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Autor Mónica Rosa Trujillo Honeysberg
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Comentario :
Médica Pediatra Infectóloga, Hospital Pablo Tobón Uribe
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Documentos disponibles escritos por este autor (23)
Clasificado(s) por (Año de edición descendente) Refinar búsquedaCMV Reactivation Following Allogeneic Transplantation in Children From a High-Seroprevalence Population: A Single-Center Experience in Colombia / Laura Fernanda Niño Serna ; Alejandro Díaz Díaz ; Mónica Rosa Trujillo Honeysberg ; Natalia Builes R. ; Arias, Andrés ; Aristizábal, Beatriz H
Título : CMV Reactivation Following Allogeneic Transplantation in Children From a High-Seroprevalence Population: A Single-Center Experience in Colombia Tipo de documento : documento electrónico Autores : Laura Fernanda Niño Serna, Autor ; Alejandro Díaz Díaz, Autor ; Mónica Rosa Trujillo Honeysberg, Autor ; Natalia Builes R., Autor ; Arias, Andrés, Autor ; Aristizábal, Beatriz H, Autor Fecha de publicación : 2025 Títulos uniformes : Pediatric Transplantation Idioma : Inglés (eng) Palabras clave : CMV; cytomegalovirus infection; haploidentical; hematopoietic stem cell transplantation; pediatrics; transplantation Resumen : Introduction: Cytomegalovirus (CMV) infection is a frequent complication among hematopoietic stem cell transplant (HSCT) recipients. Data regarding CMV reactivation in children in underdeveloped countries is scarce. This is especially notable considering the increasing utilization of haploidentical-related HSCT with the post-transplant cyclophosphamide platform. This study aimed to describe the incidence, clinical characteristics, and evolution of children with CMV reactivation after HSCT and the possible impact of unmanipulated stem cells with PTCy for GvHD prophylaxis. Methods: Retrospective cohort study of children undergoing hematopoietic stem cell transplantation from January 2012 to June 2022. Baseline characteristics and the clinical course were described. Duration of treatment, initial viral load, and time to clearance of DNAemia by type of transplant were compared using the Kruskal-Wallis test. Survival analysis was performed with the Kaplan–Meier method and log-rank test. All statistical analysis was performed using SPSS software, version 20.0. Results: One hundred sixty-six children were included. Among them, 87% of recipients and 88% of donors were CMV positive. The cumulative incidence of cytomegalovirus DNAemia was 28% at 100 days post-transplantation. There were no differences between different donor types. Overall survival at 1 year was 60%, and non-relapse mortality was observed in 28%. CMV reactivation did not appear to negatively impact 1-year overall survival (OS). Conclusions: Our study found no differences in CMV reactivation rates, treatment duration, viral clearance times, co-infections, or 1-year overall survival across different HSCT donor types. Studies are needed to establish more precise criteria for monitoring recipients, particularly in regions where unmanipulated stem cells with PTCy for GvHD prophylaxis are increasing. © 2025 Wiley Periodicals LLC. Mención de responsabilidad : Arias, Andres, Builes, Natalia, Niño-Serna, Laura, Diaz, Alejandro, Aristizabal, Beatriz H., Trujillo, Monica. Referencia : Pediatr Transplant . 2025 Feb;29(1):e70033 DOI (Digital Object Identifier) : 10.1111/petr.70033 PMID : 39837777 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/39837777/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis CMV Reactivation Following Allogeneic Transplantation in Children From a High-Seroprevalence Population: A Single-Center Experience in Colombia [documento electrónico] / Laura Fernanda Niño Serna, Autor ; Alejandro Díaz Díaz, Autor ; Mónica Rosa Trujillo Honeysberg, Autor ; Natalia Builes R., Autor ; Arias, Andrés, Autor ; Aristizábal, Beatriz H, Autor . - 2025.
