Inicio
Información del autor
Autor Martín Ochoa Escudero
Comentario :
Médico Radiólogo, Hospital Pablo Tobón Uribe
|
Documentos disponibles escritos por este autor (16)
Clasificado(s) por (Año de edición descendente) Refinar búsquedaEspondiloartropatía destructiva no infecciosa en un paciente en hemodiálisis / Arbey Aristizabal Álzate ; John Fredy Nieto Ríos ; Catalina Ocampo Kohn ; Dahyana Cadavid Aljure ; Martín Ochoa Escudero ; Gustavo Adolfo Zuluaga Valencia
Título : Espondiloartropatía destructiva no infecciosa en un paciente en hemodiálisis Otros títulos : Destructive noninfectious spondyloarthropathy in a hemodialysis patient Tipo de documento : documento electrónico Autores : Arbey Aristizabal Álzate, ; John Fredy Nieto Ríos, ; Catalina Ocampo Kohn, ; Dahyana Cadavid Aljure, ; Martín Ochoa Escudero, ; Gustavo Adolfo Zuluaga Valencia, Fecha de publicación : 2022 Títulos uniformes : Acta Médica Colombiana Idioma : Español (spa) Palabras clave : espondiloartropatía destructiva enfermedad renal crónica diálisis paraplejia Resumen : La espondiloartropatía destructiva es una patología osteoarticular presente en algunos pacientes con enfermedad crónica que puede afectar varios niveles de la columna vertebral y puede ser asintomática, generar dolor o causar complicaciones que ponen en peligro la integridad de la médula espinal y/o la vida. Presentamos el caso de un hombre de 70 años con enfermedad renal crónica terminal en hemodiálisis quien consultó por dolor dorsal y paraplejia, en quien se diagnosticó espondiloartropatía destructiva no infecciosa por imágenes y estudio histopatológico. Este caso nos muestra la importancia de pensar en esta patología y la necesidad de un enfoque multidisciplinario en el diagnóstico y manejo. Mención de responsabilidad : Arbey Aristizabal-Alzate, Kelly Johanna Betancur-Salazar, John Fredy Nieto-Ríos, Catalina Ocampo-Kohn, Dahyana Cadavid-Aljure, Martin Ochoa-Escudero, Gustavo Zuluaga-Valencia, Lina María Serna Higuita Referencia : Acta méd. colomb ; 47(1): 44-48, ene.-mar. 2022. DOI (Digital Object Identifier) : 10.36104/amc.2022.2193 Derechos de uso : CC BY En línea : http://www.actamedicacolombiana.com/ojs/index.php/actamed/article/view/2193 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6023 Espondiloartropatía destructiva no infecciosa en un paciente en hemodiálisis = Destructive noninfectious spondyloarthropathy in a hemodialysis patient [documento electrónico] / Arbey Aristizabal Álzate, ; John Fredy Nieto Ríos, ; Catalina Ocampo Kohn, ; Dahyana Cadavid Aljure, ; Martín Ochoa Escudero, ; Gustavo Adolfo Zuluaga Valencia, . - 2022.
