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Autor Leonardo Fabio Moreno Gómez
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Jefe Sección Neurología, Hospital Pablo Tobón Uribe
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Documentos disponibles escritos por este autor (8)
Clasificado(s) por (Año de edición descendente) Refinar búsquedaDetecting Parkinson’s disease and its cognitive phenotypes via automated semantic analyses of action stories / Leonardo Fabio Moreno Gómez
Título : Detecting Parkinson’s disease and its cognitive phenotypes via automated semantic analyses of action stories Tipo de documento : documento electrónico Autores : Leonardo Fabio Moreno Gómez, Fecha de publicación : 2022 Títulos uniformes : NPJ Parkinson's Disease Idioma : Inglés (eng) Resumen : Action-concept outcomes are useful targets to identify Parkinson’s disease (PD) patients and differentiate between those with and without mild cognitive impairment (PD-MCI, PD-nMCI). Yet, most approaches employ burdensome examiner-dependent tasks, limiting their utility. We introduce a framework capturing action-concept markers automatically in natural speech. Patients from both subgroups and controls retold an action-laden and a non-action-laden text (AT, nAT). In each retelling, we weighed action and non-action concepts through our automated Proximity-to-Reference-Semantic-Field (P-RSF) metric, for analysis via ANCOVAs (controlling for cognitive dysfunction) and support vector machines. Patients were differentiated from controls based on AT (but not nAT) P-RSF scores. The same occurred in PD-nMCI patients. Conversely, PD-MCI patients exhibited reduced P-RSF scores for both texts. Direct discrimination between patient subgroups was not systematic, but it yielded best outcomes via AT scores. Our approach outperformed classifiers based on corpus-derived embeddings. This framework opens scalable avenues to support PD diagnosis and phenotyping. Mención de responsabilidad : Adolfo M. García, Daniel Escobar-Grisales, Juan Camilo Vásquez Correa, Yamile Bocanegra, Leonardo Moreno, Jairo Carmona & Juan Rafael Orozco-Arroyave Referencia : NPJ Parkinsons Dis. 2022 Nov 25;8(1):163. DOI (Digital Object Identifier) : 10.1038/s41531-022-00422-8 PMID : 36434017 Derechos de uso : CC BY En línea : https://www.nature.com/articles/s41531-022-00422-8 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6081 Detecting Parkinson’s disease and its cognitive phenotypes via automated semantic analyses of action stories [documento electrónico] / Leonardo Fabio Moreno Gómez, . - 2022.
Obra : NPJ Parkinson's Disease
Idioma : Inglés (eng)
Resumen : Action-concept outcomes are useful targets to identify Parkinson’s disease (PD) patients and differentiate between those with and without mild cognitive impairment (PD-MCI, PD-nMCI). Yet, most approaches employ burdensome examiner-dependent tasks, limiting their utility. We introduce a framework capturing action-concept markers automatically in natural speech. Patients from both subgroups and controls retold an action-laden and a non-action-laden text (AT, nAT). In each retelling, we weighed action and non-action concepts through our automated Proximity-to-Reference-Semantic-Field (P-RSF) metric, for analysis via ANCOVAs (controlling for cognitive dysfunction) and support vector machines. Patients were differentiated from controls based on AT (but not nAT) P-RSF scores. The same occurred in PD-nMCI patients. Conversely, PD-MCI