What to Look for in Chest X?Rays of Pediatric Patients With COVID?19: Insights From a Colombian Cohort / Alejandro Díaz Díaz ; Burgos, Claudia ; Mendez, Laura Melissa ; Rodriguez, María Margarita ; Martinez, Arianna ; Sanchez, Paola ; Tovar, Carolina ; Naranjo Vanegas, Melisa ; Friedrich, Gabriela ; Vásquez Hoyos, Pablo ; Mesa Rubio, María Lucía ; Triana Rodriguez, Gustavo Adolfo ; Royero Arias, Mónica ; Echeverry, Jessica ; Gamo, Tamara ; Moreno, Luz Ángela ; Baquero, Olga Lucía ; Marina Mejía, Luz ; Restrepo Gualteros, Sonia ; Navarro Ramirez, Luis Miguel ; Moreno Lopez, Sergio ; Piñeros, Juan Gabriel ; Álvarez Moreno, Carlos ; Gutierrez, Iván Felipe ; Galvis Diaz, Clara ; Nieto, José Manuel ; Gastesi, Irati ; Moraleda, Cinta ; Tagarro García, Alfredo ; Ramirez Varela, Andrea  

Público ISBD Título : What to Look for in Chest X?Rays of Pediatric Patients With COVID?19: Insights From a Colombian Cohort Tipo de documento : documento electrónico Autores : Alejandro Díaz Díaz, Autor ; Burgos, Claudia, Autor ; Mendez, Laura Melissa, Autor ; Rodriguez, María Margarita, Autor ; Martinez, Arianna, Autor ; Sanchez, Paola, Autor ; Tovar, Carolina, Autor ; Naranjo Vanegas, Melisa, Autor ; Friedrich, Gabriela, Autor ; Vásquez Hoyos, Pablo, Autor ; Mesa Rubio, María Lucía, Autor ; Triana Rodriguez, Gustavo Adolfo, Autor ; Royero Arias, Mónica, Autor ; Echeverry, Jessica, Autor ; Gamo, Tamara, Autor ; Moreno, Luz Ángela, Autor ; Baquero, Olga Lucía, Autor ; Marina Mejía, Luz, Autor ; Restrepo Gualteros, Sonia, Autor ; Navarro Ramirez, Luis Miguel, Autor ; Moreno Lopez, Sergio, Autor ; Piñeros, Juan Gabriel, Autor ; Álvarez Moreno, Carlos, Autor ; Gutierrez, Iván Felipe, Autor ; Galvis Diaz, Clara, Autor ; Nieto, José Manuel, Autor ; Gastesi, Irati, Autor ; Moraleda, Cinta, Autor ; Tagarro García, Alfredo, Autor ; Ramirez Varela, Andrea, Autor Fecha de publicación : 2025 Títulos uniformes : Pediatric Pulmonology Idioma : Inglés (eng) Palabras clave : COVID?19 | diagnostic imaging | EPICO study | intensive care unit | pediatric infection | radiology | SARS?CoV?2 Resumen : Despite advancements in vaccination and the transition from pandemic to endemic, SARS-CoV-2 continues to pose a medical challenge, particularly among children. In this context, imaging diagnostics, such as chest x-rays, are crucial to the initial treatment of patients. This study aims to characterize the radiological findings in pediatric patients with confirmed SARS-CoV-2 infection in Colombia between April 2020 and November 2021, as well as describe the clinical presentation, including those admission to intensive care. Methods: In Colombia, a multicenter cohort comprised patients aged 29 days to 17 years with confirmed SARS-CoV-2 infection and chest X-ray taken within 72 h of hospitalization. In two separate groups, four radiologists evaluated the images. A fifth radiologist reviewed all the X-rays; and subsequently, these readings were used to calculate the kappa coefficient and to solve discrepancies among the other radiologists. The results were compared from admission to intensive care. Results: Analysis was conducted on 392 patients with a median age of 2 years, the majority of whom (42%) were infants. Sixty-eight percent of the radiographs had normal results. Peribronchial thickening and interstitial opacity were the most common aberrant findings (59%), followed by alveolar opacity (12%). 88 percent of findings were bilateral. In our cohort, peribronchial thickening was the most common radiological pattern found in patients admitted the PICU and with ventilatory failure. Interobserver agreement was low for peribronchial thickening (kappa = 0.1), but higher for consolidations and alveolar opacities (kappa = 0.4 and 0.5, respectively). Conclusion: In pediatric patients with SARS-CoV-2, radiological findings are nonspecific and interobserver agreement is minimal. Although consolidation and alveolar opacities demonstrated greater concordance, they did not appear to reflect the clinical presentation; therefore, our results can suggest chest radiography is not considered useful for determining the severity of COVID-19 in Mención de responsabilidad : Claudia Burgos, Laura Melissa Mendez, María Margarita Rodriguez, Arianna Martinez, Paola Sanchez, Carolina Tovar, Melisa Naranjo Vanegas, Gabriela Friedrich, Pablo Vásquez Hoyos, María Lucía Mesa Rubio, Referencia : Pediatr Pulmonol . 2025 Mar;60(3):e27495. doi: 10.1002/ppul.27495. DOI (Digital Object Identifier) : 10.1002/ppul.27495 PMID : 40018994 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40018994/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis What to Look for in Chest X?Rays of Pediatric Patients With COVID?19: Insights From a Colombian Cohort [documento electrónico] / Alejandro Díaz Díaz, Autor ; Burgos, Claudia, Autor ; Mendez, Laura Melissa, Autor ; Rodriguez, María Margarita, Autor ; Martinez, Arianna, Autor ; Sanchez, Paola, Autor ; Tovar, Carolina, Autor ; Naranjo Vanegas, Melisa, Autor ; Friedrich, Gabriela, Autor ; Vásquez Hoyos, Pablo, Autor ; Mesa Rubio, María Lucía, Autor ; Triana Rodriguez, Gustavo Adolfo, Autor ; Royero Arias, Mónica, Autor ; Echeverry, Jessica, Autor ; Gamo, Tamara, Autor ; Moreno, Luz Ángela, Autor ; Baquero, Olga Lucía, Autor ; Marina Mejía, Luz, Autor ; Restrepo Gualteros, Sonia, Autor ; Navarro Ramirez, Luis Miguel, Autor ; Moreno Lopez, Sergio, Autor ; Piñeros, Juan Gabriel, Autor ; Álvarez Moreno, Carlos, Autor ; Gutierrez, Iván Felipe, Autor ; Galvis Diaz, Clara, Autor ; Nieto, José Manuel, Autor ; Gastesi, Irati, Autor ; Moraleda, Cinta, Autor ; Tagarro García, Alfredo, Autor ; Ramirez Varela, Andrea, Autor . - 2025. Obra : Pediatric Pulmonology Idioma : Inglés (eng) Palabras clave : COVID?19 | diagnostic imaging | EPICO study | intensive care unit | pediatric infection | radiology | SARS?CoV?2 Resumen : Despite advancements in vaccination and the transition from pandemic to endemic, SARS-CoV-2 continues to pose a medical challenge, particularly among children. In this context, imaging diagnostics, such as chest x-rays, are crucial to the initial treatment of patients. This study aims to characterize the radiological findings in pediatric patients with confirmed SARS-CoV-2 infection in Colombia between April 2020 and November 2021, as well as describe the clinical presentation, including those admission to intensive care. Methods: In Colombia, a multicenter cohort comprised patients aged 29 days to 17 years with confirmed SARS-CoV-2 infection and chest X-ray taken within 72 h of hospitalization. In two separate groups, four radiologists evaluated the images. A fifth radiologist reviewed all the X-rays; and subsequently, these readings were used to calculate the kappa coefficient and to solve discrepancies among the other radiologists. The results were compared from admission to intensive care. Results: Analysis was conducted on 392 patients with a median age of 2 years, the majority of whom (42%) were infants. Sixty-eight percent of the radiographs had normal results. Peribronchial thickening and interstitial opacity were the most common aberrant findings (59%), followed by alveolar opacity (12%). 88 percent of findings were bilateral. In our cohort, peribronchial thickening was the most common radiological pattern found in patients admitted the PICU and with ventilatory failure. Interobserver agreement was low for peribronchial thickening (kappa = 0.1), but higher for consolidations and alveolar opacities (kappa = 0.4 and 0.5, respectively). Conclusion: In pediatric patients with SARS-CoV-2, radiological findings are nonspecific and interobserver agreement is minimal. Although consolidation and alveolar opacities demonstrated greater concordance, they did not appear to reflect the clinical presentation; therefore, our results can suggest chest radiography is not considered useful for determining the severity of COVID-19 in Mención de responsabilidad : Claudia Burgos, Laura Melissa Mendez, María Margarita Rodriguez, Arianna Martinez, Paola Sanchez, Carolina Tovar, Melisa Naranjo Vanegas, Gabriela Friedrich, Pablo Vásquez Hoyos, María Lucía Mesa Rubio, Referencia : Pediatr Pulmonol . 2025 Mar;60(3):e27495. doi: 10.1002/ppul.27495. DOI (Digital Object Identifier) : 10.1002/ppul.27495 PMID : 40018994 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40018994/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Handgrip strength as a predictor of 1?year mortality after hip fracture surgery in the Colombian Andes Mountains / Toro, Angél    

Público ISBD Título : Handgrip strength as a predictor of 1?year mortality after hip fracture surgery in the Colombian Andes Mountains Tipo de documento : documento electrónico Autores : Toro, Angél, Autor ; González, Fernando Iván, Autor ; Botero, Sandra, Autor ; García, Hernán David, Autor ; Duque, Gustavo, Autor ; Gómez, Fernando, Autor Fecha de publicación : 2025 Títulos uniformes : Osteoporosis International ISBN/ISSN/DL : 98700011909 Idioma : Inglés (eng) Palabras clave : Aging; Colombia  Handgrip strength; Hip fracture  Mortality  Older persons. Clasificación: AC-2025-001 Resumen : Abstract Hip fracture is a public health problem recognized worldwide and a potentially catastrophic threat for older persons, even carrying a demonstrated excess of mortality. Handgrip strength (HGS) has been identified as a predictor of different outcomes (mainly mortality and disability) in several groups with hip fracture. Purpose: The aim of this study was to determine the association between low HGS and 1-year mortality in a cohort of older patients over 60 years old with fragility hip fractures who underwent surgery in the Colombian Andes Mountains. Methods: A total of 126 patients (median age 81 years, women 77%) with a fragility hip fracture during 2019-2020 were admitted to a tertiary care hospital. HGS was measured using dynamometry upon admission, and data about sociodemographic, clinical and functional, laboratory, and surgical intervention variables were collected. They were followed up until discharge. Those who survived were contacted by telephone at one, three, and 12 months. Bivariate, multivariate, and Kaplan-Meier analyses with survival curves were performed. Results: The prevalence of low HGS in the cohort was 71.4%, and these patients were older, had poorer functional and cognitive status, higher comorbidity, higher surgical risk, time from admission to surgery > 72 h, lower hemoglobin and albumin values, and greater intra-hospital mortality at one and three months (all p Mención de responsabilidad : Luis-Ángel Toro 1, Fernando-Iván González 2, Sandra Botero 3, Hernán-David García 1, Gustavo Duque 4 5, Fernando Gómez 6 Referencia : Osteoporos Int . 2025 Jan;36(1):61-69. Epub 2024 Oct 17 DOI (Digital Object Identifier) : 10.1007/s00198-024-07258-3 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/39419826/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Handgrip strength as a predictor of 1?year mortality after hip fracture surgery in the Colombian Andes Mountains [documento electrónico] / Toro, Angél, Autor ; González, Fernando Iván, Autor ; Botero, Sandra, Autor ; García, Hernán David, Autor ; Duque, Gustavo, Autor ; Gómez, Fernando, Autor . - 2025. ISSN : 98700011909 Obra : Osteoporosis International Idioma : Inglés (eng) Palabras clave : Aging; Colombia  Handgrip strength; Hip fracture  Mortality  Older persons. Clasificación: AC-2025-001 Resumen : Abstract Hip fracture is a public health problem recognized worldwide and a potentially catastrophic threat for older persons, even carrying a demonstrated excess of mortality. Handgrip strength (HGS) has been identified as a predictor of different outcomes (mainly mortality and disability) in several groups with hip fracture. Purpose: The aim of this study was to determine the association between low HGS and 1-year mortality in a cohort of older patients over 60 years old with fragility hip fractures who underwent surgery in the Colombian Andes Mountains. Methods: A total of 126 patients (median age 81 years, women 77%) with a fragility hip fracture during 2019-2020 were admitted to a tertiary care hospital. HGS was measured using dynamometry upon admission, and data about sociodemographic, clinical and functional, laboratory, and surgical intervention variables were collected. They were followed up until discharge. Those who survived were contacted by telephone at one, three, and 12 months. Bivariate, multivariate, and Kaplan-Meier analyses with survival curves were performed. Results: The prevalence of low HGS in the cohort was 71.4%, and these patients were older, had poorer functional and cognitive status, higher comorbidity, higher surgical risk, time from admission to surgery > 72 h, lower hemoglobin and albumin values, and greater intra-hospital mortality at one and three months (all p Mención de responsabilidad : Luis-Ángel Toro 1, Fernando-Iván González 2, Sandra Botero 3, Hernán-David García 1, Gustavo Duque 4 5, Fernando Gómez 6 Referencia : Osteoporos Int . 2025 Jan;36(1):61-69. Epub 2024 Oct 17 DOI (Digital Object Identifier) : 10.1007/s00198-024-07258-3 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/39419826/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Handgrip strength as a predictor of 1?year mortality after hip fracture surgery in the Colombian Andes Mountains URL