Obra : Acta Médica Colombiana
Idioma : Español (spa)
Palabras clave : espondiloartropatía destructiva enfermedad renal crónica diálisis paraplejia Resumen : La espondiloartropatía destructiva es una patología osteoarticular presente en algunos pacientes con enfermedad crónica que puede afectar varios niveles de la columna vertebral y puede ser asintomática, generar dolor o causar complicaciones que ponen en peligro la integridad de la médula espinal y/o la vida. Presentamos el caso de un hombre de 70 años con enfermedad renal crónica terminal en hemodiálisis quien consultó por dolor dorsal y paraplejia, en quien se diagnosticó espondiloartropatía destructiva no infecciosa por imágenes y estudio histopatológico. Este caso nos muestra la importancia de pensar en esta patología y la necesidad de un enfoque multidisciplinario en el diagnóstico y manejo. Mención de responsabilidad : Arbey Aristizabal-Alzate, Kelly Johanna Betancur-Salazar, John Fredy Nieto-Ríos, Catalina Ocampo-Kohn, Dahyana Cadavid-Aljure, Martin Ochoa-Escudero, Gustavo Zuluaga-Valencia, Lina María Serna Higuita Referencia : Acta méd. colomb ; 47(1): 44-48, ene.-mar. 2022. DOI (Digital Object Identifier) : 10.36104/amc.2022.2193 Derechos de uso : CC BY En línea : http://www.actamedicacolombiana.com/ojs/index.php/actamed/article/view/2193 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6023 Reserva
Reservar este documentoEjemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001863 AC-2022-029 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
AC-2022-029Adobe Acrobat PDF
Título : Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, Fecha de publicación : 2021 Títulos uniformes : Brain Communications Idioma : Inglés (eng) Palabras clave : Presenilin-1 thalamus MRI PET imaging preclinical Resumen : Histopathological reports suggest that subregions of the thalamus, which regulates multiple physiological and cognitive processes, are not uniformly affected by Alzheimer’s disease. Despite this, structural neuroimaging studies often consider the thalamus as a single region. Identification of in vivo Alzheimer’s-dependent volumetric changes in thalamic subregions may aid the characterization of early nuclei-specific neurodegeneration in Alzheimer’s disease. Here, we leveraged access to the largest single-mutation cohort of autosomal-dominant Alzheimer’s disease to test whether cross-sectional abnormalities in subregional thalamic volumes are evident in non-demented mutation carriers (n = 31), compared to non-carriers (n = 36), and whether subregional thalamic volume is associated with age, markers of brain pathology, and cognitive performance. Using automatic parcellation we examined the thalamus in six subregions (anterior, lateral, ventral, intralaminar, medial, posterior) and their relation to age and brain pathology (amyloid and tau), as measured by PET imaging. No between-group differences were observed in the volume of the thalamic subregions. In carriers, lower volume in the medial subregion was related to increased cortical amyloid and entorhinal tau burden. These findings suggest that thalamic Alzheimer’s-related volumetric reductions are not uniform even in preclinical and prodromal stages of autosomal-dominant Alzheimer’s disease and therefore, this structure should not be considered as a single, unitary structure in Alzheimer’s disease research. Mención de responsabilidad : Enmanuelle Pardilla-Delgado, PhD, Heirangi Torrico-Teave, BS, Justin S Sanchez, BA, Liliana A Ramirez-Gomez, MD, Ana Baena, MA, Yamile Bocanegra, PhD, Clara Vila-Castelar, PhD, Joshua T Fox-Fuller, MA, Edmarie Guzmán-Vélez, PhD, Jairo Martínez, BA, Sergio Alvarez, MD, Martin Ochoa-Escudero, MD, Francisco Lopera, MD, Yakeel T Quiroz, PhD Referencia : Brain Commun. 2021 May 10;3(2):fcab101. DOI (Digital Object Identifier) : 10.1093/braincomms/fcab101 PMID : 34095834 Derechos de uso : CC BY En línea : https://academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcab1 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5783 Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease [documento electrónico] / Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, . - 2021.
Obra : Brain Communications
Idioma : Inglés (eng)
