| Título : |
Course of the experimental murine infection induced by sporothrix schenckii conidia according to depth of inoculation |
| Tipo de documento : |
documento electrónico |
| Autores : |
Fabio Uribe Jaramillo, ; Ángela Inés Zuluaga Cadena, ; Ángela Restrepo Moreno, |
| Fecha de publicación : |
1993 |
| Títulos uniformes : |
Journal of Medical and Veterinary Mycology
|
| Idioma : |
Inglés (eng) |
| Resumen : |
Balb/c mice were infected intradermally (ID) or subcutaneously (SC) with Sporothrix schenckii conidia, in an attempt to demonstrate the role played by the depth of inoculation on the course of the infectious process. Animals were observed weekly up to 6 weeks and the time of appearance, as well as the aspect of the lesions, was recorded. Thirty percent of the animals were autopsied and their organs subjected to histopathological study. All animals, irrespective of the route of inoculation, developed clinically detectable sporotrichosis; the resulting lesions (nodules, drained or undrained abscesses, pustules) tended towards spontaneous healing; most of the ID-inoculated mice healed after 3 weeks post-infection while the SC group took longer (5 weeks). Histologically, all the animals that were killed had inflammatory foci, but a larger proportion (57%) of those infected SC exhibited granuloma formation in comparison with the animals infected by the ID route (16·6%). During the first week post-inoculation, the enlargement of the inguinal lymph node did not coincide with the presence of histologically detectable hypertrophy; however, after 2 weeks, 70–80% of all animals had both types of abnormality. Our results indicate that irrespective of the route of inoculation all the mice developed clinically and histologically detectable sporotrichosis, albeit of a limited character. |
| Mención de responsabilidad : |
S. Restrepo-Gutierrez, M. Arango-Arteaga, F. Uribe-Jaramillo, A.I. Zuluaga-Cadena, A. Restrepo-Moreno |
| DOI (Digital Object Identifier) : |
10.1080/02681219380000541 |
| En línea : |
https://academic.oup.com/mmy/article-abstract/31/6/411/988315 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4371 |
Course of the experimental murine infection induced by sporothrix schenckii conidia according to depth of inoculation [documento electrónico] / Fabio Uribe Jaramillo, ; Ángela Inés Zuluaga Cadena, ; Ángela Restrepo Moreno, . - 1993. Obra : Journal of Medical and Veterinary MycologyIdioma : Inglés ( eng) | Resumen : |
Balb/c mice were infected intradermally (ID) or subcutaneously (SC) with Sporothrix schenckii conidia, in an attempt to demonstrate the role played by the depth of inoculation on the course of the infectious process. Animals were observed weekly up to 6 weeks and the time of appearance, as well as the aspect of the lesions, was recorded. Thirty percent of the animals were autopsied and their organs subjected to histopathological study. All animals, irrespective of the route of inoculation, developed clinically detectable sporotrichosis; the resulting lesions (nodules, drained or undrained abscesses, pustules) tended towards spontaneous healing; most of the ID-inoculated mice healed after 3 weeks post-infection while the SC group took longer (5 weeks). Histologically, all the animals that were killed had inflammatory foci, but a larger proportion (57%) of those infected SC exhibited granuloma formation in comparison with the animals infected by the ID route (16·6%). During the first week post-inoculation, the enlargement of the inguinal lymph node did not coincide with the presence of histologically detectable hypertrophy; however, after 2 weeks, 70–80% of all animals had both types of abnormality. Our results indicate that irrespective of the route of inoculation all the mice developed clinically and histologically detectable sporotrichosis, albeit of a limited character. |
| Mención de responsabilidad : |
S. Restrepo-Gutierrez, M. Arango-Arteaga, F. Uribe-Jaramillo, A.I. Zuluaga-Cadena, A. Restrepo-Moreno |
| DOI (Digital Object Identifier) : |
10.1080/02681219380000541 |
| En línea : |
https://academic.oup.com/mmy/article-abstract/31/6/411/988315 |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=4371 |
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