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Revista do Instituto de Medicina Tropical de São Paulo
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Clasificado(s) por (Año de edición descendente) Refinar búsquedaIdentification of Paracoccidioides brasiliensis in adrenal glands biopsies of two patients with paracoccidioidomycosis and adrenal insufficiency / Carlos Andrés Agudelo ; Johnayro Gutiérrez Restrepo ; Alejandro Vélez Hoyos
Título : Identification of Paracoccidioides brasiliensis in adrenal glands biopsies of two patients with paracoccidioidomycosis and adrenal insufficiency Tipo de documento : documento electrónico Autores : Carlos Andrés Agudelo, ; Johnayro Gutiérrez Restrepo, ; Alejandro Vélez Hoyos, Fecha de publicación : 2009 Títulos uniformes : Revista do Instituto de Medicina Tropical de São Paulo Idioma : Inglés (eng) Palabras clave : Paracoccidioidomycosis adrenal insufficiency cortisol Resumen : The authors report two cases of adrenal insufficiency secondary to infiltration of the adrenal glands by Paracoccidioides brasiliensis. The first patient had been treated for a chronic multifocal form of paracoccidiodomycosis 11 years ago. The diagnosis of the mycosis was done simultaneous with that of the adrenal insufficiency in the second patient. In both patients the diagnosis was done by direct visualization of fungus in adrenal biopsies. They were treated with hormonal supplements and itraconazol by 12 and six months, without relapses during the follow-up perio Mención de responsabilidad : Carlos Andrés Agudelo, Carolina Muñoz, Alex Ramírez, Jonhairo Gutierrez, Santiago Velez, Juan Camilo Perez, Alejandro Velez, Angela María Tobon, Angela Restrepo Referencia : Rev Inst Med Trop Sao Paulo. 2009 Jan-Feb;51(1):45-8. DOI (Digital Object Identifier) : 10.1590/s0036-46652009000100008 PMID : 19229390 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652009000100008&l [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3490 Identification of Paracoccidioides brasiliensis in adrenal glands biopsies of two patients with paracoccidioidomycosis and adrenal insufficiency [documento electrónico] / Carlos Andrés Agudelo, ; Johnayro Gutiérrez Restrepo, ; Alejandro Vélez Hoyos, . - 2009.
Obra : Revista do Instituto de Medicina Tropical de São Paulo
Idioma : Inglés (eng)
Palabras clave : Paracoccidioidomycosis adrenal insufficiency cortisol Resumen : The authors report two cases of adrenal insufficiency secondary to infiltration of the adrenal glands by Paracoccidioides brasiliensis. The first patient had been treated for a chronic multifocal form of paracoccidiodomycosis 11 years ago. The diagnosis of the mycosis was done simultaneous with that of the adrenal insufficiency in the second patient. In both patients the diagnosis was done by direct visualization of fungus in adrenal biopsies. They were treated with hormonal supplements and itraconazol by 12 and six months, without relapses during the follow-up perio Mención de responsabilidad : Carlos Andrés Agudelo, Carolina Muñoz, Alex Ramírez, Jonhairo Gutierrez, Santiago Velez, Juan Camilo Perez, Alejandro Velez, Angela María Tobon, Angela Restrepo Referencia : Rev Inst Med Trop Sao Paulo. 2009 Jan-Feb;51(1):45-8. DOI (Digital Object Identifier) : 10.1590/s0036-46652009000100008 PMID : 19229390 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652009000100008&l [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3490 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000058 AC-2009-020 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2009-020.pdfAdobe Acrobat PDF
Título : Lysozyme plays a dual role against the dimorphic fungus Paracoccidioides brasiliensis Tipo de documento : documento electrónico Autores : Beatriz Helena Aristizábal Bernal, Fecha de publicación : 2008 Títulos uniformes : Revista do Instituto de Medicina Tropical de São Paulo Idioma : Inglés (eng) Palabras clave : Lysozyme TNF- Alveolar macrophages Paracoccidioides brasiliensis Resumen : In order to determine the role of lysozyme, an antimicrobial peptide belonging to the innate immune system, against the dimorphic fungus Paracoccidioides brasiliensis, co-cultures of the MH-S murine alveolar macrophages cell line with P. brasiliensis conidia were done; assays to evaluate the effect of physiological and inflammatory concentrations of lysozyme directly on the fungus life cycle were also undertaken. We observed that TNF-α-activated macrophages significantly inhibited the conidia to yeast transition (p = 0.0043) and exerted an important fungicidal effect (p = 0.0044), killing 27% more fungal propagules in comparison with controls. Nonetheless, after adding a selective inhibitor of lysozyme, the fungicidal effect was reverted. When P. brasiliensis propagules were exposed directly to different concentrations of lysozyme, a dual effect was observed. Physiologic concentrations of the enzyme facilitated the conidia-to-yeast transition process (p Mención de responsabilidad : Damaris Lopera; Beatriz H. Aristizabal; Angela Restrepo; Luz Elena Cano; Ángel González Referencia : Rev Inst Med Trop Sao Paulo. May-Jun 2008;50(3):169-75. DOI (Digital Object Identifier) : 10.1590/S0036-46652008000300008 PMID : 18604417 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0036-46652008000300008 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4438 Lysozyme plays a dual role against the dimorphic fungus Paracoccidioides brasiliensis [documento electrónico] / Beatriz Helena Aristizábal Bernal, . - 2008.
