Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia [documento electrónico] / Sergio Iván Hoyos Duque, ; Juan Carlos Restrepo Gutiérrez, ; Gonzalo Correa Arango, ; Sergio Jaramillo Velásquez,  . - 2011.
Obra : Hepatitis Research and Treatment

Idioma : Inglés (eng)

Resumen :	Hepatocellular Carcinoma (HCC) is a leading cause of cancer-related death worldwide. Globally, the most important HCC risk factors are Hepatitis B Virus (HBV) and/or Hepatitis C Virus (HCV), chronic alcoholism, and dietary exposure to aflatoxins. We have described the epidemiological pattern of 202 HCC samples obtained from Colombian patients. Additionally we investigated HBV/HCV infections and TP53 mutations in 49 of these HCC cases. HBV biomarkers were detected in 58.1% of the cases; HBV genotypes F and D were characterized in three of the samples. The HCV biomarker was detected in 37% of the samples while HBV/HCV coinfection was found in 19.2%. Among TP53 mutations, 10.5% occur at the common aflatoxin mutation hotspot, codon 249. No data regarding chronic alcoholism was available from the cases. In conclusion, in this first study of HCC and biomarkers in a Colombian population, the main HCC risk factor was HBV infection.
Mención de responsabilidad :	Maria-Cristina Navas, Iris Suarez, Andrea Carreño, Diego Uribe, Wilson Alfredo Rios, Fabian Cortes-Mancera, Ghyslaine Martel, Beatriz Vieco, Diana Lozano, Carlos Jimenez, Doriane Gouas, German Osorio, Sergio Hoyos, Juan Carlos Restrepo, Gonzalo Correa, Sergio Jaramillo, Rocio Lopez, Luis Eduardo Bravo, Maria Patricia Arbelaez, Jean-Yves Scoazec, Behnoush Abedi-Ardekani, Regina M Santella, Isabelle Chemin, Pierre Hainaut
Referencia :	Hepat Res Treat. 2011;2011:582945.
DOI (Digital Object Identifier) :	10.1155/2011/582945
PMID :	22114738
En línea :	https://www.hindawi.com/journals/heprt/2011/582945/
Enlace permanente :	https://hospitalpablotobon.cloudbiteca.com/pmb/opac_css/index.php?lvl=notice_display&id=3587