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Documentos disponibles con este título uniforme (10)
Clasificado(s) por (Año de edición descendente) Refinar búsquedaFactors Associated With Complications in Patients With Hematological Malignancies and Febrile Neutropenia: A Cohort Study / De la Peña Lozano, Ioka ; Alvarez Payares, Jose C. ; Alvarez Lopez, Santiago ; Agámez Gómez, José E. ; Hernández Rodriguez, Juan C. ; Ramírez Roldán, Alejandra ; Molina Prado, Ángel D. ; Cardona Jaramillo, Manuela ; Trejos Tenorio, Adriana M. ; Ospina Ospina, Sigifredo ; Barrera Correa, Daniel ; Ribero Vargas, Daniel A. ; Ariza Parra, Edwin J ; Karduss Urueta, Amado J.
Título : Factors Associated With Complications in Patients With Hematological Malignancies and Febrile Neutropenia: A Cohort Study Tipo de documento : documento electrónico Autores : De la Peña Lozano, Ioka, Autor ; Alvarez Payares, Jose C., Autor ; Alvarez Lopez, Santiago, Autor ; Agámez Gómez, José E., Autor ; Hernández Rodriguez, Juan C., Autor ; Ramírez Roldán, Alejandra, Autor ; Molina Prado, Ángel D., Autor ; Cardona Jaramillo, Manuela, Autor ; Trejos Tenorio, Adriana M., Autor ; Ospina Ospina, Sigifredo, Autor ; Barrera Correa, Daniel, Autor ; Ribero Vargas, Daniel A., Autor ; Ariza Parra, Edwin J, Autor ; Karduss Urueta, Amado J., Autor Fecha de publicación : 2025 Títulos uniformes : Cureus Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave : antineoplastic agents chemotherapy-induced febrile neutropenia febrile neutropenia hematological malignancies infections mortality Resumen : Introduction Febrile neutropenia (FN) in patients with hematological malignancy (HM) is associated with multiple hospital complications including mortality. Although different strategies for early detection and prompt treatment have been established, it is a heterogeneous population with risk factors that are difficult to detect. The data available on the prediction of such complications is limited and there lies the importance of characterizing this type of patients in our environment and evaluating the factors related to the adverse outcomes. Methods The study is a retrospective cohort study conducted at San Vicente Foundation University Hospital (HUSVF) and Alma Mater Hospital of Antioquia (HAMA) in Medellín, Colombia, between January 2018 and December 2020, including patients diagnosed with FN who presented FN at the time of diagnosis or up to 30 days after receiving chemotherapy. The main objective was to determine the factors related to mortality and severe complications (ICU admission, need for vasopressors, or need for mechanical ventilation), while the secondary objective was the microbiological characterization of this population. Results Of the 190 FN episodes, 134 (70.5%) had a clinical focus of infection. A causal agent was identified in 125 episodes (65.8%), with the majority being bacteria in 112 cases (92.6%) of the isolates. The most frequently identified bacteria were Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. Gram-negative bacilli were isolated in 85 (86%) cases, and resistance was present in 38 cases (44.7%), with both extended-spectrum beta-lactamase (ESBL) and Klebsiella pneumoniae Carbapenemase (KPC) detected in nine (10.5%). In 53 (34.4%) episodes, some complications occurred during FN. The 30-day all-cause mortality was 53 (34.4%), with 27 (50.9%) of these cases associated with complications. Of the 45 (86.5%) patients who died from any cause, all did so during their first episode of FN. In the bivariate analysis, the following factors were associated with higher mortality: hypertension (OR 2.58, 95% CI 1.19-5.58; p=0.014), chronic obstructive pulmonary disease (COPD) (OR 10.2, 95% CI 1.11-93.8; p=0.013), chronic kidney disease (OR 4.27, 95% CI 0.975-18.7; p=0.038), prolonged neutropenia (OR 2.34, 95% CI 1.1-4.95; p=0.024), and lactate dehydrogenase (LDH) levels greater than two times the upper normal limit (UNL) (OR 3.24, 95% CI 1.35-7.75; p=0.007). In contrast, normal albumin levels before chemotherapy were associated with lower mortality (OR 0.381, 95% CI 0.15-0.95; p=0.036). In the multivariate analysis, none of the identified factors were statistically significant in predicting complications or mortality. Conclusión No factors related to complications or mortality were found in the multivariate analysis. However, the