Latin American Association for the study of the liver (ALEH) practice guidance for the diagnosis and treatment of non-alcoholic fatty liver disease / Juan Carlos Restrepo Gutiérrez    

Público ISBD Título : Latin American Association for the study of the liver (ALEH) practice guidance for the diagnosis and treatment of non-alcoholic fatty liver disease Tipo de documento : documento electrónico Autores : Juan Carlos Restrepo Gutiérrez, Fecha de publicación : 2020 Títulos uniformes : Annals of Hepatology Idioma : Inglés (eng) Palabras clave : Steatosis  NAFLD  NASH  Fatty liver  Clinical practice guidance  Nonalcoholic fatty liver disease  Nonalcoholic steatohepatitis  MAFLD  Cirrhosis Resumen : Non-alcoholic fatty liver disease (NAFLD) currently represents an epidemic worldwide. NAFLD is the most frequently diagnosed chronic liver disease, affecting 20–30% of the general population. Furthermore, its prevalence is predicted to increase exponentially in the next decades, concomitantly with the global epidemic of obesity, type 2 diabetes mellitus (T2DM), and sedentary lifestyle. NAFLD is a clinical syndrome that encompasses a wide spectrum of associated diseases and hepatic complications such as hepatocellular carcinoma (HCC). Moreover, this disease is believed to become the main indication for liver transplantation in the near future. Since NAFLD management represents a growing challenge for primary care physicians, the Asociación Latinoamericana para el Estudio del Hígado (ALEH) has decided to organize this Practice Guidance for the Diagnosis and Treatment of Non-Alcoholic Fatty Liver Disease, written by Latin-American specialists in different clinical areas, and destined to general practitioners, internal medicine specialists, endocrinologists, diabetologists, gastroenterologists, and hepatologists. The main purpose of this document is to improve patient care and awareness of NAFLD. The information provided in this guidance may also be useful in assisting stakeholders in the decision-making process related to NAFLD. Since new evidence is constantly emerging on different aspects of the disease, updates to this guideline will be required in future. Mención de responsabilidad : Juan Pablo Arab, Melisa Dirchwolf, Mário Reis Álvares-da-Silva, Francisco Barrera, Carlos Benítez, Marlene Castellanos-Fernandez, Graciela Castro-Narro, Norberto Chavez-Tapia, Daniela Chiodi, Helma Cotrim, Kenneth Cusi, Claudia Pinto Marques Souza de Oliveira, Javier Díaz, Eduardo Fassio, Solange Gerona, Marcos Girala, Nelia Hernandez, Sebastián Marciano, Walter Masson, Nahum Méndez-Sánchez, Nathalie Leite, Adelina Lozano, Martín Padilla, Arturo Panduro, Raymundo Paraná, Edison Parise, Marlene Perez, Jaime Poniachik, Juan Carlos Restrepo, Andrés Ruf, Marcelo Silva, Martín Tagle, Monica Tapias, Kenia Torres, Eduardo Vilar-Gomez, José Eduardo Costa Gil, Adrian Gadano, Marco Arrese Referencia : Ann Hepatol. Nov-Dec 2020;19(6):674-690. DOI (Digital Object Identifier) : 10.1016/j.aohep.2020.09.006 PMID : 33031970 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S1665268120301770 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5159 Latin American Association for the study of the liver (ALEH) practice guidance for the diagnosis and treatment of non-alcoholic fatty liver disease [documento electrónico] / Juan Carlos Restrepo Gutiérrez,  . - 2020. Obra : Annals of Hepatology Idioma : Inglés (eng) Palabras clave : Steatosis  NAFLD  NASH  Fatty liver  Clinical practice guidance  Nonalcoholic fatty liver disease  Nonalcoholic steatohepatitis  MAFLD  Cirrhosis Resumen : Non-alcoholic fatty liver disease (NAFLD) currently represents an epidemic worldwide. NAFLD is the most frequently diagnosed chronic liver disease, affecting 20–30% of the general population. Furthermore, its prevalence is predicted to increase exponentially in the next decades, concomitantly with the global epidemic of obesity, type 2 diabetes mellitus (T2DM), and sedentary lifestyle. NAFLD is a clinical syndrome that encompasses a wide spectrum of associated diseases and hepatic complications such as hepatocellular carcinoma (HCC). Moreover, this disease is believed to become the main indication for liver transplantation in the near future. Since NAFLD management represents a growing challenge for primary care physicians, the Asociación Latinoamericana para el Estudio del Hígado (ALEH) has decided to organize this Practice Guidance for the Diagnosis and Treatment of Non-Alcoholic Fatty Liver Disease, written by Latin-American specialists in different clinical areas, and destined to general practitioners, internal medicine specialists, endocrinologists, diabetologists, gastroenterologists, and hepatologists. The main purpose of this document is to improve patient care and awareness of NAFLD. The information provided in this guidance may also be useful in assisting stakeholders in the decision-making process related to NAFLD. Since new evidence is constantly emerging on different aspects of the disease, updates to this guideline will be required in future. Mención de responsabilidad : Juan Pablo Arab, Melisa Dirchwolf, Mário Reis Álvares-da-Silva, Francisco Barrera, Carlos Benítez, Marlene Castellanos-Fernandez, Graciela Castro-Narro, Norberto Chavez-Tapia, Daniela Chiodi, Helma Cotrim, Kenneth Cusi, Claudia Pinto Marques Souza de Oliveira, Javier Díaz, Eduardo Fassio, Solange Gerona, Marcos Girala, Nelia Hernandez, Sebastián Marciano, Walter Masson, Nahum Méndez-Sánchez, Nathalie Leite, Adelina Lozano, Martín Padilla, Arturo Panduro, Raymundo Paraná, Edison Parise, Marlene Perez, Jaime Poniachik, Juan Carlos Restrepo, Andrés Ruf, Marcelo Silva, Martín Tagle, Monica Tapias, Kenia Torres, Eduardo Vilar-Gomez, José Eduardo Costa Gil, Adrian Gadano, Marco Arrese Referencia : Ann Hepatol. Nov-Dec 2020;19(6):674-690. DOI (Digital Object Identifier) : 10.1016/j.aohep.2020.09.006 PMID : 33031970 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S1665268120301770 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5159

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Alcohol-related liver disease: Clinical practice guidelines by the Latin American Association for the Study of the Liver (ALEH) / Juan Carlos Restrepo Gutiérrez    

Público ISBD Título : Alcohol-related liver disease: Clinical practice guidelines by the Latin American Association for the Study of the Liver (ALEH) Tipo de documento : documento electrónico Autores : Juan Carlos Restrepo Gutiérrez, Fecha de publicación : 2019 Títulos uniformes : Annals of Hepatology Idioma : Inglés (eng) Palabras clave : Alcohol  alcohol use disorder  alcohol-related liver disease  alcoholic hepatitis  alcoholic liver disease  cirrhosis  clinical practice guidelines  corticosteroids Resumen : Alcohol-related liver disease (ALD) is a major cause of advanced chronic liver disease in Latin-America, although data on prevalence is limited. Public health policies aimed at reducing the alarming prevalence of alcohol use disorder in Latin-America should be implemented. ALD comprises a clinical-pathological spectrum that ranges from steatosis, steatohepatitis to advanced forms such as alcoholic hepatitis (AH), cirrhosis and hepatocellular carcinoma. Besides genetic factors, the amount of alcohol consumption is the most important risk factor for the development of ALD. Continuous consumption of more than 3 standard drinks per day in men and more than 2 drinks per day in women increases the risk of developing liver disease. The pathogenesis of ALD is only partially understood and recent translational studies have identified novel therapeutic targets. Early forms of ALD are often missed and most clinical attention is focused on AH, which is defined as an abrupt onset of jaundice and liver-related complications. In patients with potential confounding factors, a transjugular biopsy is recommended. The