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Pediatric Infectious Disease Journal
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Etiology and risk factors for admission to the pediatric intensive care unit in children with encephalitis in a developing country / Mónica Rosa Trujillo Honeysberg
Título : Etiology and risk factors for admission to the pediatric intensive care unit in children with encephalitis in a developing country Tipo de documento : documento electrónico Autores : Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2022 Títulos uniformes : Pediatric Infectious Disease Journal Idioma : Inglés (eng) Palabras clave : Encephalitis risk factors PICU etiology children Resumen : Objective: To describe a cohort of pediatric patients with encephalitis and their risk factors for admission to the pediatric intensive care unit (PICU). Study Design: Children ( Mención de responsabilidad : Guerrero, María P. MD; Romero, Andrés F. MD; Luengas, Miguel MD; Dávalos, Diana M. MD, MPH, DrPH; Mesa-Monsalve, Juan Gonzalo MD; Vivas-Trochez, Rosalba MD; Camacho-Moreno, German MD; Trujillo-Valencia, Mónica MD; Giraldo, Juan P. Calle MD; Mejía, Luis F. MD; Rojas-Hernández, Juan P. MD, MSc; Vinasco, Nathaly MD; Racines, Andrea Ruiz MD; Meléndez, Alejandro MD; Beltrán, Claudia P. MD; López, Pio MD; Chaucanez, Yamile MD; Patiño, Jaime MD; Rodríguez, Wilfrido Coronell MD, PhD; Salgado, Doris MD; Martínez, Marly MD; Restrepo, Andrea MD; Márquez, Kelly MD; Galvis, Diego MD; Benavidez, Iván MD; Rojas, Christian A. MD; Cantor, Erika MSC; López Medina, Eduardo MD, MSc Referencia : Pediatr Infect Dis J. 2022 Oct 1;41(10):806-812. DOI (Digital Object Identifier) : 10.1097/INF.0000000000003637 PMID : 35830514 En línea : https://journals.lww.com/pidj/Abstract/2022/10000/Etiology_and_Risk_Factors_for_ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6086 Etiology and risk factors for admission to the pediatric intensive care unit in children with encephalitis in a developing country [documento electrónico] / Mónica Rosa Trujillo Honeysberg, . - 2022.
Obra : Pediatric Infectious Disease Journal
Idioma : Inglés (eng)
Palabras clave : Encephalitis risk factors PICU etiology children Resumen : Objective: To describe a cohort of pediatric patients with encephalitis and their risk factors for admission to the pediatric intensive care unit (PICU). Study Design: Children ( Mención de responsabilidad : Guerrero, María P. MD; Romero, Andrés F. MD; Luengas, Miguel MD; Dávalos, Diana M. MD, MPH, DrPH; Mesa-Monsalve, Juan Gonzalo MD; Vivas-Trochez, Rosalba MD; Camacho-Moreno, German MD; Trujillo-Valencia, Mónica MD; Giraldo, Juan P. Calle MD; Mejía, Luis F. MD; Rojas-Hernández, Juan P. MD, MSc; Vinasco, Nathaly MD; Racines, Andrea Ruiz MD; Meléndez, Alejandro MD; Beltrán, Claudia P. MD; López, Pio MD; Chaucanez, Yamile MD; Patiño, Jaime MD; Rodríguez, Wilfrido Coronell MD, PhD; Salgado, Doris MD; Martínez, Marly MD; Restrepo, Andrea MD; Márquez, Kelly MD; Galvis, Diego MD; Benavidez, Iván MD; Rojas, Christian A. MD; Cantor, Erika MSC; López Medina, Eduardo MD, MSc Referencia : Pediatr Infect Dis J. 2022 Oct 1;41(10):806-812. DOI (Digital Object Identifier) : 10.1097/INF.0000000000003637 PMID : 35830514 En línea : https://journals.lww.com/pidj/Abstract/2022/10000/Etiology_and_Risk_Factors_for_ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6086 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001933 AC-2022-094 Archivo digital Producción Científica Artículos científicos Disponible Acute abdomen and appendicitis in 1010 pediatric patients with COVID-19 or MIS-C: a multinational experience from Latin America / Andrea Parra Buitrago ; Lina María Betancur Londoño
