Adrenal function status in patients with paracoccidioidomycosis after prolonged post-therapy follow-up [documento electrónico] / Carlos Andrés Agudelo, ; Carlos Alberto Restrepo Peláez, ; Carlos Andrés Villa Franco, ; William de Jesús Quiceno Calderón,  . - 2010.
Obra : American Journal of Tropical Medicine and Hygiene

Idioma : Inglés (eng)

Resumen :	This study assessed adrenal function in patients with paracoccididioidomycosis who had been treated to determine a possible connection between high antibody titers and adrenal dysfunction attributable to persistence of the fungus in adrenal gland. Adrenal gland function was studied in 28 previously treated patients, 2 (7.1%) of whom were shown to have adrenal insufficiency and 7 (259%) who showed a below normal response to stimuli by adrenocorticotropic hormone. Paracoccidioides brasiliensis was detected in the adrenal gland from one of the patients with adrenal insufficiency. Although the study failed to demonstrate a significant difference between high antibody titers and low cortisol levels, the proportion of adrenal insufficiency detected and the subnormal response to adrenocorticotropic hormone confirmed that adrenal damage is an important sequela of paracoccidioidomycosis. Studies with a larger number of patients should be conducted to confirm the hypothesis of persistence of P. brasiliensis in adrenal gland after therapy.
Mención de responsabilidad :	Angela M Tobón, Carlos A Agudelo, Carlos A Restrepo, Carlos A Villa, William Quiceno, Santiago Estrada, Angela Restrepo
Referencia :	Am J Trop Med Hyg. 2010 Jul;83(1):111-4.
DOI (Digital Object Identifier) :	10.4269/ajtmh.2010.09-0634
PMID :	20595488
En línea :	http://www.ajtmh.org/content/journals/10.4269/ajtmh.2010.09-0634#html_fulltext
Enlace permanente :	https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3520