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Autor Lina Marcela Cadavid Álvarez
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Comentario :
Médica Radióloga, Hospital Pablo Tobón Uribe
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Documentos disponibles escritos por este autor (9)
Clasificado(s) por (Año de edición descendente) Refinar búsquedaAdherence to treatment for tuberculosis infection in children using a comprehensive care strategy: a prospective cohort study with a historical control group / Andrea Victoria Restrepo Gouzy ; Lina Marcela Cadavid Álvarez
Título : Adherence to treatment for tuberculosis infection in children using a comprehensive care strategy: a prospective cohort study with a historical control group Tipo de documento : documento electrónico Autores : Andrea Victoria Restrepo Gouzy, Autor ; Lina Marcela Cadavid Álvarez, Autor Fecha de publicación : 2025 Títulos uniformes : Lancet Regional Health Americas Idioma : Inglés (eng) Palabras clave : Child; Comprehensive health care; Latent tuberculosis; Medication adherence; Preschool; Treatment adherence and compliance. Resumen : Background: Low adherence to treatment for tuberculosis infection (TBI) in children threatens tuberculosis (TB) control goals. This research focuses on children with close contact to TB and TBI. This study evaluated adherence to treatment of TBI using a comprehensive care strategy (CCS) for close-contact children with pulmonary TB compared with standard of care (SOC). Methods: A prospective cohort study with a historical control group was conducted on children under five, who were close contacts of patients with bacteriologically confirmed pulmonary TB in three Colombian cities (study registration number: NCT04331262). The CCS comprised clinical evaluations, rifampicin for four months, multidisciplinary care, and logistical support, while the SOC followed program regulations with isoniazid for nine months. The primary outcome was the proportion of children completing 100% treatment during follow-up, and the secondary outcome was treatment-related adverse events (AEs). Findings: 213 children in the SOC group and 86 children in the CCS group were analyzed. The treatment adherence in the SOC group was 40·8% (95% CI 34%; 48%), while in the CCS group it was 76·7% (95% CI 66%; 85%). Children exposed to CCS had 87% higher probability of adherence to TBI treatment compared to SOC (RR 1·87; 95% CI 1·52; 2·31). The incidence of AEs was lower in the CCS group (n = 3) than in those receiving SOC (n = 24). Interpretation: The CCS increases adherence to treatment for TBI in children safely compared to SOC. Future cost-effectiveness studies will help implement this strategy in programmatic settings. Funding: Colombian Ministry of Science, Technology and Innovation. Mención de responsabilidad : Iader Rodríguez-Márquez, Dione Benjumea-Bedoya, Andrea Victoria Restrepo-Gouz, Claudia Patricia Beltrán-Arroyave, Diana Marín, Fernando Nicolás Montes-Zuluaga, Juan Carlos Alzate-Ángel, Lina Marcela Cadavid-Álvarez, Lizeth Andrea Paniagua-Saldarriaga, Teresa Realpe, Yesenia Perea-Torres, Lisandra María Arango-García, Natalia Pérez-Doncel, María Patricia Arbeláez-Montoya, Jaime Robledo. Referencia : Lancet Reg Health Am . 2025 Apr 22:46:101094. doi: 10.1016/j.lana.2025.101094. DOI (Digital Object Identifier) : 10.1016/j.lana.2025.101094 PMID : 40329939 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40329939/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Adherence to treatment for tuberculosis infection in children using a comprehensive care strategy: a prospective cohort study with a historical control group [documento electrónico] / Andrea Victoria Restrepo Gouzy, Autor ; Lina Marcela Cadavid Álvarez, Autor . - 2025.
