Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type I diabetes mellitus and their close family members / Verónica Abad Londoño  

Público ISBD Título : Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type I diabetes mellitus and their close family members Tipo de documento : documento electrónico Autores : Verónica Abad Londoño, Fecha de publicación : 2009 Títulos uniformes : Annals of the New York Academy of Sciences Idioma : Inglés (eng) Palabras clave : Autoimmunity  infection  epstein barr virus  cytomegalovirus  helicobacter pylori  toxoplasma  celiac disease Resumen : Type 1 diabetes mellitus (T1DM) is an autoimmune disease with complex interactions between genetic and environmental factors. We compared antibody levels to various infectious agents and of autoimmune‐associated autoantibodies between Colombian T1DM patients, their close family members and healthy controls. Significantly lower levels of antibodies against several infectious agents were detected in the T1DM patients. These included Helicobacter pylori (P= 0.01), cytomegalovirus (P= 0.001), Epstein‐Barr virus (P= 0.02) and Toxoplasma (P= 0.001). T1DM patients had significantly higher levels of IgG‐anti‐gliadin antibodies (P= 0.001) and IgG‐antitissue transglutaminase antibodies (P= 0.03), and a borderline association with anticentromere antibodies (P= 0.06). The lower level of antibodies against infectious agents in T1DM patients may be related to their younger ages, but may also point to a protective role of those infections in T1DM development in susceptible individuals. Our results confirm the association between T1DM and celiac disease. A possible association with anticentromere antibody needs further studies. Mención de responsabilidad : Ilan Krause, Juan Manuel Anaya, Abigail Fraser, Ori Barzilai, Maya Ram Verónica Abad, Alvaro Arango, Jorge García, Yehuda Shoenfeld Referencia : Ann N Y Acad Sci. 2009 Sep;1173:633-9. DOI (Digital Object Identifier) : 10.1111/j.1749-6632.2009.04619.x PMID : 19758209 En línea : https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.04619.x Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3471 Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type I diabetes mellitus and their close family members [documento electrónico] / Verónica Abad Londoño,  . - 2009. Obra : Annals of the New York Academy of Sciences Idioma : Inglés (eng) Palabras clave : Autoimmunity  infection  epstein barr virus  cytomegalovirus  helicobacter pylori  toxoplasma  celiac disease Resumen : Type 1 diabetes mellitus (T1DM) is an autoimmune disease with complex interactions between genetic and environmental factors. We compared antibody levels to various infectious agents and of autoimmune‐associated autoantibodies between Colombian T1DM patients, their close family members and healthy controls. Significantly lower levels of antibodies against several infectious agents were detected in the T1DM patients. These included Helicobacter pylori (P= 0.01), cytomegalovirus (P= 0.001), Epstein‐Barr virus (P= 0.02) and Toxoplasma (P= 0.001). T1DM patients had significantly higher levels of IgG‐anti‐gliadin antibodies (P= 0.001) and IgG‐antitissue transglutaminase antibodies (P= 0.03), and a borderline association with anticentromere antibodies (P= 0.06). The lower level of antibodies against infectious agents in T1DM patients may be related to their younger ages, but may also point to a protective role of those infections in T1DM development in susceptible individuals. Our results confirm the association between T1DM and celiac disease. A possible association with anticentromere antibody needs further studies. Mención de responsabilidad : Ilan Krause, Juan Manuel Anaya, Abigail Fraser, Ori Barzilai, Maya Ram Verónica Abad, Alvaro Arango, Jorge García, Yehuda Shoenfeld Referencia : Ann N Y Acad Sci. 2009 Sep;1173:633-9. DOI (Digital Object Identifier) : 10.1111/j.1749-6632.2009.04619.x PMID : 19758209 En línea : https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.04619.x Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3471

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Treatment of chromoblastomycosis with itraconazole / Ángela Restrepo Moreno ; Aurelio González ; Iván Gómez ; Myrtha Arango Arteaga ; Catalina de Bedout Gómez  

Público ISBD Título : Treatment of chromoblastomycosis with itraconazole Tipo de documento : documento electrónico Autores : Ángela Restrepo Moreno, ; Aurelio González, ; Iván Gómez, ; Myrtha Arango Arteaga, ; Catalina de Bedout Gómez, Fecha de publicación : 1988 Títulos uniformes : Annals of the New York Academy of Sciences Idioma : Inglés (eng) Resumen : The results of long-term itraconazole therapy in 10 patients with active chromoblastomycosis due to F. pedrosoi were reported. Therapy consisted of 100 or 200 mg/day of itraconazole, the length of therapy depending on the patient's response (12 to 24 months). This new triazole proved effective in reducing the number, size, and severity of the lesions in nine of the patients. Those patients with minor involvement profited more from therapy and were cured; patients with moderate involvement achieved either minor or major improvement. In most cases, signs and symptoms began to improve after 6 months of therapy. Mycological tests (in which tissue samples were treated with potassium hydroxide and cultured) became negative in six patients, but the fungus was eradicated in only three patients. Itraconazole produced no side effects. In spite of the need for long-term therapy, this new azole derivative effectively controls the disease. Mención de responsabilidad : Angela Restrepo, Aurelio Gonzalez, Ivan Gomez, Myrtha Arango, Catalina De Bedout Referencia : Ann N Y Acad Sci. 1988;544:504-16 DOI (Digital Object Identifier) : 10.1111/j.1749-6632.1988.tb40448.x PMID : 2850755 En línea : https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.1988.tb4044 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4348 Treatment of chromoblastomycosis with itraconazole [documento electrónico] / Ángela Restrepo Moreno, ; Aurelio González, ; Iván Gómez, ; Myrtha Arango Arteaga, ; Catalina de Bedout Gómez,  . - 1988. Obra : Annals of the New York Academy of Sciences Idioma : Inglés (eng) Resumen : The results of long-term itraconazole therapy in 10 patients with active chromoblastomycosis due to F. pedrosoi were reported. Therapy consisted of 100 or 200 mg/day of itraconazole, the length of therapy depending on the patient's response (12 to 24 months). This new triazole proved effective in reducing the number, size, and severity of the lesions in nine of the patients. Those patients with minor involvement profited more from therapy and were cured; patients with moderate involvement achieved either minor or major improvement. In most cases, signs and symptoms began to improve after 6 months of therapy. Mycological tests (in which tissue samples were treated with potassium hydroxide and cultured) became negative in six patients, but the fungus was eradicated in only three patients. Itraconazole produced no side effects. In spite of the need for long-term therapy, this new azole derivative effectively controls the disease. Mención de responsabilidad : Angela Restrepo, Aurelio Gonzalez, Ivan Gomez, Myrtha Arango, Catalina De Bedout Referencia : Ann N Y Acad Sci. 1988;544:504-16 DOI (Digital Object Identifier) : 10.1111/j.1749-6632.1988.tb40448.x PMID : 2850755 En línea : https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.1988.tb4044 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4348

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