Moderate alcohol-associated hepatitis: A real-world multicenter study / Juan Carlos Restrepo Gutiérrez ; Díaz, Luis Antonio ; Dunn, Winston ; Mehta, Heer ; Muñoz, Karen ; Caldentey, Vicente ; Arnold, Jorge ; Ayares, Gustavo ; Mortuza, Rokhsana ; Sarin, Shiv K. ; Maiwall, Rakhi ; Zhang, Wei ; Qian, Steve ; Simonetto, Douglas ; Singal, Ashwani K. ; Elfeki, Mohamed A. ; Ramirez Cadiz, Carolina ; Malhi, Gurpreet ; Ahmed, Adan ; Homsi, Hoomam ; Abid, Zinia ; Cabezas, Joaquín ; Echavarría, Victor ; Poca, Maria ; Soriano, German ; Cuyas, Berta ; Ventura Cots, Meritxell ; Higuera De La Tijera, María Fátima ; Ayala Valverde, Maria ; Pérez, Diego ; Gomez, Jaime ; Al-Karaghouli, Mustafa ; Jalal, Prasun K. ; Ibrahim, Mohamad Ali ; García Tsao, Guadalupe ; Goyes, Daniela ; Skladaný, Lubomir ; Havaj, Daniel J. ; Adamcova Selcanova, Svetlana ; Rincón, Diego ; Chacko, Kristina R. ; Yaquich, Pamela ; Toro, Luis G. ; Shah, Vijay ; Arrese, Marco ; Kamath, Patrick S. ; Bataller, Ramon ; Arab, Juan Pablo  

Público ISBD Título : Moderate alcohol-associated hepatitis: A real-world multicenter study Tipo de documento : documento electrónico Autores : Juan Carlos Restrepo Gutiérrez, Autor ; Díaz, Luis Antonio, Autor ; Dunn, Winston, Autor ; Mehta, Heer, Autor ; Muñoz, Karen, Autor ; Caldentey, Vicente, Autor ; Arnold, Jorge, Autor ; Ayares, Gustavo, Autor ; Mortuza, Rokhsana, Autor ; Sarin, Shiv K., Autor ; Maiwall, Rakhi, Autor ; Zhang, Wei, Autor ; Qian, Steve, Autor ; Simonetto, Douglas, Autor ; Singal, Ashwani K., Autor ; Elfeki, Mohamed A., Autor ; Ramirez Cadiz, Carolina, Autor ; Malhi, Gurpreet, Autor ; Ahmed, Adan, Autor ; Homsi, Hoomam, Autor ; Abid, Zinia, Autor ; Cabezas, Joaquín, Autor ; Echavarría, Victor, Autor ; Poca, Maria, Autor ; Soriano, German, Autor ; Cuyas, Berta, Autor ; Ventura Cots, Meritxell, Autor ; Higuera De La Tijera, María Fátima, Autor ; Ayala Valverde, Maria, Autor ; Pérez, Diego, Autor ; Gomez, Jaime, Autor ; Al-Karaghouli, Mustafa, Autor ; Jalal, Prasun K., Autor ; Ibrahim, Mohamad Ali, Autor ; García Tsao, Guadalupe, Autor ; Goyes, Daniela, Autor ; Skladaný, Lubomir, Autor ; Havaj, Daniel J., Autor ; Adamcova Selcanova, Svetlana, Autor ; Rincón, Diego, Autor ; Chacko, Kristina R., Autor ; Yaquich, Pamela, Autor ; Toro, Luis G., Autor ; Shah, Vijay, Autor ; Arrese, Marco, Autor ; Kamath, Patrick S., Autor ; Bataller, Ramon, Autor ; Arab, Juan Pablo, Autor Fecha de publicación : 2025 Títulos uniformes : Hepatology Communications Idioma : Inglés (eng) Resumen : Background: Severe alcohol-associated hepatitis (sAH) is a well-characterized disease with high short-term mortality. However, there is limited research on those with a "less severe condition" (moderate AH). This study aims to characterize in-depth patients with moderate AH (mAH), including the performance of mortality scoring systems, key prognostic factors, and survival over time. Methods: A multicenter retrospective cohort study (2009-2019) included patients with mAH (MELD score ?20 at admission). Cox regression and receiver operating characteristic curves with AUC were used for analysis. Results: We included 1845 patients with AH (20 centers, 8 countries) between 2009 and 2019. mAH was defined as a MELD score ?20 at admission. Twenty-four percent met the criteria for an mAH episode. Patients with mAH tend to be older and have a higher proportion of females, with a median MELD of 17 (15-19), Maddrey discriminant function (mDF) of 33 (22-40), the trajectory of serum bilirubin of 0.83 (0.60-1.21), and neutrophil-to-lymphocyte ratio (NLR) of 5 (2.96-8.60). The primary causes of death in mAH included multiple organ failure (34.1%) and infections (16.6%). The cumulative survival rates at 30, 90, and 180 days were 94.3%, 90.4%, and 88.2%, respectively. In multivariable analysis, age was the only significant predictor of 30-day mortality (HR 1.49, 95% CI: 1.27-1.76, p Mención de responsabilidad : Idalsoaga, Francisco1,2; Díaz, Luis Antonio1,3; Dunn, Winston4; Mehta, Heer4; Muñoz, Karen5; Caldentey, Vicente5; Arnold, Jorge1; Ayares, Gustavo2; Mortuza, Rokhsana2; Sarin, Shiv K.6; Maiwall, Rakhi6; Zhang, Wei7; Qian, Steve8; Simonetto, Douglas9; Singal, Ashwani K.10; Elfeki, Mohamed A.10; Ramirez-Cadiz, Carolina11; Malhi, Gurpreet2; Ahmed, Adan2; Homsi, Hoomam2; Abid, Zinia2; Cabezas, Joaquín12,13; Echavarría, Victor12,13; Poca, Maria14; Soriano, German14; Cuyas, Berta14; Ventura Cots, Meritxell15; Higuera-De La Tijera, María Fátima16; Ayala-Valverde, Maria17; Perez, Diego17; Gomez, Jaime17; Abraldes, Juan G18; Al-Karaghouli, Mustafa18; Jalal, Prasun K.19; Ibrahim, Mohamad Ali19; García-Tsao, Guadalupe20; Goyes, Daniela20; Skladaný, Lubomir21; Havaj, Daniel J.21; Sulejova, Karolina21; Adamcova Selcanova, Svetlana21; Rincón, Diego22,23; Chacko, Kristina R.24; Restrepo, Juan C.25; Yaquich, Pamela26; Toro, Luis G.27; Shah, Vijay9; Arrese, Marco1; Kamath, Patrick S.9; Bataller, Ramon28 Referencia : Hepatology Communications 9(4):e0673, April 2025. DOI (Digital Object Identifier) : 10.1097/HC9.0000000000000673 Derechos de uso : CC BY En línea : https://journals.lww.com/hepcomm/fulltext/2025/04010/moderate_alcohol_associated [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Moderate alcohol-associated hepatitis: A real-world multicenter study [documento electrónico] / Juan Carlos Restrepo Gutiérrez, Autor ; Díaz, Luis Antonio, Autor ; Dunn, Winston, Autor ; Mehta, Heer, Autor ; Muñoz, Karen, Autor ; Caldentey, Vicente, Autor ; Arnold, Jorge, Autor ; Ayares, Gustavo, Autor ; Mortuza, Rokhsana, Autor ; Sarin, Shiv K., Autor ; Maiwall, Rakhi, Autor ; Zhang, Wei, Autor ; Qian, Steve, Autor ; Simonetto, Douglas, Autor ; Singal, Ashwani K., Autor ; Elfeki, Mohamed A., Autor ; Ramirez Cadiz, Carolina, Autor ; Malhi, Gurpreet, Autor ; Ahmed, Adan, Autor ; Homsi, Hoomam, Autor ; Abid, Zinia, Autor ; Cabezas, Joaquín, Autor ; Echavarría, Victor, Autor ; Poca, Maria, Autor ; Soriano, German, Autor ; Cuyas, Berta, Autor ; Ventura Cots, Meritxell, Autor ; Higuera De La Tijera, María Fátima, Autor ; Ayala Valverde, Maria, Autor ; Pérez, Diego, Autor ; Gomez, Jaime, Autor ; Al-Karaghouli, Mustafa, Autor ; Jalal, Prasun K., Autor ; Ibrahim, Mohamad Ali, Autor ; García Tsao, Guadalupe, Autor ; Goyes, Daniela, Autor ; Skladaný, Lubomir, Autor ; Havaj, Daniel J., Autor ; Adamcova Selcanova, Svetlana, Autor ; Rincón, Diego, Autor ; Chacko, Kristina R., Autor ; Yaquich, Pamela, Autor ; Toro, Luis G., Autor ; Shah, Vijay, Autor ; Arrese, Marco, Autor ; Kamath, Patrick S., Autor ; Bataller, Ramon, Autor ; Arab, Juan Pablo, Autor . - 2025. Obra : Hepatology Communications Idioma : Inglés (eng) Resumen : Background: Severe alcohol-associated hepatitis (sAH) is a well-characterized disease with high short-term mortality. However, there is limited research on those with a "less severe condition" (moderate AH). This study aims to characterize in-depth patients with moderate AH (mAH), including the performance of mortality scoring systems, key prognostic factors, and survival over time. Methods: A multicenter retrospective cohort study (2009-2019) included patients with mAH (MELD score ?20 at admission). Cox regression and receiver operating characteristic curves with AUC were used for analysis. Results: We included 1845 patients with AH (20 centers, 8 countries) between 2009 and 2019. mAH was defined as a MELD score ?20 at admission. Twenty-four percent met the criteria for an mAH episode. Patients with mAH tend to be older and have a higher proportion of females, with a median MELD of 17 (15-19), Maddrey discriminant function (mDF) of 33 (22-40), the trajectory of serum bilirubin of 0.83 (0.60-1.21), and neutrophil-to-lymphocyte ratio (NLR) of 5 (2.96-8.60). The primary causes of death in mAH included multiple organ failure (34.1%) and infections (16.6%). The cumulative survival rates at 30, 90, and 180 days were 94.3%, 90.4%, and 88.2%, respectively. In multivariable analysis, age was the only significant predictor of 30-day mortality (HR 1.49, 95% CI: 1.27-1.76, p Mención de responsabilidad : Idalsoaga, Francisco1,2; Díaz, Luis Antonio1,3; Dunn, Winston4; Mehta, Heer4; Muñoz, Karen5; Caldentey, Vicente5; Arnold, Jorge1; Ayares, Gustavo2; Mortuza, Rokhsana2; Sarin, Shiv K.6; Maiwall, Rakhi6; Zhang, Wei7; Qian, Steve8; Simonetto, Douglas9; Singal, Ashwani K.10; Elfeki, Mohamed A.10; Ramirez-Cadiz, Carolina11; Malhi, Gurpreet2; Ahmed, Adan2; Homsi, Hoomam2; Abid, Zinia2; Cabezas, Joaquín12,13; Echavarría, Victor12,13; Poca, Maria14; Soriano, German14; Cuyas, Berta14; Ventura Cots, Meritxell15; Higuera-De La Tijera, María Fátima16; Ayala-Valverde, Maria17; Perez, Diego17; Gomez, Jaime17; Abraldes, Juan G18; Al-Karaghouli, Mustafa18; Jalal, Prasun K.19; Ibrahim, Mohamad Ali19; García-Tsao, Guadalupe20; Goyes, Daniela20; Skladaný, Lubomir21; Havaj, Daniel J.21; Sulejova, Karolina21; Adamcova Selcanova, Svetlana21; Rincón, Diego22,23; Chacko, Kristina R.24; Restrepo, Juan C.25; Yaquich, Pamela26; Toro, Luis G.27; Shah, Vijay9; Arrese, Marco1; Kamath, Patrick S.9; Bataller, Ramon28 Referencia : Hepatology Communications 9(4):e0673, April 2025. DOI (Digital Object Identifier) : 10.1097/HC9.0000000000000673 Derechos de uso : CC BY En línea : https://journals.lww.com/hepcomm/fulltext/2025/04010/moderate_alcohol_associated [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Registro colombiano de clínicas de anticoagulación (RECCANT) y el uso de agentes reversores (RECCANT-AR): justificación y diseño / Kenny Mauricio Gálvez Cárdenas ; Seni Molina, Sebastián ; Mora, Arturo D. ; Gutiérrez Posso, Juliana ; Ñáñez, Maribel ; Victoria Salcedo, Juan D. ; Díez Sepúlveda, Julio ; Molina, Dora I. ; Montenegro, Ana C. ; Castillo, Gilberto A. ; Sánchez, Róbinson ; León Giraldo, Hoover O. ; Gómez Mesa, Juan E.  

