Association of Clinical Hypoperfusion Variables With Lactate Clearance and Hospital Mortality / Jessica María Londoño Agudelo ; Elisa Bernal Sierra ; Fabián Alberto Jaimes Barragán  

Público ISBD Título : Association of Clinical Hypoperfusion Variables With Lactate Clearance and Hospital Mortality Tipo de documento : documento electrónico Autores : Jessica María Londoño Agudelo, ; Elisa Bernal Sierra, ; Fabián Alberto Jaimes Barragán, Fecha de publicación : 2018 Títulos uniformes : Shock Idioma : Inglés (eng) Palabras clave : Hyperlactatemia  lactic acid  multiple trauma  oxygen consumption  patient outcome assessment  resuscitation  sepsis  shock  vasopressors Resumen : Background: Lactate has shown utility in assessing the prognosis of patients admitted to the hospital with confirmed or suspected shock. Some findings of the physical examination may replace it as screening tool. We have determined the correlation and association between clinical perfusion parameters and lactate at the time of admission; the correlation between the change in clinical parameters and lactate clearance after 6 and 24 h of resuscitation; and the association between clinical parameters, lactate, and mortality. Methods: Prospective cohort study of adult patients hospitalized in the emergency room with infection, polytrauma, or other causes of hypotension. We measured serum lactate, capillary refill time, shock index, and pulse pressure at 0, 6, and 24 h after admission. A Spearman's correlation was performed between clinical variables and lactate levels, as well as between changes in clinical parameters and lactate clearance. The operative characteristics of these variables were determined by area under the receiver operating characteristic curve analysis and the association between lactate, clinical variables, and mortality through logistic regression. Results: A total of 1,320 patients met the inclusion criteria, 66.7% (n = 880) confirmed infection, 19% (n = 251) polytrauma, and 14.3% (n = 189) another etiology. No significant correlation was found between any clinical variable and lactate values (r Mención de responsabilidad : Jessica Londoño, César Niño, James Díaz, Carlos Morales, Jimmy León, Elisa Bernal, Cesar Vargas, Leonardo Mejía, Carolina Hincapié, Johana Ascuntar, Alba León, Fabián Jaimes Referencia : Shock. 2018 Sep;50(3):286-292. DOI (Digital Object Identifier) : 10.1097/SHK.0000000000001066 PMID : 29206763 En línea : https://journals.lww.com/shockjournal/fulltext/2018/09000/Association_of_Clinica [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4199 Association of Clinical Hypoperfusion Variables With Lactate Clearance and Hospital Mortality [documento electrónico] / Jessica María Londoño Agudelo, ; Elisa Bernal Sierra, ; Fabián Alberto Jaimes Barragán,  . - 2018. Obra : Shock Idioma : Inglés (eng) Palabras clave : Hyperlactatemia  lactic acid  multiple trauma  oxygen consumption  patient outcome assessment  resuscitation  sepsis  shock  vasopressors Resumen : Background: Lactate has shown utility in assessing the prognosis of patients admitted to the hospital with confirmed or suspected shock. Some findings of the physical examination may replace it as screening tool. We have determined the correlation and association between clinical perfusion parameters and lactate at the time of admission; the correlation between the change in clinical parameters and lactate clearance after 6 and 24 h of resuscitation; and the association between clinical parameters, lactate, and mortality. Methods: Prospective cohort study of adult patients hospitalized in the emergency room with infection, polytrauma, or other causes of hypotension. We measured serum lactate, capillary refill time, shock index, and pulse pressure at 0, 6, and 24 h after admission. A Spearman's correlation was performed between clinical variables and lactate levels, as well as between changes in clinical parameters and lactate clearance. The operative characteristics of these variables were determined by area under the receiver operating characteristic curve analysis and the association between lactate, clinical variables, and mortality through logistic regression. Results: A total of 1,320 patients met the inclusion criteria, 66.7% (n = 880) confirmed infection, 19% (n = 251) polytrauma, and 14.3% (n = 189) another etiology. No significant correlation was found between any clinical variable and lactate values (r Mención de responsabilidad : Jessica Londoño, César Niño, James Díaz, Carlos Morales, Jimmy León, Elisa Bernal, Cesar Vargas, Leonardo Mejía, Carolina Hincapié, Johana Ascuntar, Alba León, Fabián Jaimes Referencia : Shock. 2018 Sep;50(3):286-292. DOI (Digital Object Identifier) : 10.1097/SHK.0000000000001066 PMID : 29206763 En línea : https://journals.lww.com/shockjournal/fulltext/2018/09000/Association_of_Clinica [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4199

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