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Autor Martín Ochoa Escudero
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Comentario :
Médico Radiólogo, Hospital Pablo Tobón Uribe
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Documentos disponibles escritos por este autor (18)
Clasificado(s) por (Año de edición descendente) Refinar búsquedaAssociation between Hippocampal Volume and Cognition in the Oldest?Old Individuals from Colombia / Sergio Álvarez Vallejo ; Martín Ochoa Escudero ; Kaplan, Elizabeth ; Zuluaga, Yesica ; Vasquez, Daniel ; Hincapie, Liliana ; Aguillon, David Fernando ; Madrigal, Lucia ; Baena, Ana Y ; Vila Castelar, Clara ; Giraldo Chica, Margarita M ; Ramirez Gomez, Liliana A ; Langella, Stephanie ; Arboleda Velasquez, Joseph F ; Lopera, Francisco ; Quiroz, Yakeel T
Título : Association between Hippocampal Volume and Cognition in the Oldest?Old Individuals from Colombia Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, Autor ; Martín Ochoa Escudero, Autor ; Kaplan, Elizabeth, Autor ; Zuluaga, Yesica, Autor ; Vasquez, Daniel, Autor ; Hincapie, Liliana, Autor ; Aguillon, David Fernando, Autor ; Madrigal, Lucia, Autor ; Baena, Ana Y, Autor ; Vila Castelar, Clara, Autor ; Giraldo Chica, Margarita M, Autor ; Ramirez Gomez, Liliana A, Autor ; Langella, Stephanie, Autor ; Arboleda Velasquez, Joseph F, Autor ; Lopera, Francisco, Autor ; Quiroz, Yakeel T, Autor Fecha de publicación : 2025 Títulos uniformes : Alzheimers Dement Idioma : Inglés (eng) Resumen : Life expectancy is on the rise, accompanied by an increased prevalence of cognitive impairment and Alzheimer’s disease. Despite this global trend, our understanding of the neural mechanisms underlying cognitive changes in the oldest?old (>80 years old) population remains limited. Unraveling these mechanisms may provide valuable insights and therapeutic interventions for individuals grappling with cognitive impairments in older age. Increased hippocampal volume has been associated with better cognitive function and its sparing in late life has been linked to better cognitive and functional outcomes. In this study, we examined hippocampal volume and cognitive performance in a group of the oldest?old individuals from Colombia. Mención de responsabilidad : Kaplan E, Zuluaga Y, Vasquez D, Hincapie L, Aguillon DF, Madrigal L, Baena AY, Vila?Castelar C, Alvarez S, Ochoa?Escudero M, Giraldo?Chica MM, Gomez LAR, Langella S, Arboleda?Velasquez JF, Lopera F, Quiroz YT Referencia : Alzheimers Dement. 2025 Jan 3;20(Suppl 3):e090936. DOI (Digital Object Identifier) : 10.1002/alz.090936 PMID : 11710158 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11710158/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Association between Hippocampal Volume and Cognition in the Oldest?Old Individuals from Colombia [documento electrónico] / Sergio Álvarez Vallejo, Autor ; Martín Ochoa Escudero, Autor ; Kaplan, Elizabeth, Autor ; Zuluaga, Yesica, Autor ; Vasquez, Daniel, Autor ; Hincapie, Liliana, Autor ; Aguillon, David Fernando, Autor ; Madrigal, Lucia, Autor ; Baena, Ana Y, Autor ; Vila Castelar, Clara, Autor ; Giraldo Chica, Margarita M, Autor ; Ramirez Gomez, Liliana A, Autor ; Langella, Stephanie, Autor ; Arboleda Velasquez, Joseph F, Autor ; Lopera, Francisco, Autor ; Quiroz, Yakeel T, Autor . - 2025.