Palabras clave : Presenilin-1 thalamus MRI PET imaging preclinical Resumen : Histopathological reports suggest that subregions of the thalamus, which regulates multiple physiological and cognitive processes, are not uniformly affected by Alzheimer’s disease. Despite this, structural neuroimaging studies often consider the thalamus as a single region. Identification of in vivo Alzheimer’s-dependent volumetric changes in thalamic subregions may aid the characterization of early nuclei-specific neurodegeneration in Alzheimer’s disease. Here, we leveraged access to the largest single-mutation cohort of autosomal-dominant Alzheimer’s disease to test whether cross-sectional abnormalities in subregional thalamic volumes are evident in non-demented mutation carriers (n = 31), compared to non-carriers (n = 36), and whether subregional thalamic volume is associated with age, markers of brain pathology, and cognitive performance. Using automatic parcellation we examined the thalamus in six subregions (anterior, lateral, ventral, intralaminar, medial, posterior) and their relation to age and brain pathology (amyloid and tau), as measured by PET imaging. No between-group differences were observed in the volume of the thalamic subregions. In carriers, lower volume in the medial subregion was related to increased cortical amyloid and entorhinal tau burden. These findings suggest that thalamic Alzheimer’s-related volumetric reductions are not uniform even in preclinical and prodromal stages of autosomal-dominant Alzheimer’s disease and therefore, this structure should not be considered as a single, unitary structure in Alzheimer’s disease research. Mención de responsabilidad : Enmanuelle Pardilla-Delgado, PhD, Heirangi Torrico-Teave, BS, Justin S Sanchez, BA, Liliana A Ramirez-Gomez, MD, Ana Baena, MA, Yamile Bocanegra, PhD, Clara Vila-Castelar, PhD, Joshua T Fox-Fuller, MA, Edmarie Guzmán-Vélez, PhD, Jairo Martínez, BA, Sergio Alvarez, MD, Martin Ochoa-Escudero, MD, Francisco Lopera, MD, Yakeel T Quiroz, PhD Referencia : Brain Commun. 2021 May 10;3(2):fcab101. DOI (Digital Object Identifier) : 10.1093/braincomms/fcab101 PMID : 34095834 Derechos de uso : CC BY En línea : https://academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcab1 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5783 Reserva
Reservar este documentoEjemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001710 AC-2021-033 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2021-033Adobe Acrobat PDF
Título : Cortical thickness across the lifespan in a Colombian cohort with autosomal-dominant Alzheimer's disease: A cross-sectional study Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, Fecha de publicación : 2021 Títulos uniformes : Alzheimer’s & Dementia. Diagnosis, Assessment & Disease Monitoring Idioma : Inglés (eng) Palabras clave : age-related cortical thickness familial Alzheimer's disease lifespan presenilin1 trajectory Resumen : Introduction: Cortical thinning is a marker of neurodegeneration in Alzheimer's disease (AD). We investigated the age-related trajectory of cortical thickness across the lifespan (9-59 years) in a Colombian kindred with autosomal dominant AD (ADAD). Methods: Two hundred eleven participants (105 presenilin-1 [PSEN1] E280A mutation carriers, 16 with cognitive impairment; 106 non-carriers) underwent magnetic resonance imaging. A piecewise linear regression identified change-points in the age-related trajectory of cortical thickness in carriers and non-carriers. Results: Unimpaired carriers exhibited elevated cortical thickness compared to non-carriers, and thickness more negatively correlated with age and cognition in carriers relative to non-carriers. We found increased cortical thickness in child carriers, after which thickness steadied compared to non-carriers prior to a rapid reduction in the decade leading up to the expected age at cognitive impairment in carriers. Discussion: Findings suggest that cortical thickness may fluctuate across the ADAD lifespan, from early-life increased thickness to atrophy proximal to clinical onset. Mención de responsabilidad : Joshua T. Fox-Fuller, Heirangi Torrico-Teave, Federico d'Oleire Uquillas, Kewei Chen, Yi Su, Yinghua Chen, Michael Brickhouse, Justin S. Sanchez, Cinthya Aguero, Heidi I.L. Jacobs, Olivia Hampton, Edmarie Guzmán-Vélez, Clara Vila-Castelar, Daniel C. Aguirre-Acevedo, Ana Baena, Arabiye Artola, Jairo Martinez, Celina F. Pluim, Sergio Alvarez, Martin Ochoa-Escudero, Eric M. Reiman, Reisa A. Sperling, Francisco Lopera, Keith A. Johnson, Bradford C. Dickerson, Yakeel T. Quiroz Referencia : Alzheimers Dement (Amst). 2021 Sep 14;13(1):e12233. DOI (Digital Object Identifier) : 10.1002/dad2.12233 PMID : 34541287 Derechos de uso : CC BY-NC-ND En línea : https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12233 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5885 Cortical thickness across the lifespan in a Colombian cohort with autosomal-dominant Alzheimer's disease: A cross-sectional study [documento electrónico] / Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, . - 2021.
