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Documentos disponibles con este título uniforme (4)
Clasificado(s) por (Año de edición descendente) Refinar búsquedaClinical differentiation of inflammatory bowel disease (IBD) in Latin America and the Caribbean / Fabián Juliao Baños
Título : Clinical differentiation of inflammatory bowel disease (IBD) in Latin America and the Caribbean Tipo de documento : documento electrónico Autores : Fabián Juliao Baños, Fecha de publicación : 2022 Títulos uniformes : Medicine (Baltimore) Idioma : Inglés (eng) Palabras clave : Crohn disease epidemiology inflammatory bowel disease Latin America ulcerative colitis Resumen : The aim of the present study was to describe the epidemiological and clinical characteristics of inflammatory bowel disease (IBD), including medical and surgical treatments, in several countries in Latin America and the Caribbean. IBD is recognized as a global health problem because its incidence and prevalence have increased significantly over the last few years. This multicenter retrospective cohort study included 4714 patients with IBD diagnosed from 9 countries in Latin America and the Caribbean: Colombia, Cuba, Dominican Republic, Ecuador, Mexico, Peru, Puerto Rico, Uruguay, and Venezuela. Crohn disease (CD) was more frequent in Puerto Rico (71.9%), the Dominican Republic (61.0%), and Peru (53.1%). Ulcerative colitis was more frequent in Colombia (78.6%), Venezuela (78.2%), Mexico (75.5%), Cuba (69.9%), Ecuador (64.1%), and Uruguay (60.9%). The following clinical characteristics were more frequent in the Caribbean: penetrating behavior in CD, steroid dependence, steroid resistance, intolerance to thiopurines, extraintestinal manifestations, surgeries, hospitalizations due to IBD, and family history of IBD. The factors associated with the use of biological therapy were pancolitis in ulcerative colitis, penetrating behavior in CD, steroid resistance and dependence, presence of extraintestinal manifestations, and the need for surgery. This study from Latin America and the Caribbean demonstrated the different epidemiological and clinical characteristics of IBD. Mención de responsabilidad : Yamamoto-Furusho, Jesús K. MD, PhD, MSc; Parra-Holguín, Norma N. MD; Juliao-Baños, Fabián MD; Puentes, Fabián MD; López, Rocio MD; Bosques-Padilla, Francisco MD; Torres, Esther A. MD; Nieves-Jimenéz, Humberto MD; Veitia-Velásquez, Guillermo R. MD; Jara-Alba, Maria L. MD; Bautista, Sócrates MD; Piñol-Jimenez, Felipe N. MD; Salgado-Rosado, Pablo MD; Villa-Ovalle, Keyla C. MD; Abreu-Martinez, Yudelka A. MD; Borges, Zunilda MD; Davila-Bedoya, Santiago MD; Otoya-Moreno, Guillermo MD; Iadé-Vergara, Beatriz MD Referencia : Medicine (Baltimore). 2022 Jan 21;101(3):e28624. DOI (Digital Object Identifier) : 10.1097/MD.0000000000028624 PMID : 35060539 Derechos de uso : CC BY En línea : https://journals.lww.com/md-journal/Fulltext/2022/01210/Clinical_differentiation [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6097 Clinical differentiation of inflammatory bowel disease (IBD) in Latin America and the Caribbean [documento electrónico] / Fabián Juliao Baños, . - 2022.
