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Refinar búsquedaReal-world treatment patterns and health care resource use for patients with myelofibrosis: results from the METER study / Kenny Mauricio Gálvez Cárdenas ; Gupta, Vikas ; Tomuleasa, Ciprian ; Barranco Lampón, Gilberto Israel ; Hou, Hsin-An ; Helbig, Grzegorz ; Vachhani, Pankit ; Symeonidis, Argiris ; Haznedaroglu, Ibrahim ; Tatsch, Fernando ; Chopra, Avijeet S. ; Zhang, Meng ; Vizkelety, Tamas ; Murray, Bryan ; Ross, David M.
Título : Real-world treatment patterns and health care resource use for patients with myelofibrosis: results from the METER study Tipo de documento : documento electrónico Autores : Kenny Mauricio Gálvez Cárdenas, Autor ; Gupta, Vikas, Autor ; Tomuleasa, Ciprian, Autor ; Barranco Lampón, Gilberto Israel, Autor ; Hou, Hsin-An, Autor ; Helbig, Grzegorz, Autor ; Vachhani, Pankit, Autor ; Symeonidis, Argiris, Autor ; Haznedaroglu, Ibrahim, Autor ; Tatsch, Fernando, Autor ; Chopra, Avijeet S., Autor ; Zhang, Meng, Autor ; Vizkelety, Tamas, Autor ; Murray, Bryan, Autor ; Ross, David M., Autor Fecha de publicación : 2025 Títulos uniformes : Blood Advances Idioma : Inglés (eng) Resumen : Myelofibrosis (MF), a myeloproliferative neoplasm, was most commonly treated with hydroxyurea (HU) before approval of ruxolitinib (RUX), now the standard of care. Factors that influence real-world MF treatment patterns are not well understood. The METER study was a multi-country, retrospective chart review of MF treatment patterns, treatment effectiveness, and health care resource utilization. Of 997 eligible patients, 65.9% had primary MF, and 11.7% were transfusion dependent. Median time from diagnosis to the start of initial treatment (index date) was 29 days (interquartile range [IQR], 1-140). RUX was the most common first-line (1L) therapy (49.0%), followed by HU (40.2%); 48.5% of patients remained on 1L therapy through week 156. Seventy-seven patients underwent allogeneic stem cell transplantation; transplantation was uncommon at 1L, increasing from 2.2% at week 24 to 11.0% at week 156 in patients ?70 years of age. Median overall survival was 79.1 months (95% confidence interval [95% CI], 70.8 to not estimable [NE]) in all patients, 142.3 months (95% CI, 74.1 to NE) for non-RUX patients, 77.6 months (95% CI, 64.2-85.9) for patients on RUX 1L therapy, and 72.6 months (95% CI, 62.0 to NE) for RUX 2L+ patients. Of patients who experienced ?1 corresponding event, the median hospital length of stay (LoS; n = 520), intensive care unit LoS (n = 71), and number of transfusions (n = 375) were 16 days (IQR, 7-37), 5 days (IQR, 2-13), and 12 (IQR, 4-26), respectively. Despite improvements, there were numerous hospitalization and transfusion events among these patients in routine practice. This trial was registered at www.ClinicalTrials.gov as #NCT05444972. Mención de responsabilidad : Vikas Gupta, Ciprian Tomuleasa, Gilberto Israel Barranco Lampón, Hsin-An Hou, Grzegorz Helbig, Pankit Vachhani, Argiris Symeonidis, Ibrahim Haznedaroglu, Kenny Galvez, Fernando Tatsch, Avijeet S. Chopra, Meng Zhang, Tamas Vizkelety, Bryan Murray, David M. Ross Referencia : Blood Adv . 2025 Mar 11;9(5):1105-1116. DOI (Digital Object Identifier) : 10.1182/bloodadvances.2024014625. PMID : 39729499 Derechos de uso : CC BY-NC-ND En línea : https://ashpublications.org/bloodadvances/article/9/5/1105/534845/Real-world-tre [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Real-world treatment patterns and health care resource use for patients with myelofibrosis: results from the METER study [documento electrónico] / Kenny Mauricio Gálvez Cárdenas, Autor ; Gupta, Vikas, Autor ; Tomuleasa, Ciprian, Autor ; Barranco Lampón, Gilberto Israel, Autor ; Hou, Hsin-An, Autor ; Helbig, Grzegorz, Autor ; Vachhani, Pankit, Autor ; Symeonidis, Argiris, Autor ; Haznedaroglu, Ibrahim, Autor ; Tatsch, Fernando, Autor ; Chopra, Avijeet S., Autor ; Zhang, Meng, Autor ; Vizkelety, Tamas, Autor ; Murray, Bryan, Autor ; Ross, David M., Autor . - 2025.
Obra : Blood Advances
Idioma : Inglés (eng)
Resumen : Myelofibrosis (MF), a myeloproliferative neoplasm, was most commonly treated with hydroxyurea (HU) before approval of ruxolitinib (RUX), now the standard of care. Factors that influence real-world MF treatment patterns are not well understood. The METER study was a multi-country, retrospective chart review of MF treatment patterns, treatment effectiveness, and health care resource utilization. Of 997 eligible patients, 65.9% had primary MF, and 11.7% were transfusion dependent. Median time from diagnosis to the start of initial treatment (index date) was 29 days (interquartile range [IQR], 1-140). RUX was the most common first-line (1L) therapy (49.0%), followed by HU (40.2%); 48.5% of patients remained on 1L therapy through week 156. Seventy-seven patients underwent allogeneic stem cell transplantation; transplantation was uncommon at 1L, increasing from 2.2% at week 24 to 11.0% at week 156 in patients ?70 years of age. Median overall survival was 79.1 months (95% confidence interval [95% CI], 70.8 to not estimable [NE]) in all patients, 142.3 months (95% CI, 74.1 to NE) for non-RUX patients, 77.6 months (95% CI, 64.2-85.9) for patients on RUX 1L therapy, and 72.6 months (95% CI, 62.0 to NE) for RUX 2L+ patients. Of patients who experienced ?1 corresponding event, the median hospital length of stay (LoS; n = 520), intensive care unit LoS (n = 71), and number of transfusions (n = 375) were 16 days (IQR, 7-37), 5 days (IQR, 2-13), and 12 (IQR, 4-26), respectively. Despite improvements, there were numerous hospitalization and transfusion events among these patients in routine practice. This trial was registered at www.ClinicalTrials.gov as #NCT05444972. Mención de responsabilidad : Vikas Gupta, Ciprian Tomuleasa, Gilberto Israel Barranco Lampón, Hsin-An Hou, Grzegorz Helbig, Pankit Vachhani, Argiris Symeonidis, Ibrahim Haznedaroglu, Kenny Galvez, Fernando Tatsch, Avijeet S. Chopra, Meng Zhang, Tamas Vizkelety, Bryan Murray, David M. Ross Referencia : Blood Adv . 2025 Mar 11;9(5):1105-1116. DOI (Digital Object Identifier) : 10.1182/bloodadvances.2024014625. PMID : 39729499 Derechos de uso : CC BY-NC-ND En línea : https://ashpublications.org/bloodadvances/article/9/5/1105/534845/Real-world-tre [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Real-world treatment patterns and health care resource use for patients with myelofibrosis: results from the METER studyURL
Título : Thyroid Cancer Staging: Historical Evolution and Analysis From Macrocarcinoma to Microcarcinoma Tipo de documento : documento electrónico Autores : Carlos Esteban Builes Montaño, Autor ; Londoño Bustamante, Andrés Felipe, Autor ; Julio Andrés Valencia Ferro, Autor ; Duque, Carlos S., Autor ; Tobón Ospina, Catalina, Autor ; Alejandro Vélez Hoyos, Autor ; Sánchez, Juan G., Autor ; Agudelo, Miguel, Autor ; Dueñas, Juan P., Autor ; Palacio, Maria F., Autor ; Sierra, Natalia, Autor Fecha de publicación : 2025 Títulos uniformes : Cureus Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave : classification prognosis risk staging surgery thyroid cancer tnm Resumen : The classification of thyroid cancer diagnosis and treatment has evolved dramatically since the Union for International Cancer Control (UICC) published the first staging system in 1968. A careful review of the eight published editions of well-differentiated thyroid cancer (WDTC) staging by the UICC and the American Joint Committee on Cancer (AJCC) was performed. Each edition was analyzed to clearly understand which development published and accepted by specialists treating thyroid cancer justified considering a new updated edition. This study presents a comprehensive review of the remarkable evolution of thyroid cancer staging, highlighting the various changes in several areas throughout the years and editions. There were surprising changes within the eight publications: the tumor size was progressively reduced from 4 cm in the first AJCC volume to less than 1 cm in the seventh and eighth UICC and AJCC editions, classifying these small, WDTCs known up to now as “microcarcinomas.” Extrathyroidal extension was accepted after the third edition; this description certainly plays a key role in today’s decisions to manage this tumor as a prognostic factor. The age specification of 45 years prevailed for seven consecutive publications until it was raised to 55 years in the eighth thyroid cancer staging system. Without a doubt, this iconic change allowed physicians around the world to give their 45-year-old thyroid cancer patients a more encouraging panorama of the disease with the new classification. Over the course of nearly 57 years, thyroid cancer staging has undergone remarkable changes, reaching a level of certainty that not only provides recommendations for safer treatments with less surgery and adjunctive measures but also improves survival rates and patient safety. Mención de responsabilidad : Carlos S. Duque , Carlos E. Builes-Montaño , Catalina Tobón-Ospina , Alejandro Velez Hoyos , Juan G. Sánchez , Andres F. Londoño , Miguel Agudelo , Julio A. Valencia , Juan P. Dueñas , Maria F. Palacio , Natalia Sierra Referencia : Cureus 17(4): e81972. DOI (Digital Object Identifier) : 10.7759/cureus.81972 Derechos de uso : CC BY-NC-ND En línea : https://www.cureus.com/articles/350600-thyroid-cancer-staging-historical-evoluti [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Thyroid Cancer Staging: Historical Evolution and Analysis From Macrocarcinoma to Microcarcinoma [documento electrónico] / Carlos Esteban Builes Montaño, Autor ; Londoño Bustamante, Andrés Felipe, Autor ; Julio Andrés Valencia Ferro, Autor ; Duque, Carlos S., Autor ; Tobón Ospina, Catalina, Autor ; Alejandro Vélez Hoyos, Autor ; Sánchez, Juan G., Autor ; Agudelo, Miguel, Autor ; Dueñas, Juan P., Autor ; Palacio, Maria F., Autor ; Sierra, Natalia, Autor . - 2025.