Obra : Lancet Regional Health Americas
Idioma : Inglés (eng)
Palabras clave : Child; Comprehensive health care; Latent tuberculosis; Medication adherence; Preschool; Treatment adherence and compliance. Resumen : Background: Low adherence to treatment for tuberculosis infection (TBI) in children threatens tuberculosis (TB) control goals. This research focuses on children with close contact to TB and TBI. This study evaluated adherence to treatment of TBI using a comprehensive care strategy (CCS) for close-contact children with pulmonary TB compared with standard of care (SOC). Methods: A prospective cohort study with a historical control group was conducted on children under five, who were close contacts of patients with bacteriologically confirmed pulmonary TB in three Colombian cities (study registration number: NCT04331262). The CCS comprised clinical evaluations, rifampicin for four months, multidisciplinary care, and logistical support, while the SOC followed program regulations with isoniazid for nine months. The primary outcome was the proportion of children completing 100% treatment during follow-up, and the secondary outcome was treatment-related adverse events (AEs). Findings: 213 children in the SOC group and 86 children in the CCS group were analyzed. The treatment adherence in the SOC group was 40·8% (95% CI 34%; 48%), while in the CCS group it was 76·7% (95% CI 66%; 85%). Children exposed to CCS had 87% higher probability of adherence to TBI treatment compared to SOC (RR 1·87; 95% CI 1·52; 2·31). The incidence of AEs was lower in the CCS group (n = 3) than in those receiving SOC (n = 24). Interpretation: The CCS increases adherence to treatment for TBI in children safely compared to SOC. Future cost-effectiveness studies will help implement this strategy in programmatic settings. Funding: Colombian Ministry of Science, Technology and Innovation. Mención de responsabilidad : Iader Rodríguez-Márquez, Dione Benjumea-Bedoya, Andrea Victoria Restrepo-Gouz, Claudia Patricia Beltrán-Arroyave, Diana Marín, Fernando Nicolás Montes-Zuluaga, Juan Carlos Alzate-Ángel, Lina Marcela Cadavid-Álvarez, Lizeth Andrea Paniagua-Saldarriaga, Teresa Realpe, Yesenia Perea-Torres, Lisandra María Arango-García, Natalia Pérez-Doncel, María Patricia Arbeláez-Montoya, Jaime Robledo. Referencia : Lancet Reg Health Am . 2025 Apr 22:46:101094. doi: 10.1016/j.lana.2025.101094. DOI (Digital Object Identifier) : 10.1016/j.lana.2025.101094 PMID : 40329939 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/40329939/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Irradiate awareness: Sociedad Latinoamericana de Radiología Pediátrica (SLARP) Campaign Tipo de documento : documento electrónico Autores : Lina Marcela Cadavid Álvarez, Autor ; Ugas Charcape, Carlos F, Autor Fecha de publicación : 2025 Títulos uniformes : Pediatric Radiology Idioma : Inglés (eng) Resumen : Cancer incidence in children remains a significant public health concern, with heightened radiation-induced cancer risks for those undergoing computed tomography (CT) at a young age [1]. In Latin America and the Caribbean, there were 30,194 new cases of childhood cancer in 2022, affect-ing individuals aged 0–19 years, excluding non-melanoma skin cancer [2].The use of CT scans in pediatric populations raises con-cerns about the potential carcinogenic risks associated with ionizing radiation exposure, which are attributed to factors such as direct and indirect DNA damage and the heightened radiosensitivity of cells during mitosis [3].Several studies enhance our understanding of the risks associated with ionizing radiation emitted by CT scans. Pearce et?al. found that cumulative doses of approximately 50 mGy could nearly triple leukemia risk, while doses around 60 mGy could triple the risk of brain cancer [4]. It is important to note that, given the low radiation doses used in medical imaging, the benefits of a CT exam that is medically justified will significantly outweigh the minimal potential risk of developing cancer. Mención de responsabilidad : Lina Cadavid; Carlos F Ugas Charcape Referencia : Pediatr Radiol. 2025 Jul;55(8):1741-1744 DOI (Digital Object Identifier) : 10.1007/s00247-025-06296-1 PMID : 40522471 Derechos de uso : CC BY-NC En línea : https://link.springer.com/epdf/10.1007/s00247-025-06296-1?sharing_token=xhtRES7_ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Irradiate awareness: Sociedad Latinoamericana de Radiología Pediátrica (SLARP) Campaign [documento electrónico] / Lina Marcela Cadavid Álvarez, Autor ; Ugas Charcape, Carlos F, Autor . - 2025.
