| Título : |
Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study |
| Tipo de documento : |
documento electrónico |
| Autores : |
Sergio Álvarez Vallejo, ; Andrés Ignacio Arbeláez Medina, |
| Fecha de publicación : |
2012 |
| Títulos uniformes : |
The Lancet Neurology
|
| Idioma : |
Inglés (eng) |
| Resumen : |
Background: We have previously characterised functional brain abnormalities in young adults at genetic risk for lateonset Alzheimer’s disease. To gain further knowledge on the preclinical phase of Alzheimer’s disease, we sought to characterise structural and functional MRI, CSF, and plasma biomarkers in a cohort of young adults carrying a high-penetrance autosomal dominant mutation that causes early-onset Alzheimer’s disease. Methods: Between January and August, 2010, 18–26-year-old presenilin 1 (PSEN1) E280A mutation carriers and non- carriers from the Colombian Alzheimer’s Prevention Initiative Registry in Medellín Antioquia, Colombia, hadstructural MRI, functional MRI during associative memory encoding and novel viewing and control tasks, and cognitive assessments. Consenting participants also had lumbar punctures and venepunctures. Outcome measures were task-dependent hippocampal or parahippocampal activations and precuneus or posterior cingulate deactivations, regional grey matter reductions, CSF Aβ1–42, total tau and phospho-tau181 concentrations, and plasma Aβ1–42 concentrations and Aβ1–42:Aβ1–40 ratios. Structural and functional MRI data were compared using automated brain mapping algorithms and search regions related to Alzheimer’s disease. Cognitive and fl uid biomarkers werecompared using Mann-Whitney tests. Findings 44 participants were included: 20 PSEN1 E280A mutation carriers and 24 non-carriers. The carrier and non-carrier groups did not diff er signifi cantly in their dementia ratings, neuropsychological test scores, or proportion of apolipoprotein E (APOE) ε4 carriers. Compared with non-carriers, carriers had greater right hippocampal and parahippocampal activation (p=0·001 and p |
| Mención de responsabilidad : |
Eric M Reiman, Yakeel T Quiroz, Adam S Fleisher, Kewei Chen, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio, Anne M Fagan, Aarti R Shah, Sergio Alvarez, Andrés Arbelaez, Margarita Giraldo, Natalia Acosta-Baena, Reisa A Sperling, Brad Dickerson, Chantal E Stern, Victoria Tirado, Claudia Munoz, Rebecca A Reiman, Matthew J Huentelman, Gene E Alexander, Jessica B S Langbaum, Kenneth S Kosik, Pierre N Tariot, Francisco Lopera |
| Referencia : |
Lancet Neurol. 2012 Dec;11(12):1048-56. |
| DOI (Digital Object Identifier) : |
10.1016/S1474-4422(12)70228-4 |
| PMID : |
23137948 |
| En línea : |
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(12)70228-4/fullt [...] |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3641 |
Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study [documento electrónico] / Sergio Álvarez Vallejo, ; Andrés Ignacio Arbeláez Medina, . - 2012. Obra : The Lancet NeurologyIdioma : Inglés ( eng) | Resumen : |
Background: We have previously characterised functional brain abnormalities in young adults at genetic risk for lateonset Alzheimer’s disease. To gain further knowledge on the preclinical phase of Alzheimer’s disease, we sought to characterise structural and functional MRI, CSF, and plasma biomarkers in a cohort of young adults carrying a high-penetrance autosomal dominant mutation that causes early-onset Alzheimer’s disease. Methods: Between January and August, 2010, 18–26-year-old presenilin 1 (PSEN1) E280A mutation carriers and non- carriers from the Colombian Alzheimer’s Prevention Initiative Registry in Medellín Antioquia, Colombia, hadstructural MRI, functional MRI during associative memory encoding and novel viewing and control tasks, and cognitive assessments. Consenting participants also had lumbar punctures and venepunctures. Outcome measures were task-dependent hippocampal or parahippocampal activations and precuneus or posterior cingulate deactivations, regional grey matter reductions, CSF Aβ1–42, total tau and phospho-tau181 concentrations, and plasma Aβ1–42 concentrations and Aβ1–42:Aβ1–40 ratios. Structural and functional MRI data were compared using automated brain mapping algorithms and search regions related to Alzheimer’s disease. Cognitive and fl uid biomarkers werecompared using Mann-Whitney tests. Findings 44 participants were included: 20 PSEN1 E280A mutation carriers and 24 non-carriers. The carrier and non-carrier groups did not diff er signifi cantly in their dementia ratings, neuropsychological test scores, or proportion of apolipoprotein E (APOE) ε4 carriers. Compared with non-carriers, carriers had greater right hippocampal and parahippocampal activation (p=0·001 and p |
| Mención de responsabilidad : |
Eric M Reiman, Yakeel T Quiroz, Adam S Fleisher, Kewei Chen, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio, Anne M Fagan, Aarti R Shah, Sergio Alvarez, Andrés Arbelaez, Margarita Giraldo, Natalia Acosta-Baena, Reisa A Sperling, Brad Dickerson, Chantal E Stern, Victoria Tirado, Claudia Munoz, Rebecca A Reiman, Matthew J Huentelman, Gene E Alexander, Jessica B S Langbaum, Kenneth S Kosik, Pierre N Tariot, Francisco Lopera |
| Referencia : |
Lancet Neurol. 2012 Dec;11(12):1048-56. |
| DOI (Digital Object Identifier) : |
10.1016/S1474-4422(12)70228-4 |
| PMID : |
23137948 |
| En línea : |
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(12)70228-4/fullt [...] |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3641 |
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