclusion: Our alternative treatment of coracoid fracture associated with secondary subacute AC dislocation showed satisfactory functional results.
Mención de responsabilidad :	Andres Arismendi, Hernan Gallego, Daniela Galeano, Catalina Hurtado, Ana Milena Herrera
Referencia :	JBJS Case Connect. Jul-Sep 2020;10(3):e1900637.
DOI (Digital Object Identifier) :	10.2106/JBJS.CC.19.00637
PMID :	32910608
En línea :	https://journals.lww.com/jbjscc/Abstract/2020/09000/Subacute_Acromioclavicular_D [...]
Enlace permanente :	./index.php?lvl=notice_display&id=5190

Título :	Respuesta a la carta al editor diagnóstico endoscópico de uncinariasis
Tipo de documento :	documento electrónico
Autores :	Gabriel Alonso Mosquera Klinger, Autor asociado al HPTU
Fecha de publicación :	2020
Títulos uniformes :	Revista Colombiana de Gastroenterología
Idioma :	Español (spa)
Palabras clave :	Uncinariasis  trichuris  antiparasitarios  endoscopia gastrointestinal
Mención de responsabilidad :	Gabriel Mosquera-Klinger
DOI (Digital Object Identifier) :	10.22516/25007440.565
Derechos de uso :	CC BY-NC-ND
En línea :	https://revistagastrocol.com/index.php/rcg/article/view/565
Enlace permanente :	./index.php?lvl=notice_display&id=5189

Respuesta a la carta al editor diagnóstico endoscópico de uncinariasis [documento electrónico] / Gabriel Alonso Mosquera Klinger, Autor asociado al HPTU . - 2020.
Obra : Revista Colombiana de Gastroenterología

Idioma : Español (spa)

Palabras clave :	Uncinariasis  trichuris  antiparasitarios  endoscopia gastrointestinal
Mención de responsabilidad :	Gabriel Mosquera-Klinger
DOI (Digital Object Identifier) :	10.22516/25007440.565
Derechos de uso :	CC BY-NC-ND
En línea :	https://revistagastrocol.com/index.php/rcg/article/view/565
Enlace permanente :	./index.php?lvl=notice_display&id=5189