standard therapy for AH (i.e. prednisolone) has not evolved in the last decades yet promising new therapies (i.e. G-CSF, N-acetylcysteine) have been recently proposed. In both patients with early and severe ALD, prolonged abstinence is the most efficient therapeutic measure to decrease long-term morbidity and mortality. A multidisciplinary team including alcohol addiction specialists is recommended to manage patients with ALD. Liver transplantation should be considered in the management of patients with end-stage ALD that do not recover despite abstinence. In selected cases, increasing number of centers are proposing early transplantation for patients with severe AH not responding to medical therapy. Mención de responsabilidad : Juan P Arab, Juan P Roblero, Jose Altamirano, Fernando Bessone, Roberta Chaves Araujo, Fatima Higuera-De la Tijera, Juan Carlos Restrepo, Aldo Torre, Alvaro Urzua, Douglas A Simonetto, Juan G Abraldes, Nahum Méndez-Sánchez, Fernando Contreras, Michael R Lucey, Vijay H Shah, Helena Cortez-Pinto, Ramon Bataller Referencia : Ann Hepatol. 2019 May - Jun;18(3):518-535 DOI (Digital Object Identifier) : 10.1016/j.aohep.2019.04.005 PMID : 31053546 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S1665268119300419 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4250 Alcohol-related liver disease: Clinical practice guidelines by the Latin American Association for the Study of the Liver (ALEH) [documento electrónico] / Juan Carlos Restrepo Gutiérrez,  . - 2019. Obra : Annals of Hepatology Idioma : Inglés (eng) Palabras clave : Alcohol  alcohol use disorder  alcohol-related liver disease  alcoholic hepatitis  alcoholic liver disease  cirrhosis  clinical practice guidelines  corticosteroids Resumen : Alcohol-related liver disease (ALD) is a major cause of advanced chronic liver disease in Latin-America, although data on prevalence is limited. Public health policies aimed at reducing the alarming prevalence of alcohol use disorder in Latin-America should be implemented. ALD comprises a clinical-pathological spectrum that ranges from steatosis, steatohepatitis to advanced forms such as alcoholic hepatitis (AH), cirrhosis and hepatocellular carcinoma. Besides genetic factors, the amount of alcohol consumption is the most important risk factor for the development of ALD. Continuous consumption of more than 3 standard drinks per day in men and more than 2 drinks per day in women increases the risk of developing liver disease. The pathogenesis of ALD is only partially understood and recent translational studies have identified novel therapeutic targets. Early forms of ALD are often missed and most clinical attention is focused on AH, which is defined as an abrupt onset of jaundice and liver-related complications. In patients with potential confounding factors, a transjugular biopsy is recommended. The standard therapy for AH (i.e. prednisolone) has not evolved in the last decades yet promising new therapies (i.e. G-CSF, N-acetylcysteine) have been recently proposed. In both patients with early and severe ALD, prolonged abstinence is the most efficient therapeutic measure to decrease long-term morbidity and mortality. A multidisciplinary team including alcohol addiction specialists is recommended to manage patients with ALD. Liver transplantation should be considered in the management of patients with end-stage ALD that do not recover despite abstinence. In selected cases, increasing number of centers are proposing early transplantation for patients with severe AH not responding to medical therapy. Mención de responsabilidad : Juan P Arab, Juan P Roblero, Jose Altamirano, Fernando Bessone, Roberta Chaves Araujo, Fatima Higuera-De la Tijera, Juan Carlos Restrepo, Aldo Torre, Alvaro Urzua, Douglas A Simonetto, Juan G Abraldes, Nahum Méndez-Sánchez, Fernando Contreras, Michael R Lucey, Vijay H Shah, Helena Cortez-Pinto, Ramon Bataller Referencia : Ann Hepatol. 2019 May - Jun;18(3):518-535 DOI (Digital Object Identifier) : 10.1016/j.aohep.2019.04.005 PMID : 31053546 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S1665268119300419 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4250

