A public resource of baseline data from the Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial / Sergio Álvarez Vallejo    

Público ISBD Título : A public resource of baseline data from the Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, Fecha de publicación : 2022 Títulos uniformes : Alzheimer's & Dementia Idioma : Inglés (eng) Palabras clave : Alzheimer’s disease  amyloid  antibody  data sharing  magnetic resonance imaging  positron emission tomography  presenilin 1  primary prevention  secondary prevention Resumen : Introduction: The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease (API ADAD) Trial evaluated the anti-oligomeric amyloid beta (Aβ) antibody therapy crenezumab in cognitively unimpaired members of the Colombian presenilin 1 (PSEN1) E280A kindred. We report availability, methods employed to protect confidentiality and anonymity of participants, and process for requesting and accessing baseline data. Methods: We developed mechanisms to share baseline data from the API ADAD Trial in consultation with experts and other groups sharing data from Alzheimer's disease (AD) prevention trials, balancing the need to protect anonymity and trial integrity with making data broadly available to accelerate progress in the field. We pressure-tested deliberate and inadvertent potential threats under specific assumptions, employed a system to suppress or mask both direct and indirect identifying variables, limited and firewalled data managers, and put forth specific principles requisite to receive data. Results: Baseline demographic, PSEN1 E280A and apolipoprotein E genotypes, florbetapir and fluorodeoxyglucose positron emission tomography, magnetic resonance imaging, clinical, and cognitive data can now be requested by interested researchers. Discussion: Baseline data are publicly available; treatment data and biological samples, including baseline and treatment-related blood-based biomarker data will become available in accordance with our original trial agreement and subsequently developed Collaboration for Alzheimer's Prevention principles. Sharing of these data will allow exploration of important questions including the differential effects of initiating an investigational AD prevention therapy both before as well as after measurable Aβ plaque deposition. Mención de responsabilidad : Eric M. Reiman, Jeremy J. Pruzin, Silvia Rios-Romenets, Chris Brown, Margarita Giraldo, Natalia Acosta-Baena, Carlos Tobon, Nan Hu, Yinghua Chen, Valentina Ghisays, Jessica Enos, Dhruman D. Goradia, Wendy Lee, Ji Luo, Michael Malek-Ahmadi, Hillary Protas, Ronald G. Thomas, Kewei Chen, Yi Su, Connie Boker, Diego Mastroeni, Sergio Alvarez, Yakeel T. Quiroz, Jessica B. Langbaum, Kaycee M. Sink, Francisco Lopera, Pierre N. Tariot, and the API ADAD Colombia Trial Group Referencia : Alzheimers Dement. 2022 Nov 14. DOI (Digital Object Identifier) : 10.1002/alz.12843 PMID : 36373344 Derechos de uso : CC BY-NC En línea : https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12843 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6100 A public resource of baseline data from the Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial [documento electrónico] / Sergio Álvarez Vallejo,  . - 2022. Obra : Alzheimer's & Dementia Idioma : Inglés (eng) Palabras clave : Alzheimer’s disease  amyloid  antibody  data sharing  magnetic resonance imaging  positron emission tomography  presenilin 1  primary prevention  secondary prevention Resumen : Introduction: The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease (API ADAD) Trial evaluated the anti-oligomeric amyloid beta (Aβ) antibody therapy crenezumab in cognitively unimpaired members of the Colombian presenilin 1 (PSEN1) E280A kindred. We report availability, methods employed to protect confidentiality and anonymity of participants, and process for requesting and accessing baseline data. Methods: We developed mechanisms to share baseline data from the API ADAD Trial in consultation with experts and other groups sharing data from Alzheimer's disease (AD) prevention trials, balancing the need to protect anonymity and trial integrity with making data broadly available to accelerate progress in the field. We pressure-tested deliberate and inadvertent potential threats under specific assumptions, employed a system to suppress or mask both direct and indirect identifying variables, limited and firewalled data managers, and put forth specific principles requisite to receive data. Results: Baseline demographic, PSEN1 E280A and apolipoprotein E genotypes, florbetapir and fluorodeoxyglucose positron emission tomography, magnetic resonance imaging, clinical, and cognitive data can now be requested by interested researchers. Discussion: Baseline data are publicly available; treatment data and biological samples, including baseline and treatment-related blood-based biomarker data will become available in accordance with our original trial agreement and subsequently developed Collaboration for Alzheimer's Prevention principles. Sharing of these data will allow exploration of important questions including the differential effects of initiating an investigational AD prevention therapy both before as well as after measurable Aβ plaque deposition. Mención de responsabilidad : Eric M. Reiman, Jeremy J. Pruzin, Silvia Rios-Romenets, Chris Brown, Margarita Giraldo, Natalia Acosta-Baena, Carlos Tobon, Nan Hu, Yinghua Chen, Valentina Ghisays, Jessica Enos, Dhruman D. Goradia, Wendy Lee, Ji Luo, Michael Malek-Ahmadi, Hillary Protas, Ronald G. Thomas, Kewei Chen, Yi Su, Connie Boker, Diego Mastroeni, Sergio Alvarez, Yakeel T. Quiroz, Jessica B. Langbaum, Kaycee M. Sink, Francisco Lopera, Pierre N. Tariot, and the API ADAD Colombia Trial Group Referencia : Alzheimers Dement. 2022 Nov 14. DOI (Digital Object Identifier) : 10.1002/alz.12843 PMID : 36373344 Derechos de uso : CC BY-NC En línea : https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12843 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6100