Obra : Alzheimer’s & Dementia. Diagnosis, Assessment & Disease Monitoring
Idioma : Inglés (eng)
Palabras clave : age-related cortical thickness familial Alzheimer's disease lifespan presenilin1 trajectory Resumen : Introduction: Cortical thinning is a marker of neurodegeneration in Alzheimer's disease (AD). We investigated the age-related trajectory of cortical thickness across the lifespan (9-59 years) in a Colombian kindred with autosomal dominant AD (ADAD). Methods: Two hundred eleven participants (105 presenilin-1 [PSEN1] E280A mutation carriers, 16 with cognitive impairment; 106 non-carriers) underwent magnetic resonance imaging. A piecewise linear regression identified change-points in the age-related trajectory of cortical thickness in carriers and non-carriers. Results: Unimpaired carriers exhibited elevated cortical thickness compared to non-carriers, and thickness more negatively correlated with age and cognition in carriers relative to non-carriers. We found increased cortical thickness in child carriers, after which thickness steadied compared to non-carriers prior to a rapid reduction in the decade leading up to the expected age at cognitive impairment in carriers. Discussion: Findings suggest that cortical thickness may fluctuate across the ADAD lifespan, from early-life increased thickness to atrophy proximal to clinical onset. Mención de responsabilidad : Joshua T. Fox-Fuller, Heirangi Torrico-Teave, Federico d'Oleire Uquillas, Kewei Chen, Yi Su, Yinghua Chen, Michael Brickhouse, Justin S. Sanchez, Cinthya Aguero, Heidi I.L. Jacobs, Olivia Hampton, Edmarie Guzmán-Vélez, Clara Vila-Castelar, Daniel C. Aguirre-Acevedo, Ana Baena, Arabiye Artola, Jairo Martinez, Celina F. Pluim, Sergio Alvarez, Martin Ochoa-Escudero, Eric M. Reiman, Reisa A. Sperling, Francisco Lopera, Keith A. Johnson, Bradford C. Dickerson, Yakeel T. Quiroz Referencia : Alzheimers Dement (Amst). 2021 Sep 14;13(1):e12233. DOI (Digital Object Identifier) : 10.1002/dad2.12233 PMID : 34541287 Derechos de uso : CC BY-NC-ND En línea : https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12233 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5885 Reserva
Reservar este documentoEjemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001825 AC-2021-135 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2021-135Adobe Acrobat PDF
Título : Global cardiovascular risk profile and cerebrovascular abnormalities in presymptomatic individuals with CADASIL or autosomal dominant Alzheimer's disease Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, Fecha de publicación : 2021 Títulos uniformes : Journal of Alzheimer's Disease Idioma : Inglés (eng) Palabras clave : Autosomal dominant Alzheimer’s disease CADASIL cardiovascular risk factors cerebral small vessel disease cognition magnetic resonance imaging Resumen : Background:Cardiovascular risk factors increase the risk of developing dementia, including Alzheimer’s disease and vascular dementia. Objective:Studying individuals with autosomal dominant mutations leading to the early onset of dementia, this study examines the effect of the global cardiovascular risk profile on early cognitive and neuroimaging features of Alzheimer’s disease and vascular dementia. Methods:We studied 85 non-demented and stroke-free individuals, including 20 subjects with Presenilin1 (PSEN1) E280A mutation leading to the early onset of autosomal dominant Alzheimer’s disease (ADAD), 20 subjects with NOTCH3 mutations leading to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and to the early onset of vascular dementia, and 45 non-affected family members (non-carriers). All subjects underwent clinical and neuropsychological evaluations and an MRI. The global cardiovascular risk profile was estimated using the office-based Framingham Cardiovascular Risk Profile (FCRP) score. Results:In individuals with CADASIL, a higher FCRP score was associated with a reduced hippocampal volume (B = –0.06, p Mención de responsabilidad : Schoemaker, Dorothee, Velilla-Jimenez, Lina, Zuluaga, Yesica, Baena, Ana, Ospina, Carolina, Bocanegra, Yamile, Alvarez, Sergio, Ochoa-Escudero, Martin, Guzmán-Vélez, Edmarie, Martinez, Jairo, Lopera, Francisco, Arboleda-Velasquez, Joseph F., Quiroz, Yakeel T. Referencia : J Alzheimers Dis. 2021;82(2):841-853. DOI (Digital Object Identifier) : 10.3233/JAD-210313 PMID : 34092645 En línea : https://content.iospress.com/articles/journal-of-alzheimers-disease/jad210313 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5872 Global cardiovascular risk profile and cerebrovascular abnormalities in presymptomatic individuals with CADASIL or autosomal dominant Alzheimer's disease [documento electrónico] / Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, . - 2021.
