The Global Evolution of In ammatory Bowel Disease across Four Epidemiologic Stages / Fabián Juliao Baños  

Público ISBD Título : The Global Evolution of In ammatory Bowel Disease across Four Epidemiologic Stages Tipo de documento : documento electrónico Autores : Fabián Juliao Baños, Autor Fecha de publicación : 2024 Títulos uniformes : Nature Communications Idioma : Inglés (eng) Resumen : During the 20th century, inflammatory bowel disease (IBD) was considered a disease of early-industrialized regions in North America, Europe, and Oceania. At the turn of the 21st century, incidence of IBD increased in newly-industrialized and emerging regions in Africa, Asia, and Latin America, while prevalence in early-industrialized regions started to grow steadily. Changes in incidence and prevalence denote evolution of IBD across four epidemiologic stages: Stage 1 (Emergence), characterized by low incidence and prevalence; stage 2 (Acceleration in Incidence), characterized by rapidly rising incidence and low prevalence; and stage 3 (Compounding Prevalence), characterized by decelerating, plateauing, or declining incidence and steadily rising prevalence. A fourth stage (Prevalence Equilibrium) has been proposed where the slope of prevalence plateaus due to shifting demographics of an aging IBD population, but it has not yet been evidenced. To date, these stages have been theoretical without specific incidence/prevalence indicators defining transition points. Using real-world data from 490 population-based studies comprising 80 global regions and spanning over a century (1920–2023), we show spatiotemporal transitions across stages 1–3 and model transition towards stage 4. Understanding the evolution of IBD across epidemiologic stages allows healthcare systems to better prepare for the future worldwide burden of IBD. Mención de responsabilidad : Lindsay Hracs # 1, Joseph W Windsor # 1, Julia Gorospe 1, Michael Cummings 2, Stephanie Coward 1, Michael J Buie 1, Joshua Quan 1, Quinn Goddard 1, Léa Caplan 1, Ante Markovinovi? 1, Tyler Williamson 2, Yvonne Abbey 3, Murdani Abdullah 4, Maria T Abreu 5 6, Vineet Ahuja 6 7, Raja Affendi Raja Ali 8, Mansour Altuwaijri 9, Domingo Balderramo 10, Rupa Banerjee 6 11, Eric I Benchimol 12 13 14 15, Charles N Bernstein 6 16, Eduard Brunet-Mas 17 18 19, Johan Burisch 6 20 21 22, Vui Heng Chong 23, Iris Dotan 6 24, Usha Dutta 25, Sara El Ouali 26 27, Angela Forbes 28, Anders Forss 29, Richard Gearry 6 28, Viet Hang Dao 30, Juanda Leo Hartono 31 32, Ida Hilmi 33, Phoebe Hodges 34 35, Gareth-Rhys Jones 36, Fabián Juliao-Baños 37, Jamilya Kaibullayeva 38 39, Paul Kelly 34 35, Taku Kobayashi 40 41, Paulo Gustavo Kotze 6 42, Peter L Lakatos 6 43 44, Charlie W Lees 45 46, Julajak Limsrivilai 47, Bobby Lo 20 21, Edward V Loftus Jr 6 48, Jonas F Ludvigsson 29 49, Joyce W Y Mak 50, YingLei Miao 51 52, K Referencia : Nature . 