heterogeneity of the population suggests that these outcomes are not determined by a single factor, and a study with a larger sample may be needed to confirm them. Mención de responsabilidad : Jose C. Alvarez-Payares , Santiago Alvarez-Lopez , Jose E. Agámez-Gomez , Juan C. Hernandez-Rodriguez , Alejandra Ramírez-Roldán , Ángel D. Molina-Prado , Manuela Cardona-Jaramillo , Adriana M. Trejos-Tenorio , Sigifredo Ospina-Ospina , Ioka de la Peña-Lozano , Daniel Barrera-Correa , Daniel A. Ribero-Vargas , Edwin J Ariza-Parra , Amado J. Karduss-Urueta Referencia : Cureus 17(4): e81750. DOI (Digital Object Identifier) : 10.7759/cureus.81750 Derechos de uso : CC BY-NC-ND En línea : https://www.cureus.com/articles/351187-factors-associated-with-complications-in- [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Factors Associated With Complications in Patients With Hematological Malignancies and Febrile Neutropenia: A Cohort Study [documento electrónico] / De la Peña Lozano, Ioka, Autor ; Alvarez Payares, Jose C., Autor ; Alvarez Lopez, Santiago, Autor ; Agámez Gómez, José E., Autor ; Hernández Rodriguez, Juan C., Autor ; Ramírez Roldán, Alejandra, Autor ; Molina Prado, Ángel D., Autor ; Cardona Jaramillo, Manuela, Autor ; Trejos Tenorio, Adriana M., Autor ; Ospina Ospina, Sigifredo, Autor ; Barrera Correa, Daniel, Autor ; Ribero Vargas, Daniel A., Autor ; Ariza Parra, Edwin J, Autor ; Karduss Urueta, Amado J., Autor . - 2025.
Obra : Cureus
Idioma : Inglés (eng) Idioma original : Inglés (eng)
Palabras clave : antineoplastic agents chemotherapy-induced febrile neutropenia febrile neutropenia hematological malignancies infections mortality Resumen : Introduction Febrile neutropenia (FN) in patients with hematological malignancy (HM) is associated with multiple hospital complications including mortality. Although different strategies for early detection and prompt treatment have been established, it is a heterogeneous population with risk factors that are difficult to detect. The data available on the prediction of such complications is limited and there lies the importance of characterizing this type of patients in our environment and evaluating the factors related to the adverse outcomes. Methods The study is a retrospective cohort study conducted at San Vicente Foundation University Hospital (HUSVF) and Alma Mater Hospital of Antioquia (HAMA) in Medellín, Colombia, between January 2018 and December 2020, including patients diagnosed with FN who presented FN at the time of diagnosis or up to 30 days after receiving chemotherapy. The main objective was to determine the factors related to mortality and severe complications (ICU admission, need for vasopressors, or need for mechanical ventilation), while the secondary objective was the microbiological characterization of this population. Results Of the 190 FN episodes, 134 (70.5%) had a clinical focus of infection. A causal agent was identified in 125 episodes (65.8%), with the majority being bacteria in 112 cases (92.6%) of the isolates. The most frequently identified bacteria were Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. Gram-negative bacilli were isolated in 85 (86%) cases, and resistance was present in 38 cases (44.7%), with both extended-spectrum beta-lactamase (ESBL) and Klebsiella pneumoniae Carbapenemase (KPC) detected in nine (10.5%). In 53 (34.4%) episodes, some complications occurred during FN. The 30-day all-cause mortality was 53 (34.4%), with 27 (50.9%) of these cases associated with complications. Of the 45 (86.5%) patients who died from any cause, all did so during their first episode of FN. In the bivariate analysis, the following factors were associated with higher mortality: hypertension (OR 2.58, 95% CI 1.19-5.58; p=0.014), chronic obstructive pulmonary disease (COPD) (OR 10.2, 95% CI 1.11-93.8; p=0.013), chronic kidney disease (OR 4.27, 95% CI 0.975-18.7; p=0.038), prolonged neutropenia (OR 2.34, 95% CI 1.1-4.95; p=0.024), and lactate dehydrogenase (LDH) levels greater than two times the upper normal limit (UNL) (OR 3.24, 95% CI 1.35-7.75; p=0.007). In contrast, normal albumin levels before chemotherapy were associated with lower mortality (OR 0.381, 95% CI 0.15-0.95; p=0.036). In the multivariate analysis, none of the identified factors were statistically significant in predicting complications or mortality. Conclusión