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Autor Ángela Restrepo Moreno |
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Refinar búsquedaThe fight against HIV-associated disseminated histoplasmosis in the Americas: unfolding the different stories of four centers / Ángela Restrepo Moreno
Título : The fight against HIV-associated disseminated histoplasmosis in the Americas: unfolding the different stories of four centers Tipo de documento : documento electrónico Autores : Ángela Restrepo Moreno, Fecha de publicación : 2019 Títulos uniformes : Journal of Fungi Idioma : Inglés (eng) Palabras clave : HIV Latin America awareness histoplasmosis leishmaniasis Resumen : Disseminated histoplasmosis is a major opportunistic infection of HIV-infected patients, killing thousands in Latin America each year. Yet, it remains a neglected disease that is often confused with tuberculosis, for lack of simple, affordable, and rapid diagnostic tools. There is great heterogeneity in the level of histoplasmosis awareness. The purpose of this report was to describe how the historical “awakening” to the threat of histoplasmosis came to be in four different centers that have actively described this disease: In Brazil, the Sao José hospital in Fortaleza; in Colombia, the Corporación para Investigaciones Biológicas in Medellin; in French Guiana, Cayenne Hospital; and in Guatemala, the Association de Salud Integral in Guatemala city. In Brazil and French Guiana, the search for leishmaniasis on the buffy coat or skin smears, respectively, led to the rapid realization that HIV patients were suffering from disseminated histoplasmosis. With time and progress in fungal culture, the magnitude of this problem turned it into a local priority. In Colombia and Guatemala, the story is different because for these mycology centers, it was no surprise to find histoplasmosis in HIV patients. In addition, collaborations with the CDC to evaluate antigen-detection tests resulted in researchers and clinicians developing the capacity to rapidly screen most patients and to demonstrate the very high burden of disease in these countries. While the lack of awareness is still a major problem, it is instructive to review the ways through which different centers became histoplasmosis-aware. Nevertheless, as new rapid diagnostic tools are becoming available, their implementation throughout Latin America should rapidly raise the level of awareness in order to reduce the burden of histoplasmosis deaths. Mención de responsabilidad : Mathieu Nacher, Terezinha Silva Leitao, Beatriz L Gómez, Pierre Couppié, Antoine Adenis, Lisandra Damasceno, Magalie Demar, Blanca Samayoa, Diego H Cáceres, Roger Pradinaud, Anastacio de Queiroz Sousa, Eduardo Arathoon, Angela Restrepo Referencia : J Fungi (Basel). 2019 Jun 17;5(2):51. DOI (Digital Object Identifier) : 10.3390/jof5020051 PMID : 31212897 En línea : https://www.mdpi.com/2309-608X/5/2/51 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4246 The fight against HIV-associated disseminated histoplasmosis in the Americas: unfolding the different stories of four centers [documento electrónico] / Ángela Restrepo Moreno, . - 2019.
Obra : Journal of Fungi
Idioma : Inglés (eng)
Palabras clave : HIV Latin America awareness histoplasmosis leishmaniasis Resumen : Disseminated histoplasmosis is a major opportunistic infection of HIV-infected patients, killing thousands in Latin America each year. Yet, it remains a neglected disease that is often confused with tuberculosis, for lack of simple, affordable, and rapid diagnostic tools. There is great heterogeneity in the level of histoplasmosis awareness. The purpose of this report was to describe how the historical “awakening” to the threat of histoplasmosis came to be in four different centers that have actively described this disease: In Brazil, the Sao José hospital in Fortaleza; in Colombia, the Corporación para Investigaciones Biológicas in Medellin; in French Guiana, Cayenne Hospital; and in Guatemala, the Association de Salud Integral in Guatemala city. In Brazil and French Guiana, the search for leishmaniasis on the buffy coat or skin smears, respectively, led to the rapid realization that HIV patients were suffering from disseminated histoplasmosis. With time and progress in fungal culture, the magnitude of this problem turned it into a local priority. In Colombia and Guatemala, the story is different because for these mycology centers, it was no surprise to find histoplasmosis in HIV patients. In addition, collaborations with the CDC to evaluate antigen-detection tests resulted in researchers and clinicians developing the capacity to rapidly screen most patients and to demonstrate the very high burden of disease in these countries. While the lack of awareness is still a major problem, it is instructive to review the ways through which different centers became histoplasmosis-aware. Nevertheless, as new rapid diagnostic tools are becoming available, their implementation throughout Latin America should rapidly raise the level of awareness in order to reduce the burden of histoplasmosis deaths. Mención de responsabilidad : Mathieu Nacher, Terezinha Silva Leitao, Beatriz L Gómez, Pierre Couppié, Antoine Adenis, Lisandra Damasceno, Magalie Demar, Blanca Samayoa, Diego H Cáceres, Roger Pradinaud, Anastacio de Queiroz Sousa, Eduardo Arathoon, Angela Restrepo Referencia : J Fungi (Basel). 