Characteristics, outcomes and treatment patterns in acute myeloid leukemia patients 60 years or older in Colombia: a RENEHOC-PETHEMA study / Kenny Mauricio Gálvez Cárdenas ; Laura María Díaz Correa ; Sossa Melo, Claudia ; Abello Polo, Virginia ; Salazar, Luis A. ; Peña, Angela M ; González, María Luna ; Cuervo Lozada, Diana ; Quintero Vega, Guillermo E ; Daza, Jorge ; Omaña Orduz, Olga Paola ; Mantilla, William ; Perdomo, Iván ; Guerrero Burbano, Paola Andrea ; Herrera, Juan Manuel ; Idrobo, Henry ; Rodríguez Veiga, Rebeca ; Correa Correa, Mario Ernesto ; Lobatón, José ; Bermúdez, Carlos Daniel ; Pedraza Morales, Julian Eduardo ; Serrano Casas, Juan Carlos ; Jaramillo, Francisco ; Gómez, Rigoberto ; Rosales, Carmen ; Solano, María Helena ; Varón, Carlos ; Martínez Cuadrón, David ; Montesinos, Pau  

Público ISBD Título : Characteristics, outcomes and treatment patterns in acute myeloid leukemia patients 60 years or older in Colombia: a RENEHOC-PETHEMA study Tipo de documento : documento electrónico Autores : Kenny Mauricio Gálvez Cárdenas, Autor ; Laura María Díaz Correa, Autor ; Sossa Melo, Claudia, Autor ; Abello Polo, Virginia, Autor ; Salazar, Luis A., Autor ; Peña, Angela M, Autor ; González, María Luna, Autor ; Cuervo Lozada, Diana, Autor ; Quintero Vega, Guillermo E, Autor ; Daza, Jorge, Autor ; Omaña Orduz, Olga Paola, Autor ; Mantilla, William, Autor ; Perdomo, Iván, Autor ; Guerrero Burbano, Paola Andrea, Autor ; Herrera, Juan Manuel, Autor ; Idrobo, Henry, Autor ; Rodríguez Veiga, Rebeca, Autor ; Correa Correa, Mario Ernesto, Autor ; Lobatón, José, Autor ; Bermúdez, Carlos Daniel, Autor ; Pedraza Morales, Julian Eduardo, Autor ; Serrano Casas, Juan Carlos, Autor ; Jaramillo, Francisco, Autor ; Gómez, Rigoberto, Autor ; Rosales, Carmen, Autor ; Solano, María Helena, Autor ; Varón, Carlos, Autor ; Martínez Cuadrón, David, Autor ; Montesinos, Pau, Autor Fecha de publicación : 2025 Títulos uniformes : Annals of Hematology Idioma : Inglés (eng) Palabras clave : Acute myeloid leukemia; Elderly patients; Overall survival; Treatment outcomes. Resumen : There is a limited information available on the clinical characteristics, treatment patterns and outcomes on older patients diagnosed with Acute Myeloid Leukemia (AML) in Latin-America. This multicenter retrospective study analyzed 269 patients over 60 years of age diagnosed with AML in Colombia, using data from RENEHOC-PETHEMA registry, from 2009 to 2023. The median age at diagnosis was 70 years (Range:60-98), 55% were men, 61% had an ECOG Mención de responsabilidad : Claudia Sossa-Melo, Virginia Abello-Polo, Luis A Salazar, Angela M Peña, María Luna-González 4, Diana Cuervo-Lozada, Guillermo E Quintero-Vega, Jorge Daza, Olga Paola Omaña-Orduz, William Mantilla, Iván Perdomo, Kenny Galvez, Laura María Díaz-Correa, Paola Andrea Guerrero-Burbano, Juan Manuel Herrera, Henry Idrobo, L M Gaviria, Mario Ernesto Correa-Correa, José Lobatón, Carlos Daniel Bermúdez, Julian Eduardo Pedraza-Morales, Juan Carlos Serrano-Casas, Francisco Jaramillo, Rigoberto Gómez, Carmen Rosales, María Helena Solano, Carlos Varón, Rebeca Rodríguez-Veiga, David Martínez-Cuadrón, Pau Montesinos. Referencia : Ann Hematol . 2025 Jan;104(1):369-381 DOI (Digital Object Identifier) : 10.1007/s00277-024-06120-0 PMID : 39815122 Derechos de uso : CC BY-NC-ND En línea : https://pubmed-ncbi-nlm-nih-gov.consultaremota.upb.edu.co/39815122/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Characteristics, outcomes and treatment patterns in acute myeloid leukemia patients 60 years or older in Colombia: a RENEHOC-PETHEMA study [documento electrónico] / Kenny Mauricio Gálvez Cárdenas, Autor ; Laura María Díaz Correa, Autor ; Sossa Melo, Claudia, Autor ; Abello Polo, Virginia, Autor ; Salazar, Luis A., Autor ; Peña, Angela M, Autor ; González, María Luna, Autor ; Cuervo