Obra : Alzheimers Dement
Idioma : Inglés (eng)
Resumen : Life expectancy is on the rise, accompanied by an increased prevalence of cognitive impairment and Alzheimer’s disease. Despite this global trend, our understanding of the neural mechanisms underlying cognitive changes in the oldest?old (>80 years old) population remains limited. Unraveling these mechanisms may provide valuable insights and therapeutic interventions for individuals grappling with cognitive impairments in older age. Increased hippocampal volume has been associated with better cognitive function and its sparing in late life has been linked to better cognitive and functional outcomes. In this study, we examined hippocampal volume and cognitive performance in a group of the oldest?old individuals from Colombia. Mención de responsabilidad : Kaplan E, Zuluaga Y, Vasquez D, Hincapie L, Aguillon DF, Madrigal L, Baena AY, Vila?Castelar C, Alvarez S, Ochoa?Escudero M, Giraldo?Chica MM, Gomez LAR, Langella S, Arboleda?Velasquez JF, Lopera F, Quiroz YT Referencia : Alzheimers Dement. 2025 Jan 3;20(Suppl 3):e090936. DOI (Digital Object Identifier) : 10.1002/alz.090936 PMID : 11710158 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11710158/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Associations among mild behavioral impairment symptoms, brain pathology and cognition in individuals with autosomal?dominant Alzheimer’s disease: Findings from the Colombia?Boston (COLBOS) biomarker study Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, Autor ; Martín Ochoa Escudero, Autor ; Vasquez, Daniel, Autor ; Aguillon, David Fernando, Autor ; Baena, Ana Y, Autor ; Langella, Stephanie, Autor ; Munera, Diana, Autor ; Zubiri, Victoria, Autor ; Ramos, Claudia, Autor ; Kaplan, Elizabeth, Autor ; Pluim McDowell, Celina F, Autor ; Martinez, Jairo E, Autor ; Giudicessi, Averi, Autor ; Badillo Cabrera, Alex L, Autor ; Bonillas Félix, Nikole A, Autor ; Vila Castelar, Clara, Autor ; Ramirez Gomez, Liliana A, Autor ; Lopera, Francisco, Autor ; Gatchel, Jennifer R, Autor ; Quiroz, Yakeel T, Autor Fecha de publicación : 2025 Títulos uniformes : Alzheimers Dement Idioma : Inglés (eng) Resumen : Background Neuropsychiatric symptoms (NPS) are common in early stages of Alzheimer’s disease (AD) and may be early markers of cognitive decline and dementia in older individuals. The Mild Behavioral Impairment Checklist (MBI?C) was developed to capture new?onset transdiagnostic NPS in individuals at risk of dementia. We sought to determine whether mild behavioral impairment symptoms are elevated in non?demented Presenilin?1 (PSEN1) E280A carriers, who are genetically determined to develop dementia by their 50s. We hypothesized that those with higher MBI?C total scores would have worse memory performance and greater brain pathology. Method A total of 25 mutation carriers (mean age = 36.3±7.23; 56% females; 18 cognitively?unimpaired, 7 impaired) and 30 non?carriers (70% females) from the Colombia?Boston (COLBOS) Biomarker study were included. All participants completed cognitive testing, the MBI?C (self?reported), and florbetapir (amyloid), flortaucipir (tau) PET, and structural magnetic resonance imaging. We used Mann?Whitney Test to examine group differences, and Spearman’s correlation and linear regression to examine associations among MBI?C total score, Geriatric Depression Scale?15 (GDS), Mini?Mental State Examination (MMSE), CERAD word list learning delayed recall, cortical amyloid burden, regional tau, and hippocampal volume. In sensitivity analyses, we restricted carriers to the 18 unimpaired. Resul MBI?C total scores were similar between carriers and non?carriers (p = 0.09). Compared to non?carriers, carriers had greater amyloid burden (r = 0.55; p = 0.004) and lower hippocampal volume (r = ?0.43; p = 0.034). Among all carriers, higher