2019 Jun 17;5(2):51. DOI (Digital Object Identifier) : 10.3390/jof5020051 PMID : 31212897 En línea : https://www.mdpi.com/2309-608X/5/2/51 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4246 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD001226 AC-2019-015 Archivo digital Producción Científica Artículos científicos Disponible Microbiología de las infecciones humanas / Ángela Restrepo Moreno
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado 000907 WC 100 M5-07 Ej. 2 Libro Casa 80 Instituto de Educación Disponible
Título : Inhibitory effect of deferoxamine or macrophage activation on transformation of Paracoccidioides brasiliensis conidia ingested by macrophages: reversal by holotransferrin Tipo de documento : documento electrónico Autores : Luz Elena Cano Restrepo, ; Beatriz Gómez, ; Ángela Restrepo Moreno, Fecha de publicación : 1994 Títulos uniformes : Infection and Immunity Idioma : Inglés (eng) Resumen : Conidia of P. brasiliensis ingested by murine macrophages at 37 degrees C showed enhanced transformation to yeast cells and further intracellular growth compared with conidia in culture medium alone. Treatment of macrophages with the iron chelator deferoxamine inhibited the intracellular conidium-to-yeast transformation. Cytokine-activated macrophages could also exert this inhibitory effect. Holotransferrin reversed the inhibitory effect of either deferoxamine or activated macrophages on intracellular conidium-to-yeast transformation. These results indicate that iron restriction is one of the mechanisms by which activated macrophages control the intracellular transformation of ingested conidia and growth of yeast cells. Mención de responsabilidad : L E Cano, B Gomez, E Brummer, A Restrepo, D A Stevens Referencia : Infect Immun. 1994 Apr;62(4):1494-5. PMID : 8132359 En línea : https://iai.asm.org/content/62/4/1494 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4375 Inhibitory effect of deferoxamine or macrophage activation on transformation of Paracoccidioides brasiliensis conidia ingested by macrophages: reversal by holotransferrin [documento electrónico] / Luz Elena Cano Restrepo, ; Beatriz Gómez, ; Ángela Restrepo Moreno, . - 1994.
Obra : Infection and Immunity
Idioma : Inglés (eng)
Resumen : Conidia of P. brasiliensis ingested by murine macrophages at 37 degrees C showed enhanced transformation to yeast cells and further intracellular growth compared with conidia in culture medium alone. Treatment of macrophages with the iron chelator deferoxamine inhibited the intracellular conidium-to-yeast transformation. Cytokine-activated macrophages could also exert this inhibitory effect. Holotransferrin reversed the inhibitory effect of either deferoxamine or activated macrophages on intracellular conidium-to-yeast transformation. These results indicate that iron restriction is one of the mechanisms by which activated macrophages control the intracellular transformation of ingested conidia and growth of yeast cells. Mención de responsabilidad : L E Cano, B Gomez, E Brummer, A Restrepo, D A Stevens Referencia : Infect Immun. 1994 Apr;62(4):1494-5. PMID : 8132359 En línea : https://iai.asm.org/content/62/4/1494 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4375 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000875 AC-1994-002 Archivo digital Producción Científica Artículos científicos Disponible
Título : Treatment of tropical mycoses Tipo de documento : documento electrónico Autores : Ángela Restrepo Moreno, Fecha de publicación : 1994 Títulos uniformes : Journal of the American Academy of Dermatology Idioma : Inglés (eng) Resumen : Several subcutaneous and deep-seated mycoses are either observed more frequently in the tropical areas or are restricted to certain regions within the tropics. These mycoses include sporotrichosis, chromoblastomycosis, entomophthoromycosis, eumycetoma, lobomycosis, and paracoccidioidomycosis. In sporotrichosis and paracoccidioidomycosis, therapy often results in either complete resolution or marked improvement. For decades sporotrichosis has been treated successfully with potassium iodide, but recently the triazole compounds, especially itraconazole, have proved effective and free of major side effects. The usual therapy for paracoccidioidomycosis is sulfonamides