Low immunohistochemical expression of MGMT in ACTH secreting pituitary tumors of patients with Nelson syndrome [documento electrónico] / Luis Vicente Syro Moreno,  . - 2010.
Obra : Endocrine Pathology

Idioma : Inglés (eng)

Resumen :	MGMT expression in tumors has been correlated with response to treatment with temozolomide therapy. Few medical therapies are available for Nelson syndrome, and the efficacy of such therapeutics remains limited. The aim of the present study was to assess immunohistochemical expression of MGMT in ACTH-secreting pituitary adenomas of patients with Nelson syndrome. Our material consisted of eight specimens from ACTH-secreting pituitary adenomas of patients with Nelson syndrome. Immunohistochemical staining for MGMT was performed using the streptavidin-biotin-peroxidase complex method. MGMT immunoreactivity was assessed microscopically and recorded as an estimated percentage of nuclear MGMT immunostaining (0 = none, 1=50%). Five of the eight specimens (65%) exhibited no MGMT immunoreactivity, with two out of eight cases (25%) showing slight MGMT staining (
Mención de responsabilidad :	Fateme Salehi, Bernd W Scheithauer, Veronica J Moyes, William M Drake, Luis V Syro, Branavan Manoranjan, Soniya Sharma, Eva Horvath, Kalman Kovacs
Referencia :	Endocr Pathol. 2010 Dec;21(4):227-9.
DOI (Digital Object Identifier) :	10.1007/s12022-010-9138-3
PMID :	21061089
En línea :	https://link.springer.com/article/10.1007/s12022-010-9138-3
Enlace permanente :	https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3507