2025 Jun;642(8067):458-466 DOI (Digital Object Identifier) : 10.1038/s41586-025-08940-0. Epub 2025 Apr 30 PMID : 40307548 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40307548/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis The Global Evolution of In ammatory Bowel Disease across Four Epidemiologic Stages [documento electrónico] / Fabián Juliao Baños, Autor . - 2024. Obra : Nature Communications Idioma : Inglés (eng) Resumen : During the 20th century, inflammatory bowel disease (IBD) was considered a disease of early-industrialized regions in North America, Europe, and Oceania. At the turn of the 21st century, incidence of IBD increased in newly-industrialized and emerging regions in Africa, Asia, and Latin America, while prevalence in early-industrialized regions started to grow steadily. Changes in incidence and prevalence denote evolution of IBD across four epidemiologic stages: Stage 1 (Emergence), characterized by low incidence and prevalence; stage 2 (Acceleration in Incidence), characterized by rapidly rising incidence and low prevalence; and stage 3 (Compounding Prevalence), characterized by decelerating, plateauing, or declining incidence and steadily rising prevalence. A fourth stage (Prevalence Equilibrium) has been proposed where the slope of prevalence plateaus due to shifting demographics of an aging IBD population, but it has not yet been evidenced. To date, these stages have been theoretical without specific incidence/prevalence indicators defining transition points. Using real-world data from 490 population-based studies comprising 80 global regions and spanning over a century (1920–2023), we show spatiotemporal transitions across stages 1–3 and model transition towards stage 4. Understanding the evolution of IBD across epidemiologic stages allows healthcare systems to better prepare for the future worldwide burden of IBD. Mención de responsabilidad : Lindsay Hracs # 1, Joseph W Windsor # 1, Julia Gorospe 1, Michael Cummings 2, Stephanie Coward 1, Michael J Buie 1, Joshua Quan 1, Quinn Goddard 1, Léa Caplan 1, Ante Markovinovi? 1, Tyler Williamson 2, Yvonne Abbey 3, Murdani Abdullah 4, Maria T Abreu 5 6, Vineet Ahuja 6 7, Raja Affendi Raja Ali 8, Mansour Altuwaijri 9, Domingo Balderramo 10, Rupa Banerjee 6 11, Eric I Benchimol 12 13 14 15, Charles N Bernstein 6 16, Eduard Brunet-Mas 17 18 19, Johan Burisch 6 20 21 22, Vui Heng Chong 23, Iris Dotan 6 24, Usha Dutta 25, Sara El Ouali 26 27, Angela Forbes 28, Anders Forss 29, Richard Gearry 6 28, Viet Hang Dao 30, Juanda Leo Hartono 31 32, Ida Hilmi 33, Phoebe Hodges 34 35, Gareth-Rhys Jones 36, Fabián Juliao-Baños 37, Jamilya Kaibullayeva 38 39, Paul Kelly 34 35, Taku Kobayashi 40 41, Paulo Gustavo Kotze 6 42, Peter L Lakatos 6 43 44, Charlie W Lees 45 46, Julajak Limsrivilai 47, Bobby Lo 20 21, Edward V Loftus Jr 6 48, Jonas F Ludvigsson 29 49, Joyce W Y Mak 50, YingLei Miao 51 52, K Referencia : Nature . 2025 Jun;642(8067):458-466 DOI (Digital Object Identifier) : 10.1038/s41586-025-08940-0. Epub 2025 Apr 30 PMID : 40307548 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40307548/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

