Detection of proteolytic enzymes released by the dimorphic fungus Paracoccidioides brasiliensis / Victoria Inés Bedoya Escobar ; María Soledad Naranjo Mesa ; Ángela Restrepo Moreno  

Público ISBD Título : Detection of proteolytic enzymes released by the dimorphic fungus Paracoccidioides brasiliensis Tipo de documento : documento electrónico Autores : Victoria Inés Bedoya Escobar, ; María Soledad Naranjo Mesa, ; Ángela Restrepo Moreno, Fecha de publicación : 1993 Títulos uniformes : Journal of Medical and Veterinary Mycology Idioma : Inglés (eng) Resumen : The release of proteolytic enzymes with elastinolytic and collagenolytic activity was investigated in 10 different isolates of Paracoccidioides brasiliensis. The study encompassed both the mycelial and the yeast phase of the fungus. In the mycelial phase, secretion of elastinolytic and collagenolytic enzymes was demonstrated in 70% and 80% of the isolates, respectively. None of the isolates in the yeast phase exhibited elastinolytic activity, but 90% showed collagenolytic activity. These results demonstrate that the dimorphic fungus P. brasiliensis has the ability to release proteolytic enzymes in both growth phases, although with apparently different specificities. Mención de responsabilidad : V.I. Bedoya-Escobar, M.S. Naranjo-Mesa & A. Restrepo-Moreno DOI (Digital Object Identifier) : 10.1080/02681219380000361 En línea : https://www.tandfonline.com/doi/abs/10.1080/02681219380000361 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4370 Detection of proteolytic enzymes released by the dimorphic fungus Paracoccidioides brasiliensis [documento electrónico] / Victoria Inés Bedoya Escobar, ; María Soledad Naranjo Mesa, ; Ángela Restrepo Moreno,  . - 1993. Obra : Journal of Medical and Veterinary Mycology Idioma : Inglés (eng) Resumen : The release of proteolytic enzymes with elastinolytic and collagenolytic activity was investigated in 10 different isolates of Paracoccidioides brasiliensis. The study encompassed both the mycelial and the yeast phase of the fungus. In the mycelial phase, secretion of elastinolytic and collagenolytic enzymes was demonstrated in 70% and 80% of the isolates, respectively. None of the isolates in the yeast phase exhibited elastinolytic activity, but 90% showed collagenolytic activity. These results demonstrate that the dimorphic fungus P. brasiliensis has the ability to release proteolytic enzymes in both growth phases, although with apparently different specificities. Mención de responsabilidad : V.I. Bedoya-Escobar, M.S. Naranjo-Mesa & A. Restrepo-Moreno DOI (Digital Object Identifier) : 10.1080/02681219380000361 En línea : https://www.tandfonline.com/doi/abs/10.1080/02681219380000361 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4370

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Treatment of paracoccidioidomycosis with itraconazole / María Soledad Naranjo Mesa ; Mónica Rosa Trujillo Honeysberg ; María Isabel Múnera Jaramillo ; P. Restrepo ; Iván Gómez ; Ángela Restrepo Moreno  

