Albendazole-induced granulomatous hepatitis: a case report / Juan Ignacio Marín Zuluaga ; Andres Eduardo Marín Castro ; Juan Camilo Pérez Cadavid ; Juan Carlos Restrepo Gutiérrez    

Público ISBD Título : Albendazole-induced granulomatous hepatitis: a case report Tipo de documento : documento electrónico Autores : Juan Ignacio Marín Zuluaga, ; Andres Eduardo Marín Castro, ; Juan Camilo Pérez Cadavid, ; Juan Carlos Restrepo Gutiérrez, Fecha de publicación : 2013 Títulos uniformes : Journal of Medical Case Reports Idioma : Inglés (eng) Resumen : Introduction: Drug-related hepatotoxicity is a common medical problem with implications for health systems. It constitutes a cause of acute liver failure and, in many cases, is responsible for the rejection of new pharmacological agents during efficacy and safety studies. Risk factors, as well as pathogenesis of drug-induced liver injury, are poorly understood. The diagnosis of drug-induced liver injury is challenging; it is difficult to define the cause of drug hepatotoxicity due to the heterogeneity of the clinical presentation and the absence of established criteria for accurate and reproducible identification of drug-associated liver toxicity. Case presentation: We report the case of a 25-year-old Hispanic woman admitted to our Clinical Hepatology Unit with symptoms of acute hepatitis of unknown etiology. She was diagnosed with albendazole-induced granulomatous hepatitis after ruling out other possible causes, based on laboratory studies, liver biopsy, medical history, detailed drug history, and spontaneous improvement of her liver biochemical profile after medication withdrawal. This diagnosis was supported by the Council for International Organizations of Medical Sciences-Roussel Uclaf Causality Assessment Method, which showed a likely correlation between hepatocellular damage and drug toxicity as the etiology. Conclusions: Our patient’s suspected diagnosis was albendazole-induced granulomatous hepatitis with confirmatory histologic pattern. This case deserves particular attention due to the wide use of albendazole in our country (Colombia) and the prevalent medical issue of drug-related hepatotoxicity Mención de responsabilidad : Juan Ignacio Marin Zuluaga, Andres Eduardo Marin Castro, Juan Camilo Perez Cadavid, Juan Carlos Restrepo Gutierrez Referencia : J Med Case Rep. 2013 Jul 26;7:201. DOI (Digital Object Identifier) : 10.1186/1752-1947-7-201 PMID : 23889970 Derechos de uso : CC BY En línea : https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-7-201 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4521 Albendazole-induced granulomatous hepatitis: a case report [documento electrónico] / Juan Ignacio Marín Zuluaga, ; Andres Eduardo Marín Castro, ; Juan Camilo Pérez Cadavid, ; Juan Carlos Restrepo Gutiérrez,  . - 2013. Obra : Journal of Medical Case Reports Idioma : Inglés (eng) Resumen : Introduction: Drug-related hepatotoxicity is a common medical problem with implications for health systems. It constitutes a cause of acute liver failure and, in many cases, is responsible for the rejection of new pharmacological agents during efficacy and safety studies. Risk factors, as well as pathogenesis of drug-induced liver injury, are poorly understood. The diagnosis of drug-induced liver injury is challenging; it is difficult to define the cause of drug hepatotoxicity due to the heterogeneity of the clinical presentation and the absence of established criteria for accurate and reproducible identification of drug-associated liver toxicity. Case presentation: We report the case of a 25-year-old Hispanic woman admitted to our Clinical Hepatology Unit with symptoms of acute hepatitis of unknown etiology. She was diagnosed with albendazole-induced granulomatous hepatitis after ruling out other possible causes, based on laboratory studies, liver biopsy, medical history, detailed drug history, and spontaneous improvement of her liver biochemical profile after medication withdrawal. This diagnosis was supported by the Council for International Organizations of Medical Sciences-Roussel Uclaf Causality Assessment Method, which showed a likely correlation between hepatocellular damage and drug toxicity as the etiology. Conclusions: Our patient’s suspected diagnosis was albendazole-induced granulomatous hepatitis with confirmatory histologic pattern. This case deserves particular attention due to the wide use of albendazole in our country (Colombia) and the prevalent medical issue of drug-related hepatotoxicity Mención de responsabilidad : Juan Ignacio Marin Zuluaga, Andres Eduardo Marin Castro, Juan Camilo Perez Cadavid, Juan Carlos Restrepo Gutierrez Referencia : J Med Case Rep. 2013 Jul 26;7:201. DOI (Digital Object Identifier) : 10.1186/1752-1947-7-201 PMID : 23889970 Derechos de uso : CC BY En línea : https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-7-201 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4521

