| Título : |
Inhibitory effect of deferoxamine or macrophage activation on transformation of Paracoccidioides brasiliensis conidia ingested by macrophages: reversal by holotransferrin |
| Tipo de documento : |
documento electrónico |
| Autores : |
Luz Elena Cano Restrepo, ; Beatriz Gómez, ; Ángela Restrepo Moreno, |
| Fecha de publicación : |
1994 |
| Títulos uniformes : |
Infection and Immunity
|
| Idioma : |
Inglés (eng) |
| Resumen : |
Conidia of P. brasiliensis ingested by murine macrophages at 37 degrees C showed enhanced transformation to yeast cells and further intracellular growth compared with conidia in culture medium alone. Treatment of macrophages with the iron chelator deferoxamine inhibited the intracellular conidium-to-yeast transformation. Cytokine-activated macrophages could also exert this inhibitory effect. Holotransferrin reversed the inhibitory effect of either deferoxamine or activated macrophages on intracellular conidium-to-yeast transformation. These results indicate that iron restriction is one of the mechanisms by which activated macrophages control the intracellular transformation of ingested conidia and growth of yeast cells. |
| Mención de responsabilidad : |
L E Cano, B Gomez, E Brummer, A Restrepo, D A Stevens |
| Referencia : |
Infect Immun. 1994 Apr;62(4):1494-5. |
| PMID : |
8132359 |
| En línea : |
https://iai.asm.org/content/62/4/1494 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4375 |
Inhibitory effect of deferoxamine or macrophage activation on transformation of Paracoccidioides brasiliensis conidia ingested by macrophages: reversal by holotransferrin [documento electrónico] / Luz Elena Cano Restrepo, ; Beatriz Gómez, ; Ángela Restrepo Moreno, . - 1994. Obra : Infection and ImmunityIdioma : Inglés ( eng) | Resumen : |
Conidia of P. brasiliensis ingested by murine macrophages at 37 degrees C showed enhanced transformation to yeast cells and further intracellular growth compared with conidia in culture medium alone. Treatment of macrophages with the iron chelator deferoxamine inhibited the intracellular conidium-to-yeast transformation. Cytokine-activated macrophages could also exert this inhibitory effect. Holotransferrin reversed the inhibitory effect of either deferoxamine or activated macrophages on intracellular conidium-to-yeast transformation. These results indicate that iron restriction is one of the mechanisms by which activated macrophages control the intracellular transformation of ingested conidia and growth of yeast cells. |
| Mención de responsabilidad : |
L E Cano, B Gomez, E Brummer, A Restrepo, D A Stevens |
| Referencia : |
Infect Immun. 1994 Apr;62(4):1494-5. |
| PMID : |
8132359 |
| En línea : |
https://iai.asm.org/content/62/4/1494 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4375 |
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