Obra : Revista do Instituto de Medicina Tropical de São Paulo
Idioma : Inglés (eng)
Palabras clave : Lysozyme TNF- Alveolar macrophages Paracoccidioides brasiliensis Resumen : In order to determine the role of lysozyme, an antimicrobial peptide belonging to the innate immune system, against the dimorphic fungus Paracoccidioides brasiliensis, co-cultures of the MH-S murine alveolar macrophages cell line with P. brasiliensis conidia were done; assays to evaluate the effect of physiological and inflammatory concentrations of lysozyme directly on the fungus life cycle were also undertaken. We observed that TNF-α-activated macrophages significantly inhibited the conidia to yeast transition (p = 0.0043) and exerted an important fungicidal effect (p = 0.0044), killing 27% more fungal propagules in comparison with controls. Nonetheless, after adding a selective inhibitor of lysozyme, the fungicidal effect was reverted. When P. brasiliensis propagules were exposed directly to different concentrations of lysozyme, a dual effect was observed. Physiologic concentrations of the enzyme facilitated the conidia-to-yeast transition process (p Mención de responsabilidad : Damaris Lopera; Beatriz H. Aristizabal; Angela Restrepo; Luz Elena Cano; Ángel González Referencia : Rev Inst Med Trop Sao Paulo. May-Jun 2008;50(3):169-75. DOI (Digital Object Identifier) : 10.1590/S0036-46652008000300008 PMID : 18604417 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0036-46652008000300008 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4438 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000938 AC-2008-025 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
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Título : Activity of two different triazoles in a murine model of paracoccidioidomycosis Tipo de documento : documento electrónico Autores : Susana Restrepo, ; Ángela María Tabares Velásquez, ; Ángela Restrepo Moreno, Fecha de publicación : 1992 Títulos uniformes : Revista do Instituto de Medicina Tropical de São Paulo Idioma : Inglés (eng) Palabras clave : Paracoccidioidomycosis Experimental Treatment Triazole Itraconazol Schering 39304 Resumen : A new orally absorbable triazole (Schering 39304) with a long serum half-life in man (60 hours), was tried in a murine model of progressive paracoccidioidomycosis and compared with itraconazole, another triazole which has proven effective in this mycosis. Only 15% of the infected, untreated mice survived while 53 to 75% of the animals receiving itraconazole survived. Mice treated with Schering 39304 exhibited higher (86 - 100%) survival rates. Statistically, the 5 mg/kg Sch 39304 was superior to the 50 mg/kg itraconazole dose. Lung cultures showed that 20 mg/kg/day of Sch achieved sterilization of the infectious foci. These results indicate that the new triazole will have a place in the treatment of paracoccidioidomycosis. Mención de responsabilidad : Susana Restrepo; Angela M. Tabares; Angela Restrepo Referencia : Rev Inst Med Trop Sao Paulo. 1992 Mar-Apr;34(2):171-6. DOI (Digital Object Identifier) : 10.1590/s0036-46651992000200014 PMID : 1340032 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651992000200014 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4364 Activity of two different triazoles in a murine model of paracoccidioidomycosis [documento electrónico] / Susana Restrepo, ; Ángela María Tabares Velásquez, ; Ángela Restrepo Moreno, . - 1992.
