| Título : |
Alpha subunit in clinically non-functioning pituitary adenomas: An immunohistochemical study |
| Tipo de documento : |
documento electrónico |
| Autores : |
Luis Vicente Syro Moreno, |
| Fecha de publicación : |
2017 |
| Títulos uniformes : |
Pathology, Research and Practice
|
| Idioma : |
Inglés (eng) |
| Palabras clave : |
α-Subunit Glycoprotein hormones Pituitary Pituitary hormones Pituitary tumors |
| Resumen : |
Pituitary adenomas may be classified as either functioning or non-functioning, depending on whether excess hormone secretion can be clinically identified. Of the six hormones produced in the anterior pituitary, TSH, FSH and LH are known as glycoproteins and contain two subunits (α and β). While α-subunit is identical within all of them, each β-subunit is unique and biologically specific. Independently, the α- and β-subunits are inactive and only induce a hormonal response when they are non-covalently associated. Studies have shown that in certain cases, pituitary adenomas may abnormally secrete only α-subunit, detectable in the serum or through immunohistochemical analysis. In the present study, we examined α-subunit immunoexpression in surgically removed non-functioning pituitary adenomas and analyzed its prognostic value. Results showed that expression of α-subunit in clinically non-functioning pituitary adenomas is not a rare occurrence. While there were no age/gender differences between tumors that expressed α-subunit and those that did not, α-subunit immunonegative adenomas presented with suprasellar extension more frequently and had an Ki67 proliferation greater than 3%. The use of immunohistochemical techniques to determine the presence of α-subunit may provide information on tumor cell proliferation and biologic behavior. To fully understand the role of α-subunit in pituitary adenomas more work is needed. |
| Mención de responsabilidad : |
Michael Solarski, Fabio Rotondo, Luis V Syro, Michael D Cusimano, Kalman Kovacs |
| Referencia : |
Pathol Res Pract. 2017 Sep;213(9):1130-1133. |
| DOI (Digital Object Identifier) : |
10.1016/j.prp.2017.07.010 |
| PMID : |
28780083 |
| En línea : |
https://linkinghub.elsevier.com/retrieve/pii/S034403381730626X |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4032 |
Alpha subunit in clinically non-functioning pituitary adenomas: An immunohistochemical study [documento electrónico] / Luis Vicente Syro Moreno, . - 2017. Obra : Pathology, Research and PracticeIdioma : Inglés ( eng) | Palabras clave : |
α-Subunit Glycoprotein hormones Pituitary Pituitary hormones Pituitary tumors |
| Resumen : |
Pituitary adenomas may be classified as either functioning or non-functioning, depending on whether excess hormone secretion can be clinically identified. Of the six hormones produced in the anterior pituitary, TSH, FSH and LH are known as glycoproteins and contain two subunits (α and β). While α-subunit is identical within all of them, each β-subunit is unique and biologically specific. Independently, the α- and β-subunits are inactive and only induce a hormonal response when they are non-covalently associated. Studies have shown that in certain cases, pituitary adenomas may abnormally secrete only α-subunit, detectable in the serum or through immunohistochemical analysis. In the present study, we examined α-subunit immunoexpression in surgically removed non-functioning pituitary adenomas and analyzed its prognostic value. Results showed that expression of α-subunit in clinically non-functioning pituitary adenomas is not a rare occurrence. While there were no age/gender differences between tumors that expressed α-subunit and those that did not, α-subunit immunonegative adenomas presented with suprasellar extension more frequently and had an Ki67 proliferation greater than 3%. The use of immunohistochemical techniques to determine the presence of α-subunit may provide information on tumor cell proliferation and biologic behavior. To fully understand the role of α-subunit in pituitary adenomas more work is needed. |
| Mención de responsabilidad : |
Michael Solarski, Fabio Rotondo, Luis V Syro, Michael D Cusimano, Kalman Kovacs |
| Referencia : |
Pathol Res Pract. 2017 Sep;213(9):1130-1133. |
| DOI (Digital Object Identifier) : |
10.1016/j.prp.2017.07.010 |
| PMID : |
28780083 |
| En línea : |
https://linkinghub.elsevier.com/retrieve/pii/S034403381730626X |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4032 |
|  |
Inicio
Clasificado(s) por (Año de edición descendente) Refinar búsquedaAlpha subunit in clinically non-functioning pituitary adenomas: An immunohistochemical study / Luis Vicente Syro Moreno