MBI?C total scores were associated with lower hippocampal volume (r = ?0.44; p = 0.034), greater amyloid burden (r = 0.5; p = 0.011), and worst memory performance (r = ?0.36; p = 0.021). There were no associations with tau pathology (p?values>0.05). Sensitivity analyses were consistent with previous results except for hippocampal volume (r = ?0.4; p = 0.08). Conclusión Findings suggest that NPS captured by MBI?C are associated with pathology and memory in a Colombian kindred with autosomal dominant AD, years before the median age of dementia onset in this cohort. This underscores the importance of behavioral symptoms in preclinical and prodromal ADAD. Follow?up analyses with larger samples and longitudinal assessments are needed to characterize neuropsychiatric symptom evolution as an early marker and target for intervention. Mención de responsabilidad : Daniel Vasquez, David Fernando Aguillon, Ana Y Baena, Stephanie Langella, Diana Munera, Victoria Zubiri, Claudia Ramos, Sergio Alvarez, Martin Ochoa?Escudero, Elizabeth Kaplan, Celina F Pluim McDowell, Jairo E Martinez, Averi Giudicessi, Alex L Badillo?Cabrera, Nikole A Bonillas Félix, Clara Vila?Castelar, Liliana A Ramirez Gomez, Francisco Lopera, Jennifer R Gatchel, Yakeel T Quiroz Referencia : Alzheimers Dement. 2025 Jan 3;20(Suppl 3):e088002 DOI (Digital Object Identifier) : 10.1002/alz.088002 PMID : 11709999 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11709999/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Associations among mild behavioral impairment symptoms, brain pathology and cognition in individuals with autosomal?dominant Alzheimer’s disease: Findings from the Colombia?Boston (COLBOS) biomarker study [documento electrónico] / Sergio Álvarez Vallejo, Autor ; Martín Ochoa Escudero, Autor ; Vasquez, Daniel, Autor ; Aguillon, David Fernando, Autor ; Baena, Ana Y, Autor ; Langella, Stephanie, Autor ; Munera, Diana, Autor ; Zubiri, Victoria, Autor ; Ramos, Claudia, Autor ; Kaplan, Elizabeth, Autor ; Pluim McDowell, Celina F, Autor ; Martinez, Jairo E, Autor ; Giudicessi, Averi, Autor ; Badillo Cabrera, Alex L, Autor ; Bonillas Félix, Nikole A, Autor ; Vila Castelar, Clara, Autor ; Ramirez Gomez, Liliana A, Autor ; Lopera, Francisco, Autor ; Gatchel, Jennifer R, Autor ; Quiroz, Yakeel T, Autor . - 2025.
Obra : Alzheimers Dement
Idioma : Inglés (eng)
Resumen : Background Neuropsychiatric symptoms (NPS) are common in early stages of Alzheimer’s disease (AD) and may be early markers of cognitive decline and dementia in older individuals. The Mild Behavioral Impairment Checklist (MBI?C) was developed to capture new?onset transdiagnostic NPS in individuals at risk of dementia. We sought to determine whether mild behavioral impairment symptoms are elevated in non?demented Presenilin?1 (PSEN1) E280A carriers, who are genetically determined to develop dementia by their 50s. We hypothesized that those with higher MBI?C total scores would have worse memory performance and greater brain pathology. Method A total of 25 mutation carriers (mean age = 36.3±7.23; 56% females; 18 cognitively?unimpaired, 7 impaired) and 30 non?carriers (70% females) from the Colombia?Boston (COLBOS) Biomarker study were included. All participants completed cognitive testing, the MBI?C (self?reported), and florbetapir (amyloid), flortaucipir (tau) PET, and structural magnetic resonance imaging. We used Mann?Whitney Test to examine group differences, and Spearman’s correlation and linear regression to examine associations among MBI?C total score, Geriatric Depression Scale?15 (GDS), Mini?Mental State Examination (MMSE), CERAD word list learning delayed recall, cortical amyloid burden, regional tau, and hippocampal volume. In sensitivity analyses, we restricted carriers to the 18 unimpaired. Resul MBI?C total scores were similar between carriers and