No factors related to complications or mortality were found in the multivariate analysis. However, the heterogeneity of the population suggests that these outcomes are not determined by a single factor, and a study with a larger sample may be needed to confirm them. Mención de responsabilidad : Jose C. Alvarez-Payares , Santiago Alvarez-Lopez , Jose E. Agámez-Gomez , Juan C. Hernandez-Rodriguez , Alejandra Ramírez-Roldán , Ángel D. Molina-Prado , Manuela Cardona-Jaramillo , Adriana M. Trejos-Tenorio , Sigifredo Ospina-Ospina , Ioka de la Peña-Lozano , Daniel Barrera-Correa , Daniel A. Ribero-Vargas , Edwin J Ariza-Parra , Amado J. Karduss-Urueta Referencia : Cureus 17(4): e81750. DOI (Digital Object Identifier) : 10.7759/cureus.81750 Derechos de uso : CC BY-NC-ND En línea : https://www.cureus.com/articles/351187-factors-associated-with-complications-in- [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Thyroid Cancer Staging: Historical Evolution and Analysis From Macrocarcinoma to Microcarcinoma Tipo de documento : documento electrónico Autores : Carlos Esteban Builes Montaño, Autor ; Londoño Bustamante, Andrés Felipe, Autor ; Julio Andrés Valencia Ferro, Autor ; Duque, Carlos S., Autor ; Tobón Ospina, Catalina, Autor ; Alejandro Vélez Hoyos, Autor ; Sánchez, Juan G., Autor ; Agudelo, Miguel, Autor ; Dueñas, Juan P., Autor ; Palacio, Maria F., Autor ; Sierra, Natalia, Autor Fecha de publicación : 2025 Títulos uniformes : Cureus Idioma : Inglés (eng) Idioma original : Inglés (eng) Palabras clave : classification prognosis risk staging surgery thyroid cancer tnm Resumen : The classification of thyroid cancer diagnosis and treatment has evolved dramatically since the Union for International Cancer Control (UICC) published the first staging system in 1968. A careful review of the eight published editions of well-differentiated thyroid cancer (WDTC) staging by the UICC and the American Joint Committee on Cancer (AJCC) was performed. Each edition was analyzed to clearly understand which development published and accepted by specialists treating thyroid cancer justified considering a new updated edition. This study presents a comprehensive review of the remarkable evolution of thyroid cancer staging, highlighting the various changes in several areas throughout the years and editions. There were surprising changes within the eight publications: the tumor size was progressively reduced from 4 cm in the first AJCC volume to less than 1 cm in the seventh and eighth UICC and AJCC editions, classifying these small, WDTCs known up to now as “microcarcinomas.” Extrathyroidal extension was accepted after the third edition; this description certainly plays a key role in today’s decisions to manage this tumor as a prognostic factor. The age specification of 45 years prevailed for seven consecutive publications until it was raised to 55 years in the eighth thyroid cancer staging system. Without a doubt, this iconic change allowed physicians around the world to give their 45-year-old thyroid cancer patients a more encouraging panorama of the disease with the new classification. Over the course of nearly 57 years, thyroid cancer staging has undergone remarkable changes, reaching a level of certainty that not only provides recommendations for safer treatments with less surgery and adjunctive measures but also improves survival rates and patient safety. Mención de responsabilidad : Carlos S. Duque , Carlos E. Builes-Montaño , Catalina Tobón-Ospina , Alejandro Velez Hoyos , Juan G. Sánchez , Andres F. Londoño , Miguel Agudelo , Julio A. Valencia , Juan P. Dueñas , Maria F. Palacio , Natalia Sierra Referencia : Cureus 17(4): e81972. DOI (Digital Object Identifier) : 10.7759/cureus.81972 Derechos de uso : CC BY-NC-ND En línea : https://www.cureus.com/articles/350600-thyroid-cancer-staging-historical-evoluti [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Thyroid Cancer Staging: Historical Evolution and Analysis From Macrocarcinoma to Microcarcinoma [documento electrónico] / Carlos Esteban Builes Montaño, Autor ; Londoño Bustamante, Andrés Felipe, Autor ; Julio Andrés Valencia Ferro, Autor ; Duque, Carlos S., Autor ; Tobón Ospina, Catalina, Autor ; Alejandro Vélez Hoyos, Autor ; Sánchez, Juan G., Autor ; Agudelo, Miguel, Autor ; Dueñas, Juan P., Autor ; Palacio, Maria F., Autor ; Sierra, Natalia, Autor . - 2025.
