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Annals of Hepatology
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Documentos disponibles con este título uniforme (11)
Clasificado(s) por (Año de edición descendente) Refinar búsquedaLatin American association for the study of the liver (ALEH) guidance on postoperative care after liver transplantation / Juan Carlos Restrepo Gutiérrez ; Codes, Liana ; Zapata, Rodrigo ; Mendizabal, Manuel ; Fleck Junior, Alfeu de Medeiros ; de Lucca Schiavon, Leonardo ; Sá Malbouisson, Luiz Marcelo ; Andraus, Wellington ; Gadano, Adrian ; Padilla Machaca, P Martin ; Bello Stucchi, Raquel Silveira ; Castro Narro, Graciela Elia ; Pages, Josefina ; Benedita Terrabuio, Debora Raquel ; Urzúa, Álvaro ; Guimarães Pesso, Mário ; Mainardi, Victoria ; Rodolpho, Pedro ; Imventarza, Oscar ; Gerona, Solange ; Wolff, Rodrigo ; Abdala, Edson ; Tenorio, Laura ; Cerda Reyes, Eira ; Cairo, Fernando ; Uribe, Mario ; Lisboa Bittencourt, Paulo
Título : Latin American association for the study of the liver (ALEH) guidance on postoperative care after liver transplantation Tipo de documento : documento electrónico Autores : Juan Carlos Restrepo Gutiérrez, Autor ; Codes, Liana, Autor ; Zapata, Rodrigo, Autor ; Mendizabal, Manuel, Autor ; Fleck Junior, Alfeu de Medeiros, Autor ; de Lucca Schiavon, Leonardo, Autor ; Sá Malbouisson, Luiz Marcelo, Autor ; Andraus, Wellington, Autor ; Gadano, Adrian, Autor ; Padilla Machaca, P Martin, Autor ; Bello Stucchi, Raquel Silveira, Autor ; Castro Narro, Graciela Elia, Autor ; Pages, Josefina, Autor ; Benedita Terrabuio, Debora Raquel, Autor ; Urzúa, Álvaro, Autor ; Guimarães Pesso, Mário, Autor ; Mainardi, Victoria, Autor ; Rodolpho, Pedro, Autor ; Imventarza, Oscar, Autor ; Gerona, Solange, Autor ; Wolff, Rodrigo, Autor ; Abdala, Edson, Autor ; Tenorio, Laura, Autor ; Cerda Reyes, Eira, Autor ; Cairo, Fernando, Autor ; Uribe, Mario, Autor ; Lisboa Bittencourt, Paulo, Autor Fecha de publicación : 2025 Títulos uniformes : Annals of Hepatology Idioma : Inglés (eng) Palabras clave : Immunosuppression; Latin America; Liver transplantation; Postoperative care Resumen : Liver transplantation (LT) is a well-established therapy for patients with decompensated cirrhosis and early-stage hepatocellular carcinoma. Liver transplantation activity varies sharply across Latin American (LATAM) countries due to differences in resources, expertise, and funding and local attitudes toward organ donation and transplantation. This current guidance of postoperative care after LT is the first position paper of the Latin American Association for the Study of the Liver (ALEH) Special Interest Group (SIG), drawing evidence-based recommendations regarding immediate and long-term postoperative care of LT recipients, taking into consideration their applicability in Latin America. © 2025 Fundación Clínica Médica Sur, A.C. Mención de responsabilidad : Codes, Liana; Zapata, Rodrigo; Mendizabal, Manuel; Junior, Alfeu de Medeiros Fleck; Restrepo, Juan Carlos; Schiavon, Leonardo de Lucca; Malbouisson, Luiz Marcelo Sá; Andraus, Wellington; Gadano, Adrian; Padilla-Machaca, P. Martin; Villamil, Alejandra; Stucchi, Raquel Silveira Bello; Castro-Narro, Graciela Elia; Pages, Josefina; Terrabuio, Debora Raquel Benedita; Urzúa, Alvaro; Pessoa, Mário Guimarães; Mainardi, Victoria; Pedro, Rodolpho; Imventarza, Oscar; Gerona, Solange; Wolff, Rodrigo; Abdala, Edson; Tenorio, Laura; Cerda-Reyes, Eira; Cairo, Fernando; Uribe, Mario; Bittencourt, Paulo Lisboa; Chong, Ricardo; Figueroa, Norma Marlene Perez; González, John Byron Abad; Murillo, Pablo Coste. Referencia : Ann Hepatol . 