Lozada, Diana, Autor ; Quintero Vega, Guillermo E, Autor ; Daza, Jorge, Autor ; Omaña Orduz, Olga Paola, Autor ; Mantilla, William, Autor ; Perdomo, Iván, Autor ; Guerrero Burbano, Paola Andrea, Autor ; Herrera, Juan Manuel, Autor ; Idrobo, Henry, Autor ; Rodríguez Veiga, Rebeca, Autor ; Correa Correa, Mario Ernesto, Autor ; Lobatón, José, Autor ; Bermúdez, Carlos Daniel, Autor ; Pedraza Morales, Julian Eduardo, Autor ; Serrano Casas, Juan Carlos, Autor ; Jaramillo, Francisco, Autor ; Gómez, Rigoberto, Autor ; Rosales, Carmen, Autor ; Solano, María Helena, Autor ; Varón, Carlos, Autor ; Martínez Cuadrón, David, Autor ; Montesinos, Pau, Autor . - 2025. Obra : Annals of Hematology Idioma : Inglés (eng) Palabras clave : Acute myeloid leukemia; Elderly patients; Overall survival; Treatment outcomes. Resumen : There is a limited information available on the clinical characteristics, treatment patterns and outcomes on older patients diagnosed with Acute Myeloid Leukemia (AML) in Latin-America. This multicenter retrospective study analyzed 269 patients over 60 years of age diagnosed with AML in Colombia, using data from RENEHOC-PETHEMA registry, from 2009 to 2023. The median age at diagnosis was 70 years (Range:60-98), 55% were men, 61% had an ECOG Mención de responsabilidad : Claudia Sossa-Melo, Virginia Abello-Polo, Luis A Salazar, Angela M Peña, María Luna-González 4, Diana Cuervo-Lozada, Guillermo E Quintero-Vega, Jorge Daza, Olga Paola Omaña-Orduz, William Mantilla, Iván Perdomo, Kenny Galvez, Laura María Díaz-Correa, Paola Andrea Guerrero-Burbano, Juan Manuel Herrera, Henry Idrobo, L M Gaviria, Mario Ernesto Correa-Correa, José Lobatón, Carlos Daniel Bermúdez, Julian Eduardo Pedraza-Morales, Juan Carlos Serrano-Casas, Francisco Jaramillo, Rigoberto Gómez, Carmen Rosales, María Helena Solano, Carlos Varón, Rebeca Rodríguez-Veiga, David Martínez-Cuadrón, Pau Montesinos. Referencia : Ann Hematol . 2025 Jan;104(1):369-381 DOI (Digital Object Identifier) : 10.1007/s00277-024-06120-0 PMID : 39815122 Derechos de uso : CC BY-NC-ND En línea : https://pubmed-ncbi-nlm-nih-gov.consultaremota.upb.edu.co/39815122/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Characteristics, outcomes and treatment patterns in acute myeloid leukemia patients 60 Years or older in Colombia: a RENEHOC-PETHEMA study / Laura María Díaz Correa ; Kenny Mauricio Gálvez Cárdenas  

Público ISBD Título : Characteristics, outcomes and treatment patterns in acute myeloid leukemia patients 60 Years or older in Colombia: a RENEHOC-PETHEMA study Tipo de documento : documento electrónico Autores : Laura María Díaz Correa, Autor ; Kenny Mauricio Gálvez Cárdenas, Autor Fecha de publicación : 2024 Títulos uniformes : Annals of Hematology Idioma : Inglés (eng) Palabras clave : Acute Myeloid Leukemia  Treatment Outcomes  Elderly Patients  Overall Survival Resumen : There is a limited information available on the clinical characteristics, treatment patterns and outcomes on older patients diagnosed with Acute Myeloid Leukemia (AML) in Latin-America. This multicenter retrospective study analyzed 269 patients over 60 years of age diagnosed with AML in Colombia, using data from RENEHOC-PETHEMA registry, from 2009 to 2023. The median age at diagnosis was 70 years (Range: 60–98), 55% were men, 61% had an ECOG?2, and 75.5% had de novo AML. FLT3-ITD or NPM1 mutations were performed in 23.4% and 15.6% of patients, and detected in 14.3% and 16.7% of cases, respectively. Treatment included intensive chemotherapy (IC) (36.8%), non-intensive chemotherapy (non-IC) low dose cytarabine based chemotherapy (12.6%), hypomethylating agents (HMA, with/without venetoclax) (35.3%), and supportive care (15.2%). Median overall survival (OS) was 8.2 months (10.6 months after IC, 8.8 after non-IC, 8.9 months after HMA, 8.2 months after HMA plus venetoclax, and 1.9 months