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A 60-year-old man with chronic renal failure and a costal mass: a case report and review of the literature / Germán Campuzano Zuluaga ; William Orlando Velasco Pérez ; Juan Ignacio Marín Zuluaga    

Público ISBD Título : A 60-year-old man with chronic renal failure and a costal mass: a case report and review of the literature Tipo de documento : documento electrónico Autores : Germán Campuzano Zuluaga, ; William Orlando Velasco Pérez, ; Juan Ignacio Marín Zuluaga, Fecha de publicación : 2009 Títulos uniformes : Journal of Medical Case Reports Idioma : Inglés (eng) Resumen : Introduction: Brown tumors are a rare focal manifestation of osteitis fibrosa cystica, which results from hyperparathyroidism. Chronic kidney failure may lead to secondary or tertiary hyperparathyroidism and thus to osteitis fibrosa cystica and brown tumors. Case preseentation: A 60-year-old man with a history of diabetes mellitus and chronic kidney failure presented with a 15-day history of dyspnea, cough, malaise and fever. Initially, there was little correlation between his history and his physical examination. Various pulmonary, cardiac and infectious etiologies were ruled out. A chest X-ray showed a costal mass that was further verified by tomography and gammagraphy. The mass was suspected of being neoplastic. After a failed biopsy, the mass was removed surgically and on histopathology was compatible with a giant-cell tumor versus a brown tumor caused by hyperparathyroidism. Laboratory tests showed elevated calcium, phosphate and parathyroid hormone concentrations. The patient was diagnosed with a brown tumor secondary to refractory hyperparathyroidism. Conclusion: Tending towards a diagnosis because it is more frequent or it implies more risk for the patient may delay the consideration of other diagnostic options that, although rare, fit well into the clinical context. The patient presented here was suspected to have an osseous neoplasia that would have had major implications for the patient. However, reassessment of the case led to the diagnosis of a brown tumor. Brown tumors should be an important diagnostic consideration in patients with chronic kidney failure who have secondary or tertiary hyperparathyroidism and an osseous mass. Mención de responsabilidad : Germán Campuzano-Zuluaga, William Velasco-Pérez & Juan Ignacio Marín-Zuluaga Referencia : J Med Case Rep. 2009 Aug 4;3:7285. DOI (Digital Object Identifier) : 10.4076/1752-1947-3-7285 PMID : 19830164 Derechos de uso : CC BY En línea : https://jmedicalcasereports.biomedcentral.com/articles/10.4076/1752-1947-3-7285 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3478 A 60-year-old man with chronic renal failure and a costal mass: a case report and review of the literature [documento electrónico] / Germán Campuzano Zuluaga, ; William Orlando Velasco Pérez, ; Juan Ignacio Marín Zuluaga,  . - 2009. Obra : Journal of Medical Case Reports Idioma : Inglés (eng) Resumen : Introduction: Brown tumors are a rare focal manifestation of osteitis fibrosa cystica, which results from hyperparathyroidism. Chronic kidney failure may lead to secondary or tertiary hyperparathyroidism and thus to osteitis fibrosa cystica and brown tumors. Case preseentation: A 60-year-old man with a history of diabetes mellitus and chronic kidney failure presented with a 15-day history of dyspnea, cough, malaise and fever. Initially, there was little correlation between his history and his physical examination. Various pulmonary, cardiac and infectious etiologies were ruled out. A chest X-ray showed a costal mass that was further verified by tomography and gammagraphy. The mass was suspected of being neoplastic. After a failed biopsy, the mass was removed surgically and on histopathology was compatible with a giant-cell tumor versus a brown tumor caused by hyperparathyroidism. Laboratory tests showed elevated calcium, phosphate and parathyroid hormone concentrations. The patient was diagnosed with a brown tumor secondary to refractory hyperparathyroidism. Conclusion: Tending towards a diagnosis because it is more frequent or it implies more risk for the patient may delay the consideration of other diagnostic options that, although rare, fit well into the clinical context. The patient presented here was suspected to have an osseous neoplasia that would have had major implications for the patient. However, reassessment of the case led to the diagnosis of a brown tumor. Brown tumors should be an important diagnostic consideration in patients with chronic kidney failure who have secondary or tertiary hyperparathyroidism and an osseous mass. Mención de responsabilidad : Germán Campuzano-Zuluaga, William Velasco-Pérez & Juan Ignacio Marín-Zuluaga Referencia : J Med Case Rep. 2009 Aug 4;3:7285. DOI (Digital Object Identifier) : 10.4076/1752-1947-3-7285 PMID : 19830164 Derechos de uso : CC BY En línea : https://jmedicalcasereports.biomedcentral.com/articles/10.4076/1752-1947-3-7285 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3478

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