Público ISBD Título : Registro colombiano de clínicas de anticoagulación (RECCANT) y el uso de agentes reversores (RECCANT-AR): justificación y diseño Otros títulos : Colombian registry of anticoagulation clinics (RECCANT) and the use of reversal agents (RECCANT-AR): rationale and design Tipo de documento : documento electrónico Autores : Kenny Mauricio Gálvez Cárdenas, Autor ; Seni Molina, Sebastián, Autor ; Mora, Arturo D., Autor ; Gutiérrez Posso, Juliana, Autor ; Ñáñez, Maribel, Autor ; Victoria Salcedo, Juan D., Autor ; Díez Sepúlveda, Julio, Autor ; Molina, Dora I., Autor ; Montenegro, Ana C., Autor ; Castillo, Gilberto A., Autor ; Sánchez, Róbinson, Autor ; León Giraldo, Hoover O., Autor ; Gómez Mesa, Juan E., Autor Fecha de publicación : 2025 Títulos uniformes : Revista Colombiana de Cardiología Idioma : Español (spa) Palabras clave : Colombia; Anticoagulación; Agentes reversores; Registros clínicos Resumen : Introducción: La anticoagulación es esencial para tratar enfermedades tromboembólicas y prevenir complicaciones asociadas a patologías como la fibrilación auricular. No obstante, conlleva un riesgo significativo de sangrado, lo que destaca la importancia del uso de agentes reversores. En Colombia la evidencia científica sobre estas terapias es limitada. Objetivo: Implementar el Registro Colombiano de Clínicas de Anticoagulación (RECCANT) y el Registro Colombiano de Clínicas de Anticoagulación y el uso de Agentes Reversores (RECCANT-AR), los cuales buscan llenar esta brecha de información proporcionando datos robustos y representativos sobre estos pacientes. Método: RECCANT es un estudio observacional, analítico, prospectivo y multicéntrico que incluye pacientes mayores de 18 años con indicación de manejo anticoagulante por al menos tres meses. RECCANT-AR es un estudio observacional, analítico, ambispectivo y multicéntrico que incluye pacientes mayores de 18 años que requieren agentes reversores por sangrado relevante o por necesidad de procedimientos invasivos urgentes o prioritarios. Se recopilan datos sociodemográficos, clínicos y terapéuticos utilizando la plataforma electrónica REDCap (Research Electronic Data Capture) para garantizar la seguridad y confidencialidad de la información. Resultados: RECCANT y RECCANT-AR se establecen como los primeros registros nacionales enfocados en caracterizar a pacientes anticoagulados y aquellos con requerimiento de agentes reversores. Conclusiones: RECCANT y RECCANT-AR son esenciales para abordar la brecha de conocimiento sobre anticoagulación y el uso de agentes reversores en Colombia. Al proporcionar información precisa y detallada, estos registros mejorarán la comprensión de los perfiles de los pacientes, identificarán patrones nacionales y apoyarán el desarrollo de estrategias estandarizadas para mejorar la atención y los resultados clínicos en el país. Mención de responsabilidad : Sebastián Seni Molina; Arturo D. Mora; Juliana Gutiérrez-Posso; Maribel Ñáñez; Juan D. Victoria Salcedo; Julio Díez-Sepúlveda; Dora I. Molina; Ana C. Montenegro; Kenny M. Gálvez; Gilberto A. Castillo; Róbinson Sánchez; Hoover O. León-Giraldo; Juan E. Gómez-Mesa Referencia : Rev Colomb Cardiol. 2024;31(6):379-388 DOI (Digital Object Identifier) : 10.24875/RCCAR.24000104 Derechos de uso : CC BY-NC-ND En línea : https://dialnet.unirioja.es/servlet/articulo?codigo=10113613# Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Registro colombiano de clínicas de anticoagulación (RECCANT) y el uso de agentes reversores (RECCANT-AR): justificación y diseño = Colombian registry of anticoagulation clinics (RECCANT) and the use of reversal agents (RECCANT-AR): rationale and design [documento electrónico] / Kenny Mauricio Gálvez Cárdenas, Autor ; Seni Molina, Sebastián, Autor ; Mora, Arturo D., Autor ; Gutiérrez Posso, Juliana, Autor ; Ñáñez, Maribel, Autor ; Victoria Salcedo, Juan D., Autor ; Díez Sepúlveda, Julio, Autor ; Molina, Dora I., Autor ; Montenegro, Ana C., Autor ; Castillo, Gilberto A., Autor ; Sánchez, Róbinson, Autor ; León Giraldo, Hoover O., Autor ; Gómez Mesa, Juan E., Autor . - 2025. Obra : Revista Colombiana de Cardiología Idioma : Español (spa) Palabras clave : Colombia; Anticoagulación; Agentes reversores; Registros clínicos Resumen : Introducción: La anticoagulación es esencial para tratar enfermedades tromboembólicas y prevenir complicaciones asociadas a patologías como la fibrilación auricular. No obstante, conlleva un riesgo significativo de sangrado, lo que destaca la importancia del uso de agentes reversores. En Colombia la evidencia científica sobre estas terapias es limitada. Objetivo: Implementar el Registro Colombiano de Clínicas de Anticoagulación (RECCANT) y el Registro Colombiano de Clínicas de Anticoagulación y el uso de Agentes Reversores (RECCANT-AR), los cuales buscan llenar esta brecha de información proporcionando datos robustos y representativos sobre estos pacientes. Método: RECCANT es un estudio observacional, analítico, prospectivo y multicéntrico que incluye pacientes mayores de 18 años con indicación de manejo anticoagulante por al menos tres meses. RECCANT-AR es un estudio observacional, analítico, ambispectivo y multicéntrico que incluye pacientes mayores de 18 años que requieren agentes reversores por sangrado relevante o por necesidad de procedimientos invasivos urgentes o prioritarios. Se recopilan datos sociodemográficos, clínicos y terapéuticos utilizando la plataforma electrónica REDCap (Research Electronic Data Capture) para garantizar la seguridad y confidencialidad de la información. Resultados: RECCANT y RECCANT-AR se establecen como los primeros registros nacionales enfocados en caracterizar a pacientes anticoagulados y aquellos con requerimiento de agentes reversores. Conclusiones: RECCANT y RECCANT-AR son esenciales para abordar la brecha de conocimiento sobre anticoagulación y el uso de agentes reversores en Colombia. Al proporcionar información precisa y detallada, estos registros mejorarán la comprensión de los perfiles de los pacientes, identificarán patrones nacionales y apoyarán el desarrollo de estrategias estandarizadas para mejorar la atención y los resultados clínicos en el país. Mención de responsabilidad : Sebastián Seni Molina; Arturo D. Mora; Juliana Gutiérrez-Posso; Maribel Ñáñez; Juan D. Victoria Salcedo; Julio Díez-Sepúlveda; Dora I. Molina; Ana C. Montenegro; Kenny M. Gálvez; Gilberto A. Castillo; Róbinson Sánchez; Hoover O. León-Giraldo; Juan E. Gómez-Mesa Referencia : Rev Colomb Cardiol. 2024;31(6):379-388 DOI (Digital Object Identifier) : 10.24875/RCCAR.24000104 Derechos de uso : CC BY-NC-ND En línea : https://dialnet.unirioja.es/servlet/articulo?codigo=10113613# Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Epidemiologic profile of patients with HIV/AIDS in critical care, a Colombian cohort study / Sara Catalina Penagos ; Natalia Zapata Hincapié ; Juan Pablo Villa Franco ; Juan José Castro Palacio ; Serna Patiño, Laura María ; Peláez, Juan Camilo ; Agudelo Restrepo, Carlos Andrés ; Alicia Inés Hidrón Botero ; Rivera, Sebastián ; Zapata, Silvana ; Galeano, Carlos  

Público ISBD Título : Epidemiologic profile of patients with HIV/AIDS in critical care, a Colombian cohort study Tipo de documento : documento electrónico Autores : Sara Catalina Penagos, Autor ; Natalia Zapata Hincapié, Autor ; Juan Pablo Villa Franco, Autor ; Juan José Castro Palacio, Autor ; Serna Patiño, Laura María, Autor ; Peláez, Juan Camilo, Autor ; Agudelo Restrepo, Carlos Andrés, Autor ; Alicia Inés Hidrón Botero, Autor ; Rivera, Sebastián, Autor ; Zapata, Silvana, Autor ; Galeano, Carlos, Autor Fecha de publicación : 2025 Títulos uniformes : Open Forum Infectious Diseases Idioma : Inglés (eng) Resumen : Background The underlying cause of mortality in patients with HIV/AIDS admitted to critical care units has been changing since the advent of highly active antiretroviral therapy (HAART). This study was done to describe the clinical and epidemiologic profile of patients with HIV in a low-middle income country in the HAART era Mención de responsabilidad : Juan José Castro Palacio, Laura Maria Serna Patiño, sara Penagos, Natalia Zapata, Juan pablo villa Franco, Juan Camilo Peláez, Carlos Andres Agudelo Restrepo, Alicia Hidron, sebastian Rivera, Silvana zapata, Carlos Galeano Referencia : Open Forum Infect Dis. 2025 Jan 29;12(Suppl 1):ofae631.631 DOI (Digital Object Identifier) : 10.1093/ofid/ofae631.631 PMID : 11776647 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11776647/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Epidemiologic profile of patients with HIV/AIDS in critical care, a Colombian cohort study [documento electrónico] / Sara Catalina Penagos, Autor ; Natalia Zapata Hincapié, Autor ; Juan Pablo Villa Franco, Autor ; Juan José Castro Palacio, Autor ; Serna Patiño, Laura María, Autor ; Peláez, Juan Camilo, Autor ; Agudelo Restrepo, Carlos Andrés, Autor ; Alicia Inés Hidrón Botero, Autor ; Rivera, Sebastián, Autor ; Zapata, Silvana, Autor ; Galeano, Carlos, Autor . - 2025. Obra : Open Forum Infectious Diseases Idioma : Inglés (eng) Resumen : Background The underlying cause of mortality in patients with HIV/AIDS admitted to critical care units has been changing since the advent of highly active antiretroviral therapy (HAART). This study was done to describe the clinical and epidemiologic profile of patients with HIV in a low-middle income country in the HAART era Mención de responsabilidad : Juan José Castro Palacio, Laura Maria Serna Patiño, sara Penagos, Natalia Zapata, Juan pablo villa Franco, Juan Camilo Peláez, Carlos Andres Agudelo Restrepo, Alicia Hidron, sebastian Rivera, Silvana zapata, Carlos Galeano Referencia : Open Forum Infect Dis. 2025 Jan 29;12(Suppl 1):ofae631.631 DOI (Digital Object Identifier) : 10.1093/ofid/ofae631.631 PMID : 11776647 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11776647/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Characterization of the use of the FilmArray Molecular panel for the diagnosis of central nervous system infection / Juan Pablo Villa Franco ; Santiago León Atehortúa Muñoz ; Zapata, Silvana ; Montoya Roldan, Daniel ; Isaza, Sandra Patricia ; Zapata, Carolina ; Lopez Estrada, Carolina ; Trompa, Iván  