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Sex differences in cognitive resilience in preclinical autosomal-dominant Alzheimer's disease carriers and non-carriers: Baseline findings from the API ADAD Colombia Trial / Sergio Álvarez Vallejo  

Público ISBD Título : Sex differences in cognitive resilience in preclinical autosomal-dominant Alzheimer's disease carriers and non-carriers: Baseline findings from the API ADAD Colombia Trial Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, Fecha de publicación : 2022 Títulos uniformes : Alzheimer's & Dementia Idioma : Inglés (eng) Palabras clave : Alzheimer's disease  autosomal-dominant Alzheimer's disease  cognition  neurodegeneration  pathology  preclinical  sex differences Resumen : Introduction: Females may have greater susceptibility to Alzheimer's disease (AD)-pathology. We examined the effect of sex on pathology, neurodegeneration, and memory in cognitively-unimpaired Presenilin-1 (PSEN1) E280A mutation carriers and non-carriers. Methods: We analyzed baseline data from 167 mutation carriers and 75 non-carriers (ages 30 to 53) from the Alzheimer's Prevention Initiative Autosomal Dominant AD Trial, including florbetapir- and fludeoxyglucose-PET, MRI based hippocampal volume and cognitive testing. Results: Females exhibited better delayed recall than males, controlling for age, precuneus glucose metabolism, and mutation status, although the effect was not significant among PSEN1 mutation carriers only. APOE ε4 did not modify the effect of sex on AD biomarkers and memory. Discussion: Our findings suggest that, among cognitively-unimpaired individuals at genetic risk for autosomal-dominant AD, females may have greater cognitive resilience to AD pathology and neurodegeneration than males. Further investigation of sex-specific differences in autosomal-dominant AD is key to elucidating mechanisms of AD risk and resilience. Mención de responsabilidad : Clara Vila-Castelar, Pierre N. Tariot, Kaycee M. Sink, David Clayton, Jessica B. Langbaum, Ronald G. Thomas, Yinghua Chen, Yi Su, Kewei Chen, Nan Hu, Margarita Giraldo-Chica, Carlos Tobón, Natalia Acosta-Baena, Ernesto Luna, Marisol Londoño, Paula Ospina, Victoria Tirado, Claudia Muñoz, Eliana Henao, Yamile Bocanegra, Sergio Alvarez, Silvia Rios-Romenets, Valentina Ghisays, Dhruman Goradia, Wendy Lee, Ji Luo, Michael H. Malek-Ahmadi, Hillary D. Protas, Francisco Lopera, Eric M. Reiman, Yakeel T. Quiroz, the API ADAD Colombia Trial Group Referencia : Alzheimers Dement. 