Obra : Medicine (Baltimore)
Idioma : Inglés (eng)
Palabras clave : Crohn disease epidemiology inflammatory bowel disease Latin America ulcerative colitis Resumen : The aim of the present study was to describe the epidemiological and clinical characteristics of inflammatory bowel disease (IBD), including medical and surgical treatments, in several countries in Latin America and the Caribbean. IBD is recognized as a global health problem because its incidence and prevalence have increased significantly over the last few years. This multicenter retrospective cohort study included 4714 patients with IBD diagnosed from 9 countries in Latin America and the Caribbean: Colombia, Cuba, Dominican Republic, Ecuador, Mexico, Peru, Puerto Rico, Uruguay, and Venezuela. Crohn disease (CD) was more frequent in Puerto Rico (71.9%), the Dominican Republic (61.0%), and Peru (53.1%). Ulcerative colitis was more frequent in Colombia (78.6%), Venezuela (78.2%), Mexico (75.5%), Cuba (69.9%), Ecuador (64.1%), and Uruguay (60.9%). The following clinical characteristics were more frequent in the Caribbean: penetrating behavior in CD, steroid dependence, steroid resistance, intolerance to thiopurines, extraintestinal manifestations, surgeries, hospitalizations due to IBD, and family history of IBD. The factors associated with the use of biological therapy were pancolitis in ulcerative colitis, penetrating behavior in CD, steroid resistance and dependence, presence of extraintestinal manifestations, and the need for surgery. This study from Latin America and the Caribbean demonstrated the different epidemiological and clinical characteristics of IBD. Mención de responsabilidad : Yamamoto-Furusho, Jesús K. MD, PhD, MSc; Parra-Holguín, Norma N. MD; Juliao-Baños, Fabián MD; Puentes, Fabián MD; López, Rocio MD; Bosques-Padilla, Francisco MD; Torres, Esther A. MD; Nieves-Jimenéz, Humberto MD; Veitia-Velásquez, Guillermo R. MD; Jara-Alba, Maria L. MD; Bautista, Sócrates MD; Piñol-Jimenez, Felipe N. MD; Salgado-Rosado, Pablo MD; Villa-Ovalle, Keyla C. MD; Abreu-Martinez, Yudelka A. MD; Borges, Zunilda MD; Davila-Bedoya, Santiago MD; Otoya-Moreno, Guillermo MD; Iadé-Vergara, Beatriz MD Referencia : Medicine (Baltimore). 2022 Jan 21;101(3):e28624. DOI (Digital Object Identifier) : 10.1097/MD.0000000000028624 PMID : 35060539 Derechos de uso : CC BY En línea : https://journals.lww.com/md-journal/Fulltext/2022/01210/Clinical_differentiation [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6097 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001945 AC-2022-106 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2022-106.pdfAdobe Acrobat PDF
Título : Trends in the epidemiology of inflammatory bowel disease in Colombia by demographics and region using a nationally representative claims database and characterization of inflammatory bowel disease phenotype in a case series of Colombian patients Tipo de documento : documento electrónico Autores : Fabián Juliao Baños, ; Jorge Hernando Donado Gómez, Fecha de publicación : 2021 Títulos uniformes : Medicine (Baltimore) Idioma : Inglés (eng) Palabras clave : Colombians Crohn’s disease Epidemiology Hispanics Latinos Ulcerative colitis Resumen : The incidence of inflammatory bowel disease (IBD) is on the rise in Latin America. The aims of this study were to examine epidemiologic trends of IBD in Colombia by demographics, region, urbanicity, and to describe the IBD phenotype in a large well-characterized Colombian cohort. We used a national database of 33 million adults encompassing 97.6% of the Colombian population in order to obtain epidemiologic trends of IBD using International Classification of Diseases 10codes for adults with ulcerative colitis (UC) and Crohn disease (CD). We calculated the incidence and prevalence of UC and CD from 2010–2017 and examined epidemiologic trends by urbanicity, demographics, and region. We then examined the IBD phenotype (using Montreal Classification), prevalence of IBD-related surgeries, and types of IBD-medications prescribed to adult patients attending a regional IBD clinic in Medellin, Colombia between 2001 and 2017. The incidence of UC increased from 5.59/100,000 in 2010 to 6.3/100,000 in 2017 (relative risk [RR] 1.12, confidence interval (CI) (1.09–1.18), P Mención de responsabilidad : Juliao-Baños, Fabian MD; Kock, Joshua MD, MSc; Arrubla, Mateo MD; Calixto, Omar MD; Camargo, Joselyn MD; Cruz, Lina MD; Hurtado, Juan MD; Clavijo, Absalon MD; Donado, Jorge MD, MSc; Schwartz, Seth PhD; Abreu, Maria T. MD; Damas, Oriana M. MD Referencia : Medicine (Baltimore). 2021 Feb 19;100(7):e24729. DOI (Digital Object Identifier) : 10.1097/MD.0000000000024729 PMID : 33607817 Derechos de uso : CC BY-NC En línea : https://journals.lww.com/md-journal/Fulltext/2021/02190/Trends_in_the_epidemiolo [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5760 Trends in the epidemiology of inflammatory bowel disease in Colombia by demographics and region using a nationally representative claims database and characterization of inflammatory bowel disease phenotype in a case series of Colombian patients [documento electrónico] / Fabián Juliao Baños, ; Jorge Hernando Donado Gómez, . - 2021.