patients exhibited reduced P-RSF scores for both texts. Direct discrimination between patient subgroups was not systematic, but it yielded best outcomes via AT scores. Our approach outperformed classifiers based on corpus-derived embeddings. This framework opens scalable avenues to support PD diagnosis and phenotyping. Mención de responsabilidad : Adolfo M. García, Daniel Escobar-Grisales, Juan Camilo Vásquez Correa, Yamile Bocanegra, Leonardo Moreno, Jairo Carmona & Juan Rafael Orozco-Arroyave Referencia : NPJ Parkinsons Dis. 2022 Nov 25;8(1):163. DOI (Digital Object Identifier) : 10.1038/s41531-022-00422-8 PMID : 36434017 Derechos de uso : CC BY En línea : https://www.nature.com/articles/s41531-022-00422-8 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6081 Reserva
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Título : Aporte de la 18F-FDG PET/TC en la enfermedad de Creutzfeldt-Jakob esporádica Otros títulos : Contribution of the 18F-FDG PET/CT IN sporadic Creutzfeldt-Jakob disease Tipo de documento : documento electrónico Autores : Feliza Restrepo Restrepo, ; Leonardo Fabio Moreno Gómez, ; Alejandro Delgado Quijano, ; Mónica Alexandra Vidal González, Fecha de publicación : 2021 Títulos uniformes : Revista Colombiana de Radiología Idioma : Español (spa) Palabras clave : Enfermedad de Creutzfeldt-Jakob Enfermedad por prión Tomografía por emisión de positrones Imagen por resonancia magnética Resumen : La enfermedad de Creutzfeldt-Jakob esporádica (ECJe) es un trastorno neurodegenerativo transmisible extremadamente raro, caracterizado por demencia rápidamente progresiva. En la tomografía por emisión de positrones con 18F-fluoro-2-desoxi-D-glucosa (FDG-PET) de estos pacientes se ha descrito hipometabolismo cortical bilateral parietal, frontal y occipital, sin alteraciones en el cerebelo ni en los ganglios basales, lo que podría contribuir con el diagnóstico diferencial de demencia rápidamente progresiva. Se presenta el caso de un hombre de 75 años, con antecedente de cáncer de próstata y trastorno afectivo bipolar, con dos semanas de cambios comportamentales y anímicos, déficit cognitivo, alucinaciones visuales y auditivas y desorientación espacial con rápida progresión; posteriormente presentó marcha lenta, temblor en miembros inferiores y Babinski derecho. La resonancia (RM) cerebral contrastada mostró restricción a la difusión en corteza frontal bilateral, corteza temporal y giro del cíngulo, con diagnóstico de síndrome paraneoplásico versus enfermedad por priones; FDG-PET con hipometabolismo en la corteza frontal bilateral y lóbulo temporal y parietal derechos. La medición de la proteína 14-3-3, proteína T-Tau y conversión de proteína priónica inducida por agitación en tiempo real (RT-QUIC) en líquido cefalorraquídeo confirma el diagnóstico de enfermedad por priones. Mención de responsabilidad : Sara Lucía López González, Feliza Restrepo Restrepo, Leonardo Fabio Moreno Gómez, Alejandro Delgado Quijano, Mónica Alexandra Vidal González DOI (Digital Object Identifier) : 10.53903/01212095.107 En línea : https://rcr.acronline.org/index.php/rcr/article/view/107 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6154 Aporte de la 18F-FDG PET/TC en la enfermedad de Creutzfeldt-Jakob esporádica = Contribution of the 18F-FDG PET/CT IN sporadic Creutzfeldt-Jakob disease [documento electrónico] / Feliza Restrepo Restrepo, ; Leonardo Fabio Moreno Gómez, ; Alejandro Delgado Quijano, ; Mónica Alexandra Vidal González, . - 2021.
