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Detalle del título uniforme
Journal of the Neurological Sciences
Tipo de obra :
Autre
Naturaleza de la obra :
Oeuvre
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Documentos disponibles con este título uniforme (2)
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Validation of Thwaites Index for diagnosing tuberculous meningitis in a Colombian population / Andrés Franco Chica
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Título : Validation of Thwaites Index for diagnosing tuberculous meningitis in a Colombian population Tipo de documento : documento electrónico Autores : Andrés Franco Chica, Fecha de publicación : 2016 Títulos uniformes : Journal of the Neurological Sciences Idioma : Inglés (eng) Palabras clave : Meningeal tuberculosis bacterial meningitis diagnosis sensitivity specificity ROC curve Resumen : Objective: To determine the diagnostic accuracy of Thwaites Index (TI) in a Colombian population to distinguish meningeal tuberculosis (MTB) from bacterial meningitis (BM) and from non-tuberculous meningitis. Exploratory analyses were conducted to assess the TI's validity for patients with human immunodeficiency virus (HIV) and children above six-years-old. Methods: The study included 527 patients, the TI was calculated and results compared with those of a reference standard established by expert neurologists. Sensitivity, specificity, area under the curve of receiver-operator characteristics (AUC-ROC) and likelihood ratios were calculated. Results: The AUC-ROC to distinguish MTB from non-tuberculous meningitis was 0.72 (95% CI: 0.67–0.77) for HIV negative adults. AUC-ROC was 0.62 (95% CI: 0.50–0.74) for HIV positive adults and 0.83 (95% CI: 0.68–0.97) for children. For distinguishing MTB from BM the AUC-ROC was 0.78 (95% CI: 0.73–0.83); furthermore, the AUC-ROC was 0.57 (95% CI: 0.31–0.83) for HIV positive adults and 0.86 (95% CI: 0.73–0.99) for children. Conclusion: The TI was sensitive but not specific when used to distinguish MTB from BM in HIV negative adults. In HIV positive adults the index had low diagnostic accuracy. Moreover, the TI showed discrimination capability for children over 6 years; however, research with larger samples is required in these. Mención de responsabilidad : Juan Sebastián Saavedra, Sebastián Urrego, María Eugenia Toro, Carlos Santiago Uribe, Jenny García, Olga Hernández, Juan Carlos Arango, Ángela Beatriz Pérez, Andrés Franco, Isabel Cristina Vélez, Helena Del Corral Referencia : J Neurol Sci. 2016 15;370:112-118. DOI (Digital Object Identifier) : 10.1016/j.jns.2016.09.007 PMID : 27772738 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(16)30562-7 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3973 Validation of Thwaites Index for diagnosing tuberculous meningitis in a Colombian population [documento electrónico] / Andrés Franco Chica, . - 2016.
Obra : Journal of the Neurological Sciences
Idioma : Inglés (eng)
Palabras clave : Meningeal tuberculosis bacterial meningitis diagnosis sensitivity specificity ROC curve Resumen : Objective: To determine the diagnostic accuracy of Thwaites Index (TI) in a Colombian population to distinguish meningeal tuberculosis (MTB) from bacterial meningitis (BM) and from non-tuberculous meningitis. Exploratory analyses were conducted to assess the TI's validity for patients with human immunodeficiency virus (HIV) and children above six-years-old. Methods: The study included 527 patients, the TI was calculated and results compared with those of a reference standard established by expert neurologists. Sensitivity, specificity, area under the curve of receiver-operator characteristics (AUC-ROC) and likelihood ratios were calculated. Results: The AUC-ROC to distinguish MTB from non-tuberculous meningitis was 0.72 (95% CI: 0.67–0.77) for HIV negative adults. AUC-ROC was 0.62 (95% CI: 0.50–0.74) for HIV positive adults and 0.83 (95% CI: 0.68–0.97) for children. For distinguishing MTB from BM the AUC-ROC was 0.78 (95% CI: 0.73–0.83); furthermore, the AUC-ROC was 0.57 (95% CI: 0.31–0.83) for HIV positive adults and 0.86 (95% CI: 0.73–0.99) for children. Conclusion: The TI was sensitive but not specific when used to distinguish MTB from BM in HIV negative adults. In HIV positive adults the index had low diagnostic accuracy. Moreover, the TI showed discrimination capability for children over 6 years; however, research with larger samples is required in these. Mención de responsabilidad : Juan Sebastián Saavedra, Sebastián Urrego, María Eugenia Toro, Carlos Santiago Uribe, Jenny García, Olga Hernández, Juan Carlos Arango, Ángela Beatriz Pérez, Andrés Franco, Isabel Cristina Vélez, Helena Del Corral Referencia : J Neurol Sci. 2016 15;370:112-118. DOI (Digital Object Identifier) : 10.1016/j.jns.2016.09.007 PMID : 27772738 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(16)30562-7 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3973 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000564 AC-2016-039 Archivo digital Producción Científica Artículos científicos Disponible Diagnostic yield of the palmomental reflex in patients with suspected frontal lesion / Lady Diana Ladino Malagón