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Results of Liver Transplantation for Hepatocellular Carcinoma in a Multicenter Latin American Cohort Study / Sergio Iván Hoyos Duque  

Público ISBD Título : Results of Liver Transplantation for Hepatocellular Carcinoma in a Multicenter Latin American Cohort Study Tipo de documento : documento electrónico Autores : Sergio Iván Hoyos Duque, Fecha de publicación : 2018 Títulos uniformes : Annals of Hepatology Idioma : Inglés (eng) Palabras clave : Liver cancer  prediction  candidate selection. Resumen : Background and aims: Heterogeneous data has been reported regarding liver transplantation (LT) for hepatocellular carcinoma (HCC) in Latin America. We aimed to describe treatment during waiting list, survival and recurrence of HCC after LT in a multicenter study from Latin America. Material and methods: Patients with HCC diagnosed prior to transplant (cHCC) and incidentally found in the explanted liver (iHCC) were included. Imaging-explanted features were compared in cHCC (non-discordant if pre and post-LT were within Milan, discordant if pre-LT was within and post-LT exceeding Milan). Results: Overall, 435 patients with cHCC and 92 with iHCC were included. At listing, 81% and 91% of cHCC patients were within Milan and San Francisco criteria (UCSF), respectively. Five-year survival and recurrence rates for cHCC within Milan, exceeding Milan/within UCSF and beyond UCSF were 71% and 16%; 66% and 26%; 46% and 55%, respectively. Locoregional treatment prior to LT was performed in 39% of cHCC within Milan, in 53% beyond Milan/within UCSF and in 83% exceeding UCSF (p 1,000 ng/mL 64%; p = 0.12). Discordant imaging-explanted data was observed in 29% of cHCC, showing lower survival HR 2.02 (CI 1.29; 3.15) and higher recurrence rates HR 2.34 when compared to AFP 1,000 ng/mL at listing was independently associated with a higher 5-year recurrence rate and a HR of 3.24 when compared to AFP Mención de responsabilidad : Federico Piñero, Paulo Costa, Yuri L Boteon, Sergio Hoyos Duque, Sebastian Marciano, Margarita Anders, Adriana Varón, Alina Zerega, Jaime Poniachik, Alejandro Soza, Martín Padilla Machaca, Josemaría Menéndez, Rodrigo Zapata, Mario Vilatoba, Linda Muñoz, Martín Maraschio, Martín Fauda, Lucas McCormack, Adrian Gadano, Ilka Sf Boin, Jose H Parente García, Marcelo Silva Referencia : Ann Hepatol. 2018 Mar 1;17(2):256-267. DOI (Digital Object Identifier) : 10.5604/01.3001.0010.8648 PMID : 29469048 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1665268119301589 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4188 Results of Liver Transplantation for Hepatocellular Carcinoma in a Multicenter Latin American Cohort Study [documento electrónico] / Sergio Iván Hoyos Duque,  . - 2018. Obra : Annals of Hepatology Idioma : Inglés (eng) Palabras clave : Liver cancer  prediction  candidate selection. Resumen : Background and aims: Heterogeneous data has been reported regarding liver transplantation (LT) for hepatocellular carcinoma (HCC) in Latin America. We aimed to describe treatment during waiting list, survival and recurrence of HCC after LT in a multicenter study from Latin America. Material and methods: Patients with HCC diagnosed prior to transplant (cHCC) and incidentally found in the explanted liver (iHCC) were included. Imaging-explanted features were compared in cHCC (non-discordant if pre and post-LT were within Milan, discordant if pre-LT was within and post-LT exceeding Milan). Results: Overall, 435 patients with cHCC and 92 with iHCC were included. At listing, 81% and 91% of cHCC patients were within Milan and San Francisco criteria (UCSF), respectively. Five-year survival and recurrence rates for cHCC within