| Título : |
Etiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia |
| Tipo de documento : |
documento electrónico |
| Autores : |
Sergio Iván Hoyos Duque, ; Juan Carlos Restrepo Gutiérrez, ; Gonzalo Correa Arango, ; Sergio Jaramillo Velásquez, |
| Fecha de publicación : |
2011 |
| Títulos uniformes : |
Hepatitis Research and Treatment
|
| Idioma : |
Inglés (eng) |
| Resumen : |
Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are the principal risk factor associated to end-stage liver diseases in the world. A study was carried out on end-stage liver disease cases admitted to an important hepatology unit in Medellin, the second largest city in Colombia. From 131 patients recruited in this prospective study, 71% of cases were diagnosed as cirrhosis, 12.2% as HCC, and 16.8% as cirrhosis and HCC. Regarding the risk factors of these patients, alcohol consumption was the most frequent (37.4%), followed by viral etiology (17.6%). Blood and/or hepatic tissue samples from patients with serological markers for HCV or HBV infection were characterized; on the basis of the phylogenetic analysis of HCV 5′ UTR and HBV S gene, isolates belonged to HCV/1 and HBV/F3, respectively. These results confirm the presence of strains associated with poor clinical outcome, in patients with liver disease in Colombia; additionally, HBV basal core promoter double mutant was identified in HCC cases. Here we show the first study of cirrhosis and/or HCC in Colombian and HBV and HCV molecular characterization of these patients. Viral aetiology was not the main risk factor in this cohort but alcohol consumption. |
| Mención de responsabilidad : |
Fabian Cortes-Mancera, Carmen Luisa Loureiro, Sergio Hoyos, Juan-Carlos Restrepo, Gonzalo Correa, Sergio Jaramillo, Helene Norder, Flor Helene Pujol, Maria-Cristina Navas |
| Referencia : |
Hepat Res Treat. 2011;2011:363205. |
| DOI (Digital Object Identifier) : |
10.1155/2011/363205 |
| PMID : |
21941645 |
| En línea : |
https://www.hindawi.com/journals/heprt/2011/363205/ |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
Etiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia [documento electrónico] / Sergio Iván Hoyos Duque, ; Juan Carlos Restrepo Gutiérrez, ; Gonzalo Correa Arango, ; Sergio Jaramillo Velásquez, . - 2011. Obra : Hepatitis Research and TreatmentIdioma : Inglés ( eng)
| Resumen : |
Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are the principal risk factor associated to end-stage liver diseases in the world. A study was carried out on end-stage liver disease cases admitted to an important hepatology unit in Medellin, the second largest city in Colombia. From 131 patients recruited in this prospective study, 71% of cases were diagnosed as cirrhosis, 12.2% as HCC, and 16.8% as cirrhosis and HCC. Regarding the risk factors of these patients, alcohol consumption was the most frequent (37.4%), followed by viral etiology (17.6%). Blood and/or hepatic tissue samples from patients with serological markers for HCV or HBV infection were characterized; on the basis of the phylogenetic analysis of HCV 5′ UTR and HBV S gene, isolates belonged to HCV/1 and HBV/F3, respectively. These results confirm the presence of strains associated with poor clinical outcome, in patients with liver disease in Colombia; additionally, HBV basal core promoter double mutant was identified in HCC cases. Here we show the first study of cirrhosis and/or HCC in Colombian and HBV and HCV molecular characterization of these patients. Viral aetiology was not the main risk factor in this cohort but alcohol consumption. |
| Mención de responsabilidad : |
Fabian Cortes-Mancera, Carmen Luisa Loureiro, Sergio Hoyos, Juan-Carlos Restrepo, Gonzalo Correa, Sergio Jaramillo, Helene Norder, Flor Helene Pujol, Maria-Cristina Navas |
| Referencia : |
Hepat Res Treat. 2011;2011:363205. |
| DOI (Digital Object Identifier) : |
10.1155/2011/363205 |
| PMID : |
21941645 |
| En línea : |
https://www.hindawi.com/journals/heprt/2011/363205/ |
| Enlace permanente : |
https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_dis |
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Etiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia
