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Hepatitis Research and Treatment
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Autre
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Documentos disponibles con este título uniforme (2)
Clasificado(s) por (Año de edición descendente) Refinar búsquedaEtiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia / Sergio Iván Hoyos Duque ; Juan Carlos Restrepo Gutiérrez ; Gonzalo Correa Arango ; Sergio Jaramillo Velásquez
Título : Etiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia Tipo de documento : documento electrónico Autores : Sergio Iván Hoyos Duque, ; Juan Carlos Restrepo Gutiérrez, ; Gonzalo Correa Arango, ; Sergio Jaramillo Velásquez, Fecha de publicación : 2011 Títulos uniformes : Hepatitis Research and Treatment Idioma : Inglés (eng) Resumen : Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are the principal risk factor associated to end-stage liver diseases in the world. A study was carried out on end-stage liver disease cases admitted to an important hepatology unit in Medellin, the second largest city in Colombia. From 131 patients recruited in this prospective study, 71% of cases were diagnosed as cirrhosis, 12.2% as HCC, and 16.8% as cirrhosis and HCC. Regarding the risk factors of these patients, alcohol consumption was the most frequent (37.4%), followed by viral etiology (17.6%). Blood and/or hepatic tissue samples from patients with serological markers for HCV or HBV infection were characterized; on the basis of the phylogenetic analysis of HCV 5′ UTR and HBV S gene, isolates belonged to HCV/1 and HBV/F3, respectively. These results confirm the presence of strains associated with poor clinical outcome, in patients with liver disease in Colombia; additionally, HBV basal core promoter double mutant was identified in HCC cases. Here we show the first study of cirrhosis and/or HCC in Colombian and HBV and HCV molecular characterization of these patients. Viral aetiology was not the main risk factor in this cohort but alcohol consumption. Mención de responsabilidad : Fabian Cortes-Mancera, Carmen Luisa Loureiro, Sergio Hoyos, Juan-Carlos Restrepo, Gonzalo Correa, Sergio Jaramillo, Helene Norder, Flor Helene Pujol, Maria-Cristina Navas Referencia : Hepat Res Treat. 2011;2011:363205. DOI (Digital Object Identifier) : 10.1155/2011/363205 PMID : 21941645 En línea : https://www.hindawi.com/journals/heprt/2011/363205/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3572 Etiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia [documento electrónico] / Sergio Iván Hoyos Duque, ; Juan Carlos Restrepo Gutiérrez, ; Gonzalo Correa Arango, ; Sergio Jaramillo Velásquez, . - 2011.
Obra : Hepatitis Research and Treatment
Idioma : Inglés (eng)
Resumen : Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are the principal risk factor associated to end-stage liver diseases in the world. A study was carried out on end-stage liver disease cases admitted to an important hepatology unit in Medellin, the second largest city in Colombia. From 131 patients recruited in this prospective study, 71% of cases were diagnosed as cirrhosis, 12.2% as HCC, and 16.8% as cirrhosis and HCC. Regarding the risk factors of these patients, alcohol consumption was the most frequent (37.4%), followed by viral etiology (17.6%). Blood and/or hepatic tissue samples from patients with serological markers for HCV or HBV infection were characterized; on the basis of the phylogenetic analysis of HCV 5′ UTR and HBV S gene, isolates belonged to HCV/1 and HBV/F3, respectively. These results confirm the presence of strains associated with poor clinical outcome, in patients with liver disease in Colombia; additionally, HBV basal core promoter double mutant was identified in HCC cases. Here we show the first study of cirrhosis and/or HCC in Colombian and HBV and HCV molecular characterization of these patients. Viral aetiology was not the main risk factor in this cohort but alcohol consumption. Mención de responsabilidad : Fabian Cortes-Mancera, Carmen Luisa Loureiro, Sergio Hoyos, Juan-Carlos Restrepo, Gonzalo Correa, Sergio Jaramillo, Helene Norder, Flor Helene Pujol, Maria-Cristina Navas Referencia : Hepat Res Treat. 2011;2011:363205. DOI (Digital Object Identifier) : 10.1155/2011/363205 PMID : 21941645 En línea : https://www.hindawi.com/journals/heprt/2011/363205/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3572 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000141 AC-2011-026 Archivo digital Producción Científica Artículos científicos Disponible