Obra : Journal of Alzheimer's Disease
Idioma : Inglés (eng)
Palabras clave : Autosomal dominant Alzheimer’s disease CADASIL cardiovascular risk factors cerebral small vessel disease cognition magnetic resonance imaging Resumen : Background:Cardiovascular risk factors increase the risk of developing dementia, including Alzheimer’s disease and vascular dementia. Objective:Studying individuals with autosomal dominant mutations leading to the early onset of dementia, this study examines the effect of the global cardiovascular risk profile on early cognitive and neuroimaging features of Alzheimer’s disease and vascular dementia. Methods:We studied 85 non-demented and stroke-free individuals, including 20 subjects with Presenilin1 (PSEN1) E280A mutation leading to the early onset of autosomal dominant Alzheimer’s disease (ADAD), 20 subjects with NOTCH3 mutations leading to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and to the early onset of vascular dementia, and 45 non-affected family members (non-carriers). All subjects underwent clinical and neuropsychological evaluations and an MRI. The global cardiovascular risk profile was estimated using the office-based Framingham Cardiovascular Risk Profile (FCRP) score. Results:In individuals with CADASIL, a higher FCRP score was associated with a reduced hippocampal volume (B = –0.06, p Mención de responsabilidad : Schoemaker, Dorothee, Velilla-Jimenez, Lina, Zuluaga, Yesica, Baena, Ana, Ospina, Carolina, Bocanegra, Yamile, Alvarez, Sergio, Ochoa-Escudero, Martin, Guzmán-Vélez, Edmarie, Martinez, Jairo, Lopera, Francisco, Arboleda-Velasquez, Joseph F., Quiroz, Yakeel T. Referencia : J Alzheimers Dis. 2021;82(2):841-853. DOI (Digital Object Identifier) : 10.3233/JAD-210313 PMID : 34092645 En línea : https://content.iospress.com/articles/journal-of-alzheimers-disease/jad210313 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5872 Reserva
Reservar este documentoEjemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001810 AC-2021-122 Archivo digital Producción Científica Artículos científicos Disponible
Título : Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer's disease: findings from the Colombia-Boston (COLBOS) biomarker study Tipo de documento : documento electrónico Autores : Martín Ochoa Escudero, ; Sergio Álvarez Vallejo, Fecha de publicación : 2021 Títulos uniformes : Alzheimer's Research & Therapy Idioma : Inglés (eng) Palabras clave : Alzheimer’s Amyloid Autosomal-Dominant Imaging Longitudinal Tau Resumen : Background: Neuroimaging studies of autosomal dominant Alzheimer's disease (ADAD) enable characterization of the trajectories of cerebral amyloid-β (Aβ) and tau accumulation in the decades prior to clinical symptom onset. Longitudinal rates of regional tau accumulation measured with positron emission tomography (PET) and their relationship with other biomarker and cognitive changes remain to be fully characterized in ADAD. Methods: Fourteen ADAD mutation carriers (Presenilin-1 E280A) and 15 age-matched non-carriers from the Colombian kindred underwent 2-3 sessions of Aβ (11C-Pittsburgh compound B) and tau (18F-flortaucipir) PET, structural magnetic resonance imaging, and neuropsychological evaluation over a 2-4-year follow-up period. Annualized rates of change for imaging and cognitive variables were compared between carriers and non-carriers, and relationships among baseline measurements and rates of change were assessed within carriers. Results: Longitudinal measurements were consistent with a sequence of ADAD-related changes beginning with Aβ accumulation (16 years prior to expected symptom onset, EYO), followed by entorhinal cortex (EC) tau (9 EYO), neocortical tau (6 EYO), hippocampal atrophy (6 EYO), and cognitive decline (4 EYO). Rates of tau accumulation among carriers were most rapid in parietal neocortex (~ 9%/year). EC tau PET signal at baseline was a significant predictor of subsequent neocortical tau accumulation and cognitive decline within carriers. Conclusions: Our results are consistent with the sequence of biological changes in ADAD implied by cross-sectional studies and highlight the importance of EC tau as an early biomarker and a potential link between Aβ burden and neocortical tau accumulation in ADAD. Mención de responsabilidad : Justin S. Sanchez, Bernard J. Hanseeuw, Francisco Lopera, Reisa A. Sperling, Ana Baena, Yamile Bocanegra, David Aguillon, Edmarie Guzmán-Vélez, Enmanuelle Pardilla-Delgado, Liliana Ramirez-Gomez, Clara Vila-Castelar, Jairo E. Martinez, Joshua T. Fox-Fuller, Claudia Ramos, Martin Ochoa-Escudero, Sergio Alvarez, Heidi I. L. Jacobs, Aaron P. Schultz, Jennifer R. Gatchel, J. Alex Becker, Samantha R. Katz, Danielle V. Mayblyum, Julie C. Price, Eric M. Reiman, Keith A. Johnson and Yakeel T. Quiroz Referencia : Alzheimers Res Ther. 2021 Jan 15;13(1):27. DOI (Digital Object Identifier) : 10.1186/s13195-020-00765-5 PMID : 33451357 Derechos de uso : CC BY En línea : https://alzres.biomedcentral.com/articles/10.1186/s13195-020-00765-5 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5784 Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer's disease: findings from the Colombia-Boston (COLBOS) biomarker study [documento electrónico] / Martín Ochoa Escudero, ; Sergio Álvarez Vallejo, . - 2021.