2025 Mar 7;30(2):101899. doi: 10.1016/j.aohep.2025.101899. DOI (Digital Object Identifier) : 10.1016/j.aohep.2025.101899 PMID : 40057036 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40057036/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Latin American association for the study of the liver (ALEH) guidance on postoperative care after liver transplantation [documento electrónico] / Juan Carlos Restrepo Gutiérrez, Autor ; Codes, Liana, Autor ; Zapata, Rodrigo, Autor ; Mendizabal, Manuel, Autor ; Fleck Junior, Alfeu de Medeiros, Autor ; de Lucca Schiavon, Leonardo, Autor ; Sá Malbouisson, Luiz Marcelo, Autor ; Andraus, Wellington, Autor ; Gadano, Adrian, Autor ; Padilla Machaca, P Martin, Autor ; Bello Stucchi, Raquel Silveira, Autor ; Castro Narro, Graciela Elia, Autor ; Pages, Josefina, Autor ; Benedita Terrabuio, Debora Raquel, Autor ; Urzúa, Álvaro, Autor ; Guimarães Pesso, Mário, Autor ; Mainardi, Victoria, Autor ; Rodolpho, Pedro, Autor ; Imventarza, Oscar, Autor ; Gerona, Solange, Autor ; Wolff, Rodrigo, Autor ; Abdala, Edson, Autor ; Tenorio, Laura, Autor ; Cerda Reyes, Eira, Autor ; Cairo, Fernando, Autor ; Uribe, Mario, Autor ; Lisboa Bittencourt, Paulo, Autor . - 2025.
Obra : Annals of Hepatology
Idioma : Inglés (eng)
Palabras clave : Immunosuppression; Latin America; Liver transplantation; Postoperative care Resumen : Liver transplantation (LT) is a well-established therapy for patients with decompensated cirrhosis and early-stage hepatocellular carcinoma. Liver transplantation activity varies sharply across Latin American (LATAM) countries due to differences in resources, expertise, and funding and local attitudes toward organ donation and transplantation. This current guidance of postoperative care after LT is the first position paper of the Latin American Association for the Study of the Liver (ALEH) Special Interest Group (SIG), drawing evidence-based recommendations regarding immediate and long-term postoperative care of LT recipients, taking into consideration their applicability in Latin America. © 2025 Fundación Clínica Médica Sur, A.C. Mención de responsabilidad : Codes, Liana; Zapata, Rodrigo; Mendizabal, Manuel; Junior, Alfeu de Medeiros Fleck; Restrepo, Juan Carlos; Schiavon, Leonardo de Lucca; Malbouisson, Luiz Marcelo Sá; Andraus, Wellington; Gadano, Adrian; Padilla-Machaca, P. Martin; Villamil, Alejandra; Stucchi, Raquel Silveira Bello; Castro-Narro, Graciela Elia; Pages, Josefina; Terrabuio, Debora Raquel Benedita; Urzúa, Alvaro; Pessoa, Mário Guimarães; Mainardi, Victoria; Pedro, Rodolpho; Imventarza, Oscar; Gerona, Solange; Wolff, Rodrigo; Abdala, Edson; Tenorio, Laura; Cerda-Reyes, Eira; Cairo, Fernando; Uribe, Mario; Bittencourt, Paulo Lisboa; Chong, Ricardo; Figueroa, Norma Marlene Perez; González, John Byron Abad; Murillo, Pablo Coste. Referencia : Ann Hepatol . 