Obra : Cureus
Idioma : Inglés (eng) Idioma original : Inglés (eng)
Palabras clave : classification prognosis risk staging surgery thyroid cancer tnm Resumen : The classification of thyroid cancer diagnosis and treatment has evolved dramatically since the Union for International Cancer Control (UICC) published the first staging system in 1968. A careful review of the eight published editions of well-differentiated thyroid cancer (WDTC) staging by the UICC and the American Joint Committee on Cancer (AJCC) was performed. Each edition was analyzed to clearly understand which development published and accepted by specialists treating thyroid cancer justified considering a new updated edition. This study presents a comprehensive review of the remarkable evolution of thyroid cancer staging, highlighting the various changes in several areas throughout the years and editions. There were surprising changes within the eight publications: the tumor size was progressively reduced from 4 cm in the first AJCC volume to less than 1 cm in the seventh and eighth UICC and AJCC editions, classifying these small, WDTCs known up to now as “microcarcinomas.” Extrathyroidal extension was accepted after the third edition; this description certainly plays a key role in today’s decisions to manage this tumor as a prognostic factor. The age specification of 45 years prevailed for seven consecutive publications until it was raised to 55 years in the eighth thyroid cancer staging system. Without a doubt, this iconic change allowed physicians around the world to give their 45-year-old thyroid cancer patients a more encouraging panorama of the disease with the new classification. Over the course of nearly 57 years, thyroid cancer staging has undergone remarkable changes, reaching a level of certainty that not only provides recommendations for safer treatments with less surgery and adjunctive measures but also improves survival rates and patient safety. Mención de responsabilidad : Carlos S. Duque , Carlos E. Builes-Montaño , Catalina Tobón-Ospina , Alejandro Velez Hoyos , Juan G. Sánchez , Andres F. Londoño , Miguel Agudelo , Julio A. Valencia , Juan P. Dueñas , Maria F. Palacio , Natalia Sierra Referencia : Cureus 17(4): e81972. DOI (Digital Object Identifier) : 10.7759/cureus.81972 Derechos de uso : CC BY-NC-ND En línea : https://www.cureus.com/articles/350600-thyroid-cancer-staging-historical-evoluti [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Endovascular Treatment of Acute Lower Limb Ischemia Associated with Cocaine Use: A Scoping Review Tipo de documento : documento electrónico Autores : Vanessa García Gómez, Autor ; Muñoz Durán, Julián A., Autor ; Santiago Echeverri Isaza, Autor ; José Miguel Hidalgo Oviedo, Autor ; Emilio Sanín Pérez, Autor ; Sergio Álvarez Vallejo, Autor Fecha de publicación : 2024 Títulos uniformes : Cureus Idioma : Inglés (eng) Palabras clave : acute; cocaine; crack; ischemia; lower limb. Resumen : The endovascular treatment of acute lower limb ischemia associated with cocaine use is an underexplored topic. This scoping review aims to map existing information and point out potential knowledge gaps for future research. We searched databases with a strategy of terms and keywords (Cocaine, Acute, Lower Limb, and Ischemia) for articles related to acute ischemia in the lower limbs and cocaine use. We established eligibility and exclusion criteria and searched without restrictions on language or date of publication. We obtained five case reports published between 2004 and 2015. Most of the patients were men with an average age of 38 years. Treatments were heterogeneous. Most patients showed improvement after surgical thrombectomy. The sample size and variety of interventions limit the generalizability of the results, so it is necessary to do more studies with robust methodologies to standardize treatments and improve the understanding of the condition. Mención de responsabilidad : Julián Andrés Muñoz Durán, Santiago Echeverri Isaza, José Migue Hidalgo Oviedo, Emilio Sanin, Sergio Alvarez-Vallejo, Vanessa García Gómez Referencia : Cureus . 