Obra : Revista Colombiana de Radiología
Idioma : Español (spa)
Palabras clave : Enfermedad de Creutzfeldt-Jakob Enfermedad por prión Tomografía por emisión de positrones Imagen por resonancia magnética Resumen : La enfermedad de Creutzfeldt-Jakob esporádica (ECJe) es un trastorno neurodegenerativo transmisible extremadamente raro, caracterizado por demencia rápidamente progresiva. En la tomografía por emisión de positrones con 18F-fluoro-2-desoxi-D-glucosa (FDG-PET) de estos pacientes se ha descrito hipometabolismo cortical bilateral parietal, frontal y occipital, sin alteraciones en el cerebelo ni en los ganglios basales, lo que podría contribuir con el diagnóstico diferencial de demencia rápidamente progresiva. Se presenta el caso de un hombre de 75 años, con antecedente de cáncer de próstata y trastorno afectivo bipolar, con dos semanas de cambios comportamentales y anímicos, déficit cognitivo, alucinaciones visuales y auditivas y desorientación espacial con rápida progresión; posteriormente presentó marcha lenta, temblor en miembros inferiores y Babinski derecho. La resonancia (RM) cerebral contrastada mostró restricción a la difusión en corteza frontal bilateral, corteza temporal y giro del cíngulo, con diagnóstico de síndrome paraneoplásico versus enfermedad por priones; FDG-PET con hipometabolismo en la corteza frontal bilateral y lóbulo temporal y parietal derechos. La medición de la proteína 14-3-3, proteína T-Tau y conversión de proteína priónica inducida por agitación en tiempo real (RT-QUIC) en líquido cefalorraquídeo confirma el diagnóstico de enfermedad por priones. Mención de responsabilidad : Sara Lucía López González, Feliza Restrepo Restrepo, Leonardo Fabio Moreno Gómez, Alejandro Delgado Quijano, Mónica Alexandra Vidal González DOI (Digital Object Identifier) : 10.53903/01212095.107 En línea : https://rcr.acronline.org/index.php/rcr/article/view/107 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=6154 Reserva
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Título : Resting-state EEG alpha/theta ratio related to neuropsychological test performance in Parkinson's Disease Tipo de documento : documento electrónico Autores : Leonardo Fabio Moreno Gómez, Fecha de publicación : 2021 Títulos uniformes : Clinical Neurophysiology Idioma : Inglés (eng) Palabras clave : Alpha rhythm Electroencephalography Neuropsychological tests Parkinson’s Disease Theta rhythm Resumen : Objective: To determine possible associations of hemispheric-regional alpha/theta ratio (α/θ) with neuropsychological test performance in Parkinson's Disease (PD) non-demented patients. Methods: 36 PD were matched to 36 Healthy Controls (HC). The α/θ in eight hemispheric regions was computed from the relative power spectral density of the resting-state quantitative electroencephalogram (qEEG). Correlations between α/θ and performance in several neuropsychological tests were conducted, significant findings were included in a moderation analysis. Results: The α/θ in all regions was lower in PD than in HC, with larger effect sizes in the posterior regions. Right parietal, and right and left occipital α/θ had significant positive correlations with performance in Judgement of Line Orientation Test (JLOT) in PD. Adjusted moderation analysis indicated that right, but not left, occipital α/θ influenced the JLOT performance related to PD. Conclusions: Reduction of the occipital α/θ, in particular on the right side, was associated with visuospatial performance impairment in PD. Significance: Visuospatial impairment in PD, which is highly correlated with the subsequent development of dementia, is reflected in α/θ in the right posterior regions. The right occipital α/θ may represent a useful qEEG marker for evaluating the presence of early signs of cognitive decline in PD and the subsequent risk of dementia. Mención de responsabilidad : Alberto Jaramillo-Jimenez, Jazmin Ximena Suarez-Revelo, John Fredy Ochoa-Gomez, Jairo Alexander Carmona Arroyave, Yamile Bocanegra, Francisco Lopera, Omar Buriticá, David Antonio Pineda-Salazar, Leonardo Moreno Gómez, Carlos Andrés Tobón Quintero, Miguel Germán Borda, Laura Bonanni, Dominic H Ffytche, Kolbjørn Brønnick, Dag Aarsland Referencia : Clin Neurophysiol. 2021 Jan 13;132(3):756-764. DOI (Digital Object Identifier) : 10.1016/j.clinph.2021.01.001 PMID : 33571883 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(21)00003-1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5758 Resting-state EEG alpha/theta ratio related to neuropsychological test performance in Parkinson's Disease [documento electrónico] / Leonardo Fabio Moreno Gómez, . - 2021.