with supportive care). OS was 35.2% at 1 year and 5.6% at 5 years (13.7% treated with IC). Only 1.5% of patients were transplanted in frontline. Leukemia-free survival (LFS) was 17.6 month, with 67.6% survival at 1 year and 27.3% at 5 years. Among patients treated with IC, the 5-year LFS was 41.3%, and 0% for non-IC. A shift from IC to HMA plus venetoclax regimens was observed after venetoclax marketing. This study provides new insights into the management of patients in Colombia, highlighting the need for a highly individualized approach in treating AML in elderly patients. Mención de responsabilidad : Claudia Sossa-Melo, Virginia Abello Polo, Luis A. Salazar, Angela M. Peña, María Lucrecia Luna González, Diana Marcela Cuervo-Lozada, Guillermo E. Quintero-Vega, Jorge Daza, Olga Paola Omaña-Orduz, William Mantilla, Iván Perdomo, Kenny Galvez, Laura María Díaz Correa, Paola Andrea Guerrero-Burbano, Juan Manuel Herrera, Henry Idrobo, Lina M. Gaviria, Mario Ernesto Correa Correa, José Lobatón, Carlos Daniel Bermúdez, Julian Eduardo Pedraza Morales, Juan Carlos Serrano Casas, Francisco Jaramillo, Rigoberto Gomez, Carmen Rosales, María Helena Solano, Carlos Varón, Rebeca Rodríguez Veiga, David Martínez Cuadrón, Pau Montesinos. Referencia : Annals of Hematology on January 16th, 2025 DOI (Digital Object Identifier) : 10.1007/s00277-024-06120-0. Derechos de uso : CC BY En línea : https://www.researchsquare.com/article/rs-5119261/v1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Characteristics, outcomes and treatment patterns in acute myeloid leukemia patients 60 Years or older in Colombia: a RENEHOC-PETHEMA study [documento electrónico] / Laura María Díaz Correa, Autor ; Kenny Mauricio Gálvez Cárdenas, Autor . - 2024. Obra : Annals of Hematology Idioma : Inglés (eng) Palabras clave : Acute Myeloid Leukemia  Treatment Outcomes  Elderly Patients  Overall Survival Resumen : There is a limited information available on the clinical characteristics, treatment patterns and outcomes on older patients diagnosed with Acute Myeloid Leukemia (AML) in Latin-America. This multicenter retrospective study analyzed 269 patients over 60 years of age diagnosed with AML in Colombia, using data from RENEHOC-PETHEMA registry, from 2009 to 2023. The median age at diagnosis was 70 years (Range: 60–98), 55% were men, 61% had an ECOG?2, and 75.5% had de novo AML. FLT3-ITD or NPM1 mutations were performed in 23.4% and 15.6% of patients, and detected in 14.3% and 16.7% of cases, respectively. Treatment included intensive chemotherapy (IC) (36.8%), non-intensive chemotherapy (non-IC) low dose cytarabine based chemotherapy (12.6%), hypomethylating agents (HMA, with/without venetoclax) (35.3%), and supportive care (15.2%). Median overall survival (OS) was 8.2 months (10.6 months after IC, 8.8 after non-IC, 8.9 months after HMA, 8.2 months after HMA plus venetoclax, and 1.9 months with supportive care). OS was 35.2% at 1 year and 5.6% at 5 years (13.7% treated with IC). Only 1.5% of patients were transplanted in frontline. Leukemia-free survival (LFS) was 17.6 month, with 67.6% survival at 1 year and 27.3% at 5 years. Among patients treated with IC, the 5-year LFS was 41.3%, and 0% for non-IC. A shift from IC to HMA plus venetoclax regimens was observed after venetoclax marketing. This study provides new insights into the management of patients in Colombia, highlighting the need for a highly individualized approach in treating AML in elderly patients. Mención de responsabilidad : Claudia Sossa-Melo, Virginia Abello Polo, Luis A. Salazar, Angela M. Peña, María Lucrecia Luna González, Diana Marcela Cuervo-Lozada, Guillermo E. Quintero-Vega, Jorge Daza, Olga Paola Omaña-Orduz, William Mantilla, Iván Perdomo, Kenny Galvez, Laura María Díaz Correa, Paola Andrea Guerrero-Burbano, Juan Manuel Herrera, Henry Idrobo, Lina