2025 Mar 7;30(2):101899. doi: 10.1016/j.aohep.2025.101899. DOI (Digital Object Identifier) : 10.1016/j.aohep.2025.101899 PMID : 40057036 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40057036/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Latin American expert opinion letter on the feasibility of systemic therapies in combination with locoregional therapies for hepatocellular carcinoma Tipo de documento : documento electrónico Autores : Anders, Margarita, Autor ; Mattos, Angelo Z, Autor ; Debes, José D, Autor ; Beltrán, Oscar, Autor ; Coste, Pablo, Autor ; Juan Ignacio Marín Zuluaga, Autor ; Lopes Chagas, Aline, Autor ; Menéndez, Josemaría, Autor ; Carrera Estupiñán, Enrique, Autor ; Diaz Ferrer, Javier, Autor ; Mattos, Angelo Z, Autor ; Piñero, Federico, Autor Fecha de publicación : 2025 Títulos uniformes : Annals of Hepatology Idioma : Inglés (eng) Palabras clave : Carcinoma; Drug therapy Adjuvant; Hepatocellular; Immunotherapy; Neoadjuvant therapy. Resumen : Recent advances in the systemic treatment of advanced hepatocellular carcinoma (HCC) with immunotherapy have once again reignited discussion over the role of combined therapy in earlier stages. This year, different international meetings have presented recent results from clinical trials on adjuvant therapy alone (IMBrave-050) and combined with transarterial chemoembolization (EMERALD-1 and LEAP-12). Increased enthusiasm for the use of adjuvant and neoadjuvant therapy for liver transplantation, surgery, and local-regional treatment of HCC has been shown. However, the initial results from these trials should be interpreted cautiously as we wait for final analyses and effects on overall survival. In this position paper from the special interest group from the Latin American Association for the Study of Liver Diseases (ALEH), we underline the caveats of the applicability of these potential treatments in our region, explore points of agreement, and highlight areas of uncertainty. Moreover, we underscore the role of hepatologists in the clinical decision-making process and management of these patients. Mención de responsabilidad : Marìa Margarita Anders, Angelo Z Mattos, José D Debes, Oscar Beltran, Pablo Coste, Juan Ignacio Marín, Aline Lopes Chagas, Josemaría Menéndez, Enrique Carrera Estupiñan, Javier Diaz Ferrer, Angelo A Mattos, Federico Piñero Referencia : Anders MM, Mattos AZ, Debes JD, Beltran O, Coste P, Marín JI, Chagas AL, Menéndez J, Estupiñan EC, F DOI (Digital Object Identifier) : 10.1016/j.aohep.2025.101905 PMID : 40122521 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40122521/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Latin American expert opinion letter on the feasibility of systemic therapies in combination with locoregional therapies for hepatocellular carcinoma [documento electrónico] / Anders, Margarita, Autor ; Mattos, Angelo Z, Autor ; Debes, José D, Autor ; Beltrán, Oscar, Autor ; Coste, Pablo, Autor ; Juan Ignacio Marín Zuluaga, Autor ; Lopes Chagas, Aline, Autor ; Menéndez, Josemaría, Autor ; Carrera Estupiñán, Enrique, Autor ; Diaz Ferrer, Javier, Autor ; Mattos, Angelo Z, Autor ; Piñero, Federico, Autor . - 2025.
