Hepatitis C virus seroprevalence in multi-transfused patients in Colombia [documento electrónico] / Sergio Jaramillo Velásquez, ; Jorge Hernando Donado Gómez, ; Ángela Patricia Estrada Naranjo, ; Sandra Yepes,  . - 2005.
Obra : Journal of Clinical Virology

Idioma : Inglés (eng)

Palabras clave :	HCV  prevalence  multi-transfused patients  Colombia
Resumen :	Background: Hepatitis C Vtrus (HCV) refection is a public health problem worldwide, with particular relevance m multi-transfused patients given that HCV is principally transmitted by exposure to infected blood Study design: Between February and September 2003 a cross-sectional study was carried out m four hospital centres m Bogotfi and Medellln, Colombia, to determine the risk factors for HCV refection m 500 multi-transfused patients. Results: The study population was distributed in five groups haemophlha, haemodyahsls, acute bleeding, oncologlcal illnesses and sickle cell disease or thalassemla Serum samples from patients were tested for HCV aXltlbodles (Asxym TM, Abbott) An overall prevalence (9 0%, 95% confidence interval (CI) 6 4 11 6) (45/500) of HCV infection was found Antl-HCV aXltlbodles were detected m 32 2% of patients with haemophlha, 6 1% of patients undergoing haemodlalysls, 7 1% of patients with sickle cell disease or thalassemla, 2 6% of patients with acute bleeding and 3 4% of patients with oncologlcal or hematological diseases The mare risk t; actors associated with refection by HCV were to be hemophdlc (odds ratio, OR 18 03, 95% CI 3 96 114 17), having received transfusions before 1995 (OR 12 27, 95% CI 5 57 27 69), and having received more than 48 units of blood components (OR 6 08, 95% CI 3 06 12 1) In the multlwxlate axmlysls, only the year of transfusions (before 1995) remained significantly associated with risk of infection by HCV. Conclusions: The data show a 3-fold reduction m the refection risk between 1993 and 1995, when the serological screening for HCV in blood donors was being introduced A reduction greater than 90% was achteved by 1995 when the screening coverage reached 99%
Mención de responsabilidad :	Mauricio Beltrân, Maria-Cristina Navas, Fernando De la Hoz, Maria Mercedes Muñoz, Sergio Jaramillo, Cecilia Estrada, Lucia Del Pilar Cortés, Maria Patricia Arbelâez, Jorge Donado, Gloria Barco, Martha Luna, Gustavo Adolfo Uribe, Amalia de Maldonado, Juan Carlos Restrepo, Gonzalo Correa, Paula Borda, Gloria Rey, Marlen de Neira, Angela Estrada, Sandra Yepes, Oscar Beltrân, Javier Pacheco, Iván Villegas, Jorge Boshell
Referencia :	J Clin Virol. 2005 Dec;34Suppl,2:S33-8.
DOI (Digital Object Identifier) :	10.1016/S1386-6532(05)80032-0
PMID :	16461238
En línea :	https://linkinghub.elsevier.com/retrieve/pii/S1386653205800320
Enlace permanente :	https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3438