Obra : Revista do Instituto de Medicina Tropical de São Paulo
Idioma : Inglés (eng)
Palabras clave : Paracoccidioidomycosis Experimental Treatment Triazole Itraconazol Schering 39304 Resumen : A new orally absorbable triazole (Schering 39304) with a long serum half-life in man (60 hours), was tried in a murine model of progressive paracoccidioidomycosis and compared with itraconazole, another triazole which has proven effective in this mycosis. Only 15% of the infected, untreated mice survived while 53 to 75% of the animals receiving itraconazole survived. Mice treated with Schering 39304 exhibited higher (86 - 100%) survival rates. Statistically, the 5 mg/kg Sch 39304 was superior to the 50 mg/kg itraconazole dose. Lung cultures showed that 20 mg/kg/day of Sch achieved sterilization of the infectious foci. These results indicate that the new triazole will have a place in the treatment of paracoccidioidomycosis. Mención de responsabilidad : Susana Restrepo; Angela M. Tabares; Angela Restrepo Referencia : Rev Inst Med Trop Sao Paulo. 1992 Mar-Apr;34(2):171-6. DOI (Digital Object Identifier) : 10.1590/s0036-46651992000200014 PMID : 1340032 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651992000200014 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4364 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000864 AC-1992-003 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
1992-003.pdfAdobe Acrobat PDF
Título : Predictive value of serologic tests in the diagnosis and follow-up of patients with paracoccidioidomycosis Tipo de documento : documento electrónico Autores : Luz Elena Cano Restrepo, Autor ; Ángela Restrepo Moreno, Autor Fecha de publicación : 1987 Títulos uniformes : Revista do Instituto de Medicina Tropical de São Paulo Idioma : Inglés (eng) Palabras clave : Predictive values Serologic tests Paracoccidoidomycosis Cross-reactions Systemic mycoses Resumen : A serologic study was undertaken in a group of 43 patients with active paracoccidioidomycosis who were treated in the same form (ketoconazole), for identical periods of time (6 months), and folio wed-up for various periods posttherapy. The tests employed were agar gel immunodiffusion (AGID) and complement fixation (FC). Also studied were 50 sera from patients with proven histoplasmosis and pulmonary aspergilloma, 30 patients with culturaly proven tuberculosis as well as 92 specimens from healthy individuals, residents in the endemic area for paracoccidioidomycosis. A single lot of yeast filtrate antigen was used throughout the study. The value of each test was measured according to GALEN and GAMBINO6. Both tests were highly sensitive, 89 and 93% respectively. Regarding their specificity, the AGID was totally specific while the CF exhibited 96.6% and 97% specificity in front of tuberculosis patients and healthy individuals respectively and 82% in comparison with patients with other mycoses. The concept of predictive value, that is, the certainty one has in accepting a positive test as diagnostic of paracoccidioidomycosis, favored the AGID procedure (100%) over the CF test. The latter could sort out with 93% certainty a patient with paracoccidioidomycosis among a group of healthy individuals and with 97.5% in the case of TB patients; when the group in question was composed by individuals with other deep mycoses, such certainty was lower (81%). The above results indicate that both the AGID and the CF tests furnish results of high confidence; one should not relay, however, in the CF alone as a means to establish the specific diagnosis of paracoccidioidomycosis. Mención de responsabilidad : CANO, Luz Elena and RESTREPO, Angela Referencia : Rev Inst Med Trop Sao Paulo. Sep-Oct 1987;29(5):276-83. DOI (Digital Object Identifier) : 10.1590/S0036-46651987000500003 PMID : 3136529 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0036-46651987000500003 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4344 Predictive value of serologic tests in the diagnosis and follow-up of patients with paracoccidioidomycosis [documento electrónico] / Luz Elena Cano Restrepo, Autor ; Ángela Restrepo Moreno, Autor . - 1987.