Obra : Cureus
Idioma : Inglés (eng) Idioma original : Inglés (eng)
Palabras clave : classification prognosis risk staging surgery thyroid cancer tnm Resumen : The classification of thyroid cancer diagnosis and treatment has evolved dramatically since the Union for International Cancer Control (UICC) published the first staging system in 1968. A careful review of the eight published editions of well-differentiated thyroid cancer (WDTC) staging by the UICC and the American Joint Committee on Cancer (AJCC) was performed. Each edition was analyzed to clearly understand which development published and accepted by specialists treating thyroid cancer justified considering a new updated edition. This study presents a comprehensive review of the remarkable evolution of thyroid cancer staging, highlighting the various changes in several areas throughout the years and editions. There were surprising changes within the eight publications: the tumor size was progressively reduced from 4 cm in the first AJCC volume to less than 1 cm in the seventh and eighth UICC and AJCC editions, classifying these small, WDTCs known up to now as “microcarcinomas.” Extrathyroidal extension was accepted after the third edition; this description certainly plays a key role in today’s decisions to manage this tumor as a prognostic factor. The age specification of 45 years prevailed for seven consecutive publications until it was raised to 55 years in the eighth thyroid cancer staging system. Without a doubt, this iconic change allowed physicians around the world to give their 45-year-old thyroid cancer patients a more encouraging panorama of the disease with the new classification. Over the course of nearly 57 years, thyroid cancer staging has undergone remarkable changes, reaching a level of certainty that not only provides recommendations for safer treatments with less surgery and adjunctive measures but also improves survival rates and patient safety. Mención de responsabilidad : Carlos S. Duque , Carlos E. Builes-Montaño , Catalina Tobón-Ospina , Alejandro Velez Hoyos , Juan G. Sánchez , Andres F. Londoño , Miguel Agudelo , Julio A. Valencia , Juan P. Dueñas , Maria F. Palacio , Natalia Sierra Referencia : Cureus 17(4): e81972. DOI (Digital Object Identifier) : 10.7759/cureus.81972 Derechos de uso : CC BY-NC-ND En línea : https://www.cureus.com/articles/350600-thyroid-cancer-staging-historical-evoluti [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Introduction to the minisymposium: pediatric infectious diseases in Latin America Tipo de documento : documento electrónico Autores : Cadavid, Lina, Autor ; Ugas Charcape, Carlos F, Autor ; Fazecas, Tatiana, Autor Fecha de publicación : 2025 Títulos uniformes : Pediatric Radiology Idioma : Inglés (eng) Resumen : We are pleased to present the Minisymposium on Pediatric Infectious Diseases in Latin America, featuring six pictorial reviews of key imaging fndings in neglected tropical diseases and tuberculosis. This work highlights pressing regional health challenges, including congenital ZIKV infection, hydatid disease, ascariasis, leishmaniasis, chikungunya, dengue, and CNS and osteoarticular tuberculosis. Neglected tropical diseases disproportionately afect the world’s poorest populations, with over 700,000 deaths annually. Despite recent declines, Latin America reports high incidences, particularly in tropical areas. The COVID-19 pandemic disrupted progress, reducing community interventions and access to care. Meanwhile, tuberculosis, a persistent public health issue, has recently resurged in some countries in the region. Zika virus outbreaks have highlighted its congenital CNS efects, including microcephaly, calcifcations, cerebral atrophy, and corpus callosum anomalies. Ascariasis, prevalent in areas with poor hygiene, often causes gastrointestinal or pulmonary symptoms, with imaging fndings such as real-time movement of echogenic defects on ultrasound and ground-glass or alveolar infltrates on CT. Leishmaniasis often presents with nonspecifc fndings, Dengue can cause hepatosplenomegaly, pleural efusions, gallbladder wall edema, and ascites, with severe cases leading to hemorrhagic manifestations or CNS involvement. Chikungunya typically presents with arthralgia, arthritis, and synovitis. Hydatid disease, afecting multiple organs, relies on imaging for diagnosis, with ultrasound, CT, and MRI crucial for identifying cysts and complications. Tuberculosis in children manifests in the CNS as tuberculomas or meningitis. Osteoarticular tuberculosis accounts for 10–20% of extrapulmonary cases, with common presentations including spondylitis, arthritis, and osteomyelitis. We deeply appreciate Dr. Epelman for inspiring this project, the frst to feature exclusively Latin American authors. Her invaluable guidance made this initiative possible. Through this minisymposium, the Sociedad Latinoamericana de Radiología Pediátrica (SLARP) fulflls its mission to promote regional research and share insights on globally relevant yet underexplored topics, engaging readers worldwidesuch as hepatosplenomegaly and lymphadenopathy. Mención de responsabilidad : Carlos F Ugas Charcape, Lina Cadavid, Tatiana Fazecas. Referencia : Pediatr Radiol . 2025 Jan;55(1):64. DOI (Digital Object Identifier) : 10.1007/s00247-024-06125-x PMID : 39644354 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/39644354/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Introduction to the minisymposium: pediatric infectious diseases in Latin America [documento electrónico] / Cadavid, Lina, Autor ; Ugas Charcape, Carlos F, Autor ; Fazecas, Tatiana, Autor . - 2025.
Obra : Pediatric Radiology
Idioma : Inglés (eng)
Resumen : We are pleased to present the Minisymposium on Pediatric Infectious Diseases in Latin America, featuring six pictorial reviews of key imaging fndings in neglected tropical diseases and tuberculosis. This work highlights pressing regional health challenges, including congenital ZIKV infection, hydatid disease, ascariasis, leishmaniasis, chikungunya, dengue, and CNS and osteoarticular tuberculosis. Neglected tropical diseases disproportionately afect the world’s poorest populations, with over 700,000 deaths annually. Despite recent declines, Latin America reports high incidences, particularly in tropical areas. The COVID-19 pandemic disrupted progress, reducing community interventions and access to care. Meanwhile, tuberculosis, a persistent public health issue, has recently resurged in some countries in the region. Zika virus outbreaks have highlighted its congenital CNS efects, including microcephaly, calcifcations, cerebral atrophy, and corpus callosum anomalies. Ascariasis, prevalent in areas with poor hygiene, often causes gastrointestinal or pulmonary symptoms, with imaging fndings such as real-time movement of echogenic defects on ultrasound and ground-glass or alveolar infltrates on CT. Leishmaniasis often presents with nonspecifc fndings, Dengue can cause hepatosplenomegaly, pleural efusions, gallbladder wall edema, and ascites, with severe cases leading to hemorrhagic manifestations or CNS involvement. Chikungunya typically presents with arthralgia, arthritis, and synovitis. Hydatid disease, afecting multiple organs, relies on imaging for diagnosis, with ultrasound, CT, and MRI crucial for identifying cysts and complications. Tuberculosis in children manifests in the CNS as tuberculomas or meningitis. Osteoarticular tuberculosis accounts for 10–20% of extrapulmonary cases, with common presentations including spondylitis, arthritis, and osteomyelitis. We deeply appreciate Dr. Epelman for inspiring this project, the frst to feature exclusively Latin American authors. Her invaluable guidance made this initiative possible. Through this minisymposium, the Sociedad Latinoamericana de Radiología Pediátrica (SLARP) fulflls its mission to promote regional research and share insights on globally relevant yet underexplored topics, engaging readers worldwidesuch as hepatosplenomegaly and lymphadenopathy. Mención de responsabilidad : Carlos F Ugas Charcape, Lina Cadavid, Tatiana Fazecas. Referencia : Pediatr Radiol . 2025 Jan;55(1):64. DOI (Digital Object Identifier) : 10.1007/s00247-024-06125-x PMID : 39644354 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/39644354/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Factors Associated With Complications in Patients With Hematological Malignancies and Febrile Neutropenia: A Cohort Study Tipo de documento : documento electrónico Autores : De la Peña Lozano, Ioka, Autor ; Alvarez Payares, Jose C., Autor ; Alvarez Lopez, Santiago, Autor ; Agámez Gómez, José E., Autor ; Hernández Rodriguez, Juan C., Autor ; Ramírez Roldán, Alejandra, Autor ; Molina Prado, Ángel D., Autor ; Cardona Jaramillo, Manuela, Autor ; Trejos Tenorio, Adriana M., Autor ; Ospina Ospina, Sigifredo, Autor ; Barrera Correa, Daniel, Autor ; Ribero Vargas, Daniel A., Autor ; Ariza Parra, Edwin J, Autor ; Karduss Urueta, Amado J., Autor Fecha de publicación : 2025 Títulos uniformes : Cureus Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave : antineoplastic agents chemotherapy-induced febrile neutropenia febrile neutropenia hematological malignancies infections mortality Resumen : Introduction Febrile neutropenia (FN) in patients with hematological malignancy (HM) is associated with multiple hospital complications including mortality. Although different strategies for early detection and prompt treatment have been established, it is a heterogeneous population with risk factors that are difficult to detect. The data available on the prediction of such complications is limited and there lies the importance of characterizing this type of patients in our environment and evaluating the factors related to the adverse outcomes. Methods The study is a retrospective cohort study conducted at San Vicente Foundation University Hospital (HUSVF) and Alma Mater Hospital of Antioquia (HAMA) in Medellín, Colombia, between January 2018 and December 2020, including patients diagnosed with FN who presented FN at the time of diagnosis or up to 30 days after receiving chemotherapy. The main objective was to determine the factors related to mortality and severe complications (ICU admission, need for vasopressors, or need for mechanical ventilation), while the secondary objective was the microbiological characterization of this population. Results Of the 190 FN episodes, 134 (70.5%) had a clinical focus of infection. A causal agent was identified in 125 episodes (65.8%), with the majority being bacteria in 112 cases (92.6%) of the isolates. The most frequently identified bacteria were Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. Gram-negative bacilli were isolated in 85 (86%) cases, and resistance was present in 38 cases (44.7%), with both extended-spectrum beta-lactamase (ESBL) and Klebsiella pneumoniae Carbapenemase (KPC) detected in nine (10.5%). In 53 (34.4%) episodes, some complications occurred during FN. The 30-day all-cause mortality was 53 (34.4%), with 27 (50.9%) of these cases associated with complications. Of the 45 (86.5%) patients who died from any cause, all did so during their first episode of FN. In the bivariate analysis, the following factors were associated with higher mortality: hypertension (OR 2.58, 95% CI 1.19-5.58; p=0.014), chronic obstructive pulmonary disease (COPD) (OR 10.2, 95% CI 1.11-93.8; p=0.013), chronic kidney disease (OR 4.27, 95% CI 0.975-18.7; p=0.038), prolonged neutropenia (OR 2.34, 95% CI 1.1-4.95; p=0.024), and lactate dehydrogenase (LDH) levels greater than two times the upper normal limit (UNL) (OR 3.24, 95% CI 1.35-7.75; p=0.007). In contrast, normal albumin levels before chemotherapy were associated with lower mortality (OR 0.381, 95% CI 0.15-0.95; p=0.036). In the multivariate analysis, none of the identified factors were statistically significant in predicting complications or mortality. Conclusión No factors related to complications or mortality were found in the multivariate analysis. However, the heterogeneity of the population suggests that these outcomes are not determined by a single factor, and a study with a larger sample may be needed to confirm them. Mención de responsabilidad : Jose C. Alvarez-Payares , Santiago Alvarez-Lopez , Jose E. Agámez-Gomez , Juan C. Hernandez-Rodriguez , Alejandra Ramírez-Roldán , Ángel D. Molina-Prado , Manuela Cardona-Jaramillo , Adriana M. Trejos-Tenorio , Sigifredo Ospina-Ospina , Ioka de la Peña-Lozano , Daniel Barrera-Correa , Daniel A. Ribero-Vargas , Edwin J Ariza-Parra , Amado J. Karduss-Urueta Referencia : Cureus 17(4): e81750. DOI (Digital Object Identifier) : 10.7759/cureus.81750 Derechos de uso : CC BY-NC-ND En línea : https://www.cureus.com/articles/351187-factors-associated-with-complications-in- [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Factors Associated With Complications in Patients With Hematological Malignancies and Febrile Neutropenia: A Cohort Study [documento electrónico] / De la Peña Lozano, Ioka, Autor ; Alvarez Payares, Jose C., Autor ; Alvarez Lopez, Santiago, Autor ; Agámez Gómez, José E., Autor ; Hernández Rodriguez, Juan C., Autor ; Ramírez Roldán, Alejandra, Autor ; Molina Prado, Ángel D., Autor ; Cardona Jaramillo, Manuela, Autor ; Trejos Tenorio, Adriana M., Autor ; Ospina Ospina, Sigifredo, Autor ; Barrera Correa, Daniel, Autor ; Ribero Vargas, Daniel A., Autor ; Ariza Parra, Edwin J, Autor ; Karduss Urueta, Amado J., Autor . - 2025.
