| Título : |
Gelatin tannate for acute diarrhoea and gastroenteritis in children: a systematic review and meta-analysis |
| Tipo de documento : |
documento electrónico |
| Autores : |
Laura Fernanda Niño Serna, |
| Fecha de publicación : |
2020 |
| Títulos uniformes : |
Archives of Disease in Childhood
|
| Idioma : |
Inglés (eng) |
| Palabras clave : |
Children diarrhoea gastroenteritis gelatin meta-analysis systematic review tannate |
| Resumen : |
Objective: To determine the effectiveness and safety of gelatin tannate (GT) for reducing the duration of the acute diarrhoea and gastroenteritis (ADG) in children. Design: Systematic review and meta-analysis. Data sources: MEDLINE, Embase, CINAHL, Cochrane Central Register of Controlled Trials, LILACS and grey literature, published from inception to October 2018. No language restrictions. Eligibility criteria for selecting studies: Randomised controlled trials in children with ADG, comparing GT with placebo. Results: Of 797 titles identified, we included three studies (276 children). We performed a random effects model meta-analysis for the main outcome (diarrhoea duration). We did not find significant differences between GT and placebo for diarrhoea duration (mean difference (MD)=−15.85 hours; 95% CI −42.24 to 14.82, I2=92%; three studies), stool frequency at day 2 (MD=0.11 stools/day; 95% CI −0.39 to 0.62: I2=26%; two studies), diarrhoea at day 3 (risk ratio [RR]=0.46; 95% CI 0.06 to 3.47: I2=73%; two studies), vomiting (RR=1.31; 95% CI 0.95 to 1.80: I2=0%; two studies) or adverse events (RR=0.86; 95% CI 0.27 to 2.66: I2=0%; two studies). Most common adverse events included abdominal pain and nausea. Conclusion: The effect of GT was no different to placebo for mean diarrhoea duration (low certainty on the evidence) and stool frequency at day 2 (high certainty) and for the presence of diarrhoea at day 3 (very low certainty) of vomiting (moderate certainty) and of adverse events (low certainty). |
| Mención de responsabilidad : |
Ivan D Florez, Javier M Sierra, Laura F Niño-Serna |
| Referencia : |
Arch Dis Child. 2020 Feb;105(2):141-146. |
| DOI (Digital Object Identifier) : |
10.1136/archdischild-2018-316385 |
| PMID : |
31272969 |
| En línea : |
https://adc.bmj.com/content/early/2019/07/04/archdischild-2018-316385 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4241 |
Gelatin tannate for acute diarrhoea and gastroenteritis in children: a systematic review and meta-analysis [documento electrónico] / Laura Fernanda Niño Serna, . - 2020. Obra : Archives of Disease in ChildhoodIdioma : Inglés ( eng) | Palabras clave : |
Children diarrhoea gastroenteritis gelatin meta-analysis systematic review tannate |
| Resumen : |
Objective: To determine the effectiveness and safety of gelatin tannate (GT) for reducing the duration of the acute diarrhoea and gastroenteritis (ADG) in children. Design: Systematic review and meta-analysis. Data sources: MEDLINE, Embase, CINAHL, Cochrane Central Register of Controlled Trials, LILACS and grey literature, published from inception to October 2018. No language restrictions. Eligibility criteria for selecting studies: Randomised controlled trials in children with ADG, comparing GT with placebo. Results: Of 797 titles identified, we included three studies (276 children). We performed a random effects model meta-analysis for the main outcome (diarrhoea duration). We did not find significant differences between GT and placebo for diarrhoea duration (mean difference (MD)=−15.85 hours; 95% CI −42.24 to 14.82, I2=92%; three studies), stool frequency at day 2 (MD=0.11 stools/day; 95% CI −0.39 to 0.62: I2=26%; two studies), diarrhoea at day 3 (risk ratio [RR]=0.46; 95% CI 0.06 to 3.47: I2=73%; two studies), vomiting (RR=1.31; 95% CI 0.95 to 1.80: I2=0%; two studies) or adverse events (RR=0.86; 95% CI 0.27 to 2.66: I2=0%; two studies). Most common adverse events included abdominal pain and nausea. Conclusion: The effect of GT was no different to placebo for mean diarrhoea duration (low certainty on the evidence) and stool frequency at day 2 (high certainty) and for the presence of diarrhoea at day 3 (very low certainty) of vomiting (moderate certainty) and of adverse events (low certainty). |
| Mención de responsabilidad : |
Ivan D Florez, Javier M Sierra, Laura F Niño-Serna |
| Referencia : |
Arch Dis Child. 2020 Feb;105(2):141-146. |
| DOI (Digital Object Identifier) : |
10.1136/archdischild-2018-316385 |
| PMID : |
31272969 |
| En línea : |
https://adc.bmj.com/content/early/2019/07/04/archdischild-2018-316385 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4241 |
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