Obra : Medicine (Baltimore)
Idioma : Inglés (eng)
Palabras clave : Colombians Crohn’s disease Epidemiology Hispanics Latinos Ulcerative colitis Resumen : The incidence of inflammatory bowel disease (IBD) is on the rise in Latin America. The aims of this study were to examine epidemiologic trends of IBD in Colombia by demographics, region, urbanicity, and to describe the IBD phenotype in a large well-characterized Colombian cohort. We used a national database of 33 million adults encompassing 97.6% of the Colombian population in order to obtain epidemiologic trends of IBD using International Classification of Diseases 10codes for adults with ulcerative colitis (UC) and Crohn disease (CD). We calculated the incidence and prevalence of UC and CD from 2010–2017 and examined epidemiologic trends by urbanicity, demographics, and region. We then examined the IBD phenotype (using Montreal Classification), prevalence of IBD-related surgeries, and types of IBD-medications prescribed to adult patients attending a regional IBD clinic in Medellin, Colombia between 2001 and 2017. The incidence of UC increased from 5.59/100,000 in 2010 to 6.3/100,000 in 2017 (relative risk [RR] 1.12, confidence interval (CI) (1.09–1.18), P Mención de responsabilidad : Juliao-Baños, Fabian MD; Kock, Joshua MD, MSc; Arrubla, Mateo MD; Calixto, Omar MD; Camargo, Joselyn MD; Cruz, Lina MD; Hurtado, Juan MD; Clavijo, Absalon MD; Donado, Jorge MD, MSc; Schwartz, Seth PhD; Abreu, Maria T. MD; Damas, Oriana M. MD Referencia : Medicine (Baltimore). 2021 Feb 19;100(7):e24729. DOI (Digital Object Identifier) : 10.1097/MD.0000000000024729 PMID : 33607817 Derechos de uso : CC BY-NC En línea : https://journals.lww.com/md-journal/Fulltext/2021/02190/Trends_in_the_epidemiolo [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5760 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001680 AC-2021-011 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2021-011Adobe Acrobat PDF
Título : Clinical features of Hispanic thyroid cancer cases and the role of known genetic variants on disease risk Tipo de documento : documento electrónico Autores : Carlos Simón Duque Fisher, ; Alejandro Vélez Hoyos, ; Jorge Hernando Donado Gómez, Fecha de publicación : 2016 Títulos uniformes : Medicine (Baltimore) Idioma : Inglés (eng) Palabras clave : Association Hispanics risk variants thyroid cancer Resumen : Thyroid cancer (TC) is the second most common cancer among Hispanic women. Recent genome-wide association (GWA) and candidate studies identified 6 single nucleotide polymorphisms (SNPs; rs966423, rs2439302, rs965513, rs6983267, rs944289, and rs116909374), associated with increased TC risk in Europeans but their effects on disease risk have not been comprehensively tested in Hispanics. In this study, we aimed to describe the main clinicopathological manifestations and to evaluate the effects of known SNPs on TC risk and on clinicopathological manifestations in a Hispanic population. We analyzed 281 nonmedullary TC cases and 1146 cancer-free controls recruited in a multicenter population-based study in Colombia. SNPs were genotyped by Kompetitive allele specific polymerase chain reaction (KASP) technique. Association between genetic variants and TC risk was assessed by computing odds ratios (OR) and confidence intervals (CIs). Consistent with published data in U.S. Hispanics, our cases had a high prevalence of large tumors (>2 cm, 43%) and a high female/male ratio (5:1). We detected significant associations between TC risk and rs965513A (OR = 1.41), rs944289T (OR = 1.26), rs116909374A (OR = 1.96), rs2439302G (OR = 1.19), and rs6983267G (OR = 1.18). Cases carried more risk alleles than controls (5.16 vs. 4.78, P = 4.8 × 10−6). Individuals with ≥6 risk alleles had >6-fold increased TC risk (OR = 6.33, P = 4.0 × 10−6) compared to individuals with ≤2 risk alleles. rs944289T and rs116909374A were strongly associated with follicular histology (ORs = 1.61 and 3.33, respectively); rs2439302G with large tumors (OR = 1.50); and rs965513A with regional disease (OR = 1.92). To our knowledge, this is the first study of known TC risk variants in South American Hispanics and suggests that they increase TC susceptibility in this population and can identify patients at higher risk of severe disease. Back to Top | Article Outline Mención de responsabilidad : Ana P Estrada-Florez, Mabel E Bohórquez, Ruta Sahasrabudhe, Rodrigo Prieto, Paul Lott, Carlos S Duque, Jorge Donado, Gilbert Mateus, Fernando Bolaños, Alejandro Vélez, Magdalena Echeverry, Luis G Carvajal-Carmona Referencia : Medicine (Baltimore). 2016 Aug;95(32):e4148. DOI (Digital Object Identifier) : 10.1097/MD.0000000000004148. PMID : 27512836 En línea : https://journals.lww.com/md-journal/fulltext/2016/08090/Clinical_features_of_His [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3954 Clinical features of Hispanic thyroid cancer cases and the role of known genetic variants on disease risk [documento electrónico] / Carlos Simón Duque Fisher, ; Alejandro Vélez Hoyos, ; Jorge Hernando Donado Gómez, . - 2016.