2022 Nov;18(11):2272-2282. DOI (Digital Object Identifier) : 10.1002/alz.12552 PMID : 35103388 En línea : https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12552 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6085 Sex differences in cognitive resilience in preclinical autosomal-dominant Alzheimer's disease carriers and non-carriers: Baseline findings from the API ADAD Colombia Trial [documento electrónico] / Sergio Álvarez Vallejo,  . - 2022. Obra : Alzheimer's & Dementia Idioma : Inglés (eng) Palabras clave : Alzheimer's disease  autosomal-dominant Alzheimer's disease  cognition  neurodegeneration  pathology  preclinical  sex differences Resumen : Introduction: Females may have greater susceptibility to Alzheimer's disease (AD)-pathology. We examined the effect of sex on pathology, neurodegeneration, and memory in cognitively-unimpaired Presenilin-1 (PSEN1) E280A mutation carriers and non-carriers. Methods: We analyzed baseline data from 167 mutation carriers and 75 non-carriers (ages 30 to 53) from the Alzheimer's Prevention Initiative Autosomal Dominant AD Trial, including florbetapir- and fludeoxyglucose-PET, MRI based hippocampal volume and cognitive testing. Results: Females exhibited better delayed recall than males, controlling for age, precuneus glucose metabolism, and mutation status, although the effect was not significant among PSEN1 mutation carriers only. APOE ε4 did not modify the effect of sex on AD biomarkers and memory. Discussion: Our findings suggest that, among cognitively-unimpaired individuals at genetic risk for autosomal-dominant AD, females may have greater cognitive resilience to AD pathology and neurodegeneration than males. Further investigation of sex-specific differences in autosomal-dominant AD is key to elucidating mechanisms of AD risk and resilience. Mención de responsabilidad : Clara Vila-Castelar, Pierre N. Tariot, Kaycee M. Sink, David Clayton, Jessica B. Langbaum, Ronald G. Thomas, Yinghua Chen, Yi Su, Kewei Chen, Nan Hu, Margarita Giraldo-Chica, Carlos Tobón, Natalia Acosta-Baena, Ernesto Luna, Marisol Londoño, Paula Ospina, Victoria Tirado, Claudia Muñoz, Eliana Henao, Yamile Bocanegra, Sergio Alvarez, Silvia Rios-Romenets, Valentina Ghisays, Dhruman Goradia, Wendy Lee, Ji Luo, Michael H. Malek-Ahmadi, Hillary D. Protas, Francisco Lopera, Eric M. Reiman, Yakeel T. Quiroz, the API ADAD Colombia Trial Group Referencia : Alzheimers Dement. 2022 Nov;18(11):2272-2282. DOI (Digital Object Identifier) : 10.1002/alz.12552 PMID : 35103388 En línea : https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12552 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6085

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Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease / Sergio Álvarez Vallejo ; Martín Ochoa Escudero    