Título : Acute abdomen and appendicitis in 1010 pediatric patients with COVID-19 or MIS-C: a multinational experience from Latin America Tipo de documento : documento electrónico Autores : Andrea Parra Buitrago, ; Lina María Betancur Londoño, Fecha de publicación : 2021 Títulos uniformes : Pediatric Infectious Disease Journal Idioma : Inglés (eng) Palabras clave : COVID-19 SARS-CoV-2 appendicitis children Resumen : Background: To date, there are only sporadic reports of acute abdomen and appendicitis in children with coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C). Methods: Children 17 years of age or younger assessed in 5 Latin American countries with a diagnosis of microbiologically confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and children fulfilling MIS-C definition were included. For children with acute abdomen, we investigate main radiologic patterns, surgical treatment and intraoperative findings, outcomes. Findings: One-thousand ten children were enrolled. Forty-two children (4.2%) had a clinical diagnosis of acute abdomen. Four (9.5%) were diagnosed with MIS-C and did not undergo surgery. The remaining 38 children (3.8%) underwent abdominal surgery due to suspected appendicitis, 34 of them (89.7%) had an intraoperative diagnosis of acute appendicitis (AA), while 4 of them had nonsurgical findings. Eight children died (0.8%), none of them being diagnosed with appendicitis. Children with AA were significantly older than those without (P Mención de responsabilidad : Yock-Corrales, Adriana MD; Lenzi, Jacopo PhD; Ulloa-Gutiérrez, Rolando MD; Gómez-Vargas, Jessica MD; Antúnez-Montes, Omar Yassef MD; Rios Aida, Jorge Alberto MD; del Aguila, Olguita MD; Arteaga-Menchaca, Erick MD; Campos, Francisco MD; Uribe, Fadia MD; Hernández Díaz, Roger; Buitrago, Andrea Parra MD; Londoño, Lina Maria Betancur MD; Kozicki, Verónica MD; Brizuela, Martin MD; Buonsenso, Danilo MD Referencia : Pediatr Infect Dis J. 2021 Oct 1;40(10):e364-e369. DOI (Digital Object Identifier) : 10.1097/INF.0000000000003240 PMID : 34260501 En línea : https://journals.lww.com/pidj/Fulltext/2021/10000/Acute_Abdomen_and_Appendicitis [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5867 Acute abdomen and appendicitis in 1010 pediatric patients with COVID-19 or MIS-C: a multinational experience from Latin America [documento electrónico] / Andrea Parra Buitrago, ; Lina María Betancur Londoño, . - 2021.
Obra : Pediatric Infectious Disease Journal
Idioma : Inglés (eng)
Palabras clave : COVID-19 SARS-CoV-2 appendicitis children Resumen : Background: To date, there are only sporadic reports of acute abdomen and appendicitis in children with coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C). Methods: Children 17 years of age or younger assessed in 5 Latin American countries with a diagnosis of microbiologically confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and children fulfilling MIS-C definition were included. For children with acute abdomen, we investigate main radiologic patterns, surgical treatment and intraoperative findings, outcomes. Findings: One-thousand ten children were enrolled. Forty-two children (4.2%) had a clinical diagnosis of acute abdomen. Four (9.5%) were diagnosed with MIS-C and did not undergo surgery. The remaining 38 children (3.8%) underwent abdominal surgery due to suspected appendicitis, 34 of them (89.7%) had an intraoperative diagnosis of acute appendicitis (AA), while 4 of them had nonsurgical findings. Eight children died (0.8%), none of them being diagnosed with appendicitis. Children with AA were significantly older than those without (P Mención de responsabilidad : Yock-Corrales, Adriana MD; Lenzi, Jacopo PhD; Ulloa-Gutiérrez, Rolando MD; Gómez-Vargas, Jessica MD; Antúnez-Montes, Omar Yassef MD; Rios Aida, Jorge Alberto MD; del Aguila, Olguita MD; Arteaga-Menchaca, Erick MD; Campos, Francisco MD; Uribe, Fadia MD; Hernández Díaz, Roger; Buitrago, Andrea Parra MD; Londoño, Lina Maria Betancur MD; Kozicki, Verónica MD; Brizuela, Martin MD; Buonsenso, Danilo MD Referencia : Pediatr Infect Dis J. 2021 Oct 1;40(10):e364-e369. DOI (Digital Object Identifier) : 10.1097/INF.0000000000003240 PMID : 34260501 En línea : https://journals.lww.com/pidj/Fulltext/2021/10000/Acute_Abdomen_and_Appendicitis [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5867 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001805 AC-2021-117 Archivo digital Producción Científica Artículos científicos Disponible COVID-19 and Multisystem Inflammatory Syndrome in Latin American Children: A Multinational Study / Andrea Parra Buitrago ; Lina María Betancur Londoño
Título : COVID-19 and Multisystem Inflammatory Syndrome in Latin American Children: A Multinational Study Tipo de documento : documento electrónico Autores : Andrea Parra Buitrago, ; Lina María Betancur Londoño, Fecha de publicación : 2021 Títulos uniformes : Pediatric Infectious Disease Journal Idioma : Inglés (eng) Resumen : Background: To date, there are no comprehensive data on pediatric COVID-19 from Latin America. This study aims to assess COVID-19 and Multisystem Inflammatory Syndrome (MIS-C) in Latin American children, to appropriately plan and allocate resources to face the pandemic on a local and international level. Methods: Ambispective multicenter cohort study from 5 Latin American countries. Children 18 years of age or younger with microbiologically confirmed SARS-CoV-2 infection or fulfilling MIS-C definition were included. Findings: Four hundred nine children were included, with a median age of 3.0 years (interquartile range 0.6-9.0). Of these, 95 (23.2%) were diagnosed with MIS-C. One hundred ninety-one (46.7%) children were admitted to hospital and 52 (12.7%) required admission to a pediatric intensive care unit. Ninety-two (22.5%) patients required oxygen support: 8 (2%) were started on continuous positive airway pressure and 29 (7%) on mechanical ventilation. Thirty-five (8.5%) patients required inotropic support. The following factors were associated with pediatric intensive care unit admission: preexisting medical condition (P Mención de responsabilidad : Antúnez-Montes, Omar Yassef MD; Escamilla, Maria Isabel MD; Figueroa-Uribe, Augusto Flavio MD; Arteaga-Menchaca, Erick MD; Lavariega-Saráchaga, Manuel MD; Salcedo-Lozada, Perla MD; Melchior, Priscilla MD; de Oliveira, Rodrigo Beréa MD; Tirado Caballero, Juan Carlos MD; Redondo, Hernando Pinzon MD; Montes Fontalvo, Laura Vanessa MD; Hernandez, Roger MD; Chavez, Carolina MD; Campos, Francisco MD; Uribe, Fadia MD; del Aguila, Olguita MD; Rios Aida, Jorge Alberto MD; Buitrago, Andrea Parra MD; Betancur Londoño, Lina Maria MD; Mendoza Vega, León Felipe MD; Hernández, Carolina Almeida MD; Sali, Michela PhD; Higuita Palacio, Julian Esteban MD; Gomez-Vargas, Jessica MD; Yock-Corrales, Adriana MD; Buonsenso, Danilo MD Referencia : Pediatr Infect Dis J. 2021 Jan;40(1):e1-e6. DOI (Digital Object Identifier) : 10.1097/INF.0000000000002949 PMID : 33055501 En línea : https://journals.lww.com/pidj/Fulltext/2021/01000/COVID_19_and_Multisystem_Infla [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5752 COVID-19 and Multisystem Inflammatory Syndrome in Latin American Children: A Multinational Study [documento electrónico] / Andrea Parra Buitrago, ; Lina María Betancur Londoño, . - 2021.