Obra : Pediatric Transplantation
Idioma : Inglés (eng)
Palabras clave : CMV; cytomegalovirus infection; haploidentical; hematopoietic stem cell transplantation; pediatrics; transplantation Resumen : Introduction: Cytomegalovirus (CMV) infection is a frequent complication among hematopoietic stem cell transplant (HSCT) recipients. Data regarding CMV reactivation in children in underdeveloped countries is scarce. This is especially notable considering the increasing utilization of haploidentical-related HSCT with the post-transplant cyclophosphamide platform. This study aimed to describe the incidence, clinical characteristics, and evolution of children with CMV reactivation after HSCT and the possible impact of unmanipulated stem cells with PTCy for GvHD prophylaxis. Methods: Retrospective cohort study of children undergoing hematopoietic stem cell transplantation from January 2012 to June 2022. Baseline characteristics and the clinical course were described. Duration of treatment, initial viral load, and time to clearance of DNAemia by type of transplant were compared using the Kruskal-Wallis test. Survival analysis was performed with the Kaplan–Meier method and log-rank test. All statistical analysis was performed using SPSS software, version 20.0. Results: One hundred sixty-six children were included. Among them, 87% of recipients and 88% of donors were CMV positive. The cumulative incidence of cytomegalovirus DNAemia was 28% at 100 days post-transplantation. There were no differences between different donor types. Overall survival at 1 year was 60%, and non-relapse mortality was observed in 28%. CMV reactivation did not appear to negatively impact 1-year overall survival (OS). Conclusions: Our study found no differences in CMV reactivation rates, treatment duration, viral clearance times, co-infections, or 1-year overall survival across different HSCT donor types. Studies are needed to establish more precise criteria for monitoring recipients, particularly in regions where unmanipulated stem cells with PTCy for GvHD prophylaxis are increasing. © 2025 Wiley Periodicals LLC. Mención de responsabilidad : Arias, Andres, Builes, Natalia, Niño-Serna, Laura, Diaz, Alejandro, Aristizabal, Beatriz H., Trujillo, Monica. Referencia : Pediatr Transplant . 2025 Feb;29(1):e70033 DOI (Digital Object Identifier) : 10.1111/petr.70033 PMID : 39837777 Derechos de uso : CC BY-NC-ND En línea : https://pubmed.ncbi.nlm.nih.gov/39837777/ Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Acute intrathoracic tuberculosis in children and adolescents with community-acquired pneumonia in an area with an intermediate disease burden Tipo de documento : documento electrónico Autores : Andrea Victoria Restrepo Gouzy, ; Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2022 Títulos uniformes : Pediatric Reports Idioma : Inglés (eng) Palabras clave : cohort study children adolescents community-acquired pneumonia intrathoracic tuberculosis acute tuberculosis Resumen : Tuberculosis (TB) in the pediatric population is a major challenge. Our objective was to describe the clinical and microbiological characteristics, radiological patterns, and treatment outcomes of children and adolescents (from 1 month to 17 years) with community-acquired pneumonia (CAP) caused by TB. We performed a prospective cohort study of a pediatric population between 1 month and 17 years of age and hospitalized in Medellín, Colombia, with the diagnosis of radiologically confirmed CAP that had ≤ 15 days of symptoms. The mycobacterial culture of induced sputum was used for the bacteriological confirmation; the history of TB contact, a tuberculin skin test, and clinical improvement with treatment were used to identify microbiologically negative TB cases. Among 499 children with CAP, TB was diagnosed in 12 (2.4%), of which 10 had less than 8 days of a cough, 10 had alveolar opacities, 9 were younger than 5 years old, and 2 had close contact with a TB patient. Among the TB cases, 50% (6) had microbiological confirmation, 8 had viral and/or bacterial confirmation, one patient had multidrug-resistant TB, and 10/12 had non-severe pneumonia. In countries with an intermediate TB burden, Mycobacterium tuberculosis should be included in the etiological differential diagnosis (as a cause or coinfection) of both pneumonia and severe CAP in the pediatric population. Mención de responsabilidad : Claudia Roya-Pabón, Andrea Restrepo, Olga Morales, Catalina Arango, María Angélica Maya, Marcela Bermúdez, Lucelly López, Carlos Garcés,Mónica Trujillo, Luisa Fernanda Carmona, Margarita Rosa Giraldo, Lázaro A. Vélez and Zulma Vanessa Rueda Referencia : Pediatr Rep. 2022 Feb 5;14(1):71-80. DOI (Digital Object Identifier) : 10.3390/pediatric14010011 PMID : 35225880 Derechos de uso : CC BY En línea : https://www.mdpi.com/2036-7503/14/1/11 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Acute intrathoracic tuberculosis in children and adolescents with community-acquired pneumonia in an area with an intermediate disease burden [documento electrónico] / Andrea Victoria Restrepo Gouzy, ; Mónica Rosa Trujillo Honeysberg, . - 2022.