Milan, exceeding Milan/within UCSF and beyond UCSF were 71% and 16%; 66% and 26%; 46% and 55%, respectively. Locoregional treatment prior to LT was performed in 39% of cHCC within Milan, in 53% beyond Milan/within UCSF and in 83% exceeding UCSF (p 1,000 ng/mL 64%; p = 0.12). Discordant imaging-explanted data was observed in 29% of cHCC, showing lower survival HR 2.02 (CI 1.29; 3.15) and higher recurrence rates HR 2.34 when compared to AFP 1,000 ng/mL at listing was independently associated with a higher 5-year recurrence rate and a HR of 3.24 when compared to AFP Mención de responsabilidad : Federico Piñero, Paulo Costa, Yuri L Boteon, Sergio Hoyos Duque, Sebastian Marciano, Margarita Anders, Adriana Varón, Alina Zerega, Jaime Poniachik, Alejandro Soza, Martín Padilla Machaca, Josemaría Menéndez, Rodrigo Zapata, Mario Vilatoba, Linda Muñoz, Martín Maraschio, Martín Fauda, Lucas McCormack, Adrian Gadano, Ilka Sf Boin, Jose H Parente García, Marcelo Silva Referencia : Ann Hepatol. 2018 Mar 1;17(2):256-267. DOI (Digital Object Identifier) : 10.5604/01.3001.0010.8648 PMID : 29469048 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1665268119301589 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4188

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Factors associated with recurrence and survival in liver transplant patients with HCC - a single center retrospective study / Sergio Iván Hoyos Duque ; Carlos Ernesto Guzmán Luna ; Álvaro Mena Hurtado ; Juan Carlos Restrepo Gutiérrez ; Gonzalo Correa Arango ; Juan Camilo Pérez Cadavid  

Público ISBD Título : Factors associated with recurrence and survival in liver transplant patients with HCC - a single center retrospective study Tipo de documento : documento electrónico Autores : Sergio Iván Hoyos Duque, ; Carlos Ernesto Guzmán Luna, ; Álvaro Mena Hurtado, ; Juan Carlos Restrepo Gutiérrez, ; Gonzalo Correa Arango, ; Juan Camilo Pérez Cadavid, Fecha de publicación : 2015 Títulos uniformes : Annals of Hepatology Idioma : Inglés (eng) Palabras clave : Cancer  liver transplant  cirrhosis  biopsy Resumen : Introduction: Hepatocellular carcinoma is the most common primary tumor of the liver and is diagnosed in more than a half million people worldwide each year. This study aims to assess factors associated with the recurrence and survival of patients with hepatocellular carcinoma and liver transplantation in a cohort of patients from Medellín, Colombia. Material and methods. This was a descriptive retrospective study of a consecutive series of liver transplant patients from the Pablo Tobon Uribe Hospital of Medellín from January 2004 to May 2013. Demographic, clinical, imaging, and pathology variables were analyzed. Results: Three hundred thirty liver transplants were performed during the study period, 54 cases (16.4%) had one or more hepatocellular carcinomas in the explant, and 79.6% of these patients were men. Cirrhotic patients had different etiologies, but most of them were due to alcohol abuse (22.2%), followed by hepatitis B virus infection (20.4 %), and hepatitis C virus infection (18.5%). In the pathology specimen, 51.9% had only one focus of hepatocellular carcinoma, 22.2% had two foci and 12.9% had three tumors. Recurrence of hepatocellular carcinoma occurred in 7.4% patients with an average time of 81 months. During follow-up, 25.9% of the patients died in an average time of 67.9 months (CI95 59.1-80.1 months). Conclusion: Recurrence and survival of patients with liver transplantation for hepatocellular carcinoma in this study had a similar behavior as that reported in the world literature. The factors associated with these outcomes were vascular invasion, poor tumor differentiation and satellitosis. Mención de responsabilidad : Sergio Hoyos, Jorge Escobar, Doris Cardona, Carlos Guzmán, Álvaro Mena, Germán Osorio, Camilo Pérez, Juan C Restrepo, Gonzalo Correa Referencia : Ann Hepatol. 