Público ISBD Título : Treatment of paracoccidioidomycosis with itraconazole Tipo de documento : documento electrónico Autores : María Soledad Naranjo Mesa, ; Mónica Rosa Trujillo Honeysberg, ; María Isabel Múnera Jaramillo, ; P. Restrepo, ; Iván Gómez, ; Ángela Restrepo Moreno, Fecha de publicación : 1990 Títulos uniformes : Journal of Medical and Veterinary Mycology Idioma : Inglés (eng) Resumen : Forty-seven patients with active paracoccidioidomycosis were treated with itraconazole. The majority of the patients (45) had the chronic adult form of the disease while the remaining exhibited the juvenile form. All of the patients received itraconazole, 100 mg day-1, with the exception of two for whom the clinical condition necessitated a larger dose. The mean duration of therapy was 6 months, with a range of 3–24 months. Clinically, the skin and mucous membrane lesions as well as abdominal pain, auscultatory alterations and dysphonia improved markedly during treatment with a concomitant increase in weight. However, other symptoms (cough, expectoration and dyspnoea) persisted as sequelae in some cases. As expected, adrenal insufficiency also persisted. The radiological lesions showed a gradual decrease of both scattered and confluent infiltrates, present in 67% of patients before, and in 13% at the end of treatment. On the other hand, fibrosis became more evident at the termination of therapy, increasing from 62% of patients at the beginning of therapy to 81% at the end. The mycological tests (direct examination and cultures) became negative during the first month of treatment in 42 patients (87%). A decline in specific antibody titres was observed in 72% of patients by the end of treatment. Evaluation of therapy by means of a scoring system indicated complete resolution of the disease in one patient (2%), marked improvement in 42 (89%) and minor improvement in four (8·5%); none of the patients showed a deterioration of their disease during therapy. Of fifteen patients who were followed up for 12 months post-therapy none showed clinical relapse during this period. The results of this study confirm the efficacy of itraconazole in the treatment of paracoccidioidomycosis. Mención de responsabilidad : M.S. Naranjo, M. Trujillo, M.I. Munera, P. Restrepo, I. Gomez, A. Restrepo Referencia : J Med Vet Mycol. 1990;28(1):67-76 DOI (Digital Object Identifier) : 10.1080/02681219080000091 PMID : 2163442 En línea : https://academic.oup.com/mmy/article-abstract/28/1/67/894889 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4356 Treatment of paracoccidioidomycosis with itraconazole [documento electrónico] / María Soledad Naranjo Mesa, ; Mónica Rosa Trujillo Honeysberg, ; María Isabel Múnera Jaramillo, ; P. Restrepo, ; Iván Gómez, ; Ángela Restrepo Moreno,  . - 1990. Obra : Journal of Medical and Veterinary Mycology Idioma : Inglés (eng) Resumen : Forty-seven patients with active paracoccidioidomycosis were treated with itraconazole. The majority of the patients (45) had the chronic adult form of the disease while the remaining exhibited the juvenile form. All of the patients received itraconazole, 100 mg day-1, with the exception of two for whom the clinical condition necessitated a larger dose. The mean duration of therapy was 6 months, with a range of 3–24 months. Clinically, the skin and mucous membrane lesions as well as abdominal pain, auscultatory alterations and dysphonia improved markedly during treatment with a concomitant increase in weight. However, other symptoms (cough, expectoration and dyspnoea) persisted as sequelae in some cases. As expected, adrenal insufficiency also persisted. The radiological lesions showed a gradual decrease of both scattered and confluent infiltrates, present in 67% of patients before, and in 13% at the end of treatment. On the other hand, fibrosis became more evident at the termination of therapy, increasing from 62% of patients at the beginning of therapy to 81% at the end. The mycological tests (direct examination and cultures) became negative during the first month of treatment in 42 patients (87%). A decline in specific antibody titres was observed in 72% of patients by the end of treatment. Evaluation of therapy by means of a scoring system indicated complete resolution of the disease in one patient (2%), marked improvement in 42 (89%) and minor improvement in four (8·5%); none of the patients showed a deterioration of their disease during therapy. Of fifteen patients who were followed up for 12 months post-therapy none showed clinical relapse during this period. The results of this study confirm the efficacy of itraconazole in the treatment of paracoccidioidomycosis. Mención de responsabilidad : M.S. Naranjo, M. Trujillo, M.I. Munera, P. Restrepo, I. Gomez, A. Restrepo Referencia : J Med Vet Mycol. 1990;28(1):67-76 DOI (Digital Object Identifier) : 10.1080/02681219080000091 PMID : 2163442 En línea : https://academic.oup.com/mmy/article-abstract/28/1/67/894889 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4356

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Seguimiento post-terapia de pacientes con paracoccidioidomicosis tratados con itraconazol / María Isabel Múnera Jaramillo ; María Soledad Naranjo Mesa ; Iván Gómez ; Ángela Restrepo Moreno    

Público ISBD Título : Seguimiento post-terapia de pacientes con paracoccidioidomicosis tratados con itraconazol Tipo de documento : documento electrónico Autores : María Isabel Múnera Jaramillo, ; María Soledad Naranjo Mesa, ; Iván Gómez, ; Ángela Restrepo Moreno, Fecha de publicación : 1989 Títulos uniformes : Medicina U.P.B. Idioma : Español (spa) Palabras clave : Paracoccidioidomicosis  itraconazol Resumen : Durante el período posterior a la terapia se siguió a once pacientes con paracoccidioidomicosis que completaron un ciclo de terapia con itraconazol, todos ellos durante 12 meses y 4 durante períodos más largos (24 - 48 meses). No hubo recaídas ni muertes relacionadas con la micosis. El resultado clínico y radiológico fue satisfactorio y solo quedaron hallazgos residuales como disnea y fibrosis. Las pruebas serológicas mostraron una disminución de la actividad de los anticuerpos en comparación con los resultados obtenidos al inicio de la terapia. Estos hallazgos sugieren que el itraconazol constituye un tratamiento adecuado para los pacientes con paracoccidioidomicosis. Mención de responsabilidad : María Isabel Múnera, María Soledad Naranjo, Iván Gómez, Ángela Restrepo En línea : https://revistas.upb.edu.co/index.php/medicina/article/view/5686 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5049 Seguimiento post-terapia de pacientes con paracoccidioidomicosis tratados con itraconazol [documento electrónico] / María Isabel Múnera Jaramillo, ; María Soledad Naranjo Mesa, ; Iván Gómez, ; Ángela Restrepo Moreno,  . - 1989. Obra : Medicina U.P.B. Idioma : Español (spa) Palabras clave : Paracoccidioidomicosis  itraconazol Resumen : Durante el período posterior a la terapia se siguió a once pacientes con paracoccidioidomicosis que completaron un ciclo de terapia con itraconazol, todos ellos durante 12 meses y 4 durante períodos más largos (24 - 48 meses). No hubo recaídas ni muertes relacionadas con la micosis. El resultado clínico y radiológico fue satisfactorio y solo quedaron hallazgos residuales como disnea y fibrosis. Las pruebas serológicas mostraron una disminución de la actividad de los anticuerpos en comparación con los resultados obtenidos al inicio de la terapia. Estos hallazgos sugieren que el itraconazol constituye un tratamiento adecuado para los pacientes con paracoccidioidomicosis. Mención de responsabilidad : María Isabel Múnera, María Soledad Naranjo, Iván Gómez, Ángela Restrepo En línea : https://revistas.upb.edu.co/index.php/medicina/article/view/5686 Enlace permanente : https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=5049

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