non?carriers (p = 0.09). Compared to non?carriers, carriers had greater amyloid burden (r = 0.55; p = 0.004) and lower hippocampal volume (r = ?0.43; p = 0.034). Among all carriers, higher MBI?C total scores were associated with lower hippocampal volume (r = ?0.44; p = 0.034), greater amyloid burden (r = 0.5; p = 0.011), and worst memory performance (r = ?0.36; p = 0.021). There were no associations with tau pathology (p?values>0.05). Sensitivity analyses were consistent with previous results except for hippocampal volume (r = ?0.4; p = 0.08). Conclusión Findings suggest that NPS captured by MBI?C are associated with pathology and memory in a Colombian kindred with autosomal dominant AD, years before the median age of dementia onset in this cohort. This underscores the importance of behavioral symptoms in preclinical and prodromal ADAD. Follow?up analyses with larger samples and longitudinal assessments are needed to characterize neuropsychiatric symptom evolution as an early marker and target for intervention. Mención de responsabilidad : Daniel Vasquez, David Fernando Aguillon, Ana Y Baena, Stephanie Langella, Diana Munera, Victoria Zubiri, Claudia Ramos, Sergio Alvarez, Martin Ochoa?Escudero, Elizabeth Kaplan, Celina F Pluim McDowell, Jairo E Martinez, Averi Giudicessi, Alex L Badillo?Cabrera, Nikole A Bonillas Félix, Clara Vila?Castelar, Liliana A Ramirez Gomez, Francisco Lopera, Jennifer R Gatchel, Yakeel T Quiroz Referencia : Alzheimers Dement. 2025 Jan 3;20(Suppl 3):e088002 DOI (Digital Object Identifier) : 10.1002/alz.088002 PMID : 11709999 Derechos de uso : CC BY-NC-ND En línea : https://pmc.ncbi.nlm.nih.gov/articles/PMC11709999/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Espondiloartropatía destructiva no infecciosa en un paciente en hemodiálisis Otros títulos : Destructive noninfectious spondyloarthropathy in a hemodialysis patient Tipo de documento : documento electrónico Autores : Arbey Aristizabal Álzate, ; John Fredy Nieto Ríos, ; Catalina Ocampo Kohn, ; Dahyana Cadavid Aljure, ; Martín Ochoa Escudero, ; Gustavo Adolfo Zuluaga Valencia, Fecha de publicación : 2022 Títulos uniformes : Acta Médica Colombiana Idioma : Español (spa) Palabras clave : espondiloartropatía destructiva enfermedad renal crónica diálisis paraplejia Resumen : La espondiloartropatía destructiva es una patología osteoarticular presente en algunos pacientes con enfermedad crónica que puede afectar varios niveles de la columna vertebral y puede ser asintomática, generar dolor o causar complicaciones que ponen en peligro la integridad de la médula espinal y/o la vida. Presentamos el caso de un hombre de 70 años con enfermedad renal crónica terminal en hemodiálisis quien consultó por dolor dorsal y paraplejia, en quien se diagnosticó espondiloartropatía destructiva no infecciosa por imágenes y estudio histopatológico. Este caso nos muestra la importancia de pensar en esta patología y la necesidad de un enfoque multidisciplinario en el diagnóstico y manejo. Mención de responsabilidad : Arbey Aristizabal-Alzate, Kelly Johanna Betancur-Salazar, John Fredy Nieto-Ríos, Catalina Ocampo-Kohn, Dahyana Cadavid-Aljure, Martin Ochoa-Escudero, Gustavo Zuluaga-Valencia, Lina María Serna Higuita Referencia : Acta méd. colomb ; 47(1): 44-48, ene.-mar. 2022. DOI (Digital Object Identifier) : 10.36104/amc.2022.2193 Derechos de uso : CC BY En línea : http://www.actamedicacolombiana.com/ojs/index.php/actamed/article/view/2193 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Espondiloartropatía destructiva no infecciosa en un paciente en hemodiálisis = Destructive noninfectious spondyloarthropathy in a hemodialysis patient [documento electrónico] / Arbey Aristizabal Álzate, ; John Fredy Nieto Ríos, ; Catalina Ocampo Kohn, ; Dahyana Cadavid Aljure, ; Martín Ochoa Escudero, ; Gustavo Adolfo Zuluaga Valencia, . - 2022.