Obra : Alzheimer's Research & Therapy
Idioma : Inglés (eng)
Palabras clave : Alzheimer’s Amyloid Autosomal-Dominant Imaging Longitudinal Tau Resumen : Background: Neuroimaging studies of autosomal dominant Alzheimer's disease (ADAD) enable characterization of the trajectories of cerebral amyloid-β (Aβ) and tau accumulation in the decades prior to clinical symptom onset. Longitudinal rates of regional tau accumulation measured with positron emission tomography (PET) and their relationship with other biomarker and cognitive changes remain to be fully characterized in ADAD. Methods: Fourteen ADAD mutation carriers (Presenilin-1 E280A) and 15 age-matched non-carriers from the Colombian kindred underwent 2-3 sessions of Aβ (11C-Pittsburgh compound B) and tau (18F-flortaucipir) PET, structural magnetic resonance imaging, and neuropsychological evaluation over a 2-4-year follow-up period. Annualized rates of change for imaging and cognitive variables were compared between carriers and non-carriers, and relationships among baseline measurements and rates of change were assessed within carriers. Results: Longitudinal measurements were consistent with a sequence of ADAD-related changes beginning with Aβ accumulation (16 years prior to expected symptom onset, EYO), followed by entorhinal cortex (EC) tau (9 EYO), neocortical tau (6 EYO), hippocampal atrophy (6 EYO), and cognitive decline (4 EYO). Rates of tau accumulation among carriers were most rapid in parietal neocortex (~ 9%/year). EC tau PET signal at baseline was a significant predictor of subsequent neocortical tau accumulation and cognitive decline within carriers. Conclusions: Our results are consistent with the sequence of biological changes in ADAD implied by cross-sectional studies and highlight the importance of EC tau as an early biomarker and a potential link between Aβ burden and neocortical tau accumulation in ADAD. Mención de responsabilidad : Justin S. Sanchez, Bernard J. Hanseeuw, Francisco Lopera, Reisa A. Sperling, Ana Baena, Yamile Bocanegra, David Aguillon, Edmarie Guzmán-Vélez, Enmanuelle Pardilla-Delgado, Liliana Ramirez-Gomez, Clara Vila-Castelar, Jairo E. Martinez, Joshua T. Fox-Fuller, Claudia Ramos, Martin Ochoa-Escudero, Sergio Alvarez, Heidi I. L. Jacobs, Aaron P. Schultz, Jennifer R. Gatchel, J. Alex Becker, Samantha R. Katz, Danielle V. Mayblyum, Julie C. Price, Eric M. Reiman, Keith A. Johnson and Yakeel T. Quiroz Referencia : Alzheimers Res Ther. 2021 Jan 15;13(1):27. DOI (Digital Object Identifier) : 10.1186/s13195-020-00765-5 PMID : 33451357 Derechos de uso : CC BY En línea : https://alzres.biomedcentral.com/articles/10.1186/s13195-020-00765-5 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5784 Reserva
Reservar este documentoEjemplares(1)
Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001711 AC-2021-034 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
2021-034Adobe Acrobat PDF