Obra : Pediatric Infectious Disease Journal
Idioma : Inglés (eng)
Resumen : Background: To date, there are no comprehensive data on pediatric COVID-19 from Latin America. This study aims to assess COVID-19 and Multisystem Inflammatory Syndrome (MIS-C) in Latin American children, to appropriately plan and allocate resources to face the pandemic on a local and international level. Methods: Ambispective multicenter cohort study from 5 Latin American countries. Children 18 years of age or younger with microbiologically confirmed SARS-CoV-2 infection or fulfilling MIS-C definition were included. Findings: Four hundred nine children were included, with a median age of 3.0 years (interquartile range 0.6-9.0). Of these, 95 (23.2%) were diagnosed with MIS-C. One hundred ninety-one (46.7%) children were admitted to hospital and 52 (12.7%) required admission to a pediatric intensive care unit. Ninety-two (22.5%) patients required oxygen support: 8 (2%) were started on continuous positive airway pressure and 29 (7%) on mechanical ventilation. Thirty-five (8.5%) patients required inotropic support. The following factors were associated with pediatric intensive care unit admission: preexisting medical condition (P Mención de responsabilidad : Antúnez-Montes, Omar Yassef MD; Escamilla, Maria Isabel MD; Figueroa-Uribe, Augusto Flavio MD; Arteaga-Menchaca, Erick MD; Lavariega-Saráchaga, Manuel MD; Salcedo-Lozada, Perla MD; Melchior, Priscilla MD; de Oliveira, Rodrigo Beréa MD; Tirado Caballero, Juan Carlos MD; Redondo, Hernando Pinzon MD; Montes Fontalvo, Laura Vanessa MD; Hernandez, Roger MD; Chavez, Carolina MD; Campos, Francisco MD; Uribe, Fadia MD; del Aguila, Olguita MD; Rios Aida, Jorge Alberto MD; Buitrago, Andrea Parra MD; Betancur Londoño, Lina Maria MD; Mendoza Vega, León Felipe MD; Hernández, Carolina Almeida MD; Sali, Michela PhD; Higuita Palacio, Julian Esteban MD; Gomez-Vargas, Jessica MD; Yock-Corrales, Adriana MD; Buonsenso, Danilo MD Referencia : Pediatr Infect Dis J. 2021 Jan;40(1):e1-e6. DOI (Digital Object Identifier) : 10.1097/INF.0000000000002949 PMID : 33055501 En línea : https://journals.lww.com/pidj/Fulltext/2021/01000/COVID_19_and_Multisystem_Infla [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5752 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001647 AC-2021-003 Archivo digital Producción Científica Artículos científicos Disponible Clinical Characteristics of Carbapenem-resistant Klebsiella pneumoniae Infections in Ill and Colonized Children in Colombia / Mónica Rosa Trujillo Honeysberg
Título : Clinical Characteristics of Carbapenem-resistant Klebsiella pneumoniae Infections in Ill and Colonized Children in Colombia Tipo de documento : documento electrónico Autores : Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2016 Títulos uniformes : Pediatric Infectious Disease Journal Idioma : Inglés (eng) Palabras clave : Klebsiella pneumoniae beta-lactamases children carbapenem resistance Medellin Colombia Resumen : Background: Multidrug-resistant Gram-negative infections represent a growing problem and a serious global threat. Data in children are scarce. Klebsiella pneumoniae carbapenemases (KPC) are the most common mechanism of resistance this organism has developed. We report the clinical characteristics and outcomes from a cohort of children infected or colonized with carbapenem-resistant K. pneumoniae (CRKp) at a tertiary care center in Medellín, Colombia. Methods: We performed a retrospective chart review of all pediatric cases from whom CRKp isolates were obtained from 2008 to 2013. Clinical characteristics and outcomes were recorded. Results: A total of 34 infected children (median age, 22.8 months) with 43 episodes and 55 colonized patients (median age, 33 months) were identified. All patients had at least 1 risk factor previously related with multidrug-resistant Gram-negative infections (premorbid conditions, previous exposure to antibiotics, prolonged length of stay and use of indwelling devices). Urinary tract infections, abdominal infections and bacteremia were the most common clinical presentations. Overall mortality was 38%, and it was lower when a meropenem-containing regimen was used. Colistin was the most used antibiotic either alone or in combination and was associated with 8.8% of nephrotoxicity. Conclusion: CRKp infections have high mortality in children and usually occur in children with comorbidities, prolonged hospital stay and prior antibiotic exposure. Combined therapy with meropenem-containing regimens seems to be the best option in severely ill children. Mención de responsabilidad : Alejandro Díaz, Diana Cristina Ortiz, Mónica Trujillo, Carlos Garcés, Fabian Jaimes, Andrea Victoria Restrepo Referencia : Pediatr Infect Dis J. 2016 Mar;35(3):237-41. DOI (Digital Object Identifier) : 10.1097/INF.0000000000000987 PMID : 26569194 En línea : https://journals.lww.com/pidj/Abstract/2016/03000/Clinical_Characteristics_of_Ca [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3994 Clinical Characteristics of Carbapenem-resistant Klebsiella pneumoniae Infections in Ill and Colonized Children in Colombia [documento electrónico] / Mónica Rosa Trujillo Honeysberg, . - 2016.