Obra : Pediatric Radiology
Idioma : Inglés (eng)
Resumen : Cancer incidence in children remains a significant public health concern, with heightened radiation-induced cancer risks for those undergoing computed tomography (CT) at a young age [1]. In Latin America and the Caribbean, there were 30,194 new cases of childhood cancer in 2022, affect-ing individuals aged 0–19 years, excluding non-melanoma skin cancer [2].The use of CT scans in pediatric populations raises con-cerns about the potential carcinogenic risks associated with ionizing radiation exposure, which are attributed to factors such as direct and indirect DNA damage and the heightened radiosensitivity of cells during mitosis [3].Several studies enhance our understanding of the risks associated with ionizing radiation emitted by CT scans. Pearce et?al. found that cumulative doses of approximately 50 mGy could nearly triple leukemia risk, while doses around 60 mGy could triple the risk of brain cancer [4]. It is important to note that, given the low radiation doses used in medical imaging, the benefits of a CT exam that is medically justified will significantly outweigh the minimal potential risk of developing cancer. Mención de responsabilidad : Lina Cadavid; Carlos F Ugas Charcape Referencia : Pediatr Radiol. 2025 Jul;55(8):1741-1744 DOI (Digital Object Identifier) : 10.1007/s00247-025-06296-1 PMID : 40522471 Derechos de uso : CC BY-NC En línea : https://link.springer.com/epdf/10.1007/s00247-025-06296-1?sharing_token=xhtRES7_ [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Reproducibility of a protocol for standardized reading of chest X-rays of children household contact of patients with tuberculosis Tipo de documento : documento electrónico Autores : Lina Marcela Cadavid Álvarez, ; Lucila Beatriz Molinares Arevalo, Fecha de publicación : 2022 Títulos uniformes : BMC Pediatrics Idioma : Inglés (eng) Palabras clave : Tuberculosis Pulmonary Latent Tuberculosis Clinical Protocols Radiography Thoracic Observer Variation Reproducibility of Results Resumen : Background: The interpretation of the chest radiograph may vary because it depends on the reader and due to the non-specificity of findings in tuberculosis (TB). We aim to assess the reproducibility of a standardized chest radiograph reading protocol in contacts of patients with pulmonary TB under the 5 years of age. Methods: Descriptive, cross-sectional study with children under the age of five, household contacts of patients with confirmed pulmonary TB from Medellín, Bello and Itagüí (Colombia) between Jan-01-2015 and May-31-2016. Standardized reading protocol: two radiologists, blinded independent reading, use of template (Dr. Andronikou design) in case of disagreement a third reading was performed. Kappa coefficient for intra and inter observer agreement, and prevalence ratio were estimated of sociodemographic characteristics, TB exposure and interpretation of chest X-ray. Results: From 278 children, standardized reading found 255 (91.7%) normal X-rays, 10 (3.6%) consistent with TB, and 13 (4.7%) other alterations. Global agreement was 91.3% (Kappa = 0.51). Inter-observer agreement between readers 1-2 was 90.0% (Kappa = 0.59) and 1-3 93.2% (Kappa = 0.59). Intra-observer agreement for reader 1 was 95.5% (Kappa = 0.86), 2 84.0% (Kappa = 0.51), and 3 94.7% (Kappa = 0.68). Greater inter-observer disagreement was between readers 1-2 for soft tissue density suggestive of adenopathy (4.6%), airspace opacification (1.17%) and pleural effusion (0.58%); between readers 1-3 for soft tissue density suggestive of adenopathy (4.2%), opacification of airspace (2.5%) and cavities (0.8%). Conclusions: Chest radiographs are an affordable tool that contributes to the diagnosis of TB, so having a standardized reading protocol showed good agreement and improves the reproducibility of radiograph interpretation. Mención de responsabilidad : María Margarita Lozano-Acosta, María Alejandra Rubiano-Arenas, Lina Marcela Cadavid, Guillermo Vélez-Parra, Beatriz Molinares, Diana Marcela Marín-Pineda, María Patricia Arbeláez-Montoya & Dione Benjumea-Bedoya Referencia : BMC Pediatr. 2022 May 24;22(1):307. DOI (Digital Object Identifier) : 10.1186/s12887-022-03347-6 PMID : 35610599 Derechos de uso : CC BY En línea : https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-022-03347-6 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reproducibility of a protocol for standardized reading of chest X-rays of children household contact of patients with tuberculosis [documento electrónico] / Lina Marcela Cadavid Álvarez, ; Lucila Beatriz Molinares Arevalo, . - 2022.