Público ISBD Título : Characterization of the use of the FilmArray Molecular panel for the diagnosis of central nervous system infection Tipo de documento : documento electrónico Autores : Juan Pablo Villa Franco, Autor ; Santiago León Atehortúa Muñoz, Autor ; Zapata, Silvana, Autor ; Montoya Roldan, Daniel, Autor ; Isaza, Sandra Patricia, Autor ; Zapata, Carolina, Autor ; Lopez Estrada, Carolina, Autor ; Trompa, Iván, Autor Fecha de publicación : 2025 Títulos uniformes : Open Forum Infectious Diseases Idioma : Inglés (eng) Idioma original : Inglés (eng) Resumen : The Biofire FilmArray® Meningitis/Encephalitis Panel (FAME) has proven to be a valuable tool for etiological diagnosis. Despite this, we know little about its clinical impact.This investigation aims to characterize the clinical, epidemiological, therapeutic variables and outcomes of adults with suspected meningitis and/or encephalitis (ME) who underwent FAME panel, in two 3rd level hospitals in Medellín-Colombia. Mención de responsabilidad : Silvana zapata , Daniel Montoya Roldan, Infectious disease specialist , Pablo Villa franco, Infectious diseases MD , Sandra patricia isaza, Neurologist , Santiago Atehortua, Microbiology MSC MD , Carolina Zapata, MD , Carolina Lopez estrada, Internal medicine resident , Iván Trompa, infectious diseases MD Referencia : Open Forum Infectious Diseases, Volume 12, Issue Supplement_1, February 2025, ofae631.1114 DOI (Digital Object Identifier) : 10.1093/ofid/ofae631.1114 Derechos de uso : CC BY-NC-ND En línea : https://academic.oup.com/ofid/article/12/Supplement_1/ofae631.1114/7986720?login [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Characterization of the use of the FilmArray Molecular panel for the diagnosis of central nervous system infection [documento electrónico] / Juan Pablo Villa Franco, Autor ; Santiago León Atehortúa Muñoz, Autor ; Zapata, Silvana, Autor ; Montoya Roldan, Daniel, Autor ; Isaza, Sandra Patricia, Autor ; Zapata, Carolina, Autor ; Lopez Estrada, Carolina, Autor ; Trompa, Iván, Autor . - 2025. Obra : Open Forum Infectious Diseases Idioma : Inglés (eng) Idioma original : Inglés (eng) Resumen : The Biofire FilmArray® Meningitis/Encephalitis Panel (FAME) has proven to be a valuable tool for etiological diagnosis. Despite this, we know little about its clinical impact.This investigation aims to characterize the clinical, epidemiological, therapeutic variables and outcomes of adults with suspected meningitis and/or encephalitis (ME) who underwent FAME panel, in two 3rd level hospitals in Medellín-Colombia. Mención de responsabilidad : Silvana zapata , Daniel Montoya Roldan, Infectious disease specialist , Pablo Villa franco, Infectious diseases MD , Sandra patricia isaza, Neurologist , Santiago Atehortua, Microbiology MSC MD , Carolina Zapata, MD , Carolina Lopez estrada, Internal medicine resident , Iván Trompa, infectious diseases MD Referencia : Open Forum Infectious Diseases, Volume 12, Issue Supplement_1, February 2025, ofae631.1114 DOI (Digital Object Identifier) : 10.1093/ofid/ofae631.1114 Derechos de uso : CC BY-NC-ND En línea : https://academic.oup.com/ofid/article/12/Supplement_1/ofae631.1114/7986720?login [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Risk factors and outcomes of pediatric non-invasive respiratory support failure in Latin America / Juan Camilo Jaramillo Bustamante ; Hernán Darío Herrera Salazar ; Escobar Serna, Diana Paola ; Barajas Romero, Juan Sebastian ; Peralta Palmezano, Juan Javier ; Monteverde Fernandez, Nicolas ; Serra, Jesus Alberto ; Caporal, Paula ; Menta, Soledad ; Lasso Palomino, Ruben ; Zemanate, Eliana ; Martínez, Javier ; Martínez, Luis ; Castro Zamorano, Francisca ; Carvajal, Cristobal ; Decía, Monica ; Jabornisky, Roberto ; Diaz, Franco ; Gonzalez Dambrauskas, Sebastian ; Vasquez Hoyos, Pablo  

Público ISBD Título : Risk factors and outcomes of pediatric non-invasive respiratory support failure in Latin America Tipo de documento : documento electrónico Autores : Juan Camilo Jaramillo Bustamante, Autor ; Hernán Darío Herrera Salazar, Autor ; Escobar Serna, Diana Paola, Autor ; Barajas Romero, Juan Sebastian, Autor ; Peralta Palmezano, Juan Javier, Autor ; Monteverde Fernandez, Nicolas, Autor ; Serra, Jesus Alberto, Autor ; Caporal, Paula, Autor ; Menta, Soledad, Autor ; Lasso Palomino, Ruben, Autor ; Zemanate, Eliana, Autor ; Martínez, Javier, Autor ; Martínez, Luis, Autor ; Castro Zamorano, Francisca, Autor ; Carvajal, Cristobal, Autor ; Decía, Monica, Autor ; Jabornisky, Roberto, Autor ; Diaz, Franco, Autor ; Gonzalez Dambrauskas, Sebastian, Autor ; Vasquez Hoyos, Pablo, Autor Fecha de publicación : 2025 Títulos uniformes : Journal of Intensive Medicine Idioma : Español (spa) Palabras clave : Continuous positive airway pressure; Noninvasive ventilation; Oxygen therapy; Pediatric intensive care unit; Pediatrics Resumen : Background: Noninvasive respiratory support (NRS) is standard in pediatric intensive care units (PICUs) for respiratory diseases, but its failure can lead to complications requiring invasive mechanical ventilation (IMV). This study aimed to identify risk factors for NRS failure in children with acute respiratory failure (ARF) in PICUs, and compare complications and outcomes between IMV-only and NRS failure patients. Methods: We conducted a cohort study using data from the LARed Network prospective registry (April 2017–November 2022), in children under 18 years admitted to PICUs for ARF. Cases were divided into subgroups: those managed with IMV only, those who experienced NRS failure requiring IMV, those who received NRS successfully, and those who did not require NRS or IMV. Exclusions included patients with home respiratory support prior to admission, patients without PICU discharge at the cutoff date of the analysis and those with incomplete data. Multivariate mixed models analyzed NRS failure risk factors, and complications between the IMV-only and NRS failure groups, using centers as a random effect. Results: A total of 7374 children met the inclusion criteria, with 6208 in the NRS group and 1166 in the IMV-only group. The NRS success rate was 85.3 %. Risk factors for NRS failure included age (median of 4.6 months, interquartile range of 2.1–14.2 months), history of prematurity (adjusted odds ratio [aOR]=1.53, 95 % confidence interval [CI]: 1.20 to 1.95) or malnutrition (aOR=1.85, 95 % CI: 1.18 to 2.91), suspected bacterial infection (aOR=5.12, 95 % CI: 4.05to 6.49), FiO2 >30 % (aOR=1.52, 95 % CI: 1.18 to 1.97), severe hypoxemia with SpO2/FiO2 ?150 (aOR=1.85, 95 % CI: 1.48 to 2.30), tachypnea (aOR=1.42, 95 % CI: 1.18 to 1.72), tachycardia (aOR=1.77, 95 % CI: 1.47 to 2.12), and lung consolidations (aOR=1.45, 95 % CI: 1.14 to 1.85) or interstitial infiltrates (aOR=1.29, 95 % CI: 1.05 to 1.58) on chest X-ray. There were no significant differences in morbidity, mortality, duration of IMV, or PICU length of stay between patients who received IMV only and those who experienced NRS failure. However, patients who experienced NRS failure were more likely to develop withdrawal symptoms related to sedative or opioid discontinuation and/or delirium (aOR=2.57, 95 % CI: 1.85 to 2.57). Conclusion: This study identified key risk factors for predicting NRS failure in children with acute ARF in PICUs, including younger age, prematurity, malnutrition, suspected bacterial infection, FiO2 >30 %, severe hypoxemia (SpO2/FiO2 ?150), tachypnea, tachycardia, and radiological findings such as lung consolidation and interstitial infiltrates. Compared to patients managed with IMV from the start, those who experienced NRS failure were more likely to develop withdrawal symptoms and/or delirium, although clinical outcomes such as mortality, IMV duration, and PICU length of stay were similar in both groups. © 2024 The Author(s) Mención de responsabilidad : Escobar-Serna, Diana Paola; Barajas-Romero, Juan Sebastian; Peralta-Palmezano, Juan Javier; Jaramillo-Bustamante, Juan Camilo; Monteverde-Fernandez, Nicolas; Serra, Jesus Alberto; Caporal, Paula; Menta, Soledad; Lasso-Palomino, Ruben; Zemanate, Eliana; Martínez, Javier; Herrera, Hernan; Martínez, Luis; Zamorano, Francisca Castro; Carvajal, Cristobal; Decía, Monica; Jabornisky, Roberto; Diaz, Franco; Gonzalez-Dambrauskas, Sebastian; Vasquez-Hoyos, Pablo. Referencia : Journal of Intensive Medicine Volume 5, Issue 2, April 2025, Pages 176-184 DOI (Digital Object Identifier) : 10.1016/j.jointm.2024.09.001 Derechos de uso : CC BY-NC-ND En línea : https://pdf.sciencedirectassets.com/778774/1-s2.0-S2667100X25X00025/1-s2.0-S2667 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Risk factors and outcomes of pediatric non-invasive respiratory support failure in Latin America [documento electrónico] / Juan Camilo Jaramillo Bustamante, Autor ; Hernán Darío Herrera Salazar, Autor ; Escobar Serna, Diana Paola, Autor ; Barajas Romero, Juan Sebastian, Autor ; Peralta Palmezano, Juan Javier, Autor ; Monteverde Fernandez, Nicolas, Autor ; Serra, Jesus Alberto, Autor ; Caporal, Paula, Autor ; Menta, Soledad, Autor ; Lasso Palomino, Ruben, Autor ; Zemanate, Eliana, Autor ; Martínez, Javier, Autor ; Martínez, Luis, Autor ; Castro Zamorano, Francisca, Autor ; Carvajal, Cristobal, Autor ; Decía, Monica, Autor ; Jabornisky, Roberto, Autor ; Diaz, Franco, Autor ; Gonzalez Dambrauskas, Sebastian, Autor ; Vasquez Hoyos, Pablo, Autor . - 2025. Obra : Journal of Intensive Medicine Idioma : Español (spa) Palabras clave : Continuous positive airway pressure; Noninvasive ventilation; Oxygen therapy; Pediatric intensive care unit; Pediatrics Resumen : Background: Noninvasive respiratory support (NRS) is standard in pediatric intensive care units (PICUs) for respiratory diseases, but its failure can lead to complications requiring invasive mechanical ventilation (IMV). This study aimed to identify risk factors for NRS failure in children with acute respiratory failure (ARF) in PICUs, and compare complications and outcomes between IMV-only and NRS failure patients. Methods: We conducted a cohort study using data from the LARed Network prospective registry (April 2017–November 2022), in children under 18 years admitted to PICUs for ARF. Cases were divided into subgroups: those managed with IMV only, those who experienced NRS failure requiring IMV, those who received NRS successfully, and those who did not require NRS or IMV. Exclusions included patients with home respiratory support prior to admission, patients without PICU discharge at the cutoff date of the analysis and those with incomplete data. Multivariate mixed models analyzed NRS failure risk factors, and complications between the IMV-only and NRS failure groups, using centers as a random effect. Results: A total of 7374 children met the inclusion criteria, with 6208 in the NRS group and 1166 in the IMV-only group. The NRS success rate was 85.3 %. Risk factors for NRS failure included age (median of 4.6 months, interquartile range of 2.1–14.2 months), history of prematurity (adjusted odds ratio [aOR]=1.53, 95 % confidence interval [CI]: 1.20 to 1.95) or malnutrition (aOR=1.85, 95 % CI: 1.18 to 2.91), suspected bacterial infection (aOR=5.12, 95 % CI: 4.05to 6.49), FiO2 >30 % (aOR=1.52, 95 % CI: 1.18 to 1.97), severe hypoxemia with SpO2/FiO2 ?150 (aOR=1.85, 95 % CI: 1.48 to 2.30), tachypnea (aOR=1.42, 95 % CI: 1.18 to 1.72), tachycardia (aOR=1.77, 95 % CI: 1.47 to 2.12), and lung consolidations (aOR=1.45, 95 % CI: 1.14 to 1.85) or interstitial infiltrates (aOR=1.29, 95 % CI: 1.05 to 1.58) on chest X-ray. There were no significant differences in morbidity, mortality, duration of IMV, or PICU length of stay between patients who received IMV only and those who experienced NRS failure. However, patients who experienced NRS failure were more likely to develop withdrawal symptoms related to sedative or opioid discontinuation and/or delirium (aOR=2.57, 95 % CI: 1.85 to 2.57). Conclusion: This study identified key risk factors for predicting NRS failure in children with acute ARF in PICUs, including younger age, prematurity, malnutrition, suspected bacterial infection, FiO2 >30 %, severe hypoxemia (SpO2/FiO2 ?150), tachypnea, tachycardia, and radiological findings such as lung consolidation and interstitial infiltrates. Compared to patients managed with IMV from the start, those who experienced NRS failure were more likely to develop withdrawal symptoms and/or delirium, although clinical outcomes such as mortality, IMV duration, and PICU length of stay were similar in both groups. © 2024 The Author(s) Mención de responsabilidad : Escobar-Serna, Diana Paola; Barajas-Romero, Juan Sebastian; Peralta-Palmezano, Juan Javier; Jaramillo-Bustamante, Juan Camilo; Monteverde-Fernandez, Nicolas; Serra, Jesus Alberto; Caporal, Paula; Menta, Soledad; Lasso-Palomino, Ruben; Zemanate, Eliana; Martínez, Javier; Herrera, Hernan; Martínez, Luis; Zamorano, Francisca Castro; Carvajal, Cristobal; Decía, Monica; Jabornisky, Roberto; Diaz, Franco; Gonzalez-Dambrauskas, Sebastian; Vasquez-Hoyos, Pablo. Referencia : Journal of Intensive Medicine Volume 5, Issue 2, April 2025, Pages 176-184 DOI (Digital Object Identifier) : 10.1016/j.jointm.2024.09.001 Derechos de uso : CC BY-NC-ND En línea : https://pdf.sciencedirectassets.com/778774/1-s2.0-S2667100X25X00025/1-s2.0-S2667 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Connectome-based predictive modeling of brain pathology and cognition in autosomal dominant Alzheimer's disease / Sergio Álvarez Vallejo ; Tripathi, Vaibhav ; Fox Fuller, Joshua ; Malotaux, Vincent ; Baena, Ana Y ; Bonillas Felix, Nikole ; Aguillon, David Fernando ; Lopera, Francisco ; Somers, David C.  

