The Road Less Traveled: Alternative Pathways for Action-Verb Processing in Parkinson’s Disease / Omar Fredy Buriticá Henao  

Público ISBD Título : The Road Less Traveled: Alternative Pathways for Action-Verb Processing in Parkinson’s Disease Tipo de documento : documento electrónico Autores : Omar Fredy Buriticá Henao, Fecha de publicación : 2017 Títulos uniformes : Journal of Alzheimer's Disease Idioma : Inglés (eng) Palabras clave : Functional magnetic resonance imaging  language  motor cortex  Parkinson’s disease  semantics Resumen : Action verbs are critically embodied in motor brain networks. In Parkinson’s disease (PD), damage to the latter compromises access to such words. However, patients are not fully incapable of processing them, as their performance is far from floor level. Here we tested the hypothesis that action-verb processing in PD may rely on alternative disembodied semantic circuits. Seventeen PD patients and 15 healthy controls listened to action verbs and nouns during functional MRI scanning. Using cluster-mass analysis with a permutation test, we assessed task-related functional connectivity considering seeds differentially engaged by action and non-action words (namely, putamen and M1 versus posterior superior temporal lobe, respectively). The putamen seed showed reduced connectivity within the basal ganglia in patients for both lexical categories. However, only action verbs recruited different cortical networks in each group. Specifically, the M1 seed exhibited more anterior connectivity for controls and more posterior connectivity for patients, with no differences in the temporal seed. Moreover, the patients’ level of basal ganglia atrophy positively correlated with their reliance on M1-posterior connectivity during action-verb processing. PD patients seem to have processed action verbs via non-motor cortical networks subserving amodal semantics. Such circuits may afford alternative pathways to process words when default embodied mechanisms are disturbed. Moreover, the greater the level of basal ganglia atrophy, the greater the patients’ reliance on this alternative route. Our findings offer new insights into differential neurofunctional mechanisms recruited to process action semantics in PD. Mención de responsabilidad : Sofía Abrevaya, Lucas Sedeño, Sol Fitipaldi, David Pineda, Francisco Lopera, Omar Buritica, Andrés Villegas, Catalina Bustamante, Diana Gomez, Natalia Trujillo, Ricardo Pautassi, Agustín Ibáñez, Adolfo M García Referencia : J Alzheimers Dis. 2017;55(4):1429-1435. DOI (Digital Object Identifier) : 10.3233/JAD-160737 PMID : 27834777 En línea : https://content.iospress.com/articles/journal-of-alzheimers-disease/jad160737 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4017 The Road Less Traveled: Alternative Pathways for Action-Verb Processing in Parkinson’s Disease [documento electrónico] / Omar Fredy Buriticá Henao,  . - 2017. Obra : Journal of Alzheimer's Disease Idioma : Inglés (eng) Palabras clave : Functional magnetic resonance imaging  language  motor cortex  Parkinson’s disease  semantics Resumen : Action verbs are critically embodied in motor brain networks. In Parkinson’s disease (PD), damage to the latter compromises access to such words. However, patients are not fully incapable of processing them, as their performance is far from floor level. Here we tested the hypothesis that action-verb processing in PD may rely on alternative disembodied semantic circuits. Seventeen PD patients and 15 healthy controls listened to action verbs and nouns during functional MRI scanning. Using cluster-mass analysis with a permutation test, we assessed task-related functional connectivity considering seeds differentially engaged by action and non-action words (namely, putamen and M1 versus posterior superior temporal lobe, respectively). The putamen seed showed reduced connectivity within the basal ganglia in patients for both lexical categories. However, only action verbs recruited different cortical networks in each group. Specifically, the M1 seed exhibited more anterior connectivity for controls and more posterior connectivity for patients, with no differences in the temporal seed. Moreover, the patients’ level of basal ganglia atrophy positively correlated with their reliance on M1-posterior connectivity during action-verb processing. PD patients seem to have processed action verbs via non-motor cortical networks subserving amodal semantics. Such circuits may afford alternative pathways to process words when default embodied mechanisms are disturbed. Moreover, the greater the level of basal ganglia atrophy, the greater the patients’ reliance on this alternative route. Our findings offer new insights into differential neurofunctional mechanisms recruited to process action semantics in PD. Mención de responsabilidad : Sofía Abrevaya, Lucas Sedeño, Sol Fitipaldi, David Pineda, Francisco Lopera, Omar Buritica, Andrés Villegas, Catalina Bustamante, Diana Gomez, Natalia Trujillo, Ricardo Pautassi, Agustín Ibáñez, Adolfo M García Referencia : J Alzheimers Dis. 2017;55(4):1429-1435. DOI (Digital Object Identifier) : 10.3233/JAD-160737 PMID : 27834777 En línea : https://content.iospress.com/articles/journal-of-alzheimers-disease/jad160737 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4017