Obra : Annals of Hepatology
Idioma : Inglés (eng)
Palabras clave : Carcinoma; Drug therapy Adjuvant; Hepatocellular; Immunotherapy; Neoadjuvant therapy. Resumen : Recent advances in the systemic treatment of advanced hepatocellular carcinoma (HCC) with immunotherapy have once again reignited discussion over the role of combined therapy in earlier stages. This year, different international meetings have presented recent results from clinical trials on adjuvant therapy alone (IMBrave-050) and combined with transarterial chemoembolization (EMERALD-1 and LEAP-12). Increased enthusiasm for the use of adjuvant and neoadjuvant therapy for liver transplantation, surgery, and local-regional treatment of HCC has been shown. However, the initial results from these trials should be interpreted cautiously as we wait for final analyses and effects on overall survival. In this position paper from the special interest group from the Latin American Association for the Study of Liver Diseases (ALEH), we underline the caveats of the applicability of these potential treatments in our region, explore points of agreement, and highlight areas of uncertainty. Moreover, we underscore the role of hepatologists in the clinical decision-making process and management of these patients. Mención de responsabilidad : Marìa Margarita Anders, Angelo Z Mattos, José D Debes, Oscar Beltran, Pablo Coste, Juan Ignacio Marín, Aline Lopes Chagas, Josemaría Menéndez, Enrique Carrera Estupiñan, Javier Diaz Ferrer, Angelo A Mattos, Federico Piñero Referencia : Anders MM, Mattos AZ, Debes JD, Beltran O, Coste P, Marín JI, Chagas AL, Menéndez J, Estupiñan EC, F DOI (Digital Object Identifier) : 10.1016/j.aohep.2025.101905 PMID : 40122521 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40122521/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : O-6 EXPLORING THE IMPACT OF INFECTIONS IN PATIENTS WITH ALCOHOL- ASSOCIATED HEPATITIS IN LATIN AMERICA Tipo de documento : documento electrónico Autores : Juan Carlos Restrepo Gutiérrez, Autor Fecha de publicación : 2024 Títulos uniformes : Annals of Hepatology Idioma : Inglés (eng) Resumen : Introduction and Methods Severe alcohol-associated hepatitis (AH) is frequently associated with higher infection risk. This study aimed to assess the impact of infections in patients with AH in a multinational cohort in Latin America. Materials and Methods Multicenter prospective cohort study including patients with AH (2015-2022). We recorded clinical information, and the impact of infections was assessed using competing-risk models. Results We included 511 patients from 24 centers in 8 countries (Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Mexico, and Peru). The mean age was 50.1±11.9 years, 426 (83.9%) were men, 264 (58.2%) had a previous diagnosis of cirrhosis, and the median MELD at diagnosis was 24.6 [19.6–30.6] points. Out of the total, 25.9% died, and only 3.7% underwent liver transplantation during follow-up. Also, 44.5% of patients developed an infection. Of them, 50.9% presented with infection at admission, 30.8% developed an infection during hospitalization, and 18.3% presented an infection in both situations. The most common localizations at admission were pulmonary (32.4%), urinary tract (33.1%), spontaneous bacterial peritonitis (15.9%), and cutaneous (9.7%). The main localizations during hospitalization were pulmonary (34.4%), urinary tract (25.8%), spontaneous bacterial peritonitis (14.0%), and bacteremia (8.6%%). The incidence of multidrug-resistant (MDR) organisms was 11.2% at admission and 10.3% during hospitalization, while the incidence of extensively drug-resistant (XDR) organisms was 1.4% and 4.7%, respectively. The presence of infection was associated with higher mortality (sub-distribution hazard ratio [sHR] 1.92, 95%CI:1.56–2.37; p Mención de responsabilidad : Luis Antonio Díaz, Francisco Idalsoaga, Gustavo Ayares, Jorge Arnold, Katherine Maldonado, María Ayala, Diego Perez, Jaime Gomez, Rodrigo Escarate, Eduardo Fuentes, Juan Pablo Roblero, Blanca Norero, Raul Lazarte, José Antonio Velarde, Janett Jacobo, Jacqueline Córdova, Fátima Higuera-de-la-Tijera, Jesús Varela, Scherezada Mejía, Rita Silva, Cristina Melo, Roberta C. Araujo, Gustavo Henrique Pereira, Claudia Couto,fernando Bessone, Mario Tanno, Gustavo Romero, Manuel Mendizabal, Sebastián Marciano, Gonzalo Gomez,Melisa Dirchwolf, Pedro Montes, Patricia Guerra, Geraldine Ramos, Juan Carlos Restrepo, Enrique Carrera, Mayur Brahmania, Ashwani Singal, Ramón Bataller, Vijay Shah, Patrick S. Kamath,Marco Arrese,Juan Pablo Arab Referencia : Annals of Hepatology Volume 29, Supplement 1, February 2024, 101256 DOI (Digital Object Identifier) : 10.1016/j.aohep.2023.101256 Derechos de uso : CC BY-NC-ND En línea : https://www.sciencedirect.com/science/article/pii/S1665268123003599 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis O-6 EXPLORING THE IMPACT OF INFECTIONS IN PATIENTS WITH ALCOHOL- ASSOCIATED HEPATITIS IN LATIN AMERICA [documento electrónico] / Juan Carlos Restrepo Gutiérrez, Autor . - 2024.