Obra : Clinical Neurophysiology
Idioma : Inglés (eng)
Palabras clave : Alpha rhythm Electroencephalography Neuropsychological tests Parkinson’s Disease Theta rhythm Resumen : Objective: To determine possible associations of hemispheric-regional alpha/theta ratio (α/θ) with neuropsychological test performance in Parkinson's Disease (PD) non-demented patients. Methods: 36 PD were matched to 36 Healthy Controls (HC). The α/θ in eight hemispheric regions was computed from the relative power spectral density of the resting-state quantitative electroencephalogram (qEEG). Correlations between α/θ and performance in several neuropsychological tests were conducted, significant findings were included in a moderation analysis. Results: The α/θ in all regions was lower in PD than in HC, with larger effect sizes in the posterior regions. Right parietal, and right and left occipital α/θ had significant positive correlations with performance in Judgement of Line Orientation Test (JLOT) in PD. Adjusted moderation analysis indicated that right, but not left, occipital α/θ influenced the JLOT performance related to PD. Conclusions: Reduction of the occipital α/θ, in particular on the right side, was associated with visuospatial performance impairment in PD. Significance: Visuospatial impairment in PD, which is highly correlated with the subsequent development of dementia, is reflected in α/θ in the right posterior regions. The right occipital α/θ may represent a useful qEEG marker for evaluating the presence of early signs of cognitive decline in PD and the subsequent risk of dementia. Mención de responsabilidad : Alberto Jaramillo-Jimenez, Jazmin Ximena Suarez-Revelo, John Fredy Ochoa-Gomez, Jairo Alexander Carmona Arroyave, Yamile Bocanegra, Francisco Lopera, Omar Buriticá, David Antonio Pineda-Salazar, Leonardo Moreno Gómez, Carlos Andrés Tobón Quintero, Miguel Germán Borda, Laura Bonanni, Dominic H Ffytche, Kolbjørn Brønnick, Dag Aarsland Referencia : Clin Neurophysiol. 2021 Jan 13;132(3):756-764. DOI (Digital Object Identifier) : 10.1016/j.clinph.2021.01.001 PMID : 33571883 En línea : https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(21)00003-1 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5758 Reserva
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Título : Subjective cognitive and communicative complaints and health-related quality of life in Parkinson's disease with and without mild cognitive impairment Otros títulos : Quejas subjetivas cognitivas y comunicativas y calidad de vida relacionada con la salud en la enfermedad de Parkinson con y sin deterioro cognitivo leve Tipo de documento : documento electrónico Autores : Leonardo Fabio Moreno Gómez, Fecha de publicación : 2021 Títulos uniformes : Revista Colombiana de Psiquiatría Idioma : Inglés (eng) Palabras clave : Parkinson’s disease Health-related quality of life Quality of life Cognitive decline Mild cognitive impairment Resumen : Introduction: Mild Cognitive Impairment (MCI) is common in Parkinson's Disease (PD). Few studies have compared the Health-Related Quality of Life (HRQoL) in patients with and without MCI due to PD (PD-MCI), and its correlation to patients’ subjective cognitive and communicative difficulties has not been explored. Objective: We aimed to compare HRQoL in PD-MCI and PD without MCI (PD-nMCI), and explore its possible relationship to subjective cognitive and communicative complaints. Methods: We included 29 PD-nMCI and 11 PD-MCI patients. The HRQoL was assessed with the Parkinson's Disease Questionnaire-39 (PDQ-39): its Cognition dimension was used as a measure of subjective cognitive complaints, its Communication dimension for subjective communicative complaints, and the summary index (PDQ-39 SI) as an indicator of HRQoL. Non-parametric partial correlations between the Cognition and Communication dimensions, and the adjusted PDQ-39 