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Unspeakable motion: Selective action-verb impairments in Parkinson’s disease patients without mild cognitive impairment / Omar Fredy Buriticá Henao ; Leonardo Fabio Moreno Gómez  

Público ISBD Título : Unspeakable motion: Selective action-verb impairments in Parkinson’s disease patients without mild cognitive impairment Tipo de documento : documento electrónico Autores : Omar Fredy Buriticá Henao, ; Leonardo Fabio Moreno Gómez, Fecha de publicación : 2017 Títulos uniformes : Brain & Language Idioma : Inglés (eng) Palabras clave : Parkinson’s disease  Mild cognitive impairment  Picture naming  Action verbs  Manipulable nouns  Motor semantics Resumen : Parkinson's disease (PD) patients show marked impairments in processing action verbs, and to a lesser extent, concrete (specially, manipulable) nouns. However, it is still unclear to what extent deficits in each of these categories are influenced by more general cognitive dysfunctions, and whether they are modulated by the words' implied motility. To examine these issues, we evaluated 49 non-demented PD patients and 49 healthy volunteers in an oral production task. The patients were divided into two groups depending on the presence or absence of mild cognitive impairment (PD-MCI and PD-nMCI, respectively). Participants named pictures of actions varying in motion content (low and high) and of objects varying in manipulability (low and high). The PD-MCI group showed deficits across all four categories. However, PD-nMCI patients exhibited a selective difficulty for high-motion action verbs. This finding corroborates and refines previous results suggesting that disturbances of action-related lexico-semantic information in PD constitute a sui generis alteration manifested early in the course of the disease's physiopathology. Moreover, it suggests that the grounding of action verbs on motor circuits could depend on fine-grained intracategorical semantic distinctions. Mención de responsabilidad : Yamile Bocanegra, Adolfo M García, Francisco Lopera, David Pineda, Ana Baena, Paula Ospina, Diana Alzate, Omar Buriticá, Leonardo Moreno, Agustín Ibáñez, Fernando Cuetos Referencia : Brain Lang. 2017 May;168:37-46. DOI (Digital Object Identifier) : 10.1016/j.bandl.2017.01.005 PMID : 28131052 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0093934X16301262 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4038 Unspeakable motion: Selective action-verb impairments in Parkinson’s disease patients without mild cognitive impairment [documento electrónico] / Omar Fredy Buriticá Henao, ; Leonardo Fabio Moreno Gómez,  . - 2017. Obra : Brain & Language Idioma : Inglés (eng) Palabras clave : Parkinson’s disease  Mild cognitive impairment  Picture naming  Action verbs  Manipulable nouns  Motor semantics Resumen : Parkinson's disease (PD) patients show marked impairments in processing action verbs, and to a lesser extent, concrete (specially, manipulable) nouns. However, it is still unclear to what extent deficits in each of these categories are influenced by more general cognitive dysfunctions, and whether they are modulated by the words' implied motility. To examine these issues, we evaluated 49 non-demented PD patients and 49 healthy volunteers in an oral production task. The patients were divided into two groups depending on the presence or absence of mild cognitive impairment (PD-MCI and PD-nMCI, respectively). Participants named pictures of actions varying in motion content (low and high) and of objects varying in manipulability (low and high). The PD-MCI group showed deficits across all four categories. However, PD-nMCI patients exhibited a selective difficulty for high-motion action verbs. This finding corroborates and refines previous results suggesting that disturbances of action-related lexico-semantic information in PD constitute a sui generis alteration manifested early in the course of the disease's physiopathology. Moreover, it suggests that the grounding of action verbs on motor circuits could depend on fine-grained intracategorical semantic distinctions. Mención de responsabilidad : Yamile Bocanegra, Adolfo M García, Francisco Lopera, David Pineda, Ana Baena, Paula Ospina, Diana Alzate, Omar Buriticá, Leonardo Moreno, Agustín Ibáñez, Fernando Cuetos Referencia : Brain Lang. 2017 May;168:37-46. DOI (Digital Object Identifier) : 10.1016/j.bandl.2017.01.005 PMID : 28131052 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0093934X16301262 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4038

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Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences / Omar Fredy Buriticá Henao  