Obra : BMC Pediatrics
Idioma : Inglés (eng)
Palabras clave : Tuberculosis Pulmonary Latent Tuberculosis Clinical Protocols Radiography Thoracic Observer Variation Reproducibility of Results Resumen : Background: The interpretation of the chest radiograph may vary because it depends on the reader and due to the non-specificity of findings in tuberculosis (TB). We aim to assess the reproducibility of a standardized chest radiograph reading protocol in contacts of patients with pulmonary TB under the 5 years of age. Methods: Descriptive, cross-sectional study with children under the age of five, household contacts of patients with confirmed pulmonary TB from Medellín, Bello and Itagüí (Colombia) between Jan-01-2015 and May-31-2016. Standardized reading protocol: two radiologists, blinded independent reading, use of template (Dr. Andronikou design) in case of disagreement a third reading was performed. Kappa coefficient for intra and inter observer agreement, and prevalence ratio were estimated of sociodemographic characteristics, TB exposure and interpretation of chest X-ray. Results: From 278 children, standardized reading found 255 (91.7%) normal X-rays, 10 (3.6%) consistent with TB, and 13 (4.7%) other alterations. Global agreement was 91.3% (Kappa = 0.51). Inter-observer agreement between readers 1-2 was 90.0% (Kappa = 0.59) and 1-3 93.2% (Kappa = 0.59). Intra-observer agreement for reader 1 was 95.5% (Kappa = 0.86), 2 84.0% (Kappa = 0.51), and 3 94.7% (Kappa = 0.68). Greater inter-observer disagreement was between readers 1-2 for soft tissue density suggestive of adenopathy (4.6%), airspace opacification (1.17%) and pleural effusion (0.58%); between readers 1-3 for soft tissue density suggestive of adenopathy (4.2%), opacification of airspace (2.5%) and cavities (0.8%). Conclusions: Chest radiographs are an affordable tool that contributes to the diagnosis of TB, so having a standardized reading protocol showed good agreement and improves the reproducibility of radiograph interpretation. Mención de responsabilidad : María Margarita Lozano-Acosta, María Alejandra Rubiano-Arenas, Lina Marcela Cadavid, Guillermo Vélez-Parra, Beatriz Molinares, Diana Marcela Marín-Pineda, María Patricia Arbeláez-Montoya & Dione Benjumea-Bedoya Referencia : BMC Pediatr. 2022 May 24;22(1):307. DOI (Digital Object Identifier) : 10.1186/s12887-022-03347-6 PMID : 35610599 Derechos de uso : CC BY En línea : https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-022-03347-6 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Malignant peripheral nerve sheath tumor in a child Tipo de documento : documento electrónico Autores : Lina Marcela Cadavid Álvarez, ; Gabriel Jaime Varela Aguirre, Fecha de publicación : 2021 Títulos uniformes : Radiology Case Reports Idioma : Inglés (eng) Palabras clave : Child Malignant peripheral nerve sheath tumor Nerve sheath neoplasms Neurofibroma Peripheral nerve Schwannoma Resumen : Among the diverse causes of posterior mediastinal masses, malignant peripheral nerve sheath tumors is a very rare neurogenic tumor. Imaging features tend to be variable. A 20-month-old toddler presented with a 3-month history of persistent diffuse thoracic and abdominal pain. A chest magnetic resonance imaging was taken and shown a posterior mediastinal lesion. Histopathology and immunohistochemical analysis confirmed the diagnosis of a malignant peripheral nerve sheath tumor with myxoid areas. Malignant peripheral nerve sheath tumors are an uncommon entity in the children with a poor prognosis. Magnetic resonance imaging is the preferred technique in children to limit the use of ionizing radiation and because has a higher contrast resolution; however, all suspicious tumors should be biopsied to make an appropriate diagnosis. Treatment is radical surgery with excision of the entire mass; however, there is a high incidence of local recurrence. Mención de responsabilidad : Brian Daniel Noreña-Rengifo MD, Lina Marcela Cadavid-Alvarez RR, Patricia Eugenia Gil-Serrano RR y Gabriel Jaime Varela-Aguirre PR Referencia : Radiol Case Rep. 2020 Nov 12;16(1):145-151. DOI (Digital Object Identifier) : 10.1016/j.radcr.2020.10.028 PMID : 33224401 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S1930-0433(20)30547-1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Malignant peripheral nerve sheath tumor in a child [documento electrónico] / Lina Marcela Cadavid Álvarez, ; Gabriel Jaime Varela Aguirre, . - 2021.