Obra : Medicine (Baltimore)
Idioma : Inglés (eng)
Palabras clave : Association Hispanics risk variants thyroid cancer Resumen : Thyroid cancer (TC) is the second most common cancer among Hispanic women. Recent genome-wide association (GWA) and candidate studies identified 6 single nucleotide polymorphisms (SNPs; rs966423, rs2439302, rs965513, rs6983267, rs944289, and rs116909374), associated with increased TC risk in Europeans but their effects on disease risk have not been comprehensively tested in Hispanics. In this study, we aimed to describe the main clinicopathological manifestations and to evaluate the effects of known SNPs on TC risk and on clinicopathological manifestations in a Hispanic population. We analyzed 281 nonmedullary TC cases and 1146 cancer-free controls recruited in a multicenter population-based study in Colombia. SNPs were genotyped by Kompetitive allele specific polymerase chain reaction (KASP) technique. Association between genetic variants and TC risk was assessed by computing odds ratios (OR) and confidence intervals (CIs). Consistent with published data in U.S. Hispanics, our cases had a high prevalence of large tumors (>2 cm, 43%) and a high female/male ratio (5:1). We detected significant associations between TC risk and rs965513A (OR = 1.41), rs944289T (OR = 1.26), rs116909374A (OR = 1.96), rs2439302G (OR = 1.19), and rs6983267G (OR = 1.18). Cases carried more risk alleles than controls (5.16 vs. 4.78, P = 4.8 × 10−6). Individuals with ≥6 risk alleles had >6-fold increased TC risk (OR = 6.33, P = 4.0 × 10−6) compared to individuals with ≤2 risk alleles. rs944289T and rs116909374A were strongly associated with follicular histology (ORs = 1.61 and 3.33, respectively); rs2439302G with large tumors (OR = 1.50); and rs965513A with regional disease (OR = 1.92). To our knowledge, this is the first study of known TC risk variants in South American Hispanics and suggests that they increase TC susceptibility in this population and can identify patients at higher risk of severe disease. Back to Top | Article Outline Mención de responsabilidad : Ana P Estrada-Florez, Mabel E Bohórquez, Ruta Sahasrabudhe, Rodrigo Prieto, Paul Lott, Carlos S Duque, Jorge Donado, Gilbert Mateus, Fernando Bolaños, Alejandro Vélez, Magdalena Echeverry, Luis G Carvajal-Carmona Referencia : Medicine (Baltimore). 2016 Aug;95(32):e4148. DOI (Digital Object Identifier) : 10.1097/MD.0000000000004148. PMID : 27512836 En línea : https://journals.lww.com/md-journal/fulltext/2016/08090/Clinical_features_of_His [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3954 Reserva
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Título : Clinical manifestations of colorectal cancer patients from a large multicenter study in Colombia Tipo de documento : documento electrónico Autores : Alejandro Vélez Hoyos, ; José Ignacio Restrepo Restrepo, ; Juan Ricardo Márquez Velásquez, Fecha de publicación : 2016 Títulos uniformes : Medicine (Baltimore) Idioma : Inglés (eng) Palabras clave : Clinicopathological features colorectal cancer (CRC) Hispanic population Resumen : Colorectal cancer (CRC) is a major public health problem, and its incidence is rising in developing countries. However, studies characterizing CRC clinicopathological features in cases from developing countries are still lacking. The goal of this study was to evaluate clinicopathological and demographic features in one of the largest CRC studies in Latin America. The study involved over 1525 CRC cases recruited in a multicenter study in Colombia between 2005 and 2014 as part of ongoing genetic and epidemiological studies. We gathered clinicopathological data such as age at diagnosis, sex, body mass index, tobacco and alcohol consumption, family history of cancer, and tumor features including location, histological type, and stage. Statistical analyses were performed to test the association between age of onset, sex, and clinical manifestations. The average age at CRC diagnosis was 57.4 years, with 26.5% of cases having early-onset CRC (diagnosed by age 50 years). Most cases were women (53.2%; P = 0.009), 49.2% were overweight or obese, 49.1% were regular alcohol drinkers, 52% were smokers/former smokers, and 12.2% reported relatives with cancer. Most tumors in the study were located in the rectum (42.7%), were adenocarcinomas (91.5%), and had advanced stage (T3–T4, 79.8%). Comparisons