Obra : Cureus
Idioma : Inglés (eng) Idioma original : Inglés (eng)
Palabras clave : antineoplastic agents chemotherapy-induced febrile neutropenia febrile neutropenia hematological malignancies infections mortality Resumen : Introduction Febrile neutropenia (FN) in patients with hematological malignancy (HM) is associated with multiple hospital complications including mortality. Although different strategies for early detection and prompt treatment have been established, it is a heterogeneous population with risk factors that are difficult to detect. The data available on the prediction of such complications is limited and there lies the importance of characterizing this type of patients in our environment and evaluating the factors related to the adverse outcomes. Methods The study is a retrospective cohort study conducted at San Vicente Foundation University Hospital (HUSVF) and Alma Mater Hospital of Antioquia (HAMA) in Medellín, Colombia, between January 2018 and December 2020, including patients diagnosed with FN who presented FN at the time of diagnosis or up to 30 days after receiving chemotherapy. The main objective was to determine the factors related to mortality and severe complications (ICU admission, need for vasopressors, or need for mechanical ventilation), while the secondary objective was the microbiological characterization of this population. Results Of the 190 FN episodes, 134 (70.5%) had a clinical focus of infection. A causal agent was identified in 125 episodes (65.8%), with the majority being bacteria in 112 cases (92.6%) of the isolates. The most frequently identified bacteria were Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. Gram-negative bacilli were isolated in 85 (86%) cases, and resistance was present in 38 cases (44.7%), with both extended-spectrum beta-lactamase (ESBL) and Klebsiella pneumoniae Carbapenemase (KPC) detected in nine (10.5%). In 53 (34.4%) episodes, some complications occurred during FN. The 30-day all-cause mortality was 53 (34.4%), with 27 (50.9%) of these cases associated with complications. Of the 45 (86.5%) patients who died from any cause, all did so during their first episode of FN. In the bivariate analysis, the following factors were associated with higher mortality: hypertension (OR 2.58, 95% CI 1.19-5.58; p=0.014), chronic obstructive pulmonary disease (COPD) (OR 10.2, 95% CI 1.11-93.8; p=0.013), chronic kidney disease (OR 4.27, 95% CI 0.975-18.7; p=0.038), prolonged neutropenia (OR 2.34, 95% CI 1.1-4.95; p=0.024), and lactate dehydrogenase (LDH) levels greater than two times the upper normal limit (UNL) (OR 3.24, 95% CI 1.35-7.75; p=0.007). In contrast, normal albumin levels before chemotherapy were associated with lower mortality (OR 0.381, 95% CI 0.15-0.95; p=0.036). In the multivariate analysis, none of the identified factors were statistically significant in predicting complications or mortality. Conclusión No factors related to complications or mortality were found in the multivariate analysis. However, the heterogeneity of the population suggests that these outcomes are not determined by a single factor, and a study with a larger sample may be needed to confirm them. Mención de responsabilidad : Jose C. Alvarez-Payares , Santiago Alvarez-Lopez , Jose E. Agámez-Gomez , Juan C. Hernandez-Rodriguez , Alejandra Ramírez-Roldán , Ángel D. Molina-Prado , Manuela Cardona-Jaramillo , Adriana M. Trejos-Tenorio , Sigifredo Ospina-Ospina , Ioka de la Peña-Lozano , Daniel Barrera-Correa , Daniel A. Ribero-Vargas , Edwin J Ariza-Parra , Amado J. Karduss-Urueta Referencia : Cureus 17(4): e81750. DOI (Digital Object Identifier) : 10.7759/cureus.81750 Derechos de uso : CC BY-NC-ND En línea : https://www.cureus.com/articles/351187-factors-associated-with-complications-in- [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Factors associated with development of end stage renal disease during hospitalization in patients with microscopic polyangiitis and granulomatosis with polyangiitis in a population of northwestern Colombia Otros títulos : Factores asociados con el desarrollo de falla renal crónica terminal durante la hospitalización en los pacientes con poliangitis microscópica y granulomatosis con poliangitis en una población del noroccidente colombiano Tipo de documento : documento electrónico Autores : Jhon Edwar García Rueda, Autor ; Cobaleda Cano, Santiago, Autor ; Andrés Felipe Echeverri García, Autor ; Trejos Tenorio, Adriana Margarita, Autor ; Javier Darío Márquez Hernández, Autor ; Luis Fernando Pinto Peñaranda, Autor Fecha de publicación : 2025 Títulos uniformes : Revista Colombiana de Reumatología Idioma : Español (spa) Palabras clave : ANCA; Microscopic polyangiitis; Polyangiitis with granulomatosis; Vasculitis Resumen : Introduction: ANCA vasculitis has been associated with increased morbidity and mortality, high disease burden, and organ damage, especially renal. Objectives: To determine factors associated with end-stage kidney disease at hospital discharge in microscopic polyangiitis and granulomatosis with polyangiitis patients, to characterize our population, hospitalization causes, treatment received, and complications during stay. Materials and methods: Adults with previous or new diagnosis of microscopic polyangiitis and granulomatosis with polyangiitis who required hospitalization between January 01, 2013, and April 30, 2021, were included. Association with end-stage kidney disease development was evaluated by Pearson's Chi2 (?2) or Fisher's test, and Student's t or Mann-Whitney U test according to the nature of the variables. Exploratory multivariate models were made including factors associated with end-stage kidney disease. Results: Forty-three patients were included, microscopic polyangiitis 55.8, and granulomatosis with polyangiitis 44.25. Twelve patients (27.9%) developed early end-stage kidney disease. High blood pressure, high urea nitrogen levels on admission, as well as pulmonary oedema, and Five Factor Score > 1 entailed a higher risk. In contrast, normal kidney function on admission was a protective factor. Rapidly progressive glomerulonephritis and arterial hypertension on admission were associated with end-stage kidney disease. In adjusted exploratory models according to vasculitis type, Birmingham Vasculitis Activity Score, diffuse alveolar haemorrhage, and plasma exchange use were identified as factors to include in multivariate models in multicentre studies. Conclusion: 88% of patients had renal involvement and 27.9% developed end-stage kidney disease. Rapidly progressive glomerulonephritis and arterial hypertension on hospital admission were associated with early development of end-stage kidney disease while normal renal function on admission was a protective factor for this outcome. © 2024 Asociación Colombiana de Reumatología Mención de responsabilidad : Cobaleda Cano, Santiago, Echeverri García, Andrés Felipe, Trejos Tenorio, Adriana Margarita, Márquez Hernández, Javier Darío, García Rueda, Jhon Edwar, Pinto Peñaranda, Luis Fernando Referencia : Revista Colombiana de Reumatología Volume 32, Issue 1, January–March 2025, Pages 16-26 DOI (Digital Object Identifier) : 10.1016/j.rcreu.2023.11.004 Derechos de uso : CC BY-NC-ND En línea : https://www.sciencedirect.com/science/article/abs/pii/S012181232300110X Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Factors associated with development of end stage renal disease during hospitalization in patients with microscopic polyangiitis and granulomatosis with polyangiitis in a population of northwestern Colombia = Factores asociados con el desarrollo de falla renal crónica terminal durante la hospitalización en los pacientes con poliangitis microscópica y granulomatosis con poliangitis en una población del noroccidente colombiano [documento electrónico] / Jhon Edwar García Rueda, Autor ; Cobaleda Cano, Santiago, Autor ; Andrés Felipe Echeverri García, Autor ; Trejos Tenorio, Adriana Margarita, Autor ; Javier Darío Márquez Hernández, Autor ; Luis Fernando Pinto Peñaranda, Autor . - 2025.