Público ISBD Título : Connectome-based predictive modeling of brain pathology and cognition in autosomal dominant Alzheimer's disease Tipo de documento : texto impreso Autores : Sergio Álvarez Vallejo, Autor ; Tripathi, Vaibhav, Autor ; Fox Fuller, Joshua, Autor ; Malotaux, Vincent, Autor ; Baena, Ana Y, Autor ; Bonillas Felix, Nikole, Autor ; Aguillon, David Fernando, Autor ; Lopera, Francisco, Autor ; Somers, David C., Autor Fecha de publicación : 2025 Títulos uniformes : Alzheimer's & Dementia Idioma : Inglés (eng) Palabras clave : ADAD  CPM  rsfMRI  predictive modeling Resumen : INTRODUCTION: Autosomal dominant Alzheimer's disease (ADAD) through genetic mutations can result in near complete expression of the disease. Tracking AD pathology development in an ADAD cohort of Presenilin-1 (PSEN1) E280A carriers’ mutation has allowed us to observe incipient tau tangles accumulation as early as 6 years prior to symptom onset. METHODS: Resting-state functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) scans were acquired in a group of PSEN1 carriers (n = 32) and non-carrier family members (n = 35). We applied connectome-based predictive modeling (CPM) to examine the relationship between the participant's functional connectome and their respective tau/amyloid-? levels and cognitive scores (word list recall). RESULTS: CPM models strongly predicted tau concentrations and cognitive scores within the carrier group. The connectivity patterns between the temporal cortex, default mode network, and other memory networks were the most informative of tau burden. DISCUSSION: These results indicate that resting-state functional magnetic resonance imaging (fMRI) methods can complement PET methods in early detection and monitoring of disease progression in ADAD. Highlights: Connectivity-based predictive modeling of tau and amyloid-? in ADAD carriers. Strong predictions for tau deposition; weaker predictions for amyloid-?. Cognitive scores for memory and mental state are predicted strongly. Connectivity between IPL, DAN, DMN, temporal cortex most predictive. © 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. Mención de responsabilidad : Vaibhav Tripathi, Joshua Fox-Fuller, Vincent Malotaux, Ana Baena, Nikole Bonillas Felix, Sergio Alvarez, David Aguillon, Francisco Lopera, David C. Somers, Yakeel T. Quiroz Referencia : Alzheimer’s Dement. 2025;21:e70061. DOI (Digital Object Identifier) : 10.1002/alz.70061 Derechos de uso : CC BY-NC-ND En línea : https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70061 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Connectome-based predictive modeling of brain pathology and cognition in autosomal dominant Alzheimer's disease [texto impreso] / Sergio Álvarez Vallejo, Autor ; Tripathi, Vaibhav, Autor ; Fox Fuller, Joshua, Autor ; Malotaux, Vincent, Autor ; Baena, Ana Y, Autor ; Bonillas Felix, Nikole, Autor ; Aguillon, David Fernando, Autor ; Lopera, Francisco, Autor ; Somers, David C., Autor . - 2025. Obra : Alzheimer's & Dementia Idioma : Inglés (eng) Palabras clave : ADAD  CPM  rsfMRI  predictive modeling Resumen : INTRODUCTION: Autosomal dominant Alzheimer's disease (ADAD) through genetic mutations can result in near complete expression of the disease. Tracking AD pathology development in an ADAD cohort of Presenilin-1 (PSEN1) E280A carriers’ mutation has allowed us to observe incipient tau tangles accumulation as early as 6 years prior to symptom onset. METHODS: Resting-state functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) scans were acquired in a group of PSEN1 carriers (n = 32) and non-carrier family members (n = 35). We applied connectome-based predictive modeling (CPM) to examine the relationship between the participant's functional connectome and their respective tau/amyloid-? levels and cognitive scores (word list recall). RESULTS: CPM models strongly predicted tau concentrations and cognitive scores within the carrier group. The connectivity patterns between the temporal cortex, default mode network, and other memory networks were the most informative of tau burden. DISCUSSION: These results indicate that resting-state functional magnetic resonance imaging (fMRI) methods can complement PET methods in early detection and monitoring of disease progression in ADAD. Highlights: Connectivity-based predictive modeling of tau and amyloid-? in ADAD carriers. Strong predictions for tau deposition; weaker predictions for amyloid-?. Cognitive scores for memory and mental state are predicted strongly. Connectivity between IPL, DAN, DMN, temporal cortex most predictive. © 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. Mención de responsabilidad : Vaibhav Tripathi, Joshua Fox-Fuller, Vincent Malotaux, Ana Baena, Nikole Bonillas Felix, Sergio Alvarez, David Aguillon, Francisco Lopera, David C. Somers, Yakeel T. Quiroz Referencia : Alzheimer’s Dement. 2025;21:e70061. DOI (Digital Object Identifier) : 10.1002/alz.70061 Derechos de uso : CC BY-NC-ND En línea : https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70061 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Características clínicas y desenlaces postquirúrgicos en pacientes con neumotórax espontáneo: análisis en un hospital de alta complejidad / Willfredy Castaño Ruiz ; Lina María Velásquez Gómez ; Sánchez Castro, Carolina ; Barrantes Moreno, Santiago ; Bernal Sierra, Sofía ; Andrés Zerrate Misas ; Vanegas, Johanna Marcela  

Público ISBD Título : Características clínicas y desenlaces postquirúrgicos en pacientes con neumotórax espontáneo: análisis en un hospital de alta complejidad Tipo de documento : documento electrónico Autores : Willfredy Castaño Ruiz, Autor ; Lina María Velásquez Gómez, Autor ; Sánchez Castro, Carolina, Autor ; Barrantes Moreno, Santiago, Autor ; Bernal Sierra, Sofía, Autor ; Andrés Zerrate Misas, Autor ; Vanegas, Johanna Marcela, Autor Fecha de publicación : 2025 Títulos uniformes : Revista Colombiana de Cirugía Idioma : Español (spa) Palabras clave : neumotórax  toracostomía  toracoscopia  procedimientos quirúrgicos torácicos  pleurodesis  complicaciones posoperatorias Resumen : Introducción. El neumotórax espontáneo es una patología infrecuente, que afecta tanto a jóvenes como a personas mayores. Puede tener alta tasa de recurrencia, generando morbilidad y, en ocasiones, mortalidad a los pacientes. En nuestro medio no disponemos de datos epidemiológicos de la enfermedad, lo que motivó la realización de este estudio. Métodos. Estudio retrospectivo de una base de datos prospectiva, que incluyó pacientes mayores de 14 años con diagnóstico de neumotórax espontáneo intervenidos quirúrgicamente en el Hospital Pablo Tobón Uribe, de Medellín, Colombia, entre enero de 2018 y diciembre de 2023. Se analizaron variables sociodemográficas, clínicas y desenlaces postquirúrgicos a 30 días de la intervención. Resultados. El sexo masculino fue el más afectado (68,2 %), el neumotórax espontáneo secundario predominó (56,8 %) y el hemitórax derecho fue la localización más común (63,6 %). Se encontró una incidencia similar entre fumadores (45,4 %) y no fumadores (52,3 %). La resección en cuña fue el tratamiento definitivo en el 50 % de los pacientes y la resección en cuña asociada a pleurodesis mecánica en el 31,8 %. La complicación más frecuente fue la fuga persistente de aire. Se registró una recurrencia de neumotórax en un paciente que había sido sometido a resección en cuña. Al final del estudio, cinco pacientes fallecieron: tres habían sido tratados únicamente con toracostomía y dos habían sido llevados a cirugía. Conclusiones. El neumotórax espontáneo es una patología infrecuente. Las causas y la población afectada varían de acuerdo con su clasificación. En nuestro medio, la tuberculosis tiene mayor relevancia por ser una enfermedad endémica. Mención de responsabilidad : Castaño Ruiz, Willfredy, Velásquez Gómez, Lina María, Sánchez Castro, Carolina, Barrantes Moreno, Santiago, Bernal Sierra, Sofía,Zerrate Misas, Andrés, Vanegas, Johanna Marcela Referencia : Rev Colomb Cir 2025, 40, 79-88. DOI (Digital Object Identifier) : 10.30944/20117582.2757 Derechos de uso : CC BY-NC-ND En línea : https://revistacirugia.org/index.php/cirugia/article/view/2757 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Características clínicas y desenlaces postquirúrgicos en pacientes con neumotórax espontáneo: análisis en un hospital de alta complejidad [documento electrónico] / Willfredy Castaño Ruiz, Autor ; Lina María Velásquez Gómez, Autor ; Sánchez Castro, Carolina, Autor ; Barrantes Moreno, Santiago, Autor ; Bernal Sierra, Sofía, Autor ; Andrés Zerrate Misas, Autor ; Vanegas, Johanna Marcela, Autor . - 2025. Obra : Revista Colombiana de Cirugía Idioma : Español (spa) Palabras clave : neumotórax  toracostomía  toracoscopia  procedimientos quirúrgicos torácicos  pleurodesis  complicaciones posoperatorias Resumen : Introducción. El neumotórax espontáneo es una patología infrecuente, que afecta tanto a jóvenes como a personas mayores. Puede tener alta tasa de recurrencia, generando morbilidad y, en ocasiones, mortalidad a los pacientes. En nuestro medio no disponemos de datos epidemiológicos de la enfermedad, lo que motivó la realización de este estudio. Métodos. Estudio retrospectivo de una base de datos prospectiva, que incluyó pacientes mayores de 14 años con diagnóstico de neumotórax espontáneo intervenidos quirúrgicamente en el Hospital Pablo Tobón Uribe, de Medellín, Colombia, entre enero de 2018 y diciembre de 2023. Se analizaron variables sociodemográficas, clínicas y desenlaces postquirúrgicos a 30 días de la intervención. Resultados. El sexo masculino fue el más afectado (68,2 %), el neumotórax espontáneo secundario predominó (56,8 %) y el hemitórax derecho fue la localización más común (63,6 %). Se encontró una incidencia similar entre fumadores (45,4 %) y no fumadores (52,3 %). La resección en cuña fue el tratamiento definitivo en el 50 % de los pacientes y la resección en cuña asociada a pleurodesis mecánica en el 31,8 %. La complicación más frecuente fue la fuga persistente de aire. Se registró una recurrencia de neumotórax en un paciente que había sido sometido a resección en cuña. Al final del estudio, cinco pacientes fallecieron: tres habían sido tratados únicamente con toracostomía y dos habían sido llevados a cirugía. Conclusiones. El neumotórax espontáneo es una patología infrecuente. Las causas y la población afectada varían de acuerdo con su clasificación. En nuestro medio, la tuberculosis tiene mayor relevancia por ser una enfermedad endémica. Mención de responsabilidad : Castaño Ruiz, Willfredy, Velásquez Gómez, Lina María, Sánchez Castro, Carolina, Barrantes Moreno, Santiago, Bernal Sierra, Sofía,Zerrate Misas, Andrés, Vanegas, Johanna Marcela Referencia : Rev Colomb Cir 2025, 40, 79-88. DOI (Digital Object Identifier) : 10.30944/20117582.2757 Derechos de uso : CC BY-NC-ND En línea : https://revistacirugia.org/index.php/cirugia/article/view/2757 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Colombian consensus on autosomal dominant polycystic kidney disease / John Mauricio Lopera Vargas ; Roncallo, Angelica ; Aguirre, Marcelo ; Conde Manotas, Juan Carlos ; Gallón Blandón, Paula Andrea ; López, José Gabriel ; Mantilla, Andrea ; Martínez, Theo ; Olivares, Orlando ; Restrepo Valencia, Cesar Augusto ; Wassermann, Alfredo Osvaldo ; Bermon, Anderson ; Barros, Luis  