Obra : Acta Médica Colombiana
Idioma : Español (spa)
Palabras clave : espondiloartropatía destructiva enfermedad renal crónica diálisis paraplejia Resumen : La espondiloartropatía destructiva es una patología osteoarticular presente en algunos pacientes con enfermedad crónica que puede afectar varios niveles de la columna vertebral y puede ser asintomática, generar dolor o causar complicaciones que ponen en peligro la integridad de la médula espinal y/o la vida. Presentamos el caso de un hombre de 70 años con enfermedad renal crónica terminal en hemodiálisis quien consultó por dolor dorsal y paraplejia, en quien se diagnosticó espondiloartropatía destructiva no infecciosa por imágenes y estudio histopatológico. Este caso nos muestra la importancia de pensar en esta patología y la necesidad de un enfoque multidisciplinario en el diagnóstico y manejo. Mención de responsabilidad : Arbey Aristizabal-Alzate, Kelly Johanna Betancur-Salazar, John Fredy Nieto-Ríos, Catalina Ocampo-Kohn, Dahyana Cadavid-Aljure, Martin Ochoa-Escudero, Gustavo Zuluaga-Valencia, Lina María Serna Higuita Referencia : Acta méd. colomb ; 47(1): 44-48, ene.-mar. 2022. DOI (Digital Object Identifier) : 10.36104/amc.2022.2193 Derechos de uso : CC BY En línea : http://www.actamedicacolombiana.com/ojs/index.php/actamed/article/view/2193 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, Fecha de publicación : 2021 Títulos uniformes : Brain Communications Idioma : Inglés (eng) Palabras clave : Presenilin-1 thalamus MRI PET imaging preclinical Resumen : Histopathological reports suggest that subregions of the thalamus, which regulates multiple physiological and cognitive processes, are not uniformly affected by Alzheimer’s disease. Despite this, structural neuroimaging studies often consider the thalamus as a single region. Identification of in vivo Alzheimer’s-dependent volumetric changes in thalamic subregions may aid the characterization of early nuclei-specific neurodegeneration in Alzheimer’s disease. Here, we leveraged access to the largest single-mutation cohort of autosomal-dominant Alzheimer’s disease to test whether cross-sectional abnormalities in subregional thalamic volumes are evident in non-demented mutation carriers (n = 31), compared to non-carriers (n = 36), and whether subregional thalamic volume is associated with age, markers of brain pathology, and cognitive performance. Using automatic parcellation we examined the thalamus in six subregions (anterior, lateral, ventral, intralaminar, medial, posterior) and their relation to age and brain pathology (amyloid and tau), as measured by PET imaging. No between-group differences were observed in the volume of the thalamic subregions. In carriers, lower volume in the medial subregion was related to increased cortical amyloid and entorhinal tau burden. These findings suggest that thalamic Alzheimer’s-related volumetric reductions are not uniform even in preclinical and prodromal stages of autosomal-dominant Alzheimer’s disease and therefore, this structure should not be considered as a single, unitary structure in Alzheimer’s disease research. Mención de responsabilidad : Enmanuelle Pardilla-Delgado, PhD, Heirangi Torrico-Teave, BS, Justin S Sanchez, BA, Liliana A Ramirez-Gomez, MD, Ana Baena, MA, Yamile Bocanegra, PhD, Clara Vila-Castelar, PhD, Joshua T Fox-Fuller, MA, Edmarie Guzmán-Vélez, PhD, Jairo Martínez, BA, Sergio Alvarez, MD, Martin Ochoa-Escudero, MD, Francisco Lopera, MD, Yakeel T Quiroz, PhD Referencia : Brain Commun. 2021 May 10;3(2):fcab101. DOI (Digital Object Identifier) : 10.1093/braincomms/fcab101 PMID : 34095834 Derechos de uso : CC BY En línea : https://academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcab1 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease [documento electrónico] / Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, . - 2021.