Obra : Radiology Case Reports
Idioma : Inglés (eng)
Palabras clave : Child Malignant peripheral nerve sheath tumor Nerve sheath neoplasms Neurofibroma Peripheral nerve Schwannoma Resumen : Among the diverse causes of posterior mediastinal masses, malignant peripheral nerve sheath tumors is a very rare neurogenic tumor. Imaging features tend to be variable. A 20-month-old toddler presented with a 3-month history of persistent diffuse thoracic and abdominal pain. A chest magnetic resonance imaging was taken and shown a posterior mediastinal lesion. Histopathology and immunohistochemical analysis confirmed the diagnosis of a malignant peripheral nerve sheath tumor with myxoid areas. Malignant peripheral nerve sheath tumors are an uncommon entity in the children with a poor prognosis. Magnetic resonance imaging is the preferred technique in children to limit the use of ionizing radiation and because has a higher contrast resolution; however, all suspicious tumors should be biopsied to make an appropriate diagnosis. Treatment is radical surgery with excision of the entire mass; however, there is a high incidence of local recurrence. Mención de responsabilidad : Brian Daniel Noreña-Rengifo MD, Lina Marcela Cadavid-Alvarez RR, Patricia Eugenia Gil-Serrano RR y Gabriel Jaime Varela-Aguirre PR Referencia : Radiol Case Rep. 2020 Nov 12;16(1):145-151. DOI (Digital Object Identifier) : 10.1016/j.radcr.2020.10.028 PMID : 33224401 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S1930-0433(20)30547-1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Primitive neuroectodermal tumor of the liver: a case report of a rare case in pediatrics Tipo de documento : documento electrónico Autores : Lina Marcela Cadavid Álvarez, ; Jorge Alberto Ochoa Gaviria, ; Juan Camilo Pérez Cadavid, Fecha de publicación : 2021 Títulos uniformes : Radiology Case Reports Idioma : Inglés (eng) Palabras clave : Primitive neuroectodermal tumor Focal hepatic lesion Ewing sarcoma Resumen : Primitive neuroectodermal tumors (PNETs) belong to the Ewing sarcoma family of tumors. These lesions are highly aggressive and are usually found in paravertebral regions, lower limbs, and thorax. However, abdominal PNETs are extremely rare, and only 3 cases of pediatric PNET of the liver have been previously reported. Most patients exhibit symptoms associated with mass effect, due to rapid tumor growth and dissemination. Therefore, an appropriate differential diagnosis is of pivotal importance in order to initiate the corresponding treatment. Here we report the case of a 4-year-old female patient who was diagnosed with PNET of the liver, and we discuss the analysis of focal liver lesions and differential diagnosis in pediatric patients. Mención de responsabilidad : Juan David Vásquez Montoya, Lina Marcela Cadavid Álvarez, Jorge Alberto Ochoa Gaviria, Juan Camilo Pérez Cadavid Referencia : Radiol Case Rep. 2021 Jun 13;16(8):2220-2225. DOI (Digital Object Identifier) : 10.1016/j.radcr.2021.05.001 PMID : 34178196 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S1930043321002909 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Primitive neuroectodermal tumor of the liver: a case report of a rare case in pediatrics [documento electrónico] / Lina Marcela Cadavid Álvarez, ; Jorge Alberto Ochoa Gaviria, ; Juan Camilo Pérez Cadavid, . - 2021.
Obra : Radiology Case Reports
Idioma : Inglés (eng)
Palabras clave : Primitive neuroectodermal tumor Focal hepatic lesion Ewing sarcoma Resumen : Primitive neuroectodermal tumors (PNETs) belong to the Ewing sarcoma family of tumors. These lesions are highly aggressive and are usually found in paravertebral regions, lower limbs, and thorax. However, abdominal PNETs are extremely rare, and only 3 cases of pediatric PNET of the liver have been previously reported. Most patients exhibit symptoms associated with mass effect, due to rapid tumor growth and dissemination. Therefore, an appropriate differential diagnosis is of pivotal importance in order to initiate the corresponding treatment. Here we report the case of a 4-year-old female patient who was diagnosed with PNET of the liver, and we discuss the analysis of focal liver lesions and differential diagnosis in pediatric patients. Mención de responsabilidad : Juan David Vásquez Montoya, Lina Marcela Cadavid Álvarez, Jorge Alberto Ochoa Gaviria, Juan Camilo Pérez Cadavid Referencia : Radiol Case Rep. 2021 Jun 13;16(8):2220-2225. DOI (Digital Object Identifier) : 10.1016/j.radcr.2021.05.001 PMID : 34178196 Derechos de uso : CC BY-NC-ND En línea : https://linkinghub.elsevier.com/retrieve/pii/S1930043321002909 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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