SI were conducted. Results: PD-MCI patients had greater subjective cognitive and communicative complaints and worse HRQoL than PD-nMCI patients. In the PD-MCI group, both subjective cognitive and communicative complaints exhibited significant direct correlations with the adjusted HRQoL scores. Conclusions: HRQoL seems to be affected in PD-MCI, and it might be influenced by greater subjective cognitive and communicative complaints. Including patient-reported outcome measures of HRQoL, and providing cognitive and speech rehabilitation, as well as psychotherapeutic strategies to face these deficits can enhance the patient-centred approach in PD. Mención de responsabilidad : Alberto Jaramillo-Jimenez, Yamile Bocanegra, Omar Buriticá, David Antonio Pineda Salazar, Leonardo Moreno Gómez, Carlos Andrés Tobón Quintero, Daniel Camilo Aguirre-Acevedo, Melissa Sierra Castrillon, Daniel Vasquez, Juan Esteban Velez-Hernandez, Miguel Germán Borda, Elkin García-Cifuentes, David Fernando Aguillón, Lucía Madrigal-Zapata, Dag Aarsland y Francisco Lopera Referencia : Rev Colomb Psiquiatr (Engl Ed). 2021 Sep 3;S0034-7450(21)00134-7. DOI (Digital Object Identifier) : 10.1016/j.rcp.2021.07.005 PMID : 34489098 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0034745021001347 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5869 Subjective cognitive and communicative complaints and health-related quality of life in Parkinson's disease with and without mild cognitive impairment = Quejas subjetivas cognitivas y comunicativas y calidad de vida relacionada con la salud en la enfermedad de Parkinson con y sin deterioro cognitivo leve [documento electrónico] / Leonardo Fabio Moreno Gómez, . - 2021.
Obra : Revista Colombiana de Psiquiatría
Idioma : Inglés (eng)
Palabras clave : Parkinson’s disease Health-related quality of life Quality of life Cognitive decline Mild cognitive impairment Resumen : Introduction: Mild Cognitive Impairment (MCI) is common in Parkinson's Disease (PD). Few studies have compared the Health-Related Quality of Life (HRQoL) in patients with and without MCI due to PD (PD-MCI), and its correlation to patients’ subjective cognitive and communicative difficulties has not been explored. Objective: We aimed to compare HRQoL in PD-MCI and PD without MCI (PD-nMCI), and explore its possible relationship to subjective cognitive and communicative complaints. Methods: We included 29 PD-nMCI and 11 PD-MCI patients. The HRQoL was assessed with the Parkinson's Disease Questionnaire-39 (PDQ-39): its Cognition dimension was used as a measure of subjective cognitive complaints, its Communication dimension for subjective communicative complaints, and the summary index (PDQ-39 SI) as an indicator of HRQoL. Non-parametric partial correlations between the Cognition and Communication dimensions, and the adjusted PDQ-39 SI were conducted. Results: PD-MCI patients had greater subjective cognitive and communicative complaints and worse HRQoL than PD-nMCI patients. In the PD-MCI group, both subjective cognitive and communicative complaints exhibited significant direct correlations with the adjusted HRQoL scores. Conclusions: HRQoL seems to be affected in PD-MCI, and it might be influenced by greater subjective cognitive and communicative complaints. Including patient-reported outcome measures of HRQoL, and providing cognitive and speech rehabilitation, as well as psychotherapeutic strategies to face these deficits can enhance the patient-centred approach in PD. Mención de responsabilidad : Alberto Jaramillo-Jimenez, Yamile Bocanegra, Omar Buriticá, David Antonio Pineda Salazar, Leonardo Moreno Gómez, Carlos Andrés Tobón Quintero, Daniel Camilo Aguirre-Acevedo, Melissa Sierra Castrillon, Daniel Vasquez, Juan Esteban Velez-Hernandez, Miguel Germán Borda, Elkin García-Cifuentes, David Fernando Aguillón, Lucía Madrigal-Zapata, Dag Aarsland y Francisco Lopera Referencia : Rev Colomb Psiquiatr (Engl Ed). 2021 Sep 3;S0034-7450(21)00134-7. DOI (Digital Object Identifier) : 10.1016/j.rcp.2021.07.005 PMID : 34489098 En línea : https://linkinghub.elsevier.com/retrieve/pii/S0034745021001347 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5869 Reserva