Público ISBD Título : Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences Tipo de documento : documento electrónico Autores : Omar Fredy Buriticá Henao, Fecha de publicación : 2015 Títulos uniformes : Cortex Idioma : Inglés (eng) Palabras clave : Parkinson's disease  syntax  action verbs  action semantics  object semantics  executive functions  mild cognitive impairment Resumen : Several studies have recently shown that basal ganglia (BG) deterioration leads to distinctive impairments in the domains of syntax, action verbs, and action semantics. In particular, such disruptions have been repeatedly observed in Parkinson's disease (PD) patients. However, it remains unclear whether these deficits are language-specific and whether they are equally dissociable from other reported disturbances –viz., processing of object semantics. To address these issues, we administered linguistic, semantic, and executive function (EFs) tasks to two groups of non-demented PD patients, with and without mild cognitive impairment (PD-MCI and PD-nMCI, respectively). We compared these two groups with each other and with matched samples of healthy controls. Our results showed that PD patients exhibited linguistic and semantic deficits even in the absence of MCI. However, not all domains were equally related to EFs and MCI across samples. Whereas EFs predicted disturbances of syntax and object semantics in both PD-nMCI and PD-MCI, they had no impact on action-verb and action-semantic impairments in either group. Critically, patients showed disruptions of action-verb production and action semantics in the absence of MCI and without any executive influence, suggesting a sui generis deficit present since early stages of the disease. These findings indicate that varied language domains are differentially related to the BG, contradicting popular approaches to neurolinguistics. Mención de responsabilidad : Yamile Bocanegra, Adolfo M García, David Pineda, Omar Buriticá, Andrés Villegas, Francisco Lopera, Diana Gómez, Catalina Gómez-Arias, Juan F Cardona, Natalia Trujillo, Agustín Ibáñez Referencia : Cortex. 2015 Aug;69:237-54. DOI (Digital Object Identifier) : 10.1016/j.cortex.2015.05.022 PMID : 26103601 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0010945215001811#abs0010 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3895 Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences [documento electrónico] / Omar Fredy Buriticá Henao,  . - 2015. Obra : Cortex Idioma : Inglés (eng) Palabras clave : Parkinson's disease  syntax  action verbs  action semantics  object semantics  executive functions  mild cognitive impairment Resumen : Several studies have recently shown that basal ganglia (BG) deterioration leads to distinctive impairments in the domains of syntax, action verbs, and action semantics. In particular, such disruptions have been repeatedly observed in Parkinson's disease (PD) patients. However, it remains unclear whether these deficits are language-specific and whether they are equally dissociable from other reported disturbances –viz., processing of object semantics. To address these issues, we administered linguistic, semantic, and executive function (EFs) tasks to two groups of non-demented PD patients, with and without mild cognitive impairment (PD-MCI and PD-nMCI, respectively). We compared these two groups with each other and with matched samples of healthy controls. Our results showed that PD patients exhibited linguistic and semantic deficits even in the absence of MCI. However, not all domains were equally related to EFs and MCI across samples. Whereas EFs predicted disturbances of syntax and object semantics in both PD-nMCI and PD-MCI, they had no impact on action-verb and action-semantic impairments in either group. Critically, patients showed disruptions of action-verb production and action semantics in the absence of MCI and without any executive influence, suggesting a sui generis deficit present since early stages of the disease. These findings indicate that varied language domains are differentially related to the BG, contradicting popular approaches to neurolinguistics. Mención de responsabilidad : Yamile Bocanegra, Adolfo M García, David Pineda, Omar Buriticá, Andrés Villegas, Francisco Lopera, Diana Gómez, Catalina Gómez-Arias, Juan F Cardona, Natalia Trujillo, Agustín Ibáñez Referencia : Cortex. 2015 Aug;69:237-54. DOI (Digital Object Identifier) : 10.1016/j.cortex.2015.05.022 PMID : 26103601 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0010945215001811#abs0010 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3895

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Enfermedad de Creutzfeldt-Jakob esporádico: síntomas neuropsiquíatricos seguidos de daño cognitivo progresivo: reporte de caso / Olga Lucía Rincón Caballero ; Alejandro Vélez Hoyos ; Luz Mey King Chio ; Dora Lilia Hernández López ; Rodrigo Isaza Bermúdez ; Basilio Vagner Ramírez ; Omar Fredy Buriticá Henao ; Andrés Reinaldo Castaño ; Sergio Jaramillo Velásquez ; Beatriz Helena Aristizábal Bernal    