Público ISBD Título : Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, Fecha de publicación : 2021 Títulos uniformes : Brain Communications Idioma : Inglés (eng) Palabras clave : Presenilin-1  thalamus  MRI  PET imaging  preclinical Resumen : Histopathological reports suggest that subregions of the thalamus, which regulates multiple physiological and cognitive processes, are not uniformly affected by Alzheimer’s disease. Despite this, structural neuroimaging studies often consider the thalamus as a single region. Identification of in vivo Alzheimer’s-dependent volumetric changes in thalamic subregions may aid the characterization of early nuclei-specific neurodegeneration in Alzheimer’s disease. Here, we leveraged access to the largest single-mutation cohort of autosomal-dominant Alzheimer’s disease to test whether cross-sectional abnormalities in subregional thalamic volumes are evident in non-demented mutation carriers (n = 31), compared to non-carriers (n = 36), and whether subregional thalamic volume is associated with age, markers of brain pathology, and cognitive performance. Using automatic parcellation we examined the thalamus in six subregions (anterior, lateral, ventral, intralaminar, medial, posterior) and their relation to age and brain pathology (amyloid and tau), as measured by PET imaging. No between-group differences were observed in the volume of the thalamic subregions. In carriers, lower volume in the medial subregion was related to increased cortical amyloid and entorhinal tau burden. These findings suggest that thalamic Alzheimer’s-related volumetric reductions are not uniform even in preclinical and prodromal stages of autosomal-dominant Alzheimer’s disease and therefore, this structure should not be considered as a single, unitary structure in Alzheimer’s disease research. Mención de responsabilidad : Enmanuelle Pardilla-Delgado, PhD, Heirangi Torrico-Teave, BS, Justin S Sanchez, BA, Liliana A Ramirez-Gomez, MD, Ana Baena, MA, Yamile Bocanegra, PhD, Clara Vila-Castelar, PhD, Joshua T Fox-Fuller, MA, Edmarie Guzmán-Vélez, PhD, Jairo Martínez, BA, Sergio Alvarez, MD, Martin Ochoa-Escudero, MD, Francisco Lopera, MD, Yakeel T Quiroz, PhD Referencia : Brain Commun. 2021 May 10;3(2):fcab101. DOI (Digital Object Identifier) : 10.1093/braincomms/fcab101 PMID : 34095834 Derechos de uso : CC BY En línea : https://academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcab1 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5783 Associations between subregional thalamic volume and brain pathology in autosomal dominant Alzheimer's disease [documento electrónico] / Sergio Álvarez Vallejo, ; Martín Ochoa Escudero,  . - 2021. Obra : Brain Communications Idioma : Inglés (eng) Palabras clave : Presenilin-1  thalamus  MRI  PET imaging  preclinical Resumen : Histopathological reports suggest that subregions of the thalamus, which regulates multiple physiological and cognitive processes, are not uniformly affected by Alzheimer’s disease. Despite this, structural neuroimaging studies often consider the thalamus as a single region. Identification of in vivo Alzheimer’s-dependent volumetric changes in thalamic subregions may aid the characterization of early nuclei-specific neurodegeneration in Alzheimer’s disease. Here, we leveraged access to the largest single-mutation cohort of autosomal-dominant Alzheimer’s disease to test whether cross-sectional abnormalities in subregional thalamic volumes are evident in non-demented mutation carriers (n = 31), compared to non-carriers (n = 36), and whether subregional thalamic volume is associated with age, markers of brain pathology, and cognitive performance. Using automatic parcellation we examined the thalamus in six subregions (anterior, lateral, ventral, intralaminar, medial, posterior) and their relation to age and brain pathology (amyloid and tau), as measured by PET imaging. No between-group differences were observed in the volume of the thalamic subregions. In carriers, lower volume in the medial subregion was related to increased cortical amyloid and entorhinal tau burden. These findings suggest that thalamic Alzheimer’s-related volumetric reductions are not uniform even in preclinical and prodromal stages of autosomal-dominant Alzheimer’s disease and therefore, this structure should not be considered as a single, unitary structure in Alzheimer’s disease research. Mención de responsabilidad : Enmanuelle Pardilla-Delgado, PhD, Heirangi Torrico-Teave, BS, Justin S Sanchez, BA, Liliana A Ramirez-Gomez, MD, Ana Baena, MA, Yamile Bocanegra, PhD, Clara Vila-Castelar, PhD, Joshua T Fox-Fuller, MA, Edmarie Guzmán-Vélez, PhD, Jairo Martínez, BA, Sergio Alvarez, MD, Martin Ochoa-Escudero, MD, Francisco Lopera, MD, Yakeel T Quiroz, PhD Referencia : Brain Commun. 2021 May 10;3(2):fcab101. DOI (Digital Object Identifier) : 10.1093/braincomms/fcab101 PMID : 34095834 Derechos de uso : CC BY En línea : https://academic.oup.com/braincomms/advance-article/doi/10.1093/braincomms/fcab1 [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5783

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Cortical thickness across the lifespan in a Colombian cohort with autosomal-dominant Alzheimer's disease: A cross-sectional study / Sergio Álvarez Vallejo ; Martín Ochoa Escudero    