2024 Feb 22;16(2):e54672. DOI (Digital Object Identifier) : 10.7759/cureus.54672 PMID : 38523932 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/38523932/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Endovascular Treatment of Acute Lower Limb Ischemia Associated with Cocaine Use: A Scoping Review [documento electrónico] / Vanessa García Gómez, Autor ; Muñoz Durán, Julián A., Autor ; Santiago Echeverri Isaza, Autor ; José Miguel Hidalgo Oviedo, Autor ; Emilio Sanín Pérez, Autor ; Sergio Álvarez Vallejo, Autor . - 2024.
Obra : Cureus
Idioma : Inglés (eng)
Palabras clave : acute; cocaine; crack; ischemia; lower limb. Resumen : The endovascular treatment of acute lower limb ischemia associated with cocaine use is an underexplored topic. This scoping review aims to map existing information and point out potential knowledge gaps for future research. We searched databases with a strategy of terms and keywords (Cocaine, Acute, Lower Limb, and Ischemia) for articles related to acute ischemia in the lower limbs and cocaine use. We established eligibility and exclusion criteria and searched without restrictions on language or date of publication. We obtained five case reports published between 2004 and 2015. Most of the patients were men with an average age of 38 years. Treatments were heterogeneous. Most patients showed improvement after surgical thrombectomy. The sample size and variety of interventions limit the generalizability of the results, so it is necessary to do more studies with robust methodologies to standardize treatments and improve the understanding of the condition. Mención de responsabilidad : Julián Andrés Muñoz Durán, Santiago Echeverri Isaza, José Migue Hidalgo Oviedo, Emilio Sanin, Sergio Alvarez-Vallejo, Vanessa García Gómez Referencia : Cureus . 2024 Feb 22;16(2):e54672. DOI (Digital Object Identifier) : 10.7759/cureus.54672 PMID : 38523932 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/38523932/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Gadoxetic Acid in MRI: A Five-Year Experience at a High-Complexity Hospital in Colombia Tipo de documento : documento electrónico Autores : Vanessa García Gómez, Autor ; Pimiento Figueroa, Jonathan, Autor ; Lopera Valle, Johan Sebastián, Autor ; Gómez Urrego, Ana M., Autor ; González, Mateo, Autor ; Huertas Duran, Claudia, Autor Fecha de publicación : 2024 Títulos uniformes : Cureus Idioma : Inglés (eng) Palabras clave : adenoma; bile ducts; contrast media; focal nodular hyperplasia; liver cell; liver diseases; magnetic resonance imaging. Resumen : Objective The objective of the study was to evaluate the use of the hepatospecific contrast agent, gadoxetic acid, for MRI in patients at a high-complexity hospital in Medellin, Colombia, from 2016 to 2022. Materials and methods This was an observational, descriptive, and retrospective cross-sectional study involving patients who had undergone MRI with gadoxetic acid from February 2016 to January 2022. The MRI studies were interpreted by two radiologists specializing in body imaging, each with at least 10 years of experience. The medical records of the identified patients were reviewed. Quantitative variables were presented using either means and standard deviations or medians and interquartile ranges, depending on the distribution of the variables. Qualitative variables were represented through absolute and relative frequencies. Results A total of 100 pharmacy records were collected, leading to a final sample of 75 patients aged between three and 91 years. The primary reason for imaging was to assess focal liver lesions in 58 patients (77.3%), with bile duct injury being the second most common indication in 16 patients (21.3%). A diagnostic alteration was noted in 69.3% of cases (52 patients). Among the 58 focal liver lesions analyzed using a hepatospecific agent, 31 cases (53.4%) were diagnosed as focal nodular hyperplasia. Conclusion Our study reinforces the clinical value of gadoxetic acid-enhanced MRI in refining diagnostic assessments, particularly in cases involving bile duct and focal hepatic lesions. Mención de responsabilidad : Jonathan Pimiento Figueroa, Johan Sebastian Lopera Valle, Ana M Gomez Urrego, Vanessa García Gómez, Mateo Gonzalez, Claudia Huertas Duran Referencia : Cureus . 