Obra : Pediatric Infectious Disease Journal
Idioma : Inglés (eng)
Palabras clave : Klebsiella pneumoniae beta-lactamases children carbapenem resistance Medellin Colombia Resumen : Background: Multidrug-resistant Gram-negative infections represent a growing problem and a serious global threat. Data in children are scarce. Klebsiella pneumoniae carbapenemases (KPC) are the most common mechanism of resistance this organism has developed. We report the clinical characteristics and outcomes from a cohort of children infected or colonized with carbapenem-resistant K. pneumoniae (CRKp) at a tertiary care center in Medellín, Colombia. Methods: We performed a retrospective chart review of all pediatric cases from whom CRKp isolates were obtained from 2008 to 2013. Clinical characteristics and outcomes were recorded. Results: A total of 34 infected children (median age, 22.8 months) with 43 episodes and 55 colonized patients (median age, 33 months) were identified. All patients had at least 1 risk factor previously related with multidrug-resistant Gram-negative infections (premorbid conditions, previous exposure to antibiotics, prolonged length of stay and use of indwelling devices). Urinary tract infections, abdominal infections and bacteremia were the most common clinical presentations. Overall mortality was 38%, and it was lower when a meropenem-containing regimen was used. Colistin was the most used antibiotic either alone or in combination and was associated with 8.8% of nephrotoxicity. Conclusion: CRKp infections have high mortality in children and usually occur in children with comorbidities, prolonged hospital stay and prior antibiotic exposure. Combined therapy with meropenem-containing regimens seems to be the best option in severely ill children. Mención de responsabilidad : Alejandro Díaz, Diana Cristina Ortiz, Mónica Trujillo, Carlos Garcés, Fabian Jaimes, Andrea Victoria Restrepo Referencia : Pediatr Infect Dis J. 2016 Mar;35(3):237-41. DOI (Digital Object Identifier) : 10.1097/INF.0000000000000987 PMID : 26569194 En línea : https://journals.lww.com/pidj/Abstract/2016/03000/Clinical_Characteristics_of_Ca [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3994 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000587 AC-2016-062 Archivo digital Producción Científica Artículos científicos Disponible Disseminated histoplasmosis in children: The role of itraconazole therapy / David Andrés Espinal Botero ; Hugo Trujillo Soto
Título : Disseminated histoplasmosis in children: The role of itraconazole therapy Tipo de documento : documento electrónico Autores : David Andrés Espinal Botero, ; Hugo Trujillo Soto, Fecha de publicación : 1996 Títulos uniformes : Pediatric Infectious Disease Journal Idioma : Inglés (eng) Resumen : Objectives: To describe the clinical characteristics and laboratory diagnosis of seven children with disseminated histoplasmosis and evaluate the effectiveness of itraconazole therapy in this severe form of the mycosis as well as to determine the long term results of such treatment. Methods: The diagnosis of histoplasmosis was based on the direct observation of Histoplasma capsulatum var. capsulatum and/or on the isolation of the fungus from pathologic materials; the results of the serologic tests were taken into consideration. Chest roentgenograms also contributed to the diagnosis. Patients: The patients were seven rural children, five girls and two boys, ages 1 to 14 years (mean, 4.6), with a confirmed diagnosis of disseminated histoplasmosis and who had no underlying disease other than malnourishment. Results: The seven children experienced a subacute febrile syndrome for 4 months accompanied by anorexia, weight loss and signs of reticuloendothelial involvement such as lymph node hypertrophy, hepatomegaly and/or splenomegaly. The lung revealed roentgenographic alterations consisting mainly of nodular infiltrates. All patients received itraconazole orally in a mean dosage of 7.2 mg/kg/day, for variable periods (3 to 12 months), depending on the individual response and the toxic effects of the medication. One of the patients who was improving after 1 month of treatment was taken from the hospital by his guardian against medical advice and died shortly afterward. The remaining six patients responded