Público ISBD Título : Cortical thickness across the lifespan in a Colombian cohort with autosomal-dominant Alzheimer's disease: A cross-sectional study Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, Fecha de publicación : 2021 Títulos uniformes : Alzheimer’s & Dementia. Diagnosis, Assessment & Disease Monitoring Idioma : Inglés (eng) Palabras clave : age-related  cortical thickness  familial Alzheimer's disease  lifespan  presenilin1  trajectory Resumen : Introduction: Cortical thinning is a marker of neurodegeneration in Alzheimer's disease (AD). We investigated the age-related trajectory of cortical thickness across the lifespan (9-59 years) in a Colombian kindred with autosomal dominant AD (ADAD). Methods: Two hundred eleven participants (105 presenilin-1 [PSEN1] E280A mutation carriers, 16 with cognitive impairment; 106 non-carriers) underwent magnetic resonance imaging. A piecewise linear regression identified change-points in the age-related trajectory of cortical thickness in carriers and non-carriers. Results: Unimpaired carriers exhibited elevated cortical thickness compared to non-carriers, and thickness more negatively correlated with age and cognition in carriers relative to non-carriers. We found increased cortical thickness in child carriers, after which thickness steadied compared to non-carriers prior to a rapid reduction in the decade leading up to the expected age at cognitive impairment in carriers. Discussion: Findings suggest that cortical thickness may fluctuate across the ADAD lifespan, from early-life increased thickness to atrophy proximal to clinical onset. Mención de responsabilidad : Joshua T. Fox-Fuller, Heirangi Torrico-Teave, Federico d'Oleire Uquillas, Kewei Chen, Yi Su, Yinghua Chen, Michael Brickhouse, Justin S. Sanchez, Cinthya Aguero, Heidi I.L. Jacobs, Olivia Hampton, Edmarie Guzmán-Vélez, Clara Vila-Castelar, Daniel C. Aguirre-Acevedo, Ana Baena, Arabiye Artola, Jairo Martinez, Celina F. Pluim, Sergio Alvarez, Martin Ochoa-Escudero, Eric M. Reiman, Reisa A. Sperling, Francisco Lopera, Keith A. Johnson, Bradford C. Dickerson, Yakeel T. Quiroz Referencia : Alzheimers Dement (Amst). 2021 Sep 14;13(1):e12233. DOI (Digital Object Identifier) : 10.1002/dad2.12233 PMID : 34541287 Derechos de uso : CC BY-NC-ND En línea : https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12233 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5885 Cortical thickness across the lifespan in a Colombian cohort with autosomal-dominant Alzheimer's disease: A cross-sectional study [documento electrónico] / Sergio Álvarez Vallejo, ; Martín Ochoa Escudero,  . - 2021. Obra : Alzheimer’s & Dementia. Diagnosis, Assessment & Disease Monitoring Idioma : Inglés (eng) Palabras clave : age-related  cortical thickness  familial Alzheimer's disease  lifespan  presenilin1  trajectory Resumen : Introduction: Cortical thinning is a marker of neurodegeneration in Alzheimer's disease (AD). We investigated the age-related trajectory of cortical thickness across the lifespan (9-59 years) in a Colombian kindred with autosomal dominant AD (ADAD). Methods: Two hundred eleven participants (105 presenilin-1 [PSEN1] E280A mutation carriers, 16 with cognitive impairment; 106 non-carriers) underwent magnetic resonance imaging. A piecewise linear regression identified change-points in the age-related trajectory of cortical thickness in carriers and non-carriers. Results: Unimpaired carriers exhibited elevated cortical thickness compared to non-carriers, and thickness more negatively correlated with age and cognition in carriers relative to non-carriers. We found increased cortical thickness in child carriers, after which thickness steadied compared to non-carriers prior to a rapid reduction in the decade leading up to the expected age at cognitive impairment in carriers. Discussion: Findings suggest that cortical thickness may fluctuate across the ADAD lifespan, from early-life increased thickness to atrophy proximal to clinical onset. Mención de responsabilidad : Joshua T. Fox-Fuller, Heirangi Torrico-Teave, Federico d'Oleire Uquillas, Kewei Chen, Yi Su, Yinghua Chen, Michael Brickhouse, Justin S. Sanchez, Cinthya Aguero, Heidi I.L. Jacobs, Olivia Hampton, Edmarie Guzmán-Vélez, Clara Vila-Castelar, Daniel C. Aguirre-Acevedo, Ana Baena, Arabiye Artola, Jairo Martinez, Celina F. Pluim, Sergio Alvarez, Martin Ochoa-Escudero, Eric M. Reiman, Reisa A. Sperling, Francisco Lopera, Keith A. Johnson, Bradford C. Dickerson, Yakeel T. Quiroz Referencia : Alzheimers Dement (Amst). 2021 Sep 14;13(1):e12233. DOI (Digital Object Identifier) : 10.1002/dad2.12233 PMID : 34541287 Derechos de uso : CC BY-NC-ND En línea : https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12233 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5885