Obra : Brain Communications
Idioma : Inglés (eng)
Palabras clave : Presenilin-1 thalamus MRI PET imaging preclinical Resumen : Histopathological reports suggest that subregions of the thalamus, which regulates multiple physiological and cognitive processes, are not uniformly affected by Alzheimer’s disease. Despite this, structural neuroimaging studies often consider the thalamus as a single region. Identification of in vivo Alzheimer’s-dependent volumetric changes in thalamic subregions may aid the characterization of early nuclei-specific neurodegeneration in Alzheimer’s disease. Here, we leveraged access to the largest single-mutation cohort of autosomal-dominant Alzheimer’s disease to test whether cross-sectional abnormalities in subregional thalamic volumes are evident in non-demented mutation carriers (n = 31), compared to non-carriers (n = 36), and whether subregional thalamic volume is associated with age, markers of brain pathology, and cognitive performance. Using automatic parcellation we examined the thalamus in six subregions (anterior, lateral, ventral, intralaminar, medial, posterior) and their relation to age and brain pathology (amyloid and tau), as measured by PET imaging. No between-group differences were observed in the volume of the thalamic subregions. In carriers, lower volume in the medial subregion was related to increased cortical amyloid and entorhinal tau burden. These findings suggest that thalamic Alzheimer’s-related volumetric reductions are not uniform even in preclinical and prodromal stages of autosomal-dominant Alzheimer’s disease and therefore, this structure should not be considered as a single, unitary structure in Alzheimer’s disease research. Mención de responsabilidad : Enmanuelle Pardilla-Delgado, PhD, Heirangi Torrico-Teave, BS, Justin S Sanchez, BA, Liliana A Ramirez-Gomez, MD, Ana Baena, MA, Yamile Bocanegra, PhD, Clara Vila-Castelar, PhD, Joshua T Fox-Fuller, MA, Edmarie Guzmán-Vélez, PhD, Jairo Martínez, BA, Sergio Alvarez, MD, Martin Ochoa-Escudero, MD, Francisco Lopera, MD, Yakeel T Quiroz, PhD Referencia : Brain Commun. 2021 May 10;3(2):fcab101. DOI (Digital Object Identifier) : 10.1093/braincomms/fcab101 PMID : 34095834 Derechos de uso : CC BY En línea : https://academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcab1 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Cortical thickness across the lifespan in a Colombian cohort with autosomal-dominant Alzheimer's disease: A cross-sectional study Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, Fecha de publicación : 2021 Títulos uniformes : Alzheimer’s & Dementia. Diagnosis, Assessment & Disease Monitoring Idioma : Inglés (eng) Palabras clave : age-related cortical thickness familial Alzheimer's disease lifespan presenilin1 trajectory Resumen : Introduction: Cortical thinning is a marker of neurodegeneration in Alzheimer's disease (AD). We investigated the age-related trajectory of cortical thickness across the lifespan (9-59 years) in a Colombian kindred with autosomal dominant AD (ADAD). Methods: Two hundred eleven participants (105 presenilin-1 [PSEN1] E280A mutation carriers, 16 with cognitive impairment; 106 non-carriers) underwent magnetic resonance imaging. A piecewise linear regression identified change-points in the age-related trajectory of cortical thickness in carriers and non-carriers. Results: Unimpaired carriers exhibited elevated cortical thickness compared to non-carriers, and thickness more negatively correlated with age and cognition in carriers relative to non-carriers. We found increased cortical