2024 Apr 12;16(4):e58150 DOI (Digital Object Identifier) : 10.7759/cureus.58150 PMID : 38741819 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/38741819/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Gadoxetic Acid in MRI: A Five-Year Experience at a High-Complexity Hospital in Colombia [documento electrónico] / Vanessa García Gómez, Autor ; Pimiento Figueroa, Jonathan, Autor ; Lopera Valle, Johan Sebastián, Autor ; Gómez Urrego, Ana M., Autor ; González, Mateo, Autor ; Huertas Duran, Claudia, Autor . - 2024.
Obra : Cureus
Idioma : Inglés (eng)
Palabras clave : adenoma; bile ducts; contrast media; focal nodular hyperplasia; liver cell; liver diseases; magnetic resonance imaging. Resumen : Objective The objective of the study was to evaluate the use of the hepatospecific contrast agent, gadoxetic acid, for MRI in patients at a high-complexity hospital in Medellin, Colombia, from 2016 to 2022. Materials and methods This was an observational, descriptive, and retrospective cross-sectional study involving patients who had undergone MRI with gadoxetic acid from February 2016 to January 2022. The MRI studies were interpreted by two radiologists specializing in body imaging, each with at least 10 years of experience. The medical records of the identified patients were reviewed. Quantitative variables were presented using either means and standard deviations or medians and interquartile ranges, depending on the distribution of the variables. Qualitative variables were represented through absolute and relative frequencies. Results A total of 100 pharmacy records were collected, leading to a final sample of 75 patients aged between three and 91 years. The primary reason for imaging was to assess focal liver lesions in 58 patients (77.3%), with bile duct injury being the second most common indication in 16 patients (21.3%). A diagnostic alteration was noted in 69.3% of cases (52 patients). Among the 58 focal liver lesions analyzed using a hepatospecific agent, 31 cases (53.4%) were diagnosed as focal nodular hyperplasia. Conclusion Our study reinforces the clinical value of gadoxetic acid-enhanced MRI in refining diagnostic assessments, particularly in cases involving bile duct and focal hepatic lesions. Mención de responsabilidad : Jonathan Pimiento Figueroa, Johan Sebastian Lopera Valle, Ana M Gomez Urrego, Vanessa García Gómez, Mateo Gonzalez, Claudia Huertas Duran Referencia : Cureus . 2024 Apr 12;16(4):e58150 DOI (Digital Object Identifier) : 10.7759/cureus.58150 PMID : 38741819 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/38741819/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Cardio-oncology clinical assessment and screening in patients undergoing high toxicity chemotherapy: a retrospective cohort study Tipo de documento : documento electrónico Autores : Andrés Felipe Miranda Arboleda, ; Juan Guillermo Gamboa Arroyave, Fecha de publicación : 2022 Títulos uniformes : Cureus Idioma : Inglés (eng) Palabras clave : cardio-oncology solid tumors hematological malignancies chemotherapy cardiotoxicity Resumen : Objective: To describe the clinical characteristics and cardio-oncological assessment in patients undertaking highly toxic chemotherapy and/or chest radiotherapy in a high-complexity hospital. Methods: A single-center retrospective cohort study was carried out between January 1st, 2017 and December 31st, 2019. The medical records of patients with solid or hematological neoplasms were reviewed. Descriptive information was obtained on demographic characteristics, chemotherapeutic