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Global cardiovascular risk profile and cerebrovascular abnormalities in presymptomatic individuals with CADASIL or autosomal dominant Alzheimer's disease / Sergio Álvarez Vallejo ; Martín Ochoa Escudero  

Público ISBD Título : Global cardiovascular risk profile and cerebrovascular abnormalities in presymptomatic individuals with CADASIL or autosomal dominant Alzheimer's disease Tipo de documento : documento electrónico Autores : Sergio Álvarez Vallejo, ; Martín Ochoa Escudero, Fecha de publicación : 2021 Títulos uniformes : Journal of Alzheimer's Disease Idioma : Inglés (eng) Palabras clave : Autosomal dominant Alzheimer’s disease  CADASIL  cardiovascular risk factors  cerebral small vessel disease  cognition  magnetic resonance imaging Resumen : Background:Cardiovascular risk factors increase the risk of developing dementia, including Alzheimer’s disease and vascular dementia. Objective:Studying individuals with autosomal dominant mutations leading to the early onset of dementia, this study examines the effect of the global cardiovascular risk profile on early cognitive and neuroimaging features of Alzheimer’s disease and vascular dementia. Methods:We studied 85 non-demented and stroke-free individuals, including 20 subjects with Presenilin1 (PSEN1) E280A mutation leading to the early onset of autosomal dominant Alzheimer’s disease (ADAD), 20 subjects with NOTCH3 mutations leading to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and to the early onset of vascular dementia, and 45 non-affected family members (non-carriers). All subjects underwent clinical and neuropsychological evaluations and an MRI. The global cardiovascular risk profile was estimated using the office-based Framingham Cardiovascular Risk Profile (FCRP) score. Results:In individuals with CADASIL, a higher FCRP score was associated with a reduced hippocampal volume (B = –0.06, p  Mención de responsabilidad : Schoemaker, Dorothee, Velilla-Jimenez, Lina, Zuluaga, Yesica, Baena, Ana, Ospina, Carolina, Bocanegra, Yamile, Alvarez, Sergio, Ochoa-Escudero, Martin, Guzmán-Vélez, Edmarie, Martinez, Jairo, Lopera, Francisco, Arboleda-Velasquez, Joseph F., Quiroz, Yakeel T. Referencia : J Alzheimers Dis. 2021;82(2):841-853. DOI (Digital Object Identifier) : 10.3233/JAD-210313 PMID : 34092645 En línea : https://content.iospress.com/articles/journal-of-alzheimers-disease/jad210313 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5872 Global cardiovascular risk profile and cerebrovascular abnormalities in presymptomatic individuals with CADASIL or autosomal dominant Alzheimer's disease [documento electrónico] / Sergio Álvarez Vallejo, ; Martín Ochoa Escudero,  . - 2021. Obra : Journal of Alzheimer's Disease Idioma : Inglés (eng) Palabras clave : Autosomal dominant Alzheimer’s disease  CADASIL  cardiovascular risk factors  cerebral small vessel disease  cognition  magnetic resonance imaging Resumen : Background:Cardiovascular risk factors increase the risk of developing dementia, including Alzheimer’s disease and vascular dementia. Objective:Studying individuals with autosomal dominant mutations leading to the early onset of dementia, this study examines the effect of the global cardiovascular risk profile on early cognitive and neuroimaging features of Alzheimer’s disease and vascular dementia. Methods:We studied 85 non-demented and stroke-free individuals, including 20 subjects with Presenilin1 (PSEN1) E280A mutation leading to the early onset of autosomal dominant Alzheimer’s disease (ADAD), 20 subjects with NOTCH3 mutations leading to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and to the early onset of vascular dementia, and 45 non-affected family members (non-carriers). All subjects underwent clinical and neuropsychological evaluations and an MRI. The global cardiovascular risk profile was estimated using the office-based Framingham Cardiovascular Risk Profile (FCRP) score. Results:In individuals with CADASIL, a higher FCRP score was associated with a reduced hippocampal volume (B = –0.06, p  Mención de responsabilidad : Schoemaker, Dorothee, Velilla-Jimenez, Lina, Zuluaga, Yesica, Baena, Ana, Ospina, Carolina, Bocanegra, Yamile, Alvarez, Sergio, Ochoa-Escudero, Martin, Guzmán-Vélez, Edmarie, Martinez, Jairo, Lopera, Francisco, Arboleda-Velasquez, Joseph F., Quiroz, Yakeel T. Referencia : J Alzheimers Dis. 2021;82(2):841-853. DOI (Digital Object Identifier) : 10.3233/JAD-210313 PMID : 34092645 En línea : https://content.iospress.com/articles/journal-of-alzheimers-disease/jad210313 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5872