2015 Jan-Feb;14(1):58-63. PMID : 25536642 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1665268119308014 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3871 Factors associated with recurrence and survival in liver transplant patients with HCC - a single center retrospective study [documento electrónico] / Sergio Iván Hoyos Duque, ; Carlos Ernesto Guzmán Luna, ; Álvaro Mena Hurtado, ; Juan Carlos Restrepo Gutiérrez, ; Gonzalo Correa Arango, ; Juan Camilo Pérez Cadavid,  . - 2015. Obra : Annals of Hepatology Idioma : Inglés (eng) Palabras clave : Cancer  liver transplant  cirrhosis  biopsy Resumen : Introduction: Hepatocellular carcinoma is the most common primary tumor of the liver and is diagnosed in more than a half million people worldwide each year. This study aims to assess factors associated with the recurrence and survival of patients with hepatocellular carcinoma and liver transplantation in a cohort of patients from Medellín, Colombia. Material and methods. This was a descriptive retrospective study of a consecutive series of liver transplant patients from the Pablo Tobon Uribe Hospital of Medellín from January 2004 to May 2013. Demographic, clinical, imaging, and pathology variables were analyzed. Results: Three hundred thirty liver transplants were performed during the study period, 54 cases (16.4%) had one or more hepatocellular carcinomas in the explant, and 79.6% of these patients were men. Cirrhotic patients had different etiologies, but most of them were due to alcohol abuse (22.2%), followed by hepatitis B virus infection (20.4 %), and hepatitis C virus infection (18.5%). In the pathology specimen, 51.9% had only one focus of hepatocellular carcinoma, 22.2% had two foci and 12.9% had three tumors. Recurrence of hepatocellular carcinoma occurred in 7.4% patients with an average time of 81 months. During follow-up, 25.9% of the patients died in an average time of 67.9 months (CI95 59.1-80.1 months). Conclusion: Recurrence and survival of patients with liver transplantation for hepatocellular carcinoma in this study had a similar behavior as that reported in the world literature. The factors associated with these outcomes were vascular invasion, poor tumor differentiation and satellitosis. Mención de responsabilidad : Sergio Hoyos, Jorge Escobar, Doris Cardona, Carlos Guzmán, Álvaro Mena, Germán Osorio, Camilo Pérez, Juan C Restrepo, Gonzalo Correa Referencia : Ann Hepatol. 2015 Jan-Feb;14(1):58-63. PMID : 25536642 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1665268119308014 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3871

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Wnt/beta-catenin signaling pathway in hepatocellular carcinomas cases from Colombia / Sergio Iván Hoyos Duque ; Juan Camilo Pérez Cadavid  

Público ISBD Título : Wnt/beta-catenin signaling pathway in hepatocellular carcinomas cases from Colombia Tipo de documento : documento electrónico Autores : Sergio Iván Hoyos Duque, ; Juan Camilo Pérez Cadavid, Fecha de publicación : 2015 Títulos uniformes : Annals of Hepatology Idioma : Inglés (eng) Palabras clave : HCC  Subcellular localization  Wnt/β-catenin  CTNNB1  Mutation  HBV infection Resumen : Background and aim: Hepatocellular carcinoma (HCC) is the most common primary liver cancer diagnosed worldwide. Deregulation of Wnt/?-catenin pathway has been associated with the development of HCC in a substantial number of cases in Europe and far less in Asia. Nothing is known about this pathway in HCC cases from South America. This study aimed to investigate the frequency of mutations in ?-catenin gene (CTNNB1) and the subcellular localization of ?-catenin in HCC cases from Colombia. Material and methods: We determine by direct sequencing the frequency of mutations in exon 3 of CTNNB1 gene and by immunohistochemistry the subcellular localization of ?-catenin in 54 samples of HCC obtained from three pathology units in Bogota and Medellin cities. Results: Only three HCC cases (5.6%) were found mutated at residues (G34E, S45P, P44S, T41I) important for phosphorylation and ubiquitination of ?