Público ISBD Título : Colombian consensus on autosomal dominant polycystic kidney disease Otros títulos : Consenso colombiano sobre la poliquistosis renal autosómica dominante Tipo de documento : documento electrónico Autores : John Mauricio Lopera Vargas, Autor ; Roncallo, Angelica, Autor ; Aguirre, Marcelo, Autor ; Conde Manotas, Juan Carlos, Autor ; Gallón Blandón, Paula Andrea, Autor ; López, José Gabriel, Autor ; Mantilla, Andrea, Autor ; Martínez, Theo, Autor ; Olivares, Orlando, Autor ; Restrepo Valencia, Cesar Augusto, Autor ; Wassermann, Alfredo Osvaldo, Autor ; Bermon, Anderson, Autor ; Barros, Luis, Autor Fecha de publicación : 2025 Títulos uniformes : Revista Colombiana de Nefrología Idioma : Inglés (eng) Idioma original : Español (spa) Palabras clave : Autosomal Dominant; Chronic; Cystic; hypertension; Kidney Diseases; Polycystic Kidney; Renal Disease; Renal Insufficiency; tolvaptan Resumen : Autosomal dominant polycystic kidney disease (ADPKD) is the most common cause of inherited adult nephropathy and stage 5 chronic kidney disease of genetic origin, it is a heterogeneo-us disease with phenotypic variability in relation to progression. All measures aimed at slowing the progression of renal disease should be established. Purpose: To generate evidence-based recommendations for the diagnosis, follow-up and treatment of patients with ADPKD, defining patients with rapid disease progression, guide general and specific treatment with the agent tolvaptan, establish recommendations for access to renal replacement therapies including transplantation, through an expert consensus. Methodology: Based on the formulation of pragmatic research questions related to ADPKD, a search for evidence was conducted in Pubmed, Scopus and Ovid between January 2012 and July 2023. The articles were selected by means of a systematic review and through the modified Delphi consensus methodology. The Oxford scale was applied to quantify the level of evidence of the total selected scien-tific articles. All final recommendations were categorised by grade according to the NHS guidelines classification. Results: A total of 18 recommendations were formulated for the diagnosis, treatment and follow-up of ADPKD. A panel of 10 thematic experts, a methodological expert and 2 external reviewers actively participated in the elaboration of the consensus. Conclusions: The recommendations based on evidence and clinical expertise adapted to the Colombian context will allow standardised guidance at national and regional level, the diagnosis and treatment of patients with ADPKD and provide guidance on the use and application of tolvaptan. © 2025, Asociacion Colombiana de Nefrologia e Hipertension Arterial. All rights reserved. Mención de responsabilidad : Roncallo Angelica, Aguirre Marcelo, Conde Manotas Juan Carlos, Gallón Blandón Paula Andrea, Lopera Mauricio, López José Gabriel, Mantilla Andrea, Martínez Theo, Olivares Orlando, Restrepo-Valencia Cesar Augusto, Wassermann Alfredo Osvaldo, Bermon Anderson, Barros Luis. Referencia : Colomb. Nefrol. [Internet]. 11 de febrero de 2025 [citado 28 de abril de 2025];12(1). DOI (Digital Object Identifier) : 10.22265/acnef.12.1.801 Derechos de uso : CC BY-NC-ND En línea : https://revistanefrologia.org/index.php/rcn/article/view/801 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Colombian consensus on autosomal dominant polycystic kidney disease = Consenso colombiano sobre la poliquistosis renal autosómica dominante [documento electrónico] / John Mauricio Lopera Vargas, Autor ; Roncallo, Angelica, Autor ; Aguirre, Marcelo, Autor ; Conde Manotas, Juan Carlos, Autor ; Gallón Blandón, Paula Andrea, Autor ; López, José Gabriel, Autor ; Mantilla, Andrea, Autor ; Martínez, Theo, Autor ; Olivares, Orlando, Autor ; Restrepo Valencia, Cesar Augusto, Autor ; Wassermann, Alfredo Osvaldo, Autor ; Bermon, Anderson, Autor ; Barros, Luis, Autor . - 2025. Obra : Revista Colombiana de Nefrología Idioma : Inglés (eng) Idioma original : Español (spa) Palabras clave : Autosomal Dominant; Chronic; Cystic; hypertension; Kidney Diseases; Polycystic Kidney; Renal Disease; Renal Insufficiency; tolvaptan Resumen : Autosomal dominant polycystic kidney disease (ADPKD) is the most common cause of inherited adult nephropathy and stage 5 chronic kidney disease of genetic origin, it is a heterogeneo-us disease with phenotypic variability in relation to progression. All measures aimed at slowing the progression of renal disease should be established. Purpose: To generate evidence-based recommendations for the diagnosis, follow-up and treatment of patients with ADPKD, defining patients with rapid disease progression, guide general and specific treatment with the agent tolvaptan, establish recommendations for access to renal replacement therapies including transplantation, through an expert consensus. Methodology: Based on the formulation of pragmatic research questions related to ADPKD, a search for evidence was conducted in Pubmed, Scopus and Ovid between January 2012 and July 2023. The articles were selected by means of a systematic review and through the modified Delphi consensus methodology. The Oxford scale was applied to quantify the level of evidence of the total selected scien-tific articles. All final recommendations were categorised by grade according to the NHS guidelines classification. Results: A total of 18 recommendations were formulated for the diagnosis, treatment and follow-up of ADPKD. A panel of 10 thematic experts, a methodological expert and 2 external reviewers actively participated in the elaboration of the consensus. Conclusions: The recommendations based on evidence and clinical expertise adapted to the Colombian context will allow standardised guidance at national and regional level, the diagnosis and treatment of patients with ADPKD and provide guidance on the use and application of tolvaptan. © 2025, Asociacion Colombiana de Nefrologia e Hipertension Arterial. All rights reserved. Mención de responsabilidad : Roncallo Angelica, Aguirre Marcelo, Conde Manotas Juan Carlos, Gallón Blandón Paula Andrea, Lopera Mauricio, López José Gabriel, Mantilla Andrea, Martínez Theo, Olivares Orlando, Restrepo-Valencia Cesar Augusto, Wassermann Alfredo Osvaldo, Bermon Anderson, Barros Luis. Referencia : Colomb. Nefrol. [Internet]. 11 de febrero de 2025 [citado 28 de abril de 2025];12(1). DOI (Digital Object Identifier) : 10.22265/acnef.12.1.801 Derechos de uso : CC BY-NC-ND En línea : https://revistanefrologia.org/index.php/rcn/article/view/801 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Evolving Models of Community-Based Pediatric Palliative Care in Eight Countries Across Latin America / Lopera Solano, Juliana ; García Ulloa, Zulema ; García Quintero, Ximena ; Nakashima Paniagua, Yuriko ; Rivas, Silvia ; Gana, Monica A. ; Torelli, Antonella E. ; Gutiérrez, Hazel M. ; Gómez García, Wendy Cristhyna ; Chacón, Sandra ; Bernadá, Mercedes ; McNeil, Michael J.  

Público ISBD Título : Evolving Models of Community-Based Pediatric Palliative Care in Eight Countries Across Latin America Tipo de documento : documento electrónico Autores : Lopera Solano, Juliana, Autor ; García Ulloa, Zulema, Autor ; García Quintero, Ximena, Autor ; Nakashima Paniagua, Yuriko, Autor ; Rivas, Silvia, Autor ; Gana, Monica A., Autor ; Torelli, Antonella E., Autor ; Gutiérrez, Hazel M., Autor ; Gómez García, Wendy Cristhyna, Autor ; Chacón, Sandra, Autor ; Bernadá, Mercedes, Autor ; McNeil, Michael J., Autor Fecha de publicación : 2025 Títulos uniformes : Journal of Pain and Symptom Management Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave : Pediatric palliative care; community-based palliative care; home-based palliative care; palliative care delivery programs; pediatric hospice care. Resumen : Context: High-quality pediatric palliative care is best achieved through a comprehensive interdisciplinary effort that actively involves the family and engages resources within the community. Community-based palliative care specifically strives to incorporate palliative care into local healthcare systems, adapting the most suitable model of care to each unique context. Objectives: In Latin America (LATAM), there is a paucity of palliative care teams, especially pediatric palliative care teams, working outside the hospital setting and immersed in the community. Thus, it is essential to learn more about the different community-based pediatric palliative care programs in Latin America and understand their successes in providing high quality community palliative care for children in resource-constrained settings METHODS: Eight LATAM leaders from outpatient Pediatric Palliative Care (PPC) programs, invited by St. Jude Global PPC network, participated in the study based on program alignment, operational status, and willingness. While not a systematic assessment, this sample includes benchmark Community-Based Pediatric Palliative Care (CBPPC) programs. Participants completed an online survey covering program characteristics, services, team composition, funding, implementation strategies, barriers and facilitators for success. A descriptive analysis summarized the findings, highlighting the diversity of these programs. Results: We found that the programs offer a range of services provided by an interdisciplinary team, including home-based care, telemedicine, and outpatient care. Additionally, we highlight two hospice facilities dedicated to providing pediatric palliative care. Community-based palliative care programs in Latin America are advancing patient care through community networks and alliances and are offering individualized, high-quality care tailored to the needs of patients and their families. Conclusion: This information is essential to understand how to develop successful community-based palliative care programs for children in other resource-constrained settings around the globe. Mención de responsabilidad : Zulema García Ulloa MD Ximena García-Quintero MD Yuriko Nakashima-Paniagua MD Silvia Rivas MD Monica A. Gana Antonella E. Torelli RN Hazel M. Gutiérrez MD Juliana Lopera MD Wendy Cristhyna Gómez García MD sandra Chacón MD Mercedes Bernadá MD Michael J. McNeil MD Referencia : J Pain Symptom Manage . 2025 Jun;69(6):e747-e754 DOI (Digital Object Identifier) : 10.1016/j.jpainsymman.2025.02.474. PMID : 40057248 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40057248/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Evolving Models of Community-Based Pediatric Palliative Care in Eight Countries Across Latin America [documento electrónico] / Lopera Solano, Juliana, Autor ; García Ulloa, Zulema, Autor ; García Quintero, Ximena, Autor ; Nakashima Paniagua, Yuriko, Autor ; Rivas, Silvia, Autor ; Gana, Monica A., Autor ; Torelli, Antonella E., Autor ; Gutiérrez, Hazel M., Autor ; Gómez García, Wendy Cristhyna, Autor ; Chacón, Sandra, Autor ; Bernadá, Mercedes, Autor ; McNeil, Michael J., Autor . - 2025. Obra : Journal of Pain and Symptom Management Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave : Pediatric palliative care; community-based palliative care; home-based palliative care; palliative care delivery programs; pediatric hospice care. Resumen : Context: High-quality pediatric palliative care is best achieved through a comprehensive interdisciplinary effort that actively involves the family and engages resources within the community. Community-based palliative care specifically strives to incorporate palliative care into local healthcare systems, adapting the most suitable model of care to each unique context. Objectives: In Latin America (LATAM), there is a paucity of palliative care teams, especially pediatric palliative care teams, working outside the hospital setting and immersed in the community. Thus, it is essential to learn more about the different community-based pediatric palliative care programs in Latin America and understand their successes in providing high quality community palliative care for children in resource-constrained settings METHODS: Eight LATAM leaders from outpatient Pediatric Palliative Care (PPC) programs, invited by St. Jude Global PPC network, participated in the study based on program alignment, operational status, and willingness. While not a systematic assessment, this sample includes benchmark Community-Based Pediatric Palliative Care (CBPPC) programs. Participants completed an online survey covering program characteristics, services, team composition, funding, implementation strategies, barriers and facilitators for success. A descriptive analysis summarized the findings, highlighting the diversity of these programs. Results: We found that the programs offer a range of services provided by an interdisciplinary team, including home-based care, telemedicine, and outpatient care. Additionally, we highlight two hospice facilities dedicated to providing pediatric palliative care. Community-based palliative care programs in Latin America are advancing patient care through community networks and alliances and are offering individualized, high-quality care tailored to the needs of patients and their families. Conclusion: This information is essential to understand how to develop successful community-based palliative care programs for children in other resource-constrained settings around the globe. Mención de responsabilidad : Zulema García Ulloa MD Ximena García-Quintero MD Yuriko Nakashima-Paniagua MD Silvia Rivas MD Monica A. Gana Antonella E. Torelli RN Hazel M. Gutiérrez MD Juliana Lopera MD Wendy Cristhyna Gómez García MD sandra Chacón MD Mercedes Bernadá MD Michael J. McNeil MD Referencia : J Pain Symptom Manage . 2025 Jun;69(6):e747-e754 DOI (Digital Object Identifier) : 10.1016/j.jpainsymman.2025.02.474. PMID : 40057248 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40057248/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Clinical characteristics and post-surgical outcomes in patients with spontaneous pneumothorax: Analysis in a high-complex complexity hospital / Willfredy Castaño Ruiz ; Lina María Velásquez Gómez ; Sánchez Castro, Carolina ; Barrantes Moreno, Santiago ; Bernal Sierra, Sofía ; Andrés Zerrate Misas ; Vanegas, Johanna Marcela  