or amphotericin B; the former requires prolonged treatment, whereas the latter causes a significant degree of toxicity. Various azole derivatives (ketoconazole, fluconazole, saperconazole, and itraconazole) allow shorter treatment courses, can be given orally, and are more effective. Presently, itraconazole is the drug of choice. Chromoblastomycosis is a difficult condition to treat, especially if it is caused by Fonsecaea pedrosoi. Several therapeutic approaches have been used, including heat, surgery, cryotherapy, thiabendazole, amphotericin B combined with flucytosine, and azole derivatives, but their success has been modest. A 65% response rate has been obtained with itraconazole given for periods of 6 to 19 months; in limited trials, saperconazole appears to be more effective and requires shorter treatment courses. Only a few patients with eumycetoma respond to therapy; 70% of patients with Madurella mycetomatis respond to prolonged treatment with ketoconazole. Griseofulvin has been tried in nonresponders with partial success. Limited data in patients with Fusarium species eumycetoma indicate good responses to itraconazole. Eumycetoma caused by Pseudallescheria boydii or Acremonium species has been refractory to therapy. Therapy of entomophthoromycosis is also difficult because the diagnosis is usually established late and not all patients respond to therapy; this situation applies to infection caused by either Basidiobolus haptosporus or Conidiobolus coronatus. Although there is no consensus, African physicians prefer to use potassium iodide or trimethoprim-sulfamethoxazole. Isolated reports indicate that the azole derivatives, including the triazoles, may be effective. As for lobomycosis, all attempts at medical treatment have failed. Surgery is successful only when the lesion is small and can be fully resected; repeated cryotherapy appears to be more successful. Mención de responsabilidad : Angela Restrepo, MD, PhD Referencia : J Am Acad Dermatol. 1994 Sep;31(3 Pt 2):S91-102. DOI (Digital Object Identifier) : 10.1016/s0190-9622(08)81277-7 PMID : 8077517 En línea : https://www.jaad.org/article/S0190-9622(08)81277-7/abstract Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4374 Treatment of tropical mycoses [documento electrónico] / Ángela Restrepo Moreno, . - 1994.
Obra : Journal of the American Academy of Dermatology
Idioma : Inglés (eng)
Resumen : Several subcutaneous and deep-seated mycoses are either observed more frequently in the tropical areas or are restricted to certain regions within the tropics. These mycoses include sporotrichosis, chromoblastomycosis, entomophthoromycosis, eumycetoma, lobomycosis, and paracoccidioidomycosis. In sporotrichosis and paracoccidioidomycosis, therapy often results in either complete resolution or marked improvement. For decades sporotrichosis has been treated successfully with potassium iodide, but recently the triazole compounds, especially itraconazole, have proved effective and free of major side effects. The usual therapy for paracoccidioidomycosis is sulfonamides or amphotericin B; the former requires prolonged treatment, whereas the latter causes a significant degree of toxicity. Various azole derivatives (ketoconazole, fluconazole, saperconazole, and itraconazole) allow shorter treatment courses, can be given orally, and are more effective. Presently, itraconazole is the drug of choice. Chromoblastomycosis is a difficult condition to treat, especially if it is caused by Fonsecaea pedrosoi. Several therapeutic approaches have been used, including heat, surgery, cryotherapy, thiabendazole, amphotericin B combined with flucytosine, and azole derivatives, but their success has been modest. A 65% response rate has been obtained with itraconazole given for periods of 6 to 19 months; in limited trials, saperconazole appears to be more effective and requires shorter treatment courses. Only a few patients with eumycetoma respond to therapy; 70% of patients with Madurella mycetomatis respond to prolonged treatment with ketoconazole. Griseofulvin has been tried in nonresponders with partial success. Limited data in patients with Fusarium species eumycetoma indicate good responses to itraconazole. Eumycetoma caused by Pseudallescheria boydii or Acremonium species has been refractory to therapy. Therapy of entomophthoromycosis is also difficult because the diagnosis is usually established late and not all patients respond to therapy; this situation applies to infection caused by either Basidiobolus haptosporus or Conidiobolus coronatus. Although there is no consensus, African physicians prefer to use potassium iodide or trimethoprim-sulfamethoxazole. Isolated reports indicate that the azole derivatives, including the triazoles, may be effective. As for lobomycosis, all attempts at medical treatment have failed. Surgery is successful only when the lesion is small and can be fully resected; repeated cryotherapy appears to be more successful. Mención de responsabilidad : Angela Restrepo, MD, PhD Referencia : J Am Acad Dermatol. 1994 Sep;31(3 Pt 2):S91-102. DOI (Digital Object Identifier) : 10.1016/s0190-9622(08)81277-7 PMID : 8077517 En línea : https://www.jaad.org/article/S0190-9622(08)81277-7/abstract Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4374 Reserva