-catenin protein. Strikingly, nuclear or cytoplasmic accumulation of ?-catenin, hallmark of Wnt pathway activation, was found in 42.6% HCC cases (23/54). Interestingly, ?-catenin accumulation was significantly more frequent in young patients and hepatitis B virus-related HCC. Conclusions: Although, CTNNB1 exon 3 mutations are not frequent in HCC from Colombian patients, our findings indicate that Wnt/?-catenin signaling is activated in 42.6% of HCC samples. Furthermore, Wnt signaling was demonstrated in HCC cases associated of HBV infection, one of the most important HCC risk factors in Colombia. Mención de responsabilidad : Iris Suarez M, Diego Uribe, Carlos M Jaramillo, German Osorio, Juan C Perez, Rocio Lopez, Sergio Hoyos, Pierre Hainaut, Pascal Pineau, Maria-C Navas Referencia : Ann Hepatol. 2015 Jan-Feb;14(1):64-74. PMID : 25536643 En línea : http://annalsofhepatology.com/vista?accion=viewArticle&idart=1140 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3920 Wnt/beta-catenin signaling pathway in hepatocellular carcinomas cases from Colombia [documento electrónico] / Sergio Iván Hoyos Duque, ; Juan Camilo Pérez Cadavid,  . - 2015. Obra : Annals of Hepatology Idioma : Inglés (eng) Palabras clave : HCC  Subcellular localization  Wnt/β-catenin  CTNNB1  Mutation  HBV infection Resumen : Background and aim: Hepatocellular carcinoma (HCC) is the most common primary liver cancer diagnosed worldwide. Deregulation of Wnt/?-catenin pathway has been associated with the development of HCC in a substantial number of cases in Europe and far less in Asia. Nothing is known about this pathway in HCC cases from South America. This study aimed to investigate the frequency of mutations in ?-catenin gene (CTNNB1) and the subcellular localization of ?-catenin in HCC cases from Colombia. Material and methods: We determine by direct sequencing the frequency of mutations in exon 3 of CTNNB1 gene and by immunohistochemistry the subcellular localization of ?-catenin in 54 samples of HCC obtained from three pathology units in Bogota and Medellin cities. Results: Only three HCC cases (5.6%) were found mutated at residues (G34E, S45P, P44S, T41I) important for phosphorylation and ubiquitination of ?-catenin protein. Strikingly, nuclear or cytoplasmic accumulation of ?-catenin, hallmark of Wnt pathway activation, was found in 42.6% HCC cases (23/54). Interestingly, ?-catenin accumulation was significantly more frequent in young patients and hepatitis B virus-related HCC. Conclusions: Although, CTNNB1 exon 3 mutations are not frequent in HCC from Colombian patients, our findings indicate that Wnt/?-catenin signaling is activated in 42.6% of HCC samples. Furthermore, Wnt signaling was demonstrated in HCC cases associated of HBV infection, one of the most important HCC risk factors in Colombia. Mención de responsabilidad : Iris Suarez M, Diego Uribe, Carlos M Jaramillo, German Osorio, Juan C Perez, Rocio Lopez, Sergio Hoyos, Pierre Hainaut, Pascal Pineau, Maria-C Navas Referencia : Ann Hepatol. 2015 Jan-Feb;14(1):64-74. PMID : 25536643 En línea : http://annalsofhepatology.com/vista?accion=viewArticle&idart=1140 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3920

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Acute liver failure due to white phosphorus ingestion / Óscar Mauricio Santos Sánchez ; Juan Carlos Restrepo Gutiérrez ; Gonzalo Correa Arango ; María Elsy Sepúlveda Hincapie ; Nora Luz Yepes Palacio ; Sergio Iván Hoyos Duque ; Carlos Ernesto Guzmán Luna  

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Orthotopic liver transplantation in an adult with situs inversus: an easy way to fit the liver / Sergio Iván Hoyos Duque ; Gonzalo Correa Arango ; Juan Carlos Restrepo Gutiérrez ; Hernán Darío Franco Yepes ; Andrés Cárdenas  

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