Obra : Revista do Instituto de Medicina Tropical de São Paulo
Idioma : Inglés (eng)
Palabras clave : Predictive values Serologic tests Paracoccidoidomycosis Cross-reactions Systemic mycoses Resumen : A serologic study was undertaken in a group of 43 patients with active paracoccidioidomycosis who were treated in the same form (ketoconazole), for identical periods of time (6 months), and folio wed-up for various periods posttherapy. The tests employed were agar gel immunodiffusion (AGID) and complement fixation (FC). Also studied were 50 sera from patients with proven histoplasmosis and pulmonary aspergilloma, 30 patients with culturaly proven tuberculosis as well as 92 specimens from healthy individuals, residents in the endemic area for paracoccidioidomycosis. A single lot of yeast filtrate antigen was used throughout the study. The value of each test was measured according to GALEN and GAMBINO6. Both tests were highly sensitive, 89 and 93% respectively. Regarding their specificity, the AGID was totally specific while the CF exhibited 96.6% and 97% specificity in front of tuberculosis patients and healthy individuals respectively and 82% in comparison with patients with other mycoses. The concept of predictive value, that is, the certainty one has in accepting a positive test as diagnostic of paracoccidioidomycosis, favored the AGID procedure (100%) over the CF test. The latter could sort out with 93% certainty a patient with paracoccidioidomycosis among a group of healthy individuals and with 97.5% in the case of TB patients; when the group in question was composed by individuals with other deep mycoses, such certainty was lower (81%). The above results indicate that both the AGID and the CF tests furnish results of high confidence; one should not relay, however, in the CF alone as a means to establish the specific diagnosis of paracoccidioidomycosis. Mención de responsabilidad : CANO, Luz Elena and RESTREPO, Angela Referencia : Rev Inst Med Trop Sao Paulo. Sep-Oct 1987;29(5):276-83. DOI (Digital Object Identifier) : 10.1590/S0036-46651987000500003 PMID : 3136529 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0036-46651987000500003 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4344 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000845 AC-1987-002 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
1987-002.pdfAdobe Acrobat PDF
Título : In vitro susceptibility of Paracoccidioides brasiliensis yeast form to antifungal agents Tipo de documento : documento electrónico Autores : Ángela Restrepo Moreno, ; Catalina de Bedout Gómez, ; Ángela María Tabares Velásquez, Fecha de publicación : 1984 Títulos uniformes : Revista do Instituto de Medicina Tropical de São Paulo Idioma : Inglés (eng) Resumen : A study was conducted to determine the susceptibility of P. brasiliensis yeast form to amphotericin B (A), ketoconazole (K), 5-fluorocytosine (5-FC) and rifampin (R). The three isolates tested produced minimal inhibitory concentrations (MICs) (mcg/ml) in the following range: A: 0.09-0.18; K: 0.001-0.007; 5-FC: 62.5-250 and R: 40-80. The minimal fungicidal concentrations (MFC) were several times higher than the corresponding MICs. Precise MFC for 5-FC were not obtained (> 500 mcg/ml). Combination of K plus A proved synergic, with the fractional inhibitory concentration (FIC) indices revealing synergy when the drugs were combined at the 1 to 1 and 1 to 5 MIC ratios. R (40 mcg/ml) appeared to antagonize K. These results indicate promise for the combined use of K plus A as a therapeutical regimen. Mención de responsabilidad : RESTREPO, Angela and TABARES, Catalina de Bedout and Angela M. Referencia : Rev Inst Med Trop Sao Paulo. Nov-Dec 1984;26(6):322-8. DOI (Digital Object Identifier) : 10.1590/S0036-46651984000600006 PMID : 6100138 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0036-46651984000600006 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4329 In vitro susceptibility of Paracoccidioides brasiliensis yeast form to antifungal agents [documento electrónico] / Ángela Restrepo Moreno, ; Catalina de Bedout Gómez, ; Ángela María Tabares Velásquez, . - 1984.
Obra : Revista do Instituto de Medicina Tropical de São Paulo
Idioma : Inglés (eng)
Resumen : A study was conducted to determine the susceptibility of P. brasiliensis yeast form to amphotericin B (A), ketoconazole (K), 5-fluorocytosine (5-FC) and rifampin (R). The three isolates tested produced minimal inhibitory concentrations (MICs) (mcg/ml) in the following range: A: 0.09-0.18; K: 0.001-0.007; 5-FC: 62.5-250 and R: 40-80. The minimal fungicidal concentrations (MFC) were several times higher than the corresponding MICs. Precise MFC for 5-FC were not obtained (> 500 mcg/ml). Combination of K plus A proved synergic, with the fractional inhibitory concentration (FIC) indices revealing synergy when the drugs were combined at the 1 to 1 and 1 to 5 MIC ratios. R (40 mcg/ml) appeared to antagonize K. These results indicate promise for the combined use of K plus A as a therapeutical regimen. Mención de responsabilidad : RESTREPO, Angela and TABARES, Catalina de Bedout and Angela M. Referencia : Rev Inst Med Trop Sao Paulo. Nov-Dec 1984;26(6):322-8. DOI (Digital Object Identifier) : 10.1590/S0036-46651984000600006 PMID : 6100138 Derechos de uso : CC BY-NC En línea : http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0036-46651984000600006 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4329 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000830 AC-1984-003 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
1984-003.pdfAdobe Acrobat PDF