Título : Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia Tipo de documento : documento electrónico Autores : Sergio Iván Hoyos Duque, ; Juan Carlos Restrepo Gutiérrez, ; Gonzalo Correa Arango, ; Sergio Jaramillo Velásquez, Fecha de publicación : 2011 Títulos uniformes : Hepatitis Research and Treatment Idioma : Inglés (eng) Resumen : Hepatocellular Carcinoma (HCC) is a leading cause of cancer-related death worldwide. Globally, the most important HCC risk factors are Hepatitis B Virus (HBV) and/or Hepatitis C Virus (HCV), chronic alcoholism, and dietary exposure to aflatoxins. We have described the epidemiological pattern of 202 HCC samples obtained from Colombian patients. Additionally we investigated HBV/HCV infections and TP53 mutations in 49 of these HCC cases. HBV biomarkers were detected in 58.1% of the cases; HBV genotypes F and D were characterized in three of the samples. The HCV biomarker was detected in 37% of the samples while HBV/HCV coinfection was found in 19.2%. Among TP53 mutations, 10.5% occur at the common aflatoxin mutation hotspot, codon 249. No data regarding chronic alcoholism was available from the cases. In conclusion, in this first study of HCC and biomarkers in a Colombian population, the main HCC risk factor was HBV infection. Mención de responsabilidad : Maria-Cristina Navas, Iris Suarez, Andrea Carreño, Diego Uribe, Wilson Alfredo Rios, Fabian Cortes-Mancera, Ghyslaine Martel, Beatriz Vieco, Diana Lozano, Carlos Jimenez, Doriane Gouas, German Osorio, Sergio Hoyos, Juan Carlos Restrepo, Gonzalo Correa, Sergio Jaramillo, Rocio Lopez, Luis Eduardo Bravo, Maria Patricia Arbelaez, Jean-Yves Scoazec, Behnoush Abedi-Ardekani, Regina M Santella, Isabelle Chemin, Pierre Hainaut Referencia : Hepat Res Treat. 2011;2011:582945. DOI (Digital Object Identifier) : 10.1155/2011/582945 PMID : 22114738 En línea : https://www.hindawi.com/journals/heprt/2011/582945/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3587 Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia [documento electrónico] / Sergio Iván Hoyos Duque, ; Juan Carlos Restrepo Gutiérrez, ; Gonzalo Correa Arango, ; Sergio Jaramillo Velásquez, . - 2011.
Obra : Hepatitis Research and Treatment
Idioma : Inglés (eng)
Resumen : Hepatocellular Carcinoma (HCC) is a leading cause of cancer-related death worldwide. Globally, the most important HCC risk factors are Hepatitis B Virus (HBV) and/or Hepatitis C Virus (HCV), chronic alcoholism, and dietary exposure to aflatoxins. We have described the epidemiological pattern of 202 HCC samples obtained from Colombian patients. Additionally we investigated HBV/HCV infections and TP53 mutations in 49 of these HCC cases. HBV biomarkers were detected in 58.1% of the cases; HBV genotypes F and D were characterized in three of the samples. The HCV biomarker was detected in 37% of the samples while HBV/HCV coinfection was found in 19.2%. Among TP53 mutations, 10.5% occur at the common aflatoxin mutation hotspot, codon 249. No data regarding chronic alcoholism was available from the cases. In conclusion, in this first study of HCC and biomarkers in a Colombian population, the main HCC risk factor was HBV infection. Mención de responsabilidad : Maria-Cristina Navas, Iris Suarez, Andrea Carreño, Diego Uribe, Wilson Alfredo Rios, Fabian Cortes-Mancera, Ghyslaine Martel, Beatriz Vieco, Diana Lozano, Carlos Jimenez, Doriane Gouas, German Osorio, Sergio Hoyos, Juan Carlos Restrepo, Gonzalo Correa, Sergio Jaramillo, Rocio Lopez, Luis Eduardo Bravo, Maria Patricia Arbelaez, Jean-Yves Scoazec, Behnoush Abedi-Ardekani, Regina M Santella, Isabelle Chemin, Pierre Hainaut Referencia : Hepat Res Treat. 2011;2011:582945. DOI (Digital Object Identifier) : 10.1155/2011/582945 PMID : 22114738 En línea : https://www.hindawi.com/journals/heprt/2011/582945/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3587 Reserva
Reservar este documentoEjemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000157 AC-2011-042 Archivo digital Producción Científica Artículos científicos Disponible