to the treatment with marked clinical improvement and showed negative cultures and decreases in anti-H. capsulatum antibody titers after 3 months of treatment. Only one patient, the youngest and most severely affected child, exhibited hepatotoxicity, which subsided when itraconazole was discontinued. Extended follow-up studies revealed no relapses. Conclusion: The results of this study indicate that itraconazole is effective for treatment of disseminated childhood histoplasmosis. More studies should be performed to determine the most appropriate dosage and the optimal duration of itraconazole treatment in children. Mención de responsabilidad : ANGELA TOBÓN;LILLIANA FRANCO;DAVID ESPINAL;IVAN GÓMEZ;MYRTHA ARANGO;HUGO TRUJILLO;ANGELA RESTREPO Referencia : Pediatr Infect Dis J. 1996 Nov;15(11):1002-8. DOI (Digital Object Identifier) : 10.1097/00006454-199611000-00014 PMID : 8933549 En línea : https://insights.ovid.com/crossref?an=00006454-199611000-00014 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4378 Disseminated histoplasmosis in children: The role of itraconazole therapy [documento electrónico] / David Andrés Espinal Botero, ; Hugo Trujillo Soto, . - 1996.
Obra : Pediatric Infectious Disease Journal
Idioma : Inglés (eng)
Resumen : Objectives: To describe the clinical characteristics and laboratory diagnosis of seven children with disseminated histoplasmosis and evaluate the effectiveness of itraconazole therapy in this severe form of the mycosis as well as to determine the long term results of such treatment. Methods: The diagnosis of histoplasmosis was based on the direct observation of Histoplasma capsulatum var. capsulatum and/or on the isolation of the fungus from pathologic materials; the results of the serologic tests were taken into consideration. Chest roentgenograms also contributed to the diagnosis. Patients: The patients were seven rural children, five girls and two boys, ages 1 to 14 years (mean, 4.6), with a confirmed diagnosis of disseminated histoplasmosis and who had no underlying disease other than malnourishment. Results: The seven children experienced a subacute febrile syndrome for 4 months accompanied by anorexia, weight loss and signs of reticuloendothelial involvement such as lymph node hypertrophy, hepatomegaly and/or splenomegaly. The lung revealed roentgenographic alterations consisting mainly of nodular infiltrates. All patients received itraconazole orally in a mean dosage of 7.2 mg/kg/day, for variable periods (3 to 12 months), depending on the individual response and the toxic effects of the medication. One of the patients who was improving after 1 month of treatment was taken from the hospital by his guardian against medical advice and died shortly afterward. The remaining six patients responded to the treatment with marked clinical improvement and showed negative cultures and decreases in anti-H. capsulatum antibody titers after 3 months of treatment. Only one patient, the youngest and most severely affected child, exhibited hepatotoxicity, which subsided when itraconazole was discontinued. Extended follow-up studies revealed no relapses. Conclusion: The results of this study indicate that itraconazole is effective for treatment of disseminated childhood histoplasmosis. More studies should be performed to determine the most appropriate dosage and the optimal duration of itraconazole treatment in children. Mención de responsabilidad : ANGELA TOBÓN;LILLIANA FRANCO;DAVID ESPINAL;IVAN GÓMEZ;MYRTHA ARANGO;HUGO TRUJILLO;ANGELA RESTREPO Referencia : Pediatr Infect Dis J. 1996 Nov;15(11):1002-8. DOI (Digital Object Identifier) : 10.1097/00006454-199611000-00014 PMID : 8933549 En línea : https://insights.ovid.com/crossref?an=00006454-199611000-00014 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4378 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000878 AC-1996-001 Archivo digital Producción Científica Artículos científicos Disponible Gastrospirillum hominis in a child with chronic gastritis / Hugo Trujillo Soto ; David Andrés Espinal BoteroPermalinkBacteriology of middle ear fluid specimens obtained by tympanocentesis from 111 Colombian children with acute otitis media / Hugo Trujillo Soto ; Ricardo Callejas ; Gloria Isabel Mejía de Rodríguez ; Lucero Castrillón de P.Permalink