Obra : Revista Colombiana de Reumatología
Idioma : Español (spa)
Palabras clave : ANCA; Microscopic polyangiitis; Polyangiitis with granulomatosis; Vasculitis Resumen : Introduction: ANCA vasculitis has been associated with increased morbidity and mortality, high disease burden, and organ damage, especially renal. Objectives: To determine factors associated with end-stage kidney disease at hospital discharge in microscopic polyangiitis and granulomatosis with polyangiitis patients, to characterize our population, hospitalization causes, treatment received, and complications during stay. Materials and methods: Adults with previous or new diagnosis of microscopic polyangiitis and granulomatosis with polyangiitis who required hospitalization between January 01, 2013, and April 30, 2021, were included. Association with end-stage kidney disease development was evaluated by Pearson's Chi2 (?2) or Fisher's test, and Student's t or Mann-Whitney U test according to the nature of the variables. Exploratory multivariate models were made including factors associated with end-stage kidney disease. Results: Forty-three patients were included, microscopic polyangiitis 55.8, and granulomatosis with polyangiitis 44.25. Twelve patients (27.9%) developed early end-stage kidney disease. High blood pressure, high urea nitrogen levels on admission, as well as pulmonary oedema, and Five Factor Score > 1 entailed a higher risk. In contrast, normal kidney function on admission was a protective factor. Rapidly progressive glomerulonephritis and arterial hypertension on admission were associated with end-stage kidney disease. In adjusted exploratory models according to vasculitis type, Birmingham Vasculitis Activity Score, diffuse alveolar haemorrhage, and plasma exchange use were identified as factors to include in multivariate models in multicentre studies. Conclusion: 88% of patients had renal involvement and 27.9% developed end-stage kidney disease. Rapidly progressive glomerulonephritis and arterial hypertension on hospital admission were associated with early development of end-stage kidney disease while normal renal function on admission was a protective factor for this outcome. © 2024 Asociación Colombiana de Reumatología Mención de responsabilidad : Cobaleda Cano, Santiago, Echeverri García, Andrés Felipe, Trejos Tenorio, Adriana Margarita, Márquez Hernández, Javier Darío, García Rueda, Jhon Edwar, Pinto Peñaranda, Luis Fernando Referencia : Revista Colombiana de Reumatología Volume 32, Issue 1, January–March 2025, Pages 16-26 DOI (Digital Object Identifier) : 10.1016/j.rcreu.2023.11.004 Derechos de uso : CC BY-NC-ND En línea : https://www.sciencedirect.com/science/article/abs/pii/S012181232300110X Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD002319 AC-2025-002 Archivo digital Producción Científica Artículos científicos Disponible
Título : Adrenaline for the early resuscitation of children with sepsis - a randomizedcontrolled pilot study (ANDES CHILD): study protocol and analysis plan Tipo de documento : documento electrónico Autores : Juan Camilo Jaramillo Bustamante, Autor ; Lopera Múnera, Natalia, Autor ; Ortiz, Jorge, Autor ; Casson, Nils, Autor ; Iramain, Ricardo, Autor ; Pavlicich, Viviana, Autor ; Flauzino de Oliveira, Claudio, Autor ; Mozun, Rebeca, Autor ; Schlapbach, Luregn J, Autor ; Jabornisky, Roberto, Autor Fecha de publicación : 2025 Títulos uniformes : Intensive Care Medicine – Paediatric and Neonatal Idioma : Inglés (eng) Palabras clave : Adrenaline Child Inotrope Resuscitation Sepsis Septic shock Resumen : Purpose Sepsis is a leading cause of pediatric morbidity and mortality worldwide. Current guidelines recommend fluid bolus administration of 40–60 mL/kg as part of initial resuscitation, despite limited evidence and concerns about potential harm from high fluid volumes. The ANDES-CHILD pilot study hypothesizes that early initiation of inotropes is feasible and reduces fluid use compared to standard resuscitation. Methods Multicenter open label randomized controlled pilot trial conducted in three Pediatric Emergency Departments in Latin America. Children aged 28 days to 18 years with presumed septic shock will be randomized in a 1:1 ratio to receive either early adrenaline infusion after 20 mL/kg fluid bolus versus standard resuscitation with 40–60 mL/kg fluid bolus prior to initiating inotropes. The primary outcome is feasibility, with survival free of organ support censored at 28 days as the exploratory primary clinical outcome. The study will enroll 40 patients, representing approximately 10% of a full trial, with follow-up at 28 days. Baseline characteristics, adverse events and protocol violations will be summarized descriptively. Outcomes will be analyzed using difference estimates with 95% confidence intervals. An intention-to-treat approach will be used for statistical analysis. Discussion This pragmatic pilot study will generate essential data to evaluate the feasibility and guide the design of a full trial aimed to assessing the benefits of early inotrope use in pediatric septic shock. The study was registered on ClinicalTrials.gov prior to the start of recruitment (NCT06478797). Recruitment started on July 18, 2024. Mención de responsabilidad : Natalia Lopera-Múnera1, Jorge Ortiz2, Nils Casson3, Ricardo Iramain2, Viviana Pavlicich1, Juan Camilo Jaramillo-Bustamante, Claudio Flauzino de Oliveira, Rebeca Mozun, Luregn J Schlapbach6, and Roberto Jabornisky† Referencia : Intensive Care Medicine – Paediatric and Neonatal DOI (Digital Object Identifier) : 10.1007/s44253-025-000 Derechos de uso : CC BY-NC-ND En línea : file:///C:/Users/1128458306/Downloads/Adrenaline_for_the_early_resuscitation_of_ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Adrenaline for the early resuscitation of children with sepsis - a randomizedcontrolled pilot study (ANDES CHILD): study protocol and analysis plan [documento electrónico] / Juan Camilo Jaramillo Bustamante, Autor ; Lopera Múnera, Natalia, Autor ; Ortiz, Jorge, Autor ; Casson, Nils, Autor ; Iramain, Ricardo, Autor ; Pavlicich, Viviana, Autor ; Flauzino de Oliveira, Claudio, Autor ; Mozun, Rebeca, Autor ; Schlapbach, Luregn J, Autor ; Jabornisky, Roberto, Autor . - 2025.
Obra : Intensive Care Medicine – Paediatric and Neonatal
Idioma : Inglés (eng)
Palabras clave : Adrenaline Child Inotrope Resuscitation Sepsis Septic shock Resumen : Purpose Sepsis is a leading cause of pediatric morbidity and mortality worldwide. Current guidelines recommend fluid bolus administration of 40–60 mL/kg as part of initial resuscitation, despite limited evidence and concerns about potential harm from high fluid volumes. The ANDES-CHILD pilot study hypothesizes that early initiation of inotropes is feasible and reduces fluid use compared to standard resuscitation. Methods Multicenter open label randomized controlled pilot trial conducted in three Pediatric Emergency Departments in Latin America. Children aged 28 days to 18 years with presumed septic shock will be randomized in a 1:1 ratio to receive either early adrenaline infusion after 20 mL/kg fluid bolus versus standard resuscitation with 40–60 mL/kg fluid bolus prior to initiating inotropes. The primary outcome is feasibility, with survival free of organ support censored at 28 days as the exploratory primary clinical outcome. The study will enroll 40 patients, representing approximately 10% of a full trial, with follow-up at 28 days. Baseline characteristics, adverse events and protocol violations will be summarized descriptively. Outcomes will be analyzed using difference estimates with 95% confidence intervals. An intention-to-treat approach will be used for statistical analysis. Discussion This pragmatic pilot study will generate essential data to evaluate the feasibility and guide the design of a full trial aimed to assessing the benefits of early inotrope use in pediatric septic shock. The study was registered on ClinicalTrials.gov prior to the start of recruitment (NCT06478797). Recruitment started on July 18, 2024. Mención de responsabilidad : Natalia Lopera-Múnera1, Jorge Ortiz2, Nils Casson3, Ricardo Iramain2, Viviana Pavlicich1, Juan Camilo Jaramillo-Bustamante, Claudio Flauzino de Oliveira, Rebeca Mozun, Luregn J Schlapbach6, and Roberto Jabornisky† Referencia : Intensive Care Medicine – Paediatric and Neonatal DOI (Digital Object Identifier) : 10.1007/s44253-025-000 Derechos de uso : CC BY-NC-ND En línea : file:///C:/Users/1128458306/Downloads/Adrenaline_for_the_early_resuscitation_of_ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD002353 AC-2025-036 Archivo digital Producción Científica Artículos científicos Disponible
Título : Transporte terrestre pedia?trico: revisio?n de la literatura y propuesta mnemote?cnica. ¿Co?mo optimizar los recursos? Otros títulos : Pediatric ground transport: A review of the evidence and a mnemonic proposal. How to optimize resources? Tipo de documento : documento electrónico Autores : Juan Camilo Jaramillo Bustamante, Autor ; Vallejo, Sara, Autor ; Builes Arbeláez, Nicole, Autor ; Lopera Sánchez, Natalia, Autor ; Osorio Cadavid, Natalia, Autor Fecha de publicación : 2025 Títulos uniformes : Acta Colombiana de Cuidado Intensivo Idioma : Español (spa) Palabras clave : Pediatría Transporte pediátrico Cuidado crítico Emergencias Resumen : El transporte terrestre de los pacientes pediátricos es un componente vital del sistema de atención de emergencias médicas. Requiere de una integración de los servicios pre-hospitalarios, hospital receptor y centro coordinador, para así maximizar los recursos humanos y materiales, pudiendo incluso brindar desde el ámbito extrahospitalario una atención similar a la de un servicio de urgencias o unidad de cuidados intensivos. En los países de bajos y medianos ingresos, como algunos latinoamericanos, el transporte constituye un reto mayor por múltiples razones como la falta de un sistema de coordinación nacional, la ausencia de prácticas proto-colizadas y las difíciles condiciones topográficas. La identificación y resolución de los desafíos específicos asociados con este tipo de transporte, junto con la implementación de estrategias efectivas, pueden mejorar los resultados y garantizar una atención de calidad. En este artículo se revisarán los desafíos específicos que en Colombia están asociados con el transporte terrestre pediátrico, desde la remisión de un nivel hospitalario de menor a mayor complejidad, incluyendo una evaluación inicial completa, la estabilización del paciente y un transporte seguro hasta el ingreso al servicio objetivo. Por último, se hace una propuesta mnemotécnica para mejorar la calidad a la hora de realizarlo. Mención de responsabilidad : Sara Vallejo a, Nicole Builes Arbélaez, Natalia Osorio Cadavid, Natalia Lopera Sánchez y Juan Camilo Jaramillo Bustamante DOI (Digital Object Identifier) : 10.1016/j.acci.2024.11.006 Derechos de uso : CC BY-NC-ND En línea : https://www.sciencedirect.com/science/article/abs/pii/S0122726224001162?via%3Dih [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Transporte terrestre pedia?trico: revisio?n de la literatura y propuesta mnemote?cnica. ¿Co?mo optimizar los recursos? = Pediatric ground transport: A review of the evidence and a mnemonic proposal. How to optimize resources? [documento electrónico] / Juan Camilo Jaramillo Bustamante, Autor ; Vallejo, Sara, Autor ; Builes Arbeláez, Nicole, Autor ; Lopera Sánchez, Natalia, Autor ; Osorio Cadavid, Natalia, Autor . - 2025.