Reserva

Reservar este documento

Ejemplares(1)

Código de barras	Número de Ubicación	Tipo de medio	Ubicación	Sección	Estado
DD002199	AC-2024-052	Archivo digital	Producción Científica	Artículos científicos	Disponible

Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25 / Alejandro Vélez Hoyos    

Público ISBD Título : Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25 Tipo de documento : documento electrónico Autores : Alejandro Vélez Hoyos, Fecha de publicación : 2014 Títulos uniformes : Nature Communications Idioma : Inglés (eng) Resumen : The genetic contributions to breast cancer development among Latinas are not well understood. Here we carry out a genome-wide association study of breast cancer in Latinas and identify a genome-wide significant risk variant, located 5′ of the Estrogen Receptor 1 gene (ESR1; 6q25 region). The minor allele for this variant is strongly protective (rs140068132: odds ratio (OR) 0.60, 95% confidence interval (CI) 0.53–0.67, P=9 × 10−18), originates from Indigenous Americans and is uncorrelated with previously reported risk variants at 6q25. The association is stronger for oestrogen receptor-negative disease (OR 0.34, 95% CI 0.21–0.54) than oestrogen receptor-positive disease (OR 0.63, 95% CI 0.49–0.80; P heterogeneity=0.01) and is also associated with mammographic breast density, a strong risk factor for breast cancer (P=0.001). rs140068132 is located within several transcription factor-binding sites and electrophoretic mobility shift assays with MCF-7 nuclear protein demonstrate differential binding of the G/A alleles at this locus. These results highlight the importance of conducting research in diverse populations. Mención de responsabilidad : Laura Fejerman, Nasim Ahmadiyeh, Donglei Hu, Scott Huntsman, Kenneth B Beckman, Jennifer L Caswell, Karen Tsung, Esther M John, Gabriela Torres-Mejia, Luis Carvajal-Carmona, María Magdalena Echeverry, Anna Marie D Tuazon, Carolina Ramirez, COLUMBUS Consortium; Christopher R Gignoux, Celeste Eng, Esteban Gonzalez-Burchard, Brian Henderson, Loic Le Marchand, Charles Kooperberg, Lifang Hou, Ilir Agalliu, Peter Kraft, Sara Lindström, Eliseo J Perez-Stable, Christopher A Haiman, Elad Ziv Referencia : Nat Commun. 2014 Oct 20;5:5260. DOI (Digital Object Identifier) : 10.1038/ncomms6260 PMID : 25327703 Derechos de uso : CC BY En línea : https://www.nature.com/articles/ncomms6260 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25 [documento electrónico] / Alejandro Vélez Hoyos,  . - 2014. Obra : Nature Communications Idioma : Inglés (eng) Resumen : The genetic contributions to breast cancer development among Latinas are not well understood. Here we carry out a genome-wide association study of breast cancer in Latinas and identify a genome-wide significant risk variant, located 5′ of the Estrogen Receptor 1 gene (ESR1; 6q25 region). The minor allele for this variant is strongly protective (rs140068132: odds ratio (OR) 0.60, 95% confidence interval (CI) 0.53–0.67, P=9 × 10−18), originates from Indigenous Americans and is uncorrelated with previously reported risk variants at 6q25. The association is stronger for oestrogen receptor-negative disease (OR 0.34, 95% CI 0.21–0.54) than oestrogen receptor-positive disease (OR 0.63, 95% CI 0.49–0.80; P heterogeneity=0.01) and is also associated with mammographic breast density, a strong risk factor for breast cancer (P=0.001). rs140068132 is located within several transcription factor-binding sites and electrophoretic mobility shift assays with MCF-7 nuclear protein demonstrate differential binding of the G/A alleles at this locus. These results highlight the importance of conducting research in diverse populations. Mención de responsabilidad : Laura Fejerman, Nasim Ahmadiyeh, Donglei Hu, Scott Huntsman, Kenneth B Beckman, Jennifer L Caswell, Karen Tsung, Esther M John, Gabriela Torres-Mejia, Luis Carvajal-Carmona, María Magdalena Echeverry, Anna Marie D Tuazon, Carolina Ramirez, COLUMBUS Consortium; Christopher R Gignoux, Celeste Eng, Esteban Gonzalez-Burchard, Brian Henderson, Loic Le Marchand, Charles Kooperberg, Lifang Hou, Ilir Agalliu, Peter Kraft, Sara Lindström, Eliseo J Perez-Stable, Christopher A Haiman, Elad Ziv Referencia : Nat Commun. 2014 Oct 20;5:5260. DOI (Digital Object Identifier) : 10.1038/ncomms6260 PMID : 25327703 Derechos de uso : CC BY En línea : https://www.nature.com/articles/ncomms6260 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis

Reserva

Reservar este documento

Ejemplares(1)

Código de barras	Número de Ubicación	Tipo de medio	Ubicación	Sección	Estado
DD000416	AC-2014-082	Archivo digital	Producción Científica	Artículos científicos	Disponible

Documentos electrónicos

2014-082.pdf Adobe Acrobat PDF

---

1 (1 - 2 / 2) Por página: 25 50 100 200