agents, pre-chemotherapy cardiovascular (CV) evaluation, and CV outcomes. The risk of complications was assessed using the Mayo Clinic risk score. Results: A total of 499 patients were included, the most common neoplasm was non-Hodgkin's lymphoma (21.6%), followed by breast cancer (19.4%). A very high risk of cardiotoxicity was present in 44.1% and 90% were not evaluated by cardiology. Pre-chemotherapy echocardiography was obtained in 65%, but only 19.4% underwent echocardiographic control after finishing chemotherapy. The most frequent CV outcomes were chemotherapy-related systolic dysfunction (4.4%) and rhythm disturbances (2.8%), with atrial fibrillation and atrial flutter being the most frequent arrhythmias. Conclusion: Despite the recognized CV toxicity of chemotherapeutic drugs, the majority of patients receiving highly toxic regimens at high risk of CV complications are not previously evaluated by a cardiologist and the CV workup was not routinely used in our study. The implementation of cardio-oncology programs will facilitate the identification of high-risk patients, aiming to detect and treat complications early. Mención de responsabilidad : Carlos A. Regino, Jonathan Cardona-Vélez, Jesus D. Bello Simanca, Andres F. Miranda Arboleda, Juan G. Gamboa Arroyave, Fabian Jaimes DOI (Digital Object Identifier) : 10.7759/cureus.32513 Derechos de uso : CC BY En línea : https://www.cureus.com/articles/127878-cardio-oncology-clinical-assessment-and-s [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Cardio-oncology clinical assessment and screening in patients undergoing high toxicity chemotherapy: a retrospective cohort study [documento electrónico] / Andrés Felipe Miranda Arboleda, ; Juan Guillermo Gamboa Arroyave, . - 2022.
Obra : Cureus
Idioma : Inglés (eng)
Palabras clave : cardio-oncology solid tumors hematological malignancies chemotherapy cardiotoxicity Resumen : Objective: To describe the clinical characteristics and cardio-oncological assessment in patients undertaking highly toxic chemotherapy and/or chest radiotherapy in a high-complexity hospital. Methods: A single-center retrospective cohort study was carried out between January 1st, 2017 and December 31st, 2019. The medical records of patients with solid or hematological neoplasms were reviewed. Descriptive information was obtained on demographic characteristics, chemotherapeutic agents, pre-chemotherapy cardiovascular (CV) evaluation, and CV outcomes. The risk of complications was assessed using the Mayo Clinic risk score. Results: A total of 499 patients were included, the most common neoplasm was non-Hodgkin's lymphoma (21.6%), followed by breast cancer (19.4%). A very high risk of cardiotoxicity was present in 44.1% and 90% were not evaluated by cardiology. Pre-chemotherapy echocardiography was obtained in 65%, but only 19.4% underwent echocardiographic control after finishing chemotherapy. The most frequent CV outcomes were chemotherapy-related systolic dysfunction (4.4%) and rhythm disturbances (2.8%), with atrial fibrillation and atrial flutter being the most frequent arrhythmias. Conclusion: Despite the recognized CV toxicity of chemotherapeutic drugs, the majority of patients receiving highly toxic regimens at high risk of CV complications are not previously evaluated by a cardiologist and the CV workup was not routinely used in our study. The implementation of cardio-oncology programs will facilitate the identification of high-risk patients, aiming to detect and treat complications early. Mención de responsabilidad : Carlos A. Regino, Jonathan Cardona-Vélez, Jesus D. Bello Simanca, Andres F. Miranda Arboleda, Juan G. Gamboa Arroyave, Fabian Jaimes DOI (Digital Object Identifier) : 10.7759/cureus.32513 Derechos de uso : CC BY En línea : https://www.cureus.com/articles/127878-cardio-oncology-clinical-assessment-and-s [...] Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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