Obra : Acta Colombiana de Cuidado Intensivo
Idioma : Español (spa)
Palabras clave : Pediatría Transporte pediátrico Cuidado crítico Emergencias Resumen : El transporte terrestre de los pacientes pediátricos es un componente vital del sistema de atención de emergencias médicas. Requiere de una integración de los servicios pre-hospitalarios, hospital receptor y centro coordinador, para así maximizar los recursos humanos y materiales, pudiendo incluso brindar desde el ámbito extrahospitalario una atención similar a la de un servicio de urgencias o unidad de cuidados intensivos. En los países de bajos y medianos ingresos, como algunos latinoamericanos, el transporte constituye un reto mayor por múltiples razones como la falta de un sistema de coordinación nacional, la ausencia de prácticas proto-colizadas y las difíciles condiciones topográficas. La identificación y resolución de los desafíos específicos asociados con este tipo de transporte, junto con la implementación de estrategias efectivas, pueden mejorar los resultados y garantizar una atención de calidad. En este artículo se revisarán los desafíos específicos que en Colombia están asociados con el transporte terrestre pediátrico, desde la remisión de un nivel hospitalario de menor a mayor complejidad, incluyendo una evaluación inicial completa, la estabilización del paciente y un transporte seguro hasta el ingreso al servicio objetivo. Por último, se hace una propuesta mnemotécnica para mejorar la calidad a la hora de realizarlo. Mención de responsabilidad : Sara Vallejo a, Nicole Builes Arbélaez, Natalia Osorio Cadavid, Natalia Lopera Sánchez y Juan Camilo Jaramillo Bustamante DOI (Digital Object Identifier) : 10.1016/j.acci.2024.11.006 Derechos de uso : CC BY-NC-ND En línea : https://www.sciencedirect.com/science/article/abs/pii/S0122726224001162?via%3Dih [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD002344 AC-2025-027 Archivo digital Producción Científica Artículos científicos Disponible
Título : Aneurisma roto de aorta abdominal y fístula aortocava: un hallazgo altamente letal Otros títulos : Ruptured abdominal aortic aneurysm and aortocaval fistula: a highly lethal find Tipo de documento : documento electrónico Autores : Walter Mario Ángel Jaramillo, Autor ; Forero Gaviria, Marby Sharyne, Autor ; Chanci Drago, Romario, Autor ; Guzmán Arango, Natalia, Autor ; Barrea Cuesta, Natalia, Autor ; Giraldo Echeverri, Andrés Gilberto, Autor ; Malabet Mejía, Verónica Lucía, Autor Fecha de publicación : 2025 Títulos uniformes : Jornal Vascular Brasileiro Idioma : Español (spa) Idioma original : Español (spa) Palabras clave : aneurisma de la aorta abdominal; rotura de la aorta; fístula vascular; vena cava inferior; reparación endovascular de aneurismas. Resumen : Dentro del espectro de aneurisma de aorta abdominal, se presentan diversas complicaciones asociadas a esta patología, entre ellas el desarrollo de una fístula arteriovenosa que comunica este gran vaso con la vena cava inferior a nivel infrarrenal. En este reporte, se presenta el caso de un hombre de 70 años con dolor abdominal súbito intenso asociado a síncope, el cual tuvo un hallazgo intraoperatorio de fístula aortocava en el contexto de un aneurisma de aorta abdominal roto. El paciente fue manejado de forma emergente, realizándose el cierre de la fístula y la colocación de un injerto aortobifemoral de dacrón. La fístula aortocava es una complicación rara de la patología aneurismática aórtica, cuyas manifestaciones clínicas varían según el tiempo de evolución de la enfermedad, lo que conlleva una elevada morbimortalidad antes y después de su tratamiento quirúrgico y/o intervencionista. Mención de responsabilidad : Ángel Jaramillo, Walter Mario, Forero Gaviria, Marby Sharyne, Chanci Drago, Romario, Guzmán Arango, Natalia, Barrea Cuesta, Natalia, Giraldo Echeverri, Andrés Gilberto, Malabet Mejía, Verónica Lucía Referencia : J. Vasc. Bras. 24 • 2025 DOI (Digital Object Identifier) : 10.1590/1677-5449.202401343 Derechos de uso : CC BY En línea : https://www.scielo.br/j/jvb/a/KWrpTYNWdmzcnzt3TpbDBbr/?lang=es# Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Aneurisma roto de aorta abdominal y fístula aortocava: un hallazgo altamente letal = Ruptured abdominal aortic aneurysm and aortocaval fistula: a highly lethal find [documento electrónico] / Walter Mario Ángel Jaramillo, Autor ; Forero Gaviria, Marby Sharyne, Autor ; Chanci Drago, Romario, Autor ; Guzmán Arango, Natalia, Autor ; Barrea Cuesta, Natalia, Autor ; Giraldo Echeverri, Andrés Gilberto, Autor ; Malabet Mejía, Verónica Lucía, Autor . - 2025.
Obra : Jornal Vascular Brasileiro
Idioma : Español (spa) Idioma original : Español (spa)
Palabras clave : aneurisma de la aorta abdominal; rotura de la aorta; fístula vascular; vena cava inferior; reparación endovascular de aneurismas. Resumen : Dentro del espectro de aneurisma de aorta abdominal, se presentan diversas complicaciones asociadas a esta patología, entre ellas el desarrollo de una fístula arteriovenosa que comunica este gran vaso con la vena cava inferior a nivel infrarrenal. En este reporte, se presenta el caso de un hombre de 70 años con dolor abdominal súbito intenso asociado a síncope, el cual tuvo un hallazgo intraoperatorio de fístula aortocava en el contexto de un aneurisma de aorta abdominal roto. El paciente fue manejado de forma emergente, realizándose el cierre de la fístula y la colocación de un injerto aortobifemoral de dacrón. La fístula aortocava es una complicación rara de la patología aneurismática aórtica, cuyas manifestaciones clínicas varían según el tiempo de evolución de la enfermedad, lo que conlleva una elevada morbimortalidad antes y después de su tratamiento quirúrgico y/o intervencionista. Mención de responsabilidad : Ángel Jaramillo, Walter Mario, Forero Gaviria, Marby Sharyne, Chanci Drago, Romario, Guzmán Arango, Natalia, Barrea Cuesta, Natalia, Giraldo Echeverri, Andrés Gilberto, Malabet Mejía, Verónica Lucía Referencia : J. Vasc. Bras. 24 • 2025 DOI (Digital Object Identifier) : 10.1590/1677-5449.202401343 Derechos de uso : CC BY En línea : https://www.scielo.br/j/jvb/a/KWrpTYNWdmzcnzt3TpbDBbr/?lang=es# Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD002376 AC-2025-059 Archivo digital Producción Científica Artículos científicos Disponible
Título : Sustained low-efficiency dialysis (SLED) in a referral hospital in Latin Americ Otros títulos : Diálisis sostenida de baja eficiencia (SLED) en un hospital de referencia en Latinoamérica Tipo de documento : documento electrónico Autores : Laura Fernanda Niño Serna, Autor ; Hurtado, Luis F., Autor ; Chacón, Diana C., Autor ; Mesa Abad, Juanita, Autor Fecha de publicación : 2025 Títulos uniformes : Andes Pediatrica Idioma : Inglés (eng) Idioma original : Español (spa) Palabras clave : Acute Hemodialysis; Acute Kidney Injury; Dialysis; Pediatric Critical Care; Pediatrics; Renal Replacement Therapy; Sustained Low-Efficiency Dialysis (SLED) Resumen : Sustained Low-Efficiency Dialysis (SLED) is a hybrid modality of renal replacement therapy used in critically ill patients, although there is little evidence in pediatric patients. Objective: To describe the experience with the use of SLED in a critically ill pediatric population over five years in a hospital in Colombia. Patients and Method: Descriptive observational study. All patients Mención de responsabilidad : Hurtado Luis F., Niño Serna Laura F., Chacón Diana C., Mesa Abad Juanita, Vélez Catalina. Referencia : Andes pediatr. 2025;96(1):67-73 DOI (Digital Object Identifier) : 10.32641/andespediatr.v96i1.4981 Derechos de uso : CC BY-NC-ND En línea : https://www.researchgate.net/publication/389038038_Sustained_low-efficiency_dial [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Sustained low-efficiency dialysis (SLED) in a referral hospital in Latin Americ = Diálisis sostenida de baja eficiencia (SLED) en un hospital de referencia en Latinoamérica [documento electrónico] / Laura Fernanda Niño Serna, Autor ; Hurtado, Luis F., Autor ; Chacón, Diana C., Autor ; Mesa Abad, Juanita, Autor . - 2025.