thickness in child carriers, after which thickness steadied compared to non-carriers prior to a rapid reduction in the decade leading up to the expected age at cognitive impairment in carriers. Discussion: Findings suggest that cortical thickness may fluctuate across the ADAD lifespan, from early-life increased thickness to atrophy proximal to clinical onset. Mención de responsabilidad : Joshua T. Fox-Fuller, Heirangi Torrico-Teave, Federico d'Oleire Uquillas, Kewei Chen, Yi Su, Yinghua Chen, Michael Brickhouse, Justin S. Sanchez, Cinthya Aguero, Heidi I.L. Jacobs, Olivia Hampton, Edmarie Guzmán-Vélez, Clara Vila-Castelar, Daniel C. Aguirre-Acevedo, Ana Baena, Arabiye Artola, Jairo Martinez, Celina F. Pluim, Sergio Alvarez, Martin Ochoa-Escudero, Eric M. Reiman, Reisa A. Sperling, Francisco Lopera, Keith A. Johnson, Bradford C. Dickerson, Yakeel T. Quiroz Referencia : Alzheimers Dement (Amst). 2021 Sep 14;13(1):e12233. DOI (Digital Object Identifier) : 10.1002/dad2.12233 PMID : 34541287 Derechos de uso : CC BY-NC-ND En línea : https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12233 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Cortical thickness across the lifespan in a Colombian cohort with autosomal-dominant Alzheimer's disease: A cross-sectional study [documento electrónico] / Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, . - 2021.
Obra : Alzheimer’s & Dementia. Diagnosis, Assessment & Disease Monitoring
Idioma : Inglés (eng)
Palabras clave : age-related cortical thickness familial Alzheimer's disease lifespan presenilin1 trajectory Resumen : Introduction: Cortical thinning is a marker of neurodegeneration in Alzheimer's disease (AD). We investigated the age-related trajectory of cortical thickness across the lifespan (9-59 years) in a Colombian kindred with autosomal dominant AD (ADAD). Methods: Two hundred eleven participants (105 presenilin-1 [PSEN1] E280A mutation carriers, 16 with cognitive impairment; 106 non-carriers) underwent magnetic resonance imaging. A piecewise linear regression identified change-points in the age-related trajectory of cortical thickness in carriers and non-carriers. Results: Unimpaired carriers exhibited elevated cortical thickness compared to non-carriers, and thickness more negatively correlated with age and cognition in carriers relative to non-carriers. We found increased cortical thickness in child carriers, after which thickness steadied compared to non-carriers prior to a rapid reduction in the decade leading up to the expected age at cognitive impairment in carriers. Discussion: Findings suggest that cortical thickness may fluctuate across the ADAD lifespan, from early-life increased thickness to atrophy proximal to clinical onset. Mención de responsabilidad : Joshua T. Fox-Fuller, Heirangi Torrico-Teave, Federico d'Oleire Uquillas, Kewei Chen, Yi Su, Yinghua Chen, Michael Brickhouse, Justin S. Sanchez, Cinthya Aguero, Heidi I.L. Jacobs, Olivia Hampton, Edmarie Guzmán-Vélez, Clara Vila-Castelar, Daniel C. Aguirre-Acevedo, Ana Baena, Arabiye Artola, Jairo Martinez, Celina F. Pluim, Sergio Alvarez, Martin Ochoa-Escudero, Eric M. Reiman, Reisa A. Sperling, Francisco Lopera, Keith A. Johnson, Bradford C. Dickerson, Yakeel T. Quiroz Referencia : Alzheimers Dement (Amst). 2021 Sep 14;13(1):e12233. DOI (Digital Object Identifier) : 10.1002/dad2.12233 PMID : 34541287 Derechos de uso : CC BY-NC-ND En línea : https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12233 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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