Obra : Annals of Hepatology
Idioma : Inglés (eng)
Resumen : Introduction and Methods Severe alcohol-associated hepatitis (AH) is frequently associated with higher infection risk. This study aimed to assess the impact of infections in patients with AH in a multinational cohort in Latin America. Materials and Methods Multicenter prospective cohort study including patients with AH (2015-2022). We recorded clinical information, and the impact of infections was assessed using competing-risk models. Results We included 511 patients from 24 centers in 8 countries (Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Mexico, and Peru). The mean age was 50.1±11.9 years, 426 (83.9%) were men, 264 (58.2%) had a previous diagnosis of cirrhosis, and the median MELD at diagnosis was 24.6 [19.6–30.6] points. Out of the total, 25.9% died, and only 3.7% underwent liver transplantation during follow-up. Also, 44.5% of patients developed an infection. Of them, 50.9% presented with infection at admission, 30.8% developed an infection during hospitalization, and 18.3% presented an infection in both situations. The most common localizations at admission were pulmonary (32.4%), urinary tract (33.1%), spontaneous bacterial peritonitis (15.9%), and cutaneous (9.7%). The main localizations during hospitalization were pulmonary (34.4%), urinary tract (25.8%), spontaneous bacterial peritonitis (14.0%), and bacteremia (8.6%%). The incidence of multidrug-resistant (MDR) organisms was 11.2% at admission and 10.3% during hospitalization, while the incidence of extensively drug-resistant (XDR) organisms was 1.4% and 4.7%, respectively. The presence of infection was associated with higher mortality (sub-distribution hazard ratio [sHR] 1.92, 95%CI:1.56–2.37; p Mención de responsabilidad : Luis Antonio Díaz, Francisco Idalsoaga, Gustavo Ayares, Jorge Arnold, Katherine Maldonado, María Ayala, Diego Perez, Jaime Gomez, Rodrigo Escarate, Eduardo Fuentes, Juan Pablo Roblero, Blanca Norero, Raul Lazarte, José Antonio Velarde, Janett Jacobo, Jacqueline Córdova, Fátima Higuera-de-la-Tijera, Jesús Varela, Scherezada Mejía, Rita Silva, Cristina Melo, Roberta C. Araujo, Gustavo Henrique Pereira, Claudia Couto,fernando Bessone, Mario Tanno, Gustavo Romero, Manuel Mendizabal, Sebastián Marciano, Gonzalo Gomez,Melisa Dirchwolf, Pedro Montes, Patricia Guerra, Geraldine Ramos, Juan Carlos Restrepo, Enrique Carrera, Mayur Brahmania, Ashwani Singal, Ramón Bataller, Vijay Shah, Patrick S. Kamath,Marco Arrese,Juan Pablo Arab Referencia : Annals of Hepatology Volume 29, Supplement 1, February 2024, 101256 DOI (Digital Object Identifier) : 10.1016/j.aohep.2023.101256 Derechos de uso : CC BY-NC-ND En línea : https://www.sciencedirect.com/science/article/pii/S1665268123003599 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : O-7 CURRENT PRACTICE OF LIVER TRANSPLANTATION IN LATIN AMERICAN COUNTRIES: AN ALEH INTEREST GROUP SURVEY 2023 Tipo de documento : documento electrónico Autores : Juan Carlos Restrepo Gutiérrez, Autor Fecha de publicación : 2024 Títulos uniformes : Annals of Hepatology Idioma : Inglés (eng) Resumen : Introduction and Objectives Little is known about current practice of liver transplantation (LT) in Latin American countries (LATAM). This study aimed to describe LT activity, immunosuppression protocols and policies regarding prophylaxis of cytomegalovirus (CMV) infection and hepatitis B virus (HBV) recurrence in different active LATAM centers. Materials and Methods A web-based survey with 20 questions regarding LT practice was sent to all members of ALEH LT SIG in December 2022. Results 22 centers performing 35 [5-160] LT per year from Brazil (n=5), Argentina (n=4), Chile (n=4), Ecuador (n-2), Mexico (n=2), Colombia (n=1), Costa Rica (n=1), Peru (n=1), Dominican Republic (n=1) and Uruguay (n=1) answered the survey. Tacrolimus, mycophenolate and prednisone was the main immunosuppressive regimen employed by most (72%) centers and 81% of them referred basiliximab use for induction therapy in selected patients. Tailoring of immunosuppression was universally accepted, particularly in autoimmune hepatitis (AIH) (59%), hepatocellular carcinoma (54%) kidney dysfunction (77%) and primary biliary cirrhosis (33%). Weaning of corticosteroids at three, six and 12 months after LT was reported, respectively, by 41%, 36% and 23% of the centers, but policy for lifelong corticosteroid use in AIH-transplanted subjects was commonly observed (90%). Just four centers are currently performing protocol liver biopsies, while 18 of them are considering liver biopsy prior to steroid pulse therapy. HBIG and nucleos(t)ide analogs are used in most instances (73%) for HBV recurrence prevention, whereas CMV infection prophylaxis was shown to vary sharply across centers. Of note, all but two of them referred major changes in LT practice over the years due to economical restraints. Conclusions Compliance with standard of care recommendations for management of LT was reported by most centers. Heterogeneity in practices regarding HBV infection recurrence and CMV prophylaxis may reflect local financial restraints and point to the importance of developing ALEH guidelines to encourage LT activity in LATAM. Mención de responsabilidad : Paulo Bittencourt, Liana Codes, Adrian Gadano, Alejandra Villamil, Alfeu de Medeiros Fleck Jr, Álvaro Urzua, Debora Raquel Terrabuio, Eira Cerda, Graciela Elia Castro Narro, Ignacio Roca, John Abad González, Josefina Pages, Juan Carlos Restrepo Gutierrez, Leonardo de Lucca Schiavon, Mario Uribe, Martin Padilla, Norma Marlene Perez Figueroa, Pablo Coste Murillo, Raquel Stucchi, Ricardo Chong, Rodrigo Wolff, Victoria Mainardi, Rodrigo Zapata. Referencia : Annals of Hepatology Volume 29, Supplement 1, February 2024, 101257 DOI (Digital Object Identifier) : 10.1016/j.aohep.2023.101257 Derechos de uso : CC BY-NC-ND En línea : https://www.sciencedirect.com/science/article/pii/S1665268123003605 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis O-7 CURRENT PRACTICE OF LIVER TRANSPLANTATION IN LATIN AMERICAN COUNTRIES: AN ALEH INTEREST GROUP SURVEY 2023 [documento electrónico] / Juan Carlos Restrepo Gutiérrez, Autor . - 2024.