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Título : Resting functional connectivity and mild cognitive impairment in Parkinson's disease. An electroencephalogram study Tipo de documento : documento electrónico Autores : Leonardo Fabio Moreno Gómez, Fecha de publicación : 2019 Títulos uniformes : Future Neurology Idioma : Inglés (eng) Palabras clave : cognitive impairment electroencephalography executive functions functional connectivity Parkinson’s disease resting state Resumen : Objective: Parkinson’s disease (PD) is characterized by cognitive deficits. There is not clarity about electroencephalogram (EEG) connectivity related to the cognitive profile of patients. Our objective was to evaluate connectivity over resting EEG in nondemented PD. Methods: PD subjects with and without mild cognitive impairment (MCI) were assessed using coherence from resting EEG for local, intra and interhemispheric connectivity. Results: PD subjects without MCI (PD-nMCI) had lower intra and interhemispheric coherence in alpha2 compared with controls. PD with MCI (PD-MCI) showed higher intra and posterior interhemispheric coherence in alpha2 and beta1, respectively, in comparison to PD-nMCI. PD-MCI presented lower frontal coherence in beta frequencies compared with PD-nMCI. Conclusion: EEG coherence measures indicate distinct cortical activity in PD with and without MCI. Mención de responsabilidad : Jairo Alexander Carmona Arroyave, Carlos Andrés Tobón Quintero, Jasmín Jimena Suárez Revelo, John Fredy Ochoa Gómez, Yamile Bocanegra García, Leonardo Moreno Gómez & David Antonio Pineda Salazar DOI (Digital Object Identifier) : 10.2217/fnl-2018-0048 Derechos de uso : CC BY-NC-ND En línea : https://www.futuremedicine.com/doi/10.2217/fnl-2018-0048 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4293 Resting functional connectivity and mild cognitive impairment in Parkinson's disease. An electroencephalogram study [documento electrónico] / Leonardo Fabio Moreno Gómez, . - 2019.
Obra : Future Neurology
Idioma : Inglés (eng)
Palabras clave : cognitive impairment electroencephalography executive functions functional connectivity Parkinson’s disease resting state Resumen : Objective: Parkinson’s disease (PD) is characterized by cognitive deficits. There is not clarity about electroencephalogram (EEG) connectivity related to the cognitive profile of patients. Our objective was to evaluate connectivity over resting EEG in nondemented PD. Methods: PD subjects with and without mild cognitive impairment (MCI) were assessed using coherence from resting EEG for local, intra and interhemispheric connectivity. Results: PD subjects without MCI (PD-nMCI) had lower intra and interhemispheric coherence in alpha2 compared with controls. PD with MCI (PD-MCI) showed higher intra and posterior interhemispheric coherence in alpha2 and beta1, respectively, in comparison to PD-nMCI. PD-MCI presented lower frontal coherence in beta frequencies compared with PD-nMCI. Conclusion: EEG coherence measures indicate distinct cortical activity in PD with and without MCI. Mención de responsabilidad : Jairo Alexander Carmona Arroyave, Carlos Andrés Tobón Quintero, Jasmín Jimena Suárez Revelo, John Fredy Ochoa Gómez, Yamile Bocanegra García, Leonardo Moreno Gómez & David Antonio Pineda Salazar DOI (Digital Object Identifier) : 10.2217/fnl-2018-0048 Derechos de uso : CC BY-NC-ND En línea : https://www.futuremedicine.com/doi/10.2217/fnl-2018-0048 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4293 Reserva
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