Público ISBD Título : Enfermedad de Creutzfeldt-Jakob esporádico: síntomas neuropsiquíatricos seguidos de daño cognitivo progresivo: reporte de caso Otros títulos : Sporadic creutzfeldt-jakob disease: neuropsychiatric symptoms followed by a progressive congnitive decline: a case report Tipo de documento : documento electrónico Autores : Olga Lucía Rincón Caballero, ; Alejandro Vélez Hoyos, ; Luz Mey King Chio, ; Dora Lilia Hernández López, ; Rodrigo Isaza Bermúdez, ; Basilio Vagner Ramírez, ; Omar Fredy Buriticá Henao, ; Andrés Reinaldo Castaño, ; Sergio Jaramillo Velásquez, ; Beatriz Helena Aristizábal Bernal, Fecha de publicación : 2008 Títulos uniformes : Medicina U.P.B. Idioma : Español (spa) Palabras clave : enfermedad de Creutzfeldt-Jakob  inmunoensayo  inmunohistoquímica  priones  Western blot  proteína14-3-3 Resumen : La enfermedad de Creutzfeldt-Jakob (ECJ) es la enfermedad por priones más común y es la única entre los desórdenes humanos que se puede presentar en forma familiar, esporádica y transmitida. La hipótesis prevalente, basada en numerosos estudios en ratones transgénicos, sugiere que la ECJ y otras enfermedades por priones se inician y propagan por conversión de una proteína prionica normal (PrP) en una isoforma conformacional anormal (PrPreS). Esta última se acumula en el cerebro y es una de las características bioquímicas importantes en ECJ. Se reporta el caso de una mujer de 37 años de edad, quien murió en un hospital de tercer nivel por ECJ esporádico comprobado por autopsia. Este caso muestra la importancia de un examen post-mortem para confirmar el diagnóstico. A la luz de la observación clínica, discutimos el caso, el cual debe ser considerado en pacientes que evolucionan a una demencia rápidamente progresiva. Mención de responsabilidad : Olga Lucía Rincón, Alejandro Vélez, Luz Mey King Chio, Dora Lilia Hernández, Rodrigo Isaza, Basilio Vagner, Omar Buriticá, Andrés Reinaldo Castaño, Sergio Jaramillo, Beatriz Helena Aristizábal Referencia : Med. U.P.B ; 27(1): 59-63, ene.-jun. 2008. Derechos de uso : CC BY-NC-ND En línea : https://revistas.upb.edu.co/index.php/medicina/article/view/2262 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5001 Enfermedad de Creutzfeldt-Jakob esporádico: síntomas neuropsiquíatricos seguidos de daño cognitivo progresivo: reporte de caso = Sporadic creutzfeldt-jakob disease: neuropsychiatric symptoms followed by a progressive congnitive decline: a case report [documento electrónico] / Olga Lucía Rincón Caballero, ; Alejandro Vélez Hoyos, ; Luz Mey King Chio, ; Dora Lilia Hernández López, ; Rodrigo Isaza Bermúdez, ; Basilio Vagner Ramírez, ; Omar Fredy Buriticá Henao, ; Andrés Reinaldo Castaño, ; Sergio Jaramillo Velásquez, ; Beatriz Helena Aristizábal Bernal,  . - 2008. Obra : Medicina U.P.B. Idioma : Español (spa) Palabras clave : enfermedad de Creutzfeldt-Jakob  inmunoensayo  inmunohistoquímica  priones  Western blot  proteína14-3-3 Resumen : La enfermedad de Creutzfeldt-Jakob (ECJ) es la enfermedad por priones más común y es la única entre los desórdenes humanos que se puede presentar en forma familiar, esporádica y transmitida. La hipótesis prevalente, basada en numerosos estudios en ratones transgénicos, sugiere que la ECJ y otras enfermedades por priones se inician y propagan por conversión de una proteína prionica normal (PrP) en una isoforma conformacional anormal (PrPreS). Esta última se acumula en el cerebro y es una de las características bioquímicas importantes en ECJ. Se reporta el caso de una mujer de 37 años de edad, quien murió en un hospital de tercer nivel por ECJ esporádico comprobado por autopsia. Este caso muestra la importancia de un examen post-mortem para confirmar el diagnóstico. A la luz de la observación clínica, discutimos el caso, el cual debe ser considerado en pacientes que evolucionan a una demencia rápidamente progresiva. Mención de responsabilidad : Olga Lucía Rincón, Alejandro Vélez, Luz Mey King Chio, Dora Lilia Hernández, Rodrigo Isaza, Basilio Vagner, Omar Buriticá, Andrés Reinaldo Castaño, Sergio Jaramillo, Beatriz Helena Aristizábal Referencia : Med. U.P.B ; 27(1): 59-63, ene.-jun. 2008. Derechos de uso : CC BY-NC-ND En línea : https://revistas.upb.edu.co/index.php/medicina/article/view/2262 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5001

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