Obra : Annals of Hepatology
Idioma : Inglés (eng)
Resumen : Introduction and Objectives Little is known about current practice of liver transplantation (LT) in Latin American countries (LATAM). This study aimed to describe LT activity, immunosuppression protocols and policies regarding prophylaxis of cytomegalovirus (CMV) infection and hepatitis B virus (HBV) recurrence in different active LATAM centers. Materials and Methods A web-based survey with 20 questions regarding LT practice was sent to all members of ALEH LT SIG in December 2022. Results 22 centers performing 35 [5-160] LT per year from Brazil (n=5), Argentina (n=4), Chile (n=4), Ecuador (n-2), Mexico (n=2), Colombia (n=1), Costa Rica (n=1), Peru (n=1), Dominican Republic (n=1) and Uruguay (n=1) answered the survey. Tacrolimus, mycophenolate and prednisone was the main immunosuppressive regimen employed by most (72%) centers and 81% of them referred basiliximab use for induction therapy in selected patients. Tailoring of immunosuppression was universally accepted, particularly in autoimmune hepatitis (AIH) (59%), hepatocellular carcinoma (54%) kidney dysfunction (77%) and primary biliary cirrhosis (33%). Weaning of corticosteroids at three, six and 12 months after LT was reported, respectively, by 41%, 36% and 23% of the centers, but policy for lifelong corticosteroid use in AIH-transplanted subjects was commonly observed (90%). Just four centers are currently performing protocol liver biopsies, while 18 of them are considering liver biopsy prior to steroid pulse therapy. HBIG and nucleos(t)ide analogs are used in most instances (73%) for HBV recurrence prevention, whereas CMV infection prophylaxis was shown to vary sharply across centers. Of note, all but two of them referred major changes in LT practice over the years due to economical restraints. Conclusions Compliance with standard of care recommendations for management of LT was reported by most centers. Heterogeneity in practices regarding HBV infection recurrence and CMV prophylaxis may reflect local financial restraints and point to the importance of developing ALEH guidelines to encourage LT activity in LATAM. Mención de responsabilidad : Paulo Bittencourt, Liana Codes, Adrian Gadano, Alejandra Villamil, Alfeu de Medeiros Fleck Jr, Álvaro Urzua, Debora Raquel Terrabuio, Eira Cerda, Graciela Elia Castro Narro, Ignacio Roca, John Abad González, Josefina Pages, Juan Carlos Restrepo Gutierrez, Leonardo de Lucca Schiavon, Mario Uribe, Martin Padilla, Norma Marlene Perez Figueroa, Pablo Coste Murillo, Raquel Stucchi, Ricardo Chong, Rodrigo Wolff, Victoria Mainardi, Rodrigo Zapata. Referencia : Annals of Hepatology Volume 29, Supplement 1, February 2024, 101257 DOI (Digital Object Identifier) : 10.1016/j.aohep.2023.101257 Derechos de uso : CC BY-NC-ND En línea : https://www.sciencedirect.com/science/article/pii/S1665268123003605 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Latin American Association for the study of the liver (ALEH) practice guidance for the diagnosis and treatment of non-alcoholic fatty liver disease Tipo de documento : documento electrónico Autores : Juan Carlos Restrepo Gutiérrez, Fecha de publicación : 2020 Títulos uniformes : Annals of Hepatology Idioma : Inglés (eng) Palabras clave : Steatosis NAFLD NASH Fatty liver Clinical practice guidance Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis MAFLD Cirrhosis Resumen : Non-alcoholic fatty liver disease (NAFLD) currently represents an epidemic worldwide. NAFLD is the most frequently diagnosed chronic liver disease, affecting 20–30% of the general population. Furthermore, its prevalence is predicted to increase exponentially in the next decades, concomitantly with the global epidemic of obesity, type 2 diabetes mellitus (T2DM), and sedentary lifestyle. NAFLD is a clinical syndrome that encompasses a wide spectrum of associated diseases and hepatic complications such as hepatocellular carcinoma (HCC). Moreover, this disease is believed to become the main indication for liver transplantation in the near future. Since NAFLD management represents a growing challenge for primary care physicians, the Asociación Latinoamericana para el Estudio del Hígado (ALEH) has decided to organize this Practice Guidance for the Diagnosis and Treatment of Non-Alcoholic Fatty Liver Disease, written by Latin-American specialists in different clinical