Obra : Andes Pediatrica
Idioma : Inglés (eng) Idioma original : Español (spa)
Palabras clave : Acute Hemodialysis; Acute Kidney Injury; Dialysis; Pediatric Critical Care; Pediatrics; Renal Replacement Therapy; Sustained Low-Efficiency Dialysis (SLED) Resumen : Sustained Low-Efficiency Dialysis (SLED) is a hybrid modality of renal replacement therapy used in critically ill patients, although there is little evidence in pediatric patients. Objective: To describe the experience with the use of SLED in a critically ill pediatric population over five years in a hospital in Colombia. Patients and Method: Descriptive observational study. All patients Mención de responsabilidad : Hurtado Luis F., Niño Serna Laura F., Chacón Diana C., Mesa Abad Juanita, Vélez Catalina. Referencia : Andes pediatr. 2025;96(1):67-73 DOI (Digital Object Identifier) : 10.32641/andespediatr.v96i1.4981 Derechos de uso : CC BY-NC-ND En línea : https://www.researchgate.net/publication/389038038_Sustained_low-efficiency_dial [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD002335 NIN Archivo digital Producción Científica Artículos científicos Disponible
Título : Minimally invasive osteosynthesis of distal humerus fracture with commercially available pre-contoured plate using an anterolateral fixation: mid to long-term results Tipo de documento : documento electrónico Autores : Valencia Zapata, Jaime Alberto, Autor ; Afanador, Carlos Eduardo, Autor ; Mejía, Oscar Alejandro, Autor ; Calle Díaz, Sebastián, Autor ; Jaramillo, German Alejandro, Autor ; Herrera, Ana Milena, Autor Fecha de publicación : 2025 Títulos uniformes : Medical Research Archives Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave : Humeral Fractures Distal; Fracture Fixation Internal; Bone Plates; Minimally Invasive Surgical Procedures Resumen : Background: Surgical treatment of distal diaphyseal humerus fractures (DDHF) minimally invasive plate osteosynthesis (MIPO) has gained popularity among orthopedic surgeons as it causes less soft-tissue disruption associated with other open approaches; however, the iatrogenic radial nerve injury is still a concern. Recently, a novel technique for a MIPO through anterior approach and anterolateral fixation was proposed as an alternative to reduce the risk of radial nerve damage. Aims: To determine the mid-to-long-term functional results and safety of a MIPO through an anterior approach and anterolateral fixation using a pre-contoured locking plate modified to adjust to the anatomical surface of the lateral column of the humerus. Methods: A prospective longitudinal follow-up of patients treated for a DDHF with MIPO through an anterior approach and anterolateral fixation using a pre-contoured locking plate modified to adjust to the anatomical surface of the lateral column of the humerus. Clinical evaluations included the active range of movement (AROM), functional assessment through the Mayo Elbow Performance Score (MEPS), and pain and complications. Radiographic evaluation included assessment of consolidation, residual angulations, and the optimal plate’s position. Results: This series included ten patients with 12A,12B, and 12C fractures. Patients were followed for a median of 36.9 months (9.5 – 62.5 months). At the last evaluation, the median pain level was 1.5, the median elbow flexion was 125 degrees, and the median MEPS was 85. Two patients presented radial nerve praxia, which resolved with physical therapy. Residual angulations were minimal and within the range of acceptable alignment in the osteosynthesis of a distal diaphyseal fracture of the humerus. Conclusion: This MIPO technique with an anterior approach and anterolateral fixation for meta-diaphyseal and distal diaphyseal extra-articular humerus fractures produced a stable reduction and fixation with satisfactory mid-to-long-term clinical and functional outcomes and low complication rates. Mención de responsabilidad : Valencia Zapata, Jaime Alberto, Afanador, Carlos Eduardo, Mejía, Oscar Alejandro, Calle Díaz, Sebastián, Jaramillo, German Alejandro, Herrera, Ana Milena Referencia : Medical Research Archives, [S.l.], v. 13, n. 3, mar. 2025. ISSN 2375-1924. Available at: <https://es DOI (Digital Object Identifier) : 10.18103/mra.v13i3.6425. Derechos de uso : CC BY-NC-ND En línea : https://esmed.org/MRA/mra/article/view/6425 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Minimally invasive osteosynthesis of distal humerus fracture with commercially available pre-contoured plate using an anterolateral fixation: mid to long-term results [documento electrónico] / Valencia Zapata, Jaime Alberto, Autor ; Afanador, Carlos Eduardo, Autor ; Mejía, Oscar Alejandro, Autor ; Calle Díaz, Sebastián, Autor ; Jaramillo, German Alejandro, Autor ; Herrera, Ana Milena, Autor . - 2025.
Obra : Medical Research Archives
Idioma : Inglés (eng) Idioma original : Inglés (eng)
Palabras clave : Humeral Fractures Distal; Fracture Fixation Internal; Bone Plates; Minimally Invasive Surgical Procedures Resumen : Background: Surgical treatment of distal diaphyseal humerus fractures (DDHF) minimally invasive plate osteosynthesis (MIPO) has gained popularity among orthopedic surgeons as it causes less soft-tissue disruption associated with other open approaches; however, the iatrogenic radial nerve injury is still a concern. Recently, a novel technique for a MIPO through anterior approach and anterolateral fixation was proposed as an alternative to reduce the risk of radial nerve damage. Aims: To determine the mid-to-long-term functional results and safety of a MIPO through an anterior approach and anterolateral fixation using a pre-contoured locking plate modified to adjust to the anatomical surface of the lateral column of the humerus. Methods: A prospective longitudinal follow-up of patients treated for a DDHF with MIPO through an anterior approach and anterolateral fixation using a pre-contoured locking plate modified to adjust to the anatomical surface of the lateral column of the humerus. Clinical evaluations included the active range of movement (AROM), functional assessment through the Mayo Elbow Performance Score (MEPS), and pain and complications. Radiographic evaluation included assessment of consolidation, residual angulations, and the optimal plate’s position. Results: This series included ten patients with 12A,12B, and 12C fractures. Patients were followed for a median of 36.9 months (9.5 – 62.5 months). At the last evaluation, the median pain level was 1.5, the median elbow flexion was 125 degrees, and the median MEPS was 85. Two patients presented radial nerve praxia, which resolved with physical therapy. Residual angulations were minimal and within the range of acceptable alignment in the osteosynthesis of a distal diaphyseal fracture of the humerus. Conclusion: This MIPO technique with an anterior approach and anterolateral fixation for meta-diaphyseal and distal diaphyseal extra-articular humerus fractures produced a stable reduction and fixation with satisfactory mid-to-long-term clinical and functional outcomes and low complication rates. Mención de responsabilidad : Valencia Zapata, Jaime Alberto, Afanador, Carlos Eduardo, Mejía, Oscar Alejandro, Calle Díaz, Sebastián, Jaramillo, German Alejandro, Herrera, Ana Milena Referencia : Medical Research Archives, [S.l.], v. 13, n. 3, mar. 2025. ISSN 2375-1924. Available at: <https://es DOI (Digital Object Identifier) : 10.18103/mra.v13i3.6425. Derechos de uso : CC BY-NC-ND En línea : https://esmed.org/MRA/mra/article/view/6425 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Association between inappropriate empirical antimicrobial therapy and mortality in gram-negative bloodstream infections in patients with febrile neutropenia and hematological malignancy Tipo de documento : documento electrónico Autores : Isabel Cristina Ramírez Sánchez, Autor ; Flórez Riaño, Ariel Fernando, Autor ; Rojas Castro, Oscar Julián, Autor ; Ospina, Sigifredo, Autor Fecha de publicación : 2025 Títulos uniformes : Journal of Infection and Chemotherapy Idioma : Español (spa) Idioma original : Inglés (eng) Palabras clave : Bloodstream infection; Carbapenem resistance; Empirical treatment; Febrile neutropenia; Gram-negative bacilli; Inappropriate therapy; Mortality Resumen : Background and objective: Inappropriate initial antimicrobial therapy has been associated with high mortality in patients with gram-negative bacilli bloodstream infections during febrile neutropenia following chemotherapy for hematological malignancies. The aim of this study is to determine this association in our hospital. Methods: A single center, retrospective, cohort study of bloodstream infection due to gram-negative bacilli and febrile neutropenia was conducted. Clinical characteristics, microbiological etiology, antimicrobial resistance profile, empirical and targeted antibiotic therapy, intensive care unit admission, persistent bacteremia and mortality were analyzed. Results: Of the 171 episodes of bloodstream infection due to gram-negative bacilli, empirical antimicrobial therapy was inappropriate in 43 episodes (25.1 %). There was a significant difference in mortality at 7 and 30 days between patients who received appropriate versus inappropriate empirical treatment (4.6 % versus 13.9 %, p = 0.04; 15.6 % versus 32.5 %, p = 0.016). Inappropriate empirical treatment (RR, 2.97 [95 % CI, 1.01–8.74]), shock at the time of febrile neutropenia diagnosis (RR, 6.5 [95 % CI, 1.83–23.05]) carbapenem-resistant microorganism (RR, 3.73 [95 % CI, 1.14–12.24]) and persistent bacteremia (RR, 84.6 [95 % CI, 11.3–629.4]) were associated with an increased mortality at 7 and 30 days. In the multivariate analysis, shock (RR, 4.85 [95 % CI, 2.10–11.65]) was independently associated with increased 30-day mortality, but inappropriate empirical antimicrobial therapy was not an independent prognostic determinant (RR, 1.66 [0.53–4.82]). Conclusion: Shock at the time of febrile neutropenia diagnosis contributes to mortality in patients with gram-negative bacilli bloodstream infection, in this scenario, appropriate empirical antimicrobial therapy should be encouraged. © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control Mención de responsabilidad : Flórez Riaño, Ariel Fernando, Rojas Castro, Oscar Julián, Ospina, Sigifredo, Ramírez-Sánchez, Isabel Cristina Referencia : Revista de Infecciones y Quimioterapia Volumen 31, Número 2 ,Febrero de 2025, 102538 DOI (Digital Object Identifier) : 10.1016/j.jiac.2024.10.006 PMID : 39396607 Derechos de uso : CC BY-NC-ND En línea : https://www.sciencedirect.com/science/article/abs/pii/S1341321X24002794 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Association between inappropriate empirical antimicrobial therapy and mortality in gram-negative bloodstream infections in patients with febrile neutropenia and hematological malignancy [documento electrónico] / Isabel Cristina Ramírez Sánchez, Autor ; Flórez Riaño, Ariel Fernando, Autor ; Rojas Castro, Oscar Julián, Autor ; Ospina, Sigifredo, Autor . - 2025.