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Código de barras Número de Ubicación Tipo de medio Ubicación Sección Estado DD000874 AC-1994-001 Archivo digital Producción Científica Artículos científicos Disponible
Título : Course of the experimental murine infection induced by sporothrix schenckii conidia according to depth of inoculation Tipo de documento : documento electrónico Autores : Fabio Uribe Jaramillo, ; Ángela Inés Zuluaga Cadena, ; Ángela Restrepo Moreno, Fecha de publicación : 1993 Títulos uniformes : Journal of Medical and Veterinary Mycology Idioma : Inglés (eng) Resumen : Balb/c mice were infected intradermally (ID) or subcutaneously (SC) with Sporothrix schenckii conidia, in an attempt to demonstrate the role played by the depth of inoculation on the course of the infectious process. Animals were observed weekly up to 6 weeks and the time of appearance, as well as the aspect of the lesions, was recorded. Thirty percent of the animals were autopsied and their organs subjected to histopathological study. All animals, irrespective of the route of inoculation, developed clinically detectable sporotrichosis; the resulting lesions (nodules, drained or undrained abscesses, pustules) tended towards spontaneous healing; most of the ID-inoculated mice healed after 3 weeks post-infection while the SC group took longer (5 weeks). Histologically, all the animals that were killed had inflammatory foci, but a larger proportion (57%) of those infected SC exhibited granuloma formation in comparison with the animals infected by the ID route (16·6%). During the first week post-inoculation, the enlargement of the inguinal lymph node did not coincide with the presence of histologically detectable hypertrophy; however, after 2 weeks, 70–80% of all animals had both types of abnormality. Our results indicate that irrespective of the route of inoculation all the mice developed clinically and histologically detectable sporotrichosis, albeit of a limited character. Mención de responsabilidad : S. Restrepo-Gutierrez, M. Arango-Arteaga, F. Uribe-Jaramillo, A.I. Zuluaga-Cadena, A. Restrepo-Moreno DOI (Digital Object Identifier) : 10.1080/02681219380000541 En línea : https://academic.oup.com/mmy/article-abstract/31/6/411/988315 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4371 Course of the experimental murine infection induced by sporothrix schenckii conidia according to depth of inoculation [documento electrónico] / Fabio Uribe Jaramillo, ; Ángela Inés Zuluaga Cadena, ; Ángela Restrepo Moreno, . - 1993.
Obra : Journal of Medical and Veterinary Mycology
Idioma : Inglés (eng)
Resumen : Balb/c mice were infected intradermally (ID) or subcutaneously (SC) with Sporothrix schenckii conidia, in an attempt to demonstrate the role played by the depth of inoculation on the course of the infectious process. Animals were observed weekly up to 6 weeks and the time of appearance, as well as the aspect of the lesions, was recorded. Thirty percent of the animals were autopsied and their organs subjected to histopathological study. All animals, irrespective of the route of inoculation, developed clinically detectable sporotrichosis; the resulting lesions (nodules, drained or undrained abscesses, pustules) tended towards spontaneous healing; most of the ID-inoculated mice healed after 3 weeks post-infection while the SC group took longer (5 weeks). Histologically, all the animals that were killed had inflammatory foci, but a larger proportion (57%) of those infected SC exhibited granuloma formation in comparison with the animals infected by the ID route (16·6%). During the first week post-inoculation, the enlargement of the inguinal lymph node did not coincide with the presence of histologically detectable hypertrophy; however, after 2 weeks, 70–80% of all animals had both types of abnormality. Our results indicate that irrespective of the route of inoculation all the mice developed clinically and histologically detectable sporotrichosis, albeit of a limited character. Mención de responsabilidad : S. Restrepo-Gutierrez, M. Arango-Arteaga, F. Uribe-Jaramillo, A.I. Zuluaga-Cadena, A. Restrepo-Moreno DOI (Digital Object Identifier) : 10.1080/02681219380000541 En línea : https://academic.oup.com/mmy/article-abstract/31/6/411/988315 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4371 Reserva
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