M. Gaviria, Mario Ernesto Correa Correa, José Lobatón, Carlos Daniel Bermúdez, Julian Eduardo Pedraza Morales, Juan Carlos Serrano Casas, Francisco Jaramillo, Rigoberto Gomez, Carmen Rosales, María Helena Solano, Carlos Varón, Rebeca Rodríguez Veiga, David Martínez Cuadrón, Pau Montesinos. Referencia : Annals of Hematology on January 16th, 2025 DOI (Digital Object Identifier) : 10.1007/s00277-024-06120-0. Derechos de uso : CC BY En línea : https://www.researchsquare.com/article/rs-5119261/v1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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General features and epidemiology of lymphoma in Colombia. A multicentric study / Marcos Arango Barrientos ; Juan Felipe Combariza Vallejo  

Público ISBD Título : General features and epidemiology of lymphoma in Colombia. A multicentric study Tipo de documento : documento electrónico Autores : Marcos Arango Barrientos, ; Juan Felipe Combariza Vallejo, Fecha de publicación : 2015 Títulos uniformes : Annals of Hematology Idioma : Inglés (eng) Palabras clave : Lymphoma  hodgkin lymphoma  non-Hodgkin lymphoma  Colombia Resumen : The relative frequency of the non-Hodgkin lymphoma (NHL) subtypes varies around the world. The objective of this study was to describe the general features of patients with lymphoma in Colombia. A total of 819 patients with a new diagnosis of lymphoma were included. Nighty-nine (12 %) of them had Hodgkin lymphoma (HL) and 720 (88 %) had NHL. Most cases had advanced stage disease at presentation (63.6 %). Diffuse large B cell lymphoma (DLBCL) was the most frequent diagnosis; it was seen in 40 % of patients with NHL and in 35 % of patients in the whole series. Overall survival rates at 3 years were 77 % for HL and follicular lymphoma, 54 % for DLBCL, and 45 % for T cell lymphomas. In conclusion, the distribution of specific NHL subtypes is similar to what has been reported previously in other tropical countries. Mención de responsabilidad : Juan F Combariza, Milton Lombana, Ana M Torres, Ana M Castellanos, Marcos Arango Referencia : Ann Hematol. 2015 Jun;94(6):975-80. DOI (Digital Object Identifier) : 10.1007/s00277-015-2301-7 PMID : 25645655 En línea : https://link.springer.com/article/10.1007%2Fs00277-015-2301-7 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis General features and epidemiology of lymphoma in Colombia. A multicentric study [documento electrónico] / Marcos Arango Barrientos, ; Juan Felipe Combariza Vallejo,  . - 2015. Obra : Annals of Hematology Idioma : Inglés (eng) Palabras clave : Lymphoma  hodgkin lymphoma  non-Hodgkin lymphoma  Colombia Resumen : The relative frequency of the non-Hodgkin lymphoma (NHL) subtypes varies around the world. The objective of this study was to describe the general features of patients with lymphoma in Colombia. A total of 819 patients with a new diagnosis of lymphoma were included. Nighty-nine (12 %) of them had Hodgkin lymphoma (HL) and 720 (88 %) had NHL. Most cases had advanced stage disease at presentation (63.6 %). Diffuse large B cell lymphoma (DLBCL) was the most frequent diagnosis; it was seen in 40 % of patients with NHL and in 35 % of patients in the whole series. Overall survival rates at 3 years were 77 % for HL and follicular lymphoma, 54 % for DLBCL, and 45 % for T cell lymphomas. In conclusion, the distribution of specific NHL subtypes is similar to what has been reported previously in other tropical countries. Mención de responsabilidad : Juan F Combariza, Milton Lombana, Ana M Torres, Ana M Castellanos, Marcos Arango Referencia : Ann Hematol. 2015 Jun;94(6):975-80. DOI (Digital Object Identifier) : 10.1007/s00277-015-2301-7 PMID : 25645655 En línea : https://link.springer.com/article/10.1007%2Fs00277-015-2301-7 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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