Obra : Journal of Infection and Chemotherapy
Idioma : Español (spa) Idioma original : Inglés (eng)
Palabras clave : Bloodstream infection; Carbapenem resistance; Empirical treatment; Febrile neutropenia; Gram-negative bacilli; Inappropriate therapy; Mortality Resumen : Background and objective: Inappropriate initial antimicrobial therapy has been associated with high mortality in patients with gram-negative bacilli bloodstream infections during febrile neutropenia following chemotherapy for hematological malignancies. The aim of this study is to determine this association in our hospital. Methods: A single center, retrospective, cohort study of bloodstream infection due to gram-negative bacilli and febrile neutropenia was conducted. Clinical characteristics, microbiological etiology, antimicrobial resistance profile, empirical and targeted antibiotic therapy, intensive care unit admission, persistent bacteremia and mortality were analyzed. Results: Of the 171 episodes of bloodstream infection due to gram-negative bacilli, empirical antimicrobial therapy was inappropriate in 43 episodes (25.1 %). There was a significant difference in mortality at 7 and 30 days between patients who received appropriate versus inappropriate empirical treatment (4.6 % versus 13.9 %, p = 0.04; 15.6 % versus 32.5 %, p = 0.016). Inappropriate empirical treatment (RR, 2.97 [95 % CI, 1.01–8.74]), shock at the time of febrile neutropenia diagnosis (RR, 6.5 [95 % CI, 1.83–23.05]) carbapenem-resistant microorganism (RR, 3.73 [95 % CI, 1.14–12.24]) and persistent bacteremia (RR, 84.6 [95 % CI, 11.3–629.4]) were associated with an increased mortality at 7 and 30 days. In the multivariate analysis, shock (RR, 4.85 [95 % CI, 2.10–11.65]) was independently associated with increased 30-day mortality, but inappropriate empirical antimicrobial therapy was not an independent prognostic determinant (RR, 1.66 [0.53–4.82]). Conclusion: Shock at the time of febrile neutropenia diagnosis contributes to mortality in patients with gram-negative bacilli bloodstream infection, in this scenario, appropriate empirical antimicrobial therapy should be encouraged. © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control Mención de responsabilidad : Flórez Riaño, Ariel Fernando, Rojas Castro, Oscar Julián, Ospina, Sigifredo, Ramírez-Sánchez, Isabel Cristina Referencia : Revista de Infecciones y Quimioterapia Volumen 31, Número 2 ,Febrero de 2025, 102538 DOI (Digital Object Identifier) : 10.1016/j.jiac.2024.10.006 PMID : 39396607 Derechos de uso : CC BY-NC-ND En línea : https://www.sciencedirect.com/science/article/abs/pii/S1341321X24002794 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD002324 AC-2025-007 Archivo digital Producción Científica Artículos científicos Disponible
Título : Is tPA/DNase Effective Routine Initial Therapy for Pleural Empyema? Tipo de documento : documento electrónico Autores : Willfredy Castaño Ruiz, Autor ; Liberman, Moishe, Autor Fecha de publicación : 2025 Títulos uniformes : Springer Idioma : Inglés (eng) Resumen : Following the validation of intrapleural tPA/DNAse therapy for the treatment of pleural empyema by the MIST-2 trial, the medical community has shifted the management approach for empyema, favoring less aggressive alternatives to surgery with good results. Our comprehensive literature review revealed that the treatment of empyema with a tPA/DNase regimen has been proven effective in the management of stage 2 empyema, decreasing the need for surgical intervention. However, direct comparative analyses between this treatment strategy and surgery have not yielded statistically significant differences. Mención de responsabilidad : Willfredy Castano & Moishe Liberman DOI (Digital Object Identifier) : 10.1007/978-3-031-78663-1_50 Derechos de uso : CC BY-NC-ND En línea : https://link.springer.com/chapter/10.1007/978-3-031-78663-1_50 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Is tPA/DNase Effective Routine Initial Therapy for Pleural Empyema? [documento electrónico] / Willfredy Castaño Ruiz, Autor ; Liberman, Moishe, Autor . - 2025.
Obra : Springer
Idioma : Inglés (eng)
Resumen : Following the validation of intrapleural tPA/DNAse therapy for the treatment of pleural empyema by the MIST-2 trial, the medical community has shifted the management approach for empyema, favoring less aggressive alternatives to surgery with good results. Our comprehensive literature review revealed that the treatment of empyema with a tPA/DNase regimen has been proven effective in the management of stage 2 empyema, decreasing the need for surgical intervention. However, direct comparative analyses between this treatment strategy and surgery have not yielded statistically significant differences. Mención de responsabilidad : Willfredy Castano & Moishe Liberman DOI (Digital Object Identifier) : 10.1007/978-3-031-78663-1_50 Derechos de uso : CC BY-NC-ND En línea : https://link.springer.com/chapter/10.1007/978-3-031-78663-1_50 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Latin American association for the study of the liver (ALEH) guidance on postoperative care after liver transplantation Tipo de documento : documento electrónico Autores : Juan Carlos Restrepo Gutiérrez, Autor ; Codes, Liana, Autor ; Zapata, Rodrigo, Autor ; Mendizabal, Manuel, Autor ; Fleck Junior, Alfeu de Medeiros, Autor ; de Lucca Schiavon, Leonardo, Autor ; Sá Malbouisson, Luiz Marcelo, Autor ; Andraus, Wellington, Autor ; Gadano, Adrian, Autor ; Padilla Machaca, P Martin, Autor ; Bello Stucchi, Raquel Silveira, Autor ; Castro Narro, Graciela Elia, Autor ; Pages, Josefina, Autor ; Benedita Terrabuio, Debora Raquel, Autor ; Urzúa, Álvaro, Autor ; Guimarães Pesso, Mário, Autor ; Mainardi, Victoria, Autor ; Rodolpho, Pedro, Autor ; Imventarza, Oscar, Autor ; Gerona, Solange, Autor ; Wolff, Rodrigo, Autor ; Abdala, Edson, Autor ; Tenorio, Laura, Autor ; Cerda Reyes, Eira, Autor ; Cairo, Fernando, Autor ; Uribe, Mario, Autor ; Lisboa Bittencourt, Paulo, Autor Fecha de publicación : 2025 Títulos uniformes : Annals of Hepatology Idioma : Inglés (eng) Palabras clave : Immunosuppression; Latin America; Liver transplantation; Postoperative care Resumen : Liver transplantation (LT) is a well-established therapy for patients with decompensated cirrhosis and early-stage hepatocellular carcinoma. Liver transplantation activity varies sharply across Latin American (LATAM) countries due to differences in resources, expertise, and funding and local attitudes toward organ donation and transplantation. This current guidance of postoperative care after LT is the first position paper of the Latin American Association for the Study of the Liver (ALEH) Special Interest Group (SIG), drawing evidence-based recommendations regarding immediate and long-term postoperative care of LT recipients, taking into consideration their applicability in Latin America. © 2025 Fundación Clínica Médica Sur, A.C. Mención de responsabilidad : Codes, Liana; Zapata, Rodrigo; Mendizabal, Manuel; Junior, Alfeu de Medeiros Fleck; Restrepo, Juan Carlos; Schiavon, Leonardo de Lucca; Malbouisson, Luiz Marcelo Sá; Andraus, Wellington; Gadano, Adrian; Padilla-Machaca, P. Martin; Villamil, Alejandra; Stucchi, Raquel Silveira Bello; Castro-Narro, Graciela Elia; Pages, Josefina; Terrabuio, Debora Raquel Benedita; Urzúa, Alvaro; Pessoa, Mário Guimarães; Mainardi, Victoria; Pedro, Rodolpho; Imventarza, Oscar; Gerona, Solange; Wolff, Rodrigo; Abdala, Edson; Tenorio, Laura; Cerda-Reyes, Eira; Cairo, Fernando; Uribe, Mario; Bittencourt, Paulo Lisboa; Chong, Ricardo; Figueroa, Norma Marlene Perez; González, John Byron Abad; Murillo, Pablo Coste. Referencia : Ann Hepatol . 2025 Mar 7;30(2):101899. doi: 10.1016/j.aohep.2025.101899. DOI (Digital Object Identifier) : 10.1016/j.aohep.2025.101899 PMID : 40057036 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40057036/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Latin American association for the study of the liver (ALEH) guidance on postoperative care after liver transplantation [documento electrónico] / Juan Carlos Restrepo Gutiérrez, Autor ; Codes, Liana, Autor ; Zapata, Rodrigo, Autor ; Mendizabal, Manuel, Autor ; Fleck Junior, Alfeu de Medeiros, Autor ; de Lucca Schiavon, Leonardo, Autor ; Sá Malbouisson, Luiz Marcelo, Autor ; Andraus, Wellington, Autor ; Gadano, Adrian, Autor ; Padilla Machaca, P Martin, Autor ; Bello Stucchi, Raquel Silveira, Autor ; Castro Narro, Graciela Elia, Autor ; Pages, Josefina, Autor ; Benedita Terrabuio, Debora Raquel, Autor ; Urzúa, Álvaro, Autor ; Guimarães Pesso, Mário, Autor ; Mainardi, Victoria, Autor ; Rodolpho, Pedro, Autor ; Imventarza, Oscar, Autor ; Gerona, Solange, Autor ; Wolff, Rodrigo, Autor ; Abdala, Edson, Autor ; Tenorio, Laura, Autor ; Cerda Reyes, Eira, Autor ; Cairo, Fernando, Autor ; Uribe, Mario, Autor ; Lisboa Bittencourt, Paulo, Autor . - 2025.
Obra : Annals of Hepatology
Idioma : Inglés (eng)
Palabras clave : Immunosuppression; Latin America; Liver transplantation; Postoperative care Resumen : Liver transplantation (LT) is a well-established therapy for patients with decompensated cirrhosis and early-stage hepatocellular carcinoma. Liver transplantation activity varies sharply across Latin American (LATAM) countries due to differences in resources, expertise, and funding and local attitudes toward organ donation and transplantation. This current guidance of postoperative care after LT is the first position paper of the Latin American Association for the Study of the Liver (ALEH) Special Interest Group (SIG), drawing evidence-based recommendations regarding immediate and long-term postoperative care of LT recipients, taking into consideration their applicability in Latin America. © 2025 Fundación Clínica Médica Sur, A.C. Mención de responsabilidad : Codes, Liana; Zapata, Rodrigo; Mendizabal, Manuel; Junior, Alfeu de Medeiros Fleck; Restrepo, Juan Carlos; Schiavon, Leonardo de Lucca; Malbouisson, Luiz Marcelo Sá; Andraus, Wellington; Gadano, Adrian; Padilla-Machaca, P. Martin; Villamil, Alejandra; Stucchi, Raquel Silveira Bello; Castro-Narro, Graciela Elia; Pages, Josefina; Terrabuio, Debora Raquel Benedita; Urzúa, Alvaro; Pessoa, Mário Guimarães; Mainardi, Victoria; Pedro, Rodolpho; Imventarza, Oscar; Gerona, Solange; Wolff, Rodrigo; Abdala, Edson; Tenorio, Laura; Cerda-Reyes, Eira; Cairo, Fernando; Uribe, Mario; Bittencourt, Paulo Lisboa; Chong, Ricardo; Figueroa, Norma Marlene Perez; González, John Byron Abad; Murillo, Pablo Coste. Referencia : Ann Hepatol . 2025 Mar 7;30(2):101899. doi: 10.1016/j.aohep.2025.101899. DOI (Digital Object Identifier) : 10.1016/j.aohep.2025.101899 PMID : 40057036 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40057036/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Association between Hippocampal Volume and Cognition in the Oldest?Old Individuals from Colombia Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, Autor ; Martín Ochoa Escudero, Autor ; Kaplan, Elizabeth, Autor ; Zuluaga, Yesica, Autor ; Vasquez, Daniel, Autor ; Hincapie, Liliana, Autor ; Aguillon, David Fernando, Autor ; Madrigal, Lucia, Autor ; Baena, Ana Y, Autor ; Vila Castelar, Clara, Autor ; Giraldo Chica, Margarita M, Autor ; Ramirez Gomez, Liliana A, Autor ; Langella, Stephanie, Autor ; Arboleda Velasquez, Joseph F, Autor ; Lopera, Francisco, Autor ; Quiroz, Yakeel T, Autor Fecha de publicación : 2025 Títulos uniformes : Alzheimers Dement Idioma : Inglés (eng) Resumen : Life expectancy is on the rise, accompanied by an increased prevalence of cognitive impairment and Alzheimer’s disease. Despite this global trend, our understanding of the neural mechanisms underlying cognitive changes in the oldest?old (>80 years old) population remains limited. Unraveling these mechanisms may provide valuable insights and therapeutic interventions for individuals grappling with cognitive impairments in older age. Increased hippocampal volume has been associated with better cognitive function and its sparing in late life has been linked to better cognitive and functional outcomes. In this study, we examined hippocampal volume and cognitive performance in a group of the oldest?old individuals from Colombia. Mención de responsabilidad : Kaplan E, Zuluaga Y, Vasquez D, Hincapie L, Aguillon DF, Madrigal L, Baena AY, Vila?Castelar C, Alvarez S, Ochoa?Escudero M, Giraldo?Chica MM, Gomez LAR, Langella S, Arboleda?Velasquez JF, Lopera F, Quiroz YT Referencia : Alzheimers Dement. 2025 Jan 3;20(Suppl 3):e090936. DOI (Digital Object Identifier) : 10.1002/alz.090936 PMID : 11710158 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11710158/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Association between Hippocampal Volume and Cognition in the Oldest?Old Individuals from Colombia [documento electrónico] / Sergio Álvarez Vallejo, Autor ; Martín Ochoa Escudero, Autor ; Kaplan, Elizabeth, Autor ; Zuluaga, Yesica, Autor ; Vasquez, Daniel, Autor ; Hincapie, Liliana, Autor ; Aguillon, David Fernando, Autor ; Madrigal, Lucia, Autor ; Baena, Ana Y, Autor ; Vila Castelar, Clara, Autor ; Giraldo Chica, Margarita M, Autor ; Ramirez Gomez, Liliana A, Autor ; Langella, Stephanie, Autor ; Arboleda Velasquez, Joseph F, Autor ; Lopera, Francisco, Autor ; Quiroz, Yakeel T, Autor . - 2025.