Público ISBD Título : Clinical characteristics and post-surgical outcomes in patients with spontaneous pneumothorax: Analysis in a high-complex complexity hospital Otros títulos : Características clínicas y desenlaces postquirúrgicos en pacientes con neumotórax espontáneo: Análisis en un hospital de alta complejidad Tipo de documento : documento electrónico Autores : Willfredy Castaño Ruiz, Autor ; Lina María Velásquez Gómez, Autor ; Sánchez Castro, Carolina, Autor ; Barrantes Moreno, Santiago, Autor ; Bernal Sierra, Sofía, Autor ; Andrés Zerrate Misas, Autor ; Vanegas, Johanna Marcela, Autor Fecha de publicación : 2025 Títulos uniformes : Revista Colombiana de Cirugía Idioma : Inglés (eng) Idioma original : Español (spa) Palabras clave : Pleurodesis; pneumothorax; postoperative complications; thoracic surgical procedures; thoracoscopy; thoracostomy Resumen : Introduction. Spontaneous pneumothorax is a rare pathology that affects both young and old people. It can have a high recurrence rate, resulting in morbidity and sometimes mortality of the patients. In our environment we do not have epidemiological data on the disease, which motivated this study to be carried out. Methods. Retrospective study of a prospective database, which included patients over 14 years of age, with a diagnosis of spontaneous pneumothorax who underwent surgery at the Hospital Pablo Tobón Uribe, Medellin, Colombia, between January 2018 and December 2023. Sociodemographic, clinical variables and postoperative outcomes 30 days after the intervention were analyzed. Results. Males were the most affected (68.2%), secondary spontaneous pneumothorax predominated (56.8%) and the right hemithorax was the most common location (63.6%). A similar incidence was found between smokers and non-smokers (45.4% vs. 52.3%, respectively). Wedge resection was the definitive treatment in 50% of patients and wedge resection associated with mechanical pleurodesis in 31.8%. The most common complication was persistent air leak. A recurrence of pneumothorax was recorded in a patient who had undergone wedge resection. At the end of the study, five patients died: three had been treated only with thoracostomy and two had been taken to surgery. Conclusions. Spontaneous pneumothorax is a rare pathology. The causes and the affected population vary according to the classification. In our environment, tuberculosis has greater relevance because it is an endemic disease. © 2025, Asociacion Colombiana de Cirugia. All rights reserved. Mención de responsabilidad : Sánchez-Castro, Carolina, Barrantes-Moreno, Santiago, Bernal-Sierra, Sofía, Zerrate-Misas, Andrés, Castaño-Ruiz, Willfredy, Vanegas, Johanna Marcela, Velásquez-Gómez, Lina. Referencia : Rev Colomb Cir 2025, 40, 79-88. DOI (Digital Object Identifier) : 10.30944/20117582.2757 Derechos de uso : CC BY-NC-ND En línea : https://www.revistacirugia.org/index.php/cirugia/article/view/2757 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Clinical characteristics and post-surgical outcomes in patients with spontaneous pneumothorax: Analysis in a high-complex complexity hospital = Características clínicas y desenlaces postquirúrgicos en pacientes con neumotórax espontáneo: Análisis en un hospital de alta complejidad [documento electrónico] / Willfredy Castaño Ruiz, Autor ; Lina María Velásquez Gómez, Autor ; Sánchez Castro, Carolina, Autor ; Barrantes Moreno, Santiago, Autor ; Bernal Sierra, Sofía, Autor ; Andrés Zerrate Misas, Autor ; Vanegas, Johanna Marcela, Autor . - 2025. Obra : Revista Colombiana de Cirugía Idioma : Inglés (eng) Idioma original : Español (spa) Palabras clave : Pleurodesis; pneumothorax; postoperative complications; thoracic surgical procedures; thoracoscopy; thoracostomy Resumen : Introduction. Spontaneous pneumothorax is a rare pathology that affects both young and old people. It can have a high recurrence rate, resulting in morbidity and sometimes mortality of the patients. In our environment we do not have epidemiological data on the disease, which motivated this study to be carried out. Methods. Retrospective study of a prospective database, which included patients over 14 years of age, with a diagnosis of spontaneous pneumothorax who underwent surgery at the Hospital Pablo Tobón Uribe, Medellin, Colombia, between January 2018 and December 2023. Sociodemographic, clinical variables and postoperative outcomes 30 days after the intervention were analyzed. Results. Males were the most affected (68.2%), secondary spontaneous pneumothorax predominated (56.8%) and the right hemithorax was the most common location (63.6%). A similar incidence was found between smokers and non-smokers (45.4% vs. 52.3%, respectively). Wedge resection was the definitive treatment in 50% of patients and wedge resection associated with mechanical pleurodesis in 31.8%. The most common complication was persistent air leak. A recurrence of pneumothorax was recorded in a patient who had undergone wedge resection. At the end of the study, five patients died: three had been treated only with thoracostomy and two had been taken to surgery. Conclusions. Spontaneous pneumothorax is a rare pathology. The causes and the affected population vary according to the classification. In our environment, tuberculosis has greater relevance because it is an endemic disease. © 2025, Asociacion Colombiana de Cirugia. All rights reserved. Mención de responsabilidad : Sánchez-Castro, Carolina, Barrantes-Moreno, Santiago, Bernal-Sierra, Sofía, Zerrate-Misas, Andrés, Castaño-Ruiz, Willfredy, Vanegas, Johanna Marcela, Velásquez-Gómez, Lina. Referencia : Rev Colomb Cir 2025, 40, 79-88. DOI (Digital Object Identifier) : 10.30944/20117582.2757 Derechos de uso : CC BY-NC-ND En línea : https://www.revistacirugia.org/index.php/cirugia/article/view/2757 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Direct costs of severe hypoglycemia events in individuals with diabetes mellitus: a perspective from the Colombian health system - a single-center study / Michael Andrés García Rivera ; Natalia Andrea Rojas Henao ; Hernández Herrera, Ana C. ; Juliana Díaz Giraldo ; Carlos Esteban Builes Montaño  

Público ISBD Título : Direct costs of severe hypoglycemia events in individuals with diabetes mellitus: a perspective from the Colombian health system - a single-center study Tipo de documento : documento electrónico Autores : Michael Andrés García Rivera, Autor ; Natalia Andrea Rojas Henao, Autor ; Hernández Herrera, Ana C., Autor ; Juliana Díaz Giraldo, Autor ; Carlos Esteban Builes Montaño, Autor Fecha de publicación : 2025 Títulos uniformes : Hospital Practice Idioma : Inglés (eng) Palabras clave : Diabetes mellitus; Latin America; cost of illness; diabetes complications; hypoglycemia Resumen : Background and aims: Diabetes mellitus is one of the more prevalent chronic diseases globally, and healthcare expenditures for diabetes care are on the rise. Intensive diabetes treatment has been associated with reducing the risk of chronic complications. However, hypoglycemia, the most common adverse effect, poses a significant risk to individuals' lives and is linked to high costs for healthcare systems. Methods: We conducted a retrospective cross-sectional study to determine direct costs by identifying emergency room visits due to hypoglycemia events using diagnostic codes during January 2017 to June 2019. Direct costs were calculated using billed data from the payer and information on outpatient treatment regimens. Differences in median costs were estimated based on length of stay and type of outpatient treatment. Results: Data from 101 patients and the same number of events were included. Women represented (62.4%) of the patients, the median age was 70 (IQR 59.5-80). Blood glucose levels at admission ranged from 12 mg/dL to 67 mg/dL. Most patients were on insulin for outpatient treatment. The median cost of care per hypoglycemia episode was US $345.35 (IQR US $202-727.8), and the cost per episode was higher in patients treated with regimens that included sulfonylureas. Conclusions: The management of patients admitted to the emergency department with a diagnosis of hypoglycemia places a significant burden on the Colombian healthcare system, primarily due to the associated hospitalization costs. Patients treated with regimens that included sulfonylureas incurred higher costs per episode. Prevention, patient education, and individualized treatment approaches could help alleviate the burden of hypoglycemia on both patients and the healthcare system. Mención de responsabilidad : Rojas-Henao, Natalia A; Garcia-Rivera, Michael; Hernandez-Herrera, Ana C.; Díaz-Giraldo, Juliana; Builes-Montaño, Carlos E. Referencia : Hosp Pract (1995). 2025 Feb;53(1):2439775 DOI (Digital Object Identifier) : 10.1080/21548331.2024.2439775 PMID : 39648816 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/39648816/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Direct costs of severe hypoglycemia events in individuals with diabetes mellitus: a perspective from the Colombian health system - a single-center study [documento electrónico] / Michael Andrés García Rivera, Autor ; Natalia Andrea Rojas Henao, Autor ; Hernández Herrera, Ana C., Autor ; Juliana Díaz Giraldo, Autor ; Carlos Esteban Builes Montaño, Autor . - 2025. Obra : Hospital Practice Idioma : Inglés (eng) Palabras clave : Diabetes mellitus; Latin America; cost of illness; diabetes complications; hypoglycemia Resumen : Background and aims: Diabetes mellitus is one of the more prevalent chronic diseases globally, and healthcare expenditures for diabetes care are on the rise. Intensive diabetes treatment has been associated with reducing the risk of chronic complications. However, hypoglycemia, the most common adverse effect, poses a significant risk to individuals' lives and is linked to high costs for healthcare systems. Methods: We conducted a retrospective cross-sectional study to determine direct costs by identifying emergency room visits due to hypoglycemia events using diagnostic codes during January 2017 to June 2019. Direct costs were calculated using billed data from the payer and information on outpatient treatment regimens. Differences in median costs were estimated based on length of stay and type of outpatient treatment. Results: Data from 101 patients and the same number of events were included. Women represented (62.4%) of the patients, the median age was 70 (IQR 59.5-80). Blood glucose levels at admission ranged from 12 mg/dL to 67 mg/dL. Most patients were on insulin for outpatient treatment. The median cost of care per hypoglycemia episode was US $345.35 (IQR US $202-727.8), and the cost per episode was higher in patients treated with regimens that included sulfonylureas. Conclusions: The management of patients admitted to the emergency department with a diagnosis of hypoglycemia places a significant burden on the Colombian healthcare system, primarily due to the associated hospitalization costs. Patients treated with regimens that included sulfonylureas incurred higher costs per episode. Prevention, patient education, and individualized treatment approaches could help alleviate the burden of hypoglycemia on both patients and the healthcare system. Mención de responsabilidad : Rojas-Henao, Natalia A; Garcia-Rivera, Michael; Hernandez-Herrera, Ana C.; Díaz-Giraldo, Juliana; Builes-Montaño, Carlos E. Referencia : Hosp Pract (1995). 2025 Feb;53(1):2439775 DOI (Digital Object Identifier) : 10.1080/21548331.2024.2439775 PMID : 39648816 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/39648816/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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A scoping review of the extent of the clinical research on the vitiligo extent score / Carlos Esteban Builes Montaño ; Orozco Jiménez, Sara ; Rueda Galvis, Paola ; Arango Salgado, Andrea  