areas, and destined to general practitioners, internal medicine specialists, endocrinologists, diabetologists, gastroenterologists, and hepatologists. The main purpose of this document is to improve patient care and awareness of NAFLD. The information provided in this guidance may also be useful in assisting stakeholders in the decision-making process related to NAFLD. Since new evidence is constantly emerging on different aspects of the disease, updates to this guideline will be required in future. Mención de responsabilidad : Juan Pablo Arab, Melisa Dirchwolf, Mário Reis Álvares-da-Silva, Francisco Barrera, Carlos Benítez, Marlene Castellanos-Fernandez, Graciela Castro-Narro, Norberto Chavez-Tapia, Daniela Chiodi, Helma Cotrim, Kenneth Cusi, Claudia Pinto Marques Souza de Oliveira, Javier Díaz, Eduardo Fassio, Solange Gerona, Marcos Girala, Nelia Hernandez, Sebastián Marciano, Walter Masson, Nahum Méndez-Sánchez, Nathalie Leite, Adelina Lozano, Martín Padilla, Arturo Panduro, Raymundo Paraná, Edison Parise, Marlene Perez, Jaime Poniachik, Juan Carlos Restrepo, Andrés Ruf, Marcelo Silva, Martín Tagle, Monica Tapias, Kenia Torres, Eduardo Vilar-Gomez, José Eduardo Costa Gil, Adrian Gadano, Marco Arrese Referencia : Ann Hepatol. Nov-Dec 2020;19(6):674-690. DOI (Digital Object Identifier) : 10.1016/j.aohep.2020.09.006 PMID : 33031970 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S1665268120301770 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Latin American Association for the study of the liver (ALEH) practice guidance for the diagnosis and treatment of non-alcoholic fatty liver disease [documento electrónico] / Juan Carlos Restrepo Gutiérrez, . - 2020.
Obra : Annals of Hepatology
Idioma : Inglés (eng)
Palabras clave : Steatosis NAFLD NASH Fatty liver Clinical practice guidance Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis MAFLD Cirrhosis Resumen : Non-alcoholic fatty liver disease (NAFLD) currently represents an epidemic worldwide. NAFLD is the most frequently diagnosed chronic liver disease, affecting 20–30% of the general population. Furthermore, its prevalence is predicted to increase exponentially in the next decades, concomitantly with the global epidemic of obesity, type 2 diabetes mellitus (T2DM), and sedentary lifestyle. NAFLD is a clinical syndrome that encompasses a wide spectrum of associated diseases and hepatic complications such as hepatocellular carcinoma (HCC). Moreover, this disease is believed to become the main indication for liver transplantation in the near future. Since NAFLD management represents a growing challenge for primary care physicians, the Asociación Latinoamericana para el Estudio del Hígado (ALEH) has decided to organize this Practice Guidance for the Diagnosis and Treatment of Non-Alcoholic Fatty Liver Disease, written by Latin-American specialists in different clinical areas, and destined to general practitioners, internal medicine specialists, endocrinologists, diabetologists, gastroenterologists, and hepatologists. The main purpose of this document is to improve patient care and awareness of NAFLD. The information provided in this guidance may also be useful in assisting stakeholders in the decision-making process related to NAFLD. Since new evidence is constantly emerging on different aspects of the disease, updates to this guideline will be required in future. Mención de responsabilidad : Juan Pablo Arab, Melisa Dirchwolf, Mário Reis Álvares-da-Silva, Francisco Barrera, Carlos Benítez, Marlene Castellanos-Fernandez, Graciela Castro-Narro, Norberto Chavez-Tapia, Daniela Chiodi, Helma Cotrim, Kenneth Cusi, Claudia Pinto Marques Souza de Oliveira, Javier Díaz, Eduardo Fassio, Solange Gerona, Marcos Girala, Nelia Hernandez, Sebastián Marciano, Walter Masson, Nahum Méndez-Sánchez, Nathalie Leite, Adelina Lozano, Martín Padilla, Arturo Panduro, Raymundo Paraná, Edison Parise, Marlene Perez, Jaime Poniachik, Juan Carlos Restrepo, Andrés Ruf, Marcelo Silva, Martín Tagle, Monica Tapias, Kenia Torres, Eduardo Vilar-Gomez, José Eduardo Costa Gil, Adrian Gadano, Marco Arrese Referencia : Ann Hepatol. Nov-Dec 2020;19(6):674-690. DOI (Digital Object Identifier) : 10.1016/j.aohep.2020.09.006 PMID : 33031970 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S1665268120301770 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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