Obra : Alzheimers Dement
Idioma : Inglés (eng)
Resumen : Life expectancy is on the rise, accompanied by an increased prevalence of cognitive impairment and Alzheimer’s disease. Despite this global trend, our understanding of the neural mechanisms underlying cognitive changes in the oldest?old (>80 years old) population remains limited. Unraveling these mechanisms may provide valuable insights and therapeutic interventions for individuals grappling with cognitive impairments in older age. Increased hippocampal volume has been associated with better cognitive function and its sparing in late life has been linked to better cognitive and functional outcomes. In this study, we examined hippocampal volume and cognitive performance in a group of the oldest?old individuals from Colombia. Mención de responsabilidad : Kaplan E, Zuluaga Y, Vasquez D, Hincapie L, Aguillon DF, Madrigal L, Baena AY, Vila?Castelar C, Alvarez S, Ochoa?Escudero M, Giraldo?Chica MM, Gomez LAR, Langella S, Arboleda?Velasquez JF, Lopera F, Quiroz YT Referencia : Alzheimers Dement. 2025 Jan 3;20(Suppl 3):e090936. DOI (Digital Object Identifier) : 10.1002/alz.090936 PMID : 11710158 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11710158/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : P1261 Reproductive Health Outcomes in Colombian Women with Inflammatory Bowel Disease: A Multicenter Cohort Study on Pregnancy, Fertility, and Disease Impact (REINFORCE Study) Tipo de documento : documento electrónico Autores : Osorio Castrillón, Laura Marcela, Autor ; Fabián Juliao Baños, Autor ; Parra Izquierdo, Viviana, Autor ; Frías Ordoñez, Juan Sebastián, Autor Fecha de publicación : 2025 Títulos uniformes : Journal of Crohn's and Colitis Idioma : Inglés (eng) Resumen : Background: The impact of Inflammatory Bowel Disease (IBD) on women's health, particularly in relation to reproductive health, remains an underexplored area in Latin American populations. This study aims to assess the effects of IBD on women's reproductive health, including pregnancy outcomes, fertility, and related complications, within a cohort of Colombian women. Methods: Observational, multicenter and descriptive study involving adult and pediatric patients from two IBD Centers in different cities in Colombia. The study focused on evaluating aspects of sexual and reproductive health in women with IBD, with detailed data collection on pregnancy, fertility, childbirth, and cancer screening Results: Out of a total of 121 women with IBD, 63.6% (77/121 patients) were in reproductive age (15–44 years according to World Health Organization) (Table 1), the mean age was 33.2 years (range: 17.2–44.8 years, SD: 8), with a mean age at diagnosis of 28 years (range: 9.3–45.1 years, SD: 8.8) and a disease duration of 5.2 years (range: 0.3–21.9 years, SD: 4.7). UC was more prevalent in this group (71.4%). Most women had low rates of smoking, hospitalization, and surgical interventions for IBD, and pregnancy-related complications were generally rare. The majority of births were vaginal deliveries, and breastfeeding beyond 6 months was common, suggesting protective effects against IBD risk in offspring. Notably, while HPV vaccination rates were low, the prevalence of cervical cancer was also low. Family planning was reported by 48% of participants, and 1% required assisted reproductive technologies. Statistical analysis showed no significant association between age and pregnancy complications across age groups. However, UC was significantly associated with a higher risk of pregnancy complications (OR 5.5; 95% CI: 1.9–14.9; p=0.0001), and Crohn's disease (CD) also showed a trend toward increased risk (OR 4.6; 95% CI : 0.2–20.4; p=0.00002). Previous history of hospitalization due to disease activity, surgery, and the use of biological therapy was associated with an increased risk of pregnancy complications when it occurred (OR 1.97; 95% CI: 1.6–2.5; p= 0.07 for hospitalization, OR 12.12; 95% CI: 4.2–27.8; p=0.03 for surgery, OR 5.2; 95% CI: 1.64-13.1 ;p=0.00001). Conclusion: This study underscores the significant impact of IBD on reproductive health in Colombian women, similar to trends in other populations. It emphasizes the importance of effective disease management before conception, given that the use of biological therapies that usually are associated with more severe disease, ongoing disease activity, and prior surgical interventions are risk factors for increased pregnancy complications. Mención de responsabilidad : V Parra Izquierdo , L Osorio-Castrillon , F Juliao-Baños , J Frías-Ordoñez Referencia : Journal of Crohn's and Colitis, Volume 19, Issue Supplement_1, January 2025, Pages i2282–i2283, DOI (Digital Object Identifier) : 10.1093/ecco-jcc/jjae190.1435 Derechos de uso : CC BY-NC-ND En línea : https://academic.oup.com/ecco-jcc/article/19/Supplement_1/i2282/7972126 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis P1261 Reproductive Health Outcomes in Colombian Women with Inflammatory Bowel Disease: A Multicenter Cohort Study on Pregnancy, Fertility, and Disease Impact (REINFORCE Study) [documento electrónico] / Osorio Castrillón, Laura Marcela, Autor ; Fabián Juliao Baños, Autor ; Parra Izquierdo, Viviana, Autor ; Frías Ordoñez, Juan Sebastián, Autor . - 2025.
Obra : Journal of Crohn's and Colitis
Idioma : Inglés (eng)
Resumen : Background: The impact of Inflammatory Bowel Disease (IBD) on women's health, particularly in relation to reproductive health, remains an underexplored area in Latin American populations. This study aims to assess the effects of IBD on women's reproductive health, including pregnancy outcomes, fertility, and related complications, within a cohort of Colombian women. Methods: Observational, multicenter and descriptive study involving adult and pediatric patients from two IBD Centers in different cities in Colombia. The study focused on evaluating aspects of sexual and reproductive health in women with IBD, with detailed data collection on pregnancy, fertility, childbirth, and cancer screening Results: Out of a total of 121 women with IBD, 63.6% (77/121 patients) were in reproductive age (15–44 years according to World Health Organization) (Table 1), the mean age was 33.2 years (range: 17.2–44.8 years, SD: 8), with a mean age at diagnosis of 28 years (range: 9.3–45.1 years, SD: 8.8) and a disease duration of 5.2 years (range: 0.3–21.9 years, SD: 4.7). UC was more prevalent in this group (71.4%). Most women had low rates of smoking, hospitalization, and surgical interventions for IBD, and pregnancy-related complications were generally rare. The majority of births were vaginal deliveries, and breastfeeding beyond 6 months was common, suggesting protective effects against IBD risk in offspring. Notably, while HPV vaccination rates were low, the prevalence of cervical cancer was also low. Family planning was reported by 48% of participants, and 1% required assisted reproductive technologies. Statistical analysis showed no significant association between age and pregnancy complications across age groups. However, UC was significantly associated with a higher risk of pregnancy complications (OR 5.5; 95% CI: 1.9–14.9; p=0.0001), and Crohn's disease (CD) also showed a trend toward increased risk (OR 4.6; 95% CI : 0.2–20.4; p=0.00002). Previous history of hospitalization due to disease activity, surgery, and the use of biological therapy was associated with an increased risk of pregnancy complications when it occurred (OR 1.97; 95% CI: 1.6–2.5; p= 0.07 for hospitalization, OR 12.12; 95% CI: 4.2–27.8; p=0.03 for surgery, OR 5.2; 95% CI: 1.64-13.1 ;p=0.00001). Conclusion: This study underscores the significant impact of IBD on reproductive health in Colombian women, similar to trends in other populations. It emphasizes the importance of effective disease management before conception, given that the use of biological therapies that usually are associated with more severe disease, ongoing disease activity, and prior surgical interventions are risk factors for increased pregnancy complications. Mención de responsabilidad : V Parra Izquierdo , L Osorio-Castrillon , F Juliao-Baños , J Frías-Ordoñez Referencia : Journal of Crohn's and Colitis, Volume 19, Issue Supplement_1, January 2025, Pages i2282–i2283, DOI (Digital Object Identifier) : 10.1093/ecco-jcc/jjae190.1435 Derechos de uso : CC BY-NC-ND En línea : https://academic.oup.com/ecco-jcc/article/19/Supplement_1/i2282/7972126 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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