Público ISBD Título : A scoping review of the extent of the clinical research on the vitiligo extent score Tipo de documento : documento electrónico Autores : Carlos Esteban Builes Montaño, Autor ; Orozco Jiménez, Sara, Autor ; Rueda Galvis, Paola, Autor ; Arango Salgado, Andrea, Autor Fecha de publicación : 2025 Títulos uniformes : Archives of Dermatological Research Idioma : Inglés (eng) Palabras clave : Feasibility; Outcome measurement; Reliability; Vitiligo; Vitiligo extent score Resumen : Vitiligo is a chronic skin condition with no cure. Clinical assessment and treatment evaluation rely heavily on clinometry tools and expert knowledge. The Vitiligo Extent Score has been proposed as one of the most reliable and easy-to-use clinometry tools for vitiligo. We conducted a scoping review to identify all evidence on clinical research for the Vitiligo Extent Score. Databases searched included: MEDLINE (PubMed), Embase, Open Grey, Lens, and Directory of Open Access Journals (DOAJ). We followed the approach proposed in the Joanna Briggs Institute Reviewer’s Manual and reported this review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. The results are presented in sections covering VES reliability, its smallest detectable change, minimally important change, modifications proposed to the instrument, an extension of cross-cultural validation, and comparison to other clinical scoring instruments. The systematic review identified 42 records, and 23 studies were included in the final report. The VES demonstrated good or excellent reliability across different clinical scenarios and when used by experts and non-experts. The VES has a low minimally important change that overlaps with the smallest detectable change. The instrument has been modified for various clinical scenarios, including perifollicular assessment, patient-oriented scoring, and target evaluation. To date, the VES has only been cross-culturally validated outside its developmental population for patients in Thailand. Finally, the VES has been used in clinical research to assess disease severity, its correlation with other variables, evaluate vitiligo response to therapy, and develop disease extent scores. The VES is highly reliable, easy to use, and versatile for clinical research and everyday clinical assessment. However, more cross-cultural validations are needed to extend its applicability. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025. Mención de responsabilidad : Gustavo Adolfo Triana?Rodriguez5 | Mónica Royero?Arias6 | Jessica Echeverry, Tamara Gamo, Luz ÁngelaMoreno, Olga Lucía Baquero, Luz Marina Mejía, Sonia Restrepo?Gualteros, Luis Miguel Navarro?Ramirez, Sergio Moreno?Lopez, Juan Gabriel Piñeros, Carlos Álvarez?Moreno, Alejandro Díaz?Díaz, Iván Felipe Gutierrez, Clara Galvis Diaz, José Manuel Nieto, Irati Gastesi, Cinta Moraleda, Alfredo Tagarro García, Andrea Ramirez Varela. Referencia : Arch Dermatol Res . 2025 Feb 26;317(1):498. doi: 10.1007/s00403-024-03778-4. DOI (Digital Object Identifier) : 10.1007/s00403-024-03778-4 PMID : 40009214 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40009214/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis A scoping review of the extent of the clinical research on the vitiligo extent score [documento electrónico] / Carlos Esteban Builes Montaño, Autor ; Orozco Jiménez, Sara, Autor ; Rueda Galvis, Paola, Autor ; Arango Salgado, Andrea, Autor . - 2025. Obra : Archives of Dermatological Research Idioma : Inglés (eng) Palabras clave : Feasibility; Outcome measurement; Reliability; Vitiligo; Vitiligo extent score Resumen : Vitiligo is a chronic skin condition with no cure. Clinical assessment and treatment evaluation rely heavily on clinometry tools and expert knowledge. The Vitiligo Extent Score has been proposed as one of the most reliable and easy-to-use clinometry tools for vitiligo. We conducted a scoping review to identify all evidence on clinical research for the Vitiligo Extent Score. Databases searched included: MEDLINE (PubMed), Embase, Open Grey, Lens, and Directory of Open Access Journals (DOAJ). We followed the approach proposed in the Joanna Briggs Institute Reviewer’s Manual and reported this review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. The results are presented in sections covering VES reliability, its smallest detectable change, minimally important change, modifications proposed to the instrument, an extension of cross-cultural validation, and comparison to other clinical scoring instruments. The systematic review identified 42 records, and 23 studies were included in the final report. The VES demonstrated good or excellent reliability across different clinical scenarios and when used by experts and non-experts. The VES has a low minimally important change that overlaps with the smallest detectable change. The instrument has been modified for various clinical scenarios, including perifollicular assessment, patient-oriented scoring, and target evaluation. To date, the VES has only been cross-culturally validated outside its developmental population for patients in Thailand. Finally, the VES has been used in clinical research to assess disease severity, its correlation with other variables, evaluate vitiligo response to therapy, and develop disease extent scores. The VES is highly reliable, easy to use, and versatile for clinical research and everyday clinical assessment. However, more cross-cultural validations are needed to extend its applicability. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025. Mención de responsabilidad : Gustavo Adolfo Triana?Rodriguez5 | Mónica Royero?Arias6 | Jessica Echeverry, Tamara Gamo, Luz ÁngelaMoreno, Olga Lucía Baquero, Luz Marina Mejía, Sonia Restrepo?Gualteros, Luis Miguel Navarro?Ramirez, Sergio Moreno?Lopez, Juan Gabriel Piñeros, Carlos Álvarez?Moreno, Alejandro Díaz?Díaz, Iván Felipe Gutierrez, Clara Galvis Diaz, José Manuel Nieto, Irati Gastesi, Cinta Moraleda, Alfredo Tagarro García, Andrea Ramirez Varela. Referencia : Arch Dermatol Res . 2025 Feb 26;317(1):498. doi: 10.1007/s00403-024-03778-4. DOI (Digital Object Identifier) : 10.1007/s00403-024-03778-4 PMID : 40009214 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40009214/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Real-world treatment patterns and health care resource use for patients with myelofibrosis: results from the METER study / Kenny Mauricio Gálvez Cárdenas ; Gupta, Vikas ; Tomuleasa, Ciprian ; Barranco Lampón, Gilberto Israel ; Hou, Hsin-An ; Helbig, Grzegorz ; Vachhani, Pankit ; Symeonidis, Argiris ; Haznedaroglu, Ibrahim ; Tatsch, Fernando ; Chopra, Avijeet S. ; Zhang, Meng ; Vizkelety, Tamas ; Murray, Bryan ; Ross, David M.    

Público ISBD Título : Real-world treatment patterns and health care resource use for patients with myelofibrosis: results from the METER study Tipo de documento : documento electrónico Autores : Kenny Mauricio Gálvez Cárdenas, Autor ; Gupta, Vikas, Autor ; Tomuleasa, Ciprian, Autor ; Barranco Lampón, Gilberto Israel, Autor ; Hou, Hsin-An, Autor ; Helbig, Grzegorz, Autor ; Vachhani, Pankit, Autor ; Symeonidis, Argiris, Autor ; Haznedaroglu, Ibrahim, Autor ; Tatsch, Fernando, Autor ; Chopra, Avijeet S., Autor ; Zhang, Meng, Autor ; Vizkelety, Tamas, Autor ; Murray, Bryan, Autor ; Ross, David M., Autor Fecha de publicación : 2025 Títulos uniformes : Blood Advances Idioma : Inglés (eng) Resumen : Myelofibrosis (MF), a myeloproliferative neoplasm, was most commonly treated with hydroxyurea (HU) before approval of ruxolitinib (RUX), now the standard of care. Factors that influence real-world MF treatment patterns are not well understood. The METER study was a multi-country, retrospective chart review of MF treatment patterns, treatment effectiveness, and health care resource utilization. Of 997 eligible patients, 65.9% had primary MF, and 11.7% were transfusion dependent. Median time from diagnosis to the start of initial treatment (index date) was 29 days (interquartile range [IQR], 1-140). RUX was the most common first-line (1L) therapy (49.0%), followed by HU (40.2%); 48.5% of patients remained on 1L therapy through week 156. Seventy-seven patients underwent allogeneic stem cell transplantation; transplantation was uncommon at 1L, increasing from 2.2% at week 24 to 11.0% at week 156 in patients ?70 years of age. Median overall survival was 79.1 months (95% confidence interval [95% CI], 70.8 to not estimable [NE]) in all patients, 142.3 months (95% CI, 74.1 to NE) for non-RUX patients, 77.6 months (95% CI, 64.2-85.9) for patients on RUX 1L therapy, and 72.6 months (95% CI, 62.0 to NE) for RUX 2L+ patients. Of patients who experienced ?1 corresponding event, the median hospital length of stay (LoS; n = 520), intensive care unit LoS (n = 71), and number of transfusions (n = 375) were 16 days (IQR, 7-37), 5 days (IQR, 2-13), and 12 (IQR, 4-26), respectively. Despite improvements, there were numerous hospitalization and transfusion events among these patients in routine practice. This trial was registered at www.ClinicalTrials.gov as #NCT05444972. Mención de responsabilidad : Vikas Gupta, Ciprian Tomuleasa, Gilberto Israel Barranco Lampón, Hsin-An Hou, Grzegorz Helbig, Pankit Vachhani, Argiris Symeonidis, Ibrahim Haznedaroglu, Kenny Galvez, Fernando Tatsch, Avijeet S. Chopra, Meng Zhang, Tamas Vizkelety, Bryan Murray, David M. Ross Referencia : Blood Adv . 2025 Mar 11;9(5):1105-1116. DOI (Digital Object Identifier) : 10.1182/bloodadvances.2024014625. PMID : 39729499 Derechos de uso : CC BY-NC-ND En línea : https://ashpublications.org/bloodadvances/article/9/5/1105/534845/Real-world-tre [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Real-world treatment patterns and health care resource use for patients with myelofibrosis: results from the METER study [documento electrónico] / Kenny Mauricio Gálvez Cárdenas, Autor ; Gupta, Vikas, Autor ; Tomuleasa, Ciprian, Autor ; Barranco Lampón, Gilberto Israel, Autor ; Hou, Hsin-An, Autor ; Helbig, Grzegorz, Autor ; Vachhani, Pankit, Autor ; Symeonidis, Argiris, Autor ; Haznedaroglu, Ibrahim, Autor ; Tatsch, Fernando, Autor ; Chopra, Avijeet S., Autor ; Zhang, Meng, Autor ; Vizkelety, Tamas, Autor ; Murray, Bryan, Autor ; Ross, David M., Autor . - 2025. Obra : Blood Advances Idioma : Inglés (eng) Resumen : Myelofibrosis (MF), a myeloproliferative neoplasm, was most commonly treated with hydroxyurea (HU) before approval of ruxolitinib (RUX), now the standard of care. Factors that influence real-world MF treatment patterns are not well understood. The METER study was a multi-country, retrospective chart review of MF treatment patterns, treatment effectiveness, and health care resource utilization. Of 997 eligible patients, 65.9% had primary MF, and 11.7% were transfusion dependent. Median time from diagnosis to the start of initial treatment (index date) was 29 days (interquartile range [IQR], 1-140). RUX was the most common first-line (1L) therapy (49.0%), followed by HU (40.2%); 48.5% of patients remained on 1L therapy through week 156. Seventy-seven patients underwent allogeneic stem cell transplantation; transplantation was uncommon at 1L, increasing from 2.2% at week 24 to 11.0% at week 156 in patients ?70 years of age. Median overall survival was 79.1 months (95% confidence interval [95% CI], 70.8 to not estimable [NE]) in all patients, 142.3 months (95% CI, 74.1 to NE) for non-RUX patients, 77.6 months (95% CI, 64.2-85.9) for patients on RUX 1L therapy, and 72.6 months (95% CI, 62.0 to NE) for RUX 2L+ patients. Of patients who experienced ?1 corresponding event, the median hospital length of stay (LoS; n = 520), intensive care unit LoS (n = 71), and number of transfusions (n = 375) were 16 days (IQR, 7-37), 5 days (IQR, 2-13), and 12 (IQR, 4-26), respectively. Despite improvements, there were numerous hospitalization and transfusion events among these patients in routine practice. This trial was registered at www.ClinicalTrials.gov as #NCT05444972. Mención de responsabilidad : Vikas Gupta, Ciprian Tomuleasa, Gilberto Israel Barranco Lampón, Hsin-An Hou, Grzegorz Helbig, Pankit Vachhani, Argiris Symeonidis, Ibrahim Haznedaroglu, Kenny Galvez, Fernando Tatsch, Avijeet S. Chopra, Meng Zhang, Tamas Vizkelety, Bryan Murray, David M. Ross Referencia : Blood Adv . 2025 Mar 11;9(5):1105-1116. DOI (Digital Object Identifier) : 10.1182/bloodadvances.2024014625. PMID : 39729499 Derechos de uso : CC BY-NC-ND En línea : https://ashpublications.org/bloodadvances/article/9/5/1105/534845/Real-world-tre [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

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Real-world treatment patterns and health care resource use for patients with myelofibrosis: results from the METER study URL

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