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Hemolysis in Hemodialysis, Secondary to Severe Vena Cava Stenosis / Dahyana Cadavid Aljure ; Sergio Álvarez Vallejo ; Gloria María Posada Álvarez ; Eliana María Ruiz Aguilar ; Lina Marcela Higuita Urrego ; Catalina María Guerra Álvarez ; Sandra Marcela Marín Durango ; Catalina Ocampo Kohn ; John Fredy Nieto Ríos ; Arbey Aristizabal Álzate ; Gustavo Adolfo Zuluaga Valencia  

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Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer's disease: findings from the Colombia-Boston (COLBOS) biomarker study / Martín Ochoa Escudero ; Sergio Álvarez Vallejo    

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PET evidence of preclinical cerebellar amyloid plaque deposition in autosomal dominant Alzheimer's disease-causing Presenilin-1 E280A mutation carriers / Sergio Álvarez Vallejo    

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Treatment of post-biopsy arteriovenous fistula of a renal graft by selective embolization / José Miguel Hidalgo Oviedo ; Sergio Álvarez Vallejo ; Arbey Aristizabal Álzate ; Gustavo Adolfo Zuluaga Valencia ; John Fredy Nieto Ríos  

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Trombectomía mecánica reolítica en la nueva era para el manejo endovascular de la isquemia aguda de EEII / Sergio Álvarez Vallejo  

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Características clínicas, genéticas y uso de la angiografía selectiva del páncreas en un grupo de pacientes colombianos con hiperinsulinismo congénito / Carolina Jaramillo Arango ; Catalina Mesa Muñoz ; Luz Ángela Angarita Fuentes ; Verónica Abad Londoño ; Sergio Álvarez Vallejo ; Santiago Echeverri Isaza  

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Trombectomía y trombólisis exitosas en trombosis aguda de la vena de un injerto renal con recuperación completa de su función / John Fredy Nieto Ríos ; José Miguel Hidalgo Oviedo ; Sergio Álvarez Vallejo ; Arbey Aristizabal Álzate ; Catalina Ocampo Kohn ; Gustavo Adolfo Zuluaga Valencia  

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Ecografia Doppler en la evaluación de trasplante del hígado / Lucila Beatriz Molinares Arevalo ; Martín Ochoa Escudero ; Carlos Mario González Vásquez ; Sergio Álvarez Vallejo  

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Extrahepatic portal vein aneurysm after liver transplantation in a child: case report / Lucila Beatriz Molinares Arevalo ; Sergio Álvarez Vallejo ; Vanessa García Gómez ; María Elsy Sepúlveda Hincapie ; Nora Luz Yepes Palacio  

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Hidrotórax hepático. Reporte de caso y revisión de la literatura / Juan Ignacio Marín Zuluaga ; Sergio Álvarez Vallejo ; Octavio Germán Muñoz Maya ; Óscar Mauricio Santos Sánchez ; Juan Carlos Restrepo Gutiérrez    

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