by sex found that male cases were more likely to be obese (36.5% vs 31.1%; P = 0.001), less likely to have a family history of cancer (9.7% vs 15.3%; P = 0.016), and more likely to have advanced-stage tumors (83.9% vs 76.1%; P = 0.036). Comparisons by age of onset found that early-onset cases were more likely to be women (59.3% vs 51.0%; P = 0.005) and report a family history of cancer (17.4% vs 10.2%; P = 0.001). To our knowledge, our study is the largest report of clinicopathological characterization of Hispanic CRC cases, and we suggest that further studies are needed to understand CRC etiology in diverse Hispanic populations. Mención de responsabilidad : Mabel Bohorquez, Ruta Sahasrabudhe, Angel Criollo, María Carolina Sanabria-Salas, Alejandro Vélez, Jorge Mario Castro, Juan Ricardo Marquez, Gilbert Mateus, Fernando Bolaños, Cesar Panqueva, Jose Ignacio Restrepo, Juan Dario Puerta, Raul Murillo, María Mercedes Bravo, Gustavo Hernández, Angela Rios, Rodrigo Prieto, Ian Tomlinson, Magdalena Echeverry, Luis G Carvajal-Carmona Referencia : Medicine (Baltimore). 2016 Oct;95(40):e4883. DOI (Digital Object Identifier) : 10.1097/MD.0000000000004883 PMID : 27749544 En línea : https://journals.lww.com/md-journal/fulltext/2016/10040/Clinical_manifestations_ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3941 Clinical manifestations of colorectal cancer patients from a large multicenter study in Colombia [documento electrónico] / Alejandro Vélez Hoyos, ; José Ignacio Restrepo Restrepo, ; Juan Ricardo Márquez Velásquez, . - 2016.
Obra : Medicine (Baltimore)
Idioma : Inglés (eng)
Palabras clave : Clinicopathological features colorectal cancer (CRC) Hispanic population Resumen : Colorectal cancer (CRC) is a major public health problem, and its incidence is rising in developing countries. However, studies characterizing CRC clinicopathological features in cases from developing countries are still lacking. The goal of this study was to evaluate clinicopathological and demographic features in one of the largest CRC studies in Latin America. The study involved over 1525 CRC cases recruited in a multicenter study in Colombia between 2005 and 2014 as part of ongoing genetic and epidemiological studies. We gathered clinicopathological data such as age at diagnosis, sex, body mass index, tobacco and alcohol consumption, family history of cancer, and tumor features including location, histological type, and stage. Statistical analyses were performed to test the association between age of onset, sex, and clinical manifestations. The average age at CRC diagnosis was 57.4 years, with 26.5% of cases having early-onset CRC (diagnosed by age 50 years). Most cases were women (53.2%; P = 0.009), 49.2% were overweight or obese, 49.1% were regular alcohol drinkers, 52% were smokers/former smokers, and 12.2% reported relatives with cancer. Most tumors in the study were located in the rectum (42.7%), were adenocarcinomas (91.5%), and had advanced stage (T3–T4, 79.8%). Comparisons by sex found that male cases were more likely to be obese (36.5% vs 31.1%; P = 0.001), less likely to have a family history of cancer (9.7% vs 15.3%; P = 0.016), and more likely to have advanced-stage tumors (83.9% vs 76.1%; P = 0.036). Comparisons by age of onset found that early-onset cases were more likely to be women (59.3% vs 51.0%; P = 0.005) and report a family history of cancer (17.4% vs 10.2%; P = 0.001). To our knowledge, our study is the largest report of clinicopathological characterization of Hispanic CRC cases, and we suggest that further studies are needed to understand CRC etiology in diverse Hispanic populations. Mención de responsabilidad : Mabel Bohorquez, Ruta Sahasrabudhe, Angel Criollo, María Carolina Sanabria-Salas, Alejandro Vélez, Jorge Mario Castro, Juan Ricardo Marquez, Gilbert Mateus, Fernando Bolaños, Cesar Panqueva, Jose Ignacio Restrepo, Juan Dario Puerta, Raul Murillo, María Mercedes Bravo, Gustavo Hernández, Angela Rios, Rodrigo Prieto, Ian Tomlinson, Magdalena Echeverry, Luis G Carvajal-Carmona Referencia : Medicine (Baltimore). 2016 Oct;95(40):e4883. DOI (Digital Object Identifier) : 10.1097/MD.0000000000004883 PMID : 27749544 En línea : https://journals.lww.com/md-journal/fulltext/2016/10040/Clinical_manifestations_ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3941 Reserva
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