Obra : Pediatric Reports
Idioma : Inglés (eng)
Palabras clave : cohort study children adolescents community-acquired pneumonia intrathoracic tuberculosis acute tuberculosis Resumen : Tuberculosis (TB) in the pediatric population is a major challenge. Our objective was to describe the clinical and microbiological characteristics, radiological patterns, and treatment outcomes of children and adolescents (from 1 month to 17 years) with community-acquired pneumonia (CAP) caused by TB. We performed a prospective cohort study of a pediatric population between 1 month and 17 years of age and hospitalized in Medellín, Colombia, with the diagnosis of radiologically confirmed CAP that had ≤ 15 days of symptoms. The mycobacterial culture of induced sputum was used for the bacteriological confirmation; the history of TB contact, a tuberculin skin test, and clinical improvement with treatment were used to identify microbiologically negative TB cases. Among 499 children with CAP, TB was diagnosed in 12 (2.4%), of which 10 had less than 8 days of a cough, 10 had alveolar opacities, 9 were younger than 5 years old, and 2 had close contact with a TB patient. Among the TB cases, 50% (6) had microbiological confirmation, 8 had viral and/or bacterial confirmation, one patient had multidrug-resistant TB, and 10/12 had non-severe pneumonia. In countries with an intermediate TB burden, Mycobacterium tuberculosis should be included in the etiological differential diagnosis (as a cause or coinfection) of both pneumonia and severe CAP in the pediatric population. Mención de responsabilidad : Claudia Roya-Pabón, Andrea Restrepo, Olga Morales, Catalina Arango, María Angélica Maya, Marcela Bermúdez, Lucelly López, Carlos Garcés,Mónica Trujillo, Luisa Fernanda Carmona, Margarita Rosa Giraldo, Lázaro A. Vélez and Zulma Vanessa Rueda Referencia : Pediatr Rep. 2022 Feb 5;14(1):71-80. DOI (Digital Object Identifier) : 10.3390/pediatric14010011 PMID : 35225880 Derechos de uso : CC BY En línea : https://www.mdpi.com/2036-7503/14/1/11 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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AC-2022-013Adobe Acrobat PDF
Título : Association of cancer diagnosis and therapeutic stage with mortality in pediatric patients with COVID-19, prospective multicenter cohort study from Latin America Tipo de documento : documento electrónico Autores : Alejandro Díaz Díaz, ; Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2022 Títulos uniformes : Frontiers in Pediatrics Idioma : Inglés (eng) Palabras clave : pediatric cancer pediatric COVID-19 child development PICU (pediatric intensive care unit) Resumen : Background: Children with cancer are at risk of critical disease and mortality from COVID-19 infection. In this study, we describe the clinical characteristics of pediatric patients with cancer and COVID-19 from multiple Latin American centers and risk factors associated with mortality in this population. Methods: This study is a multicenter, prospective cohort study conducted at 12 hospitals from 6 Latin American countries (Argentina, Bolivia, Colombia, Ecuador, Honduras and Peru) from April to November 2021. Patients younger than 14 years of age that had an oncological diagnosis and COVID-19 or multisystemic inflammatory syndrome in children (MIS-C) who were treated in the inpatient setting were included. The primary exposure was the diagnosis and treatment status, and the primary outcome was mortality. We defined “new diagnosis” as patients with no previous diagnosis of cancer, “established diagnosis” as patients with cancer and ongoing treatment and “relapse” as patients with cancer and ongoing treatment that had a prior cancer-free period. A frequentist analysis was performed including a multivariate logistic regression for mortality. Results: Two hundred and ten patients were included in the study; 30 (14%) died during the study period and 67% of patients who died were admitted to critical care. Demographics were similar in survivors and non-survivors. Patients with low weight for age ( Mención de responsabilidad : Jesus Ángel Dominguez-Rojas, Pablo Vásquez-Hoyos, Rodrigo Pérez-Morales, Ana María Monsalve-Quintero, Lupe Mora-Robles, Alejandro Diaz-Diaz, Silvio Fabio Torres, Ángel Castro-Dajer, Lizeth Yuliana Cabanillas-Burgos, Vladimir Aguilera-Avendaño, Edwin Mauricio Cantillano-Quintero, Anna Camporesi, Asya Agulnik, Sheena Mukkada, Giancarlo Alvarado-Gamarra, Ninoska Rojas-Soto, Ana Luisa Mendieta-Zevallos, Mariela Violeta Tello-Pezo, Liliana Vásquez-Ponce, Rubén Eduardo Lasso-Palomino, María Camila Pérez-Arroyave, Mónica Trujillo-Honeysberg, Juan Gonzalo Mesa-Monsalve, Carlos Alberto Pardo González, Juan Francisco López Cubillos, Sebastián Gonzalez-Dambrauskas and Alvaro Coronado-Munoz Referencia : Front Pediatr. 2022 May 3;10:885633. DOI (Digital Object Identifier) : 10.3389/fped.2022.885633 PMID : 35592840 Derechos de uso : CC BY En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.885633/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Association of cancer diagnosis and therapeutic stage with mortality in pediatric patients with COVID-19, prospective multicenter cohort study from Latin America [documento electrónico] / Alejandro Díaz Díaz, ; Mónica Rosa Trujillo Honeysberg, . - 2022.