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Título : Diagnostic yield of the palmomental reflex in patients with suspected frontal lesion Tipo de documento : documento electrónico Autores : Lady Diana Ladino Malagón, Fecha de publicación : 2015 Títulos uniformes : Journal of the Neurological Sciences Idioma : Inglés (eng) Palabras clave : Diagnostic test. Marinesco–Radovici neurological signs physical examination primitive reflex semiology Resumen : Background: The purpose of this study was to determine the diagnostic value of the palmomental reflex in order to identify frontal lesions in neurological outpatients. Methods: Two hundred twenty-six neurological patients with suspected intracranial lesion with an indication for magnetic resonance imaging (MRI) were included. All patients underwent the same MRI protocol. The reflex was elicited by trained and standardized nurses, and was evaluated by two neurologists. The evaluation was blind and independent. The test's accuracy was calculated. The Kappa coefficient was used to calculate the interobserver and intra observer reliability. Results: The interobserver reliability between neurologists was 0.53 with 93% of agreement (p b 0.001). The diagnostic accuracy measures were as follow: sensitivity of 19%, specificity of 93%, positive predictive value of 30%, negative predictive value of 88%, positive likelihood ratio of 2.7 and negative likelihood ratio of 0.87. The area under the curve was 0.56. Conclusion: The palmomental reflex is associated with frontal structural lesions but the sensitivity is low, indicat ing a high percentage of frontal lesions with a negative reflex. When the test is used on its own, it is insufficient to detect frontal damage. Mención de responsabilidad : Lady D Ladino, Sandra Isaza, Jorge Delgado, Simon Rascovsky, Carlos Uribe, Santiago Acebedo, William Cornejo, Lizbeth Hernandez-Ronquillo, Jose F Tellez-Zenteno Referencia : J Neurol Sci. 2015 Dec 15;359(1-2):156-60. DOI (Digital Object Identifier) : 10.1016/j.jns.2015.11.003 PMID : 26671106 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(15)30011-3 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3915 Diagnostic yield of the palmomental reflex in patients with suspected frontal lesion [documento electrónico] / Lady Diana Ladino Malagón, . - 2015.
Obra : Journal of the Neurological Sciences
Idioma : Inglés (eng)
Palabras clave : Diagnostic test. Marinesco–Radovici neurological signs physical examination primitive reflex semiology Resumen : Background: The purpose of this study was to determine the diagnostic value of the palmomental reflex in order to identify frontal lesions in neurological outpatients. Methods: Two hundred twenty-six neurological patients with suspected intracranial lesion with an indication for magnetic resonance imaging (MRI) were included. All patients underwent the same MRI protocol. The reflex was elicited by trained and standardized nurses, and was evaluated by two neurologists. The evaluation was blind and independent. The test's accuracy was calculated. The Kappa coefficient was used to calculate the interobserver and intra observer reliability. Results: The interobserver reliability between neurologists was 0.53 with 93% of agreement (p b 0.001). The diagnostic accuracy measures were as follow: sensitivity of 19%, specificity of 93%, positive predictive value of 30%, negative predictive value of 88%, positive likelihood ratio of 2.7 and negative likelihood ratio of 0.87. The area under the curve was 0.56. Conclusion: The palmomental reflex is associated with frontal structural lesions but the sensitivity is low, indicat ing a high percentage of frontal lesions with a negative reflex. When the test is used on its own, it is insufficient to detect frontal damage. Mención de responsabilidad : Lady D Ladino, Sandra Isaza, Jorge Delgado, Simon Rascovsky, Carlos Uribe, Santiago Acebedo, William Cornejo, Lizbeth Hernandez-Ronquillo, Jose F Tellez-Zenteno Referencia : J Neurol Sci. 2015 Dec 15;359(1-2):156-60. DOI (Digital Object Identifier) : 10.1016/j.jns.2015.11.003 PMID : 26671106 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(15)30011-3 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3915 Reserva
Reservar este documentoEjemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000496 AC-2015-049 Archivo digital Producción Científica Artículos científicos Disponible