Obra : Frontiers in Pediatrics
Idioma : Inglés (eng)
Palabras clave : pediatric cancer pediatric COVID-19 child development PICU (pediatric intensive care unit) Resumen : Background: Children with cancer are at risk of critical disease and mortality from COVID-19 infection. In this study, we describe the clinical characteristics of pediatric patients with cancer and COVID-19 from multiple Latin American centers and risk factors associated with mortality in this population. Methods: This study is a multicenter, prospective cohort study conducted at 12 hospitals from 6 Latin American countries (Argentina, Bolivia, Colombia, Ecuador, Honduras and Peru) from April to November 2021. Patients younger than 14 years of age that had an oncological diagnosis and COVID-19 or multisystemic inflammatory syndrome in children (MIS-C) who were treated in the inpatient setting were included. The primary exposure was the diagnosis and treatment status, and the primary outcome was mortality. We defined “new diagnosis” as patients with no previous diagnosis of cancer, “established diagnosis” as patients with cancer and ongoing treatment and “relapse” as patients with cancer and ongoing treatment that had a prior cancer-free period. A frequentist analysis was performed including a multivariate logistic regression for mortality. Results: Two hundred and ten patients were included in the study; 30 (14%) died during the study period and 67% of patients who died were admitted to critical care. Demographics were similar in survivors and non-survivors. Patients with low weight for age ( Mención de responsabilidad : Jesus Ángel Dominguez-Rojas, Pablo Vásquez-Hoyos, Rodrigo Pérez-Morales, Ana María Monsalve-Quintero, Lupe Mora-Robles, Alejandro Diaz-Diaz, Silvio Fabio Torres, Ángel Castro-Dajer, Lizeth Yuliana Cabanillas-Burgos, Vladimir Aguilera-Avendaño, Edwin Mauricio Cantillano-Quintero, Anna Camporesi, Asya Agulnik, Sheena Mukkada, Giancarlo Alvarado-Gamarra, Ninoska Rojas-Soto, Ana Luisa Mendieta-Zevallos, Mariela Violeta Tello-Pezo, Liliana Vásquez-Ponce, Rubén Eduardo Lasso-Palomino, María Camila Pérez-Arroyave, Mónica Trujillo-Honeysberg, Juan Gonzalo Mesa-Monsalve, Carlos Alberto Pardo González, Juan Francisco López Cubillos, Sebastián Gonzalez-Dambrauskas and Alvaro Coronado-Munoz Referencia : Front Pediatr. 2022 May 3;10:885633. DOI (Digital Object Identifier) : 10.3389/fped.2022.885633 PMID : 35592840 Derechos de uso : CC BY En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.885633/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Changes in the incidence of acute bacterial meningitis caused by Streptococcus pneumoniae and the implications of serotype replacement in children in Colombia after mass vaccination with PCV10 Tipo de documento : documento electrónico Autores : Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2022 Títulos uniformes : Frontiers in Pediatrics Idioma : Inglés (eng) Palabras clave : pneumococcal meningitis pediatrics infections vaccines microbiology serotype Resumen : Introduction: Acute bacterial meningitis (ABM) is a public health problem. The disease has reemerged after the introduction of pneumococcal conjugate vaccines (PCVs) due to an increase in serotypes that are not covered. The objective was to determine the changes in the disease incidence before and after the introduction of the 10-valent vaccine (PCV10) in Colombia. Methods: This multicenter study was conducted in 17 hospitals in Colombia. Data were collected from January 2008 to December 2019 in 10 hospitals in Bogotá and from January 2017 to December 2019 in seven hospitals in Cali, Medellín and Cartagena. The data were grouped into three periods: 2008–2011, 2012–2015, and 2016-2019. Results: Of the 706 cases of invasive pneumococcal disease, 81 (11.4%) corresponded to meningitis. The relative incidence in Bogotá in the first period was 0.6 per 100,000 patients ≤ 5 years, decreased to 0.4 per 100,000 patients ≤ 5 years in the second period and increased in the third period to 0.7 per 100,000 patients ≤ 5 years. Serotypes covered by PCV10 decreased from 75 to 9.1%, with Spn19A (31.8%) and Spn34 (13.6%) emerging in the third period. Increased resistance to penicillin (13 to 37%) and to ceftriaxone (5.9 to 16%) was due to the emergence of multidrug-resistant Spn19A. The total mortality rate was 23.5% and increased from 12 to 33%. Conclusions: ABM due to pneumococcus has high morbidity and mortality rates. Reemergence of the disease has been observed due to the inclusion of polymerase chain reaction (PCR) for diagnosis and replacement of circulating serotypes after the introduction of PCV10, with an increase in Spn19A, which causes death and exhibits antimicrobial resistance. Continued surveillance is needed. Mención de responsabilidad : Juan David Farfán-Albarracín, Germán Camacho-Moreno, Aura Lucia Leal, Jaime Patiño, Wilfrido Coronell, Iván Felipe Gutiérrez, Sandra Beltrán, Martha I Álvarez-Olmos, Cristina Mariño, Rocio Barrero, Juan Pablo Rojas, Fabio Espinosa, Catalina Arango-Ferreira, Maria Alejandra Suarez, Monica Trujillo, Eduardo López-Medina, Pio López, Hernando Pinzón, Nicolás Ramos, Vivian Marcela Moreno, Anita Montañez Referencia : Front Pediatr. 2022 Sep 23;10:1006887. DOI (Digital Object Identifier) : 10.3389/fped.2022.1006887 PMID : 36210950 En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.1006887/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Changes in the incidence of acute bacterial meningitis caused by Streptococcus pneumoniae and the implications of serotype replacement in children in Colombia after mass vaccination with PCV10 [documento electrónico] / Mónica Rosa Trujillo Honeysberg, . - 2022.
Obra : Frontiers in Pediatrics
Idioma : Inglés (eng)
Palabras clave : pneumococcal meningitis pediatrics infections vaccines microbiology serotype Resumen : Introduction: Acute bacterial meningitis (ABM) is a public health problem. The disease has reemerged after the introduction of pneumococcal conjugate vaccines (PCVs) due to an increase in serotypes that are not covered. The objective was to determine the changes in the disease incidence before and after the introduction of the 10-valent vaccine (PCV10) in Colombia. Methods: This multicenter study was conducted in 17 hospitals in Colombia. Data were collected from January 2008 to December 2019 in 10 hospitals in Bogotá and from January 2017 to December 2019 in seven hospitals in Cali, Medellín and Cartagena. The data were grouped into three periods: 2008–2011, 2012–2015, and 2016-2019. Results: Of the 706 cases of invasive pneumococcal disease, 81 (11.4%) corresponded to meningitis. The relative incidence in Bogotá in the first period was 0.6 per 100,000 patients ≤ 5 years, decreased to 0.4 per 100,000 patients ≤ 5 years in the second period and increased in the third period to 0.7 per 100,000 patients ≤ 5 years. Serotypes covered by PCV10 decreased from 75 to 9.1%, with Spn19A (31.8%) and Spn34 (13.6%) emerging in the third period. Increased resistance to penicillin (13 to 37%) and to ceftriaxone (5.9 to 16%) was due to the emergence of multidrug-resistant Spn19A. The total mortality rate was 23.5% and increased from 12 to 33%. Conclusions: ABM due to pneumococcus has high morbidity and mortality rates. Reemergence of the disease has been observed due to the inclusion of polymerase chain reaction (PCR) for diagnosis and replacement of circulating serotypes after the introduction of PCV10, with an increase in Spn19A, which causes death and exhibits antimicrobial resistance. Continued surveillance is needed. Mención de responsabilidad : Juan David Farfán-Albarracín, Germán Camacho-Moreno, Aura Lucia Leal, Jaime Patiño, Wilfrido Coronell, Iván Felipe Gutiérrez, Sandra Beltrán, Martha I Álvarez-Olmos, Cristina Mariño, Rocio Barrero, Juan Pablo Rojas, Fabio Espinosa, Catalina Arango-Ferreira, Maria Alejandra Suarez, Monica Trujillo, Eduardo López-Medina, Pio López, Hernando Pinzón, Nicolás Ramos, Vivian Marcela Moreno, Anita Montañez Referencia : Front Pediatr. 2022 Sep 23;10:1006887. DOI (Digital Object Identifier) : 10.3389/fped.2022.1006887 PMID : 36210950 En línea : https://www.frontiersin.org/articles/10.3389/fped.2022.1006887/full Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Título : Disseminated fusariosis in children: Report of two cases in girls with leukemia Tipo de documento : documento electrónico Autores : Andrea Victoria Restrepo Gouzy, ; Mónica Rosa Trujillo Honeysberg, Fecha de publicación : 2022 Títulos uniformes : Current Medical Mycology Idioma : Inglés (eng) Palabras clave : Invasive fungal infection Leukemia Neutropenia Fusarium spp Resumen : Background and purpose: Disseminated fusariosis is an opportunistic infection caused by the hyaline fungus Fusarium spp. and occurs mainly in patients with leukemia. Case report: Two cases of disseminated fusariosis in pediatric patients are presented. Profound and prolonged neutropenia, fever, myalgia, and skin lesions in the legs were present in two girls with leukemia undergoing chemotherapy. In the first case, infection by Fusarium spp. was confirmed by anatomopathological findings, pathogen isolation, and polymerase chain reaction. In the second case, Fusarium solani infection was confirmed by mass spectrometry using blood cultures and skin lesion samples. Conclusion: It is important to consider disseminated fusariosis in high-risk patients who present with profound and prolonged neutropenia and persistent fever that does not resolve after broad-spectrum antibiotics to initiate antifungal therapy in a timely manner. Mención de responsabilidad : Alixandra De La Espriella, Andrea Restrepo, Monica Trujillo, Karen Arango Referencia : Curr Med Mycol. 2022 Mar;8(1):39-43. DOI (Digital Object Identifier) : 10.18502/cmm.8.1.9213 PMID : 36340435 Derechos de uso : CC BY En línea : http://cmm.mazums.ac.ir/article_141948.html Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Disseminated fusariosis in children: Report of two cases in girls with leukemia [documento electrónico] / Andrea Victoria Restrepo Gouzy, ; Mónica Rosa Trujillo Honeysberg, . - 2022.
Obra : Current Medical Mycology
Idioma : Inglés (eng)
Palabras clave : Invasive fungal infection Leukemia Neutropenia Fusarium spp Resumen : Background and purpose: Disseminated fusariosis is an opportunistic infection caused by the hyaline fungus Fusarium spp. and occurs mainly in patients with leukemia. Case report: Two cases of disseminated fusariosis in pediatric patients are presented. Profound and prolonged neutropenia, fever, myalgia, and skin lesions in the legs were present in two girls with leukemia undergoing chemotherapy. In the first case, infection by Fusarium spp. was confirmed by anatomopathological findings, pathogen isolation, and polymerase chain reaction. In the second case, Fusarium solani infection was confirmed by mass spectrometry using blood cultures and skin lesion samples. Conclusion: It is important to consider disseminated fusariosis in high-risk patients who present with profound and prolonged neutropenia and persistent fever that does not resolve after broad-spectrum antibiotics to initiate antifungal therapy in a timely manner. Mención de responsabilidad : Alixandra De La Espriella, Andrea Restrepo, Monica Trujillo, Karen Arango Referencia : Curr Med Mycol. 2022 Mar;8(1):39-43. DOI (Digital Object Identifier) : 10.18502/cmm.8.1.9213 PMID : 36340435 Derechos de uso : CC BY En línea : http://cmm.mazums.ac.ir/article_141948.html Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001922